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AZIN2 (antizyme inhibitor 2)

Identity

Alias (NCBI)ADC
AZI2
AZIB1
ODC-p
ODC1L
ODCp
HGNC (Hugo) AZIN2
HGNC Alias symbODC-p
ODC1L
KIAA1945
ODCp
HGNC Alias nameornithine decarboxylase like
HGNC Previous nameADC
HGNC Previous namearginine decarboxylase
LocusID (NCBI) 113451
Atlas_Id 53943
Location 1p35.1  [Link to chromosome band 1p35]
Location_base_pair Starts at 33081153 and ends at 33123492 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AZIN2 (1p35.1) / PHIP (6q14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;6)(p35;q14) AZIN2/PHIP


External links

Nomenclature
HGNC (Hugo)AZIN2   29957
Cards
Entrez_Gene (NCBI)AZIN2  113451  antizyme inhibitor 2
AliasesADC; AZI2; AZIB1; ODC-p; 
ODC1L; ODCp
GeneCards (Weizmann)AZIN2
Ensembl hg19 (Hinxton)ENSG00000142920 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142920 [Gene_View]  ENSG00000142920 [Sequence]  chr1:33081153-33123492 [Contig_View]  AZIN2 [Vega]
ICGC DataPortalENSG00000142920
TCGA cBioPortalAZIN2
AceView (NCBI)AZIN2
Genatlas (Paris)AZIN2
WikiGenes113451
SOURCE (Princeton)AZIN2
Genetics Home Reference (NIH)AZIN2
Genomic and cartography
GoldenPath hg38 (UCSC)AZIN2  -     chr1:33081153-33123492 +  1p35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AZIN2  -     1p35.1   [Description]    (hg19-Feb_2009)
GoldenPathAZIN2 - 1p35.1 [CytoView hg19]  AZIN2 - 1p35.1 [CytoView hg38]
ImmunoBaseENSG00000142920
genome Data Viewer NCBIAZIN2 [Mapview hg19]  
OMIM608353   
Gene and transcription
Genbank (Entrez)AB075825 AK057051 AK095127 AK122697 AK315677
RefSeq transcript (Entrez)NM_001293562 NM_001301823 NM_001301824 NM_001301825 NM_001301826 NM_001350398 NM_001350399 NM_001350400 NM_001350401 NM_001350402 NM_001376722 NM_001376724 NM_001376725 NM_001376727 NM_001376729 NM_001376730 NM_001376732 NM_052998
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AZIN2
Alternative Splicing GalleryENSG00000142920
Gene ExpressionAZIN2 [ NCBI-GEO ]   AZIN2 [ EBI - ARRAY_EXPRESS ]   AZIN2 [ SEEK ]   AZIN2 [ MEM ]
Gene Expression Viewer (FireBrowse)AZIN2 [ Firebrowse - Broad ]
GenevisibleExpression of AZIN2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)113451
GTEX Portal (Tissue expression)AZIN2
Human Protein AtlasENSG00000142920-AZIN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96A70   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96A70  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96A70
Splice isoforms : SwissVarQ96A70
PhosPhoSitePlusQ96A70
Domaine pattern : Prosite (Expaxy)ODR_DC_2_1 (PS00878)    ODR_DC_2_2 (PS00879)   
Domains : Interpro (EBI)Ala_racemase/Decarboxylase_C    Azin2    De-COase2_C    De-COase2_CS    De-COase2_N    De-COase2_pyr-phos_BS    Orn/DAP/Arg_de-COase    Orn_de-COase    PLP-binding_barrel   
Domain families : Pfam (Sanger)Orn_Arg_deC_N (PF02784)    Orn_DAP_Arg_deC (PF00278)   
Domain families : Pfam (NCBI)pfam02784    pfam00278   
Conserved Domain (NCBI)AZIN2
DMDM Disease mutations113451
Blocks (Seattle)AZIN2
SuperfamilyQ96A70
Human Protein Atlas [tissue]ENSG00000142920-AZIN2 [tissue]
Peptide AtlasQ96A70
HPRD17657
IPIIPI00165042   IPI00218757   IPI00218758   IPI00411394   IPI00218760   
Protein Interaction databases
DIP (DOE-UCLA)Q96A70
IntAct (EBI)Q96A70
FunCoupENSG00000142920
BioGRIDAZIN2
STRING (EMBL)AZIN2
ZODIACAZIN2
Ontologies - Pathways
QuickGOQ96A70
