AZU1 (azurocidin 1)

2003-11-01  

Identity

HGNC
AZU1
LOCATION
19p13.3
LOCUSID
566
ALIAS
AZAMP,AZU,CAP37,HBP,HUMAZUR,NAZC,hHBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 566
MIM: 162815
HGNC: 913
Ensembl: ENSG00000172232

Variants:

dbSNP: 566
ClinVar: 566
TCGA: ENSG00000172232
COSMIC: AZU1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172232ENST00000233997P20160
ENSG00000172232ENST00000592205A0A087WXP0

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
187876422008Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages.55
118612962002Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles.38
158791412005Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances monocyte arrest under flow conditions.29
222783722012The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps.22
128260732003CAP37, a neutrophil-derived inflammatory mediator, augments leukocyte adhesion to endothelial monolayers.21
191513332009Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin).20
145151542003Azurocidin -- inactive serine proteinase homolog acting as a multifunctional inflammatory mediator.16
238834882013Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome.14
118911832002CAP37, a novel inflammatory mediator: its expression in endothelial cells and localization to atherosclerotic lesions.13
222073922012Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study.13

Citation

Dessen P

AZU1 (azurocidin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/736/azu1