Ontology : AmiGOornithine decarboxylase activity  protein binding  nucleus  cytoplasm  mitochondrion  cis-Golgi network  trans-Golgi network  cytosol  cytosol  spermatogenesis  arginine decarboxylase activity  transport vesicle  axon  dendrite  cytoplasmic vesicle  endoplasmic reticulum-Golgi intermediate compartment membrane  putrescine biosynthetic process from ornithine  negative regulation of protein catabolic process  negative regulation of protein catabolic process  ornithine decarboxylase activator activity  ornithine decarboxylase activator activity  ornithine decarboxylase activator activity  positive regulation of catalytic activity  positive regulation of catalytic activity  perikaryon  perinuclear region of cytoplasm  agmatine biosynthetic process  trans-Golgi network membrane organization  positive regulation of polyamine transmembrane transport  positive regulation of polyamine transmembrane transport  granular vesicle  
Ontology : EGO-EBIornithine decarboxylase activity  protein binding  nucleus  cytoplasm  mitochondrion  cis-Golgi network  trans-Golgi network  cytosol  cytosol  spermatogenesis  arginine decarboxylase activity  transport vesicle  axon  dendrite  cytoplasmic vesicle  endoplasmic reticulum-Golgi intermediate compartment membrane  putrescine biosynthetic process from ornithine  negative regulation of protein catabolic process  negative regulation of protein catabolic process  ornithine decarboxylase activator activity  ornithine decarboxylase activator activity  ornithine decarboxylase activator activity  positive regulation of catalytic activity  positive regulation of catalytic activity  perikaryon  perinuclear region of cytoplasm  agmatine biosynthetic process  trans-Golgi network membrane organization  positive regulation of polyamine transmembrane transport  positive regulation of polyamine transmembrane transport  granular vesicle  
NDEx NetworkAZIN2
Atlas of Cancer Signalling NetworkAZIN2
Wikipedia pathwaysAZIN2
Orthology - Evolution
OrthoDB113451
GeneTree (enSembl)ENSG00000142920
Phylogenetic Trees/Animal Genes : TreeFamAZIN2
HOGENOMQ96A70
Homologs : HomoloGeneAZIN2
Homology/Alignments : Family Browser (UCSC)AZIN2
Gene fusions - Rearrangements
Fusion : QuiverAZIN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAZIN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AZIN2
dbVarAZIN2
ClinVarAZIN2
1000_GenomesAZIN2 
Exome Variant ServerAZIN2
GNOMAD BrowserENSG00000142920
Varsome BrowserAZIN2
Genetic variants : HAPMAP113451
Genomic Variants (DGV)AZIN2 [DGVbeta]
DECIPHERAZIN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAZIN2 
Mutations
ICGC Data PortalAZIN2 
TCGA Data PortalAZIN2 
Broad Tumor PortalAZIN2
OASIS PortalAZIN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAZIN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAZIN2
Mutations and Diseases : HGMDAZIN2
BioMutasearch AZIN2
DgiDB (Drug Gene Interaction Database)AZIN2
DoCM (Curated mutations)AZIN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AZIN2 (select a term)
intoGenAZIN2
Cancer3DAZIN2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608353   
Orphanet
DisGeNETAZIN2
MedgenAZIN2
Genetic Testing Registry AZIN2
NextProtQ96A70 [Medical]
TSGene113451
GENETestsAZIN2
Target ValidationAZIN2
Huge Navigator AZIN2 [HugePedia]
snp3D : Map Gene to Disease113451
BioCentury BCIQAZIN2
ClinGenAZIN2
Clinical trials, drugs, therapy
Protein Interactions : CTD113451
Pharm GKB GenePA142672642
Clinical trialAZIN2
Miscellaneous
canSAR (ICR)AZIN2 (select the gene name)
HarmonizomeAZIN2
DataMed IndexAZIN2
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAZIN2
EVEXAZIN2
GoPubMedAZIN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:04:29 CEST 2020

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