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BAG2 (BCL2 associated athanogene 2)

Identity

Other aliasBAG-2
dJ417I1.2
HGNC (Hugo) BAG2
LocusID (NCBI) 9532
Atlas_Id 43159
Location 6p12.1  [Link to chromosome band 6p12]
Location_base_pair Starts at 57172306 and ends at 57185214 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAG2 (6p11.2) / BAG2 (6p11.2)BAG2 (6p11.2) / RNF114 (20q13.13)BAG2 (6p11.2) / ZNF451 (6p12.1)
BAG2 6p11.2 / RNF114 20q13.13BAG2 6p11.2 / ZNF451 6p12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;6)(p11;p12) BAG2/ZNF451
t(6;20)(p11;q13) BAG2/RNF114


External links

Nomenclature
HGNC (Hugo)BAG2   938
Cards
Entrez_Gene (NCBI)BAG2  9532  BCL2 associated athanogene 2
AliasesBAG-2; dJ417I1.2
GeneCards (Weizmann)BAG2
Ensembl hg19 (Hinxton)ENSG00000112208 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112208 [Gene_View]  ENSG00000112208 [Sequence]  chr6:57172306-57185214 [Contig_View]  BAG2 [Vega]
ICGC DataPortalENSG00000112208
TCGA cBioPortalBAG2
AceView (NCBI)BAG2
Genatlas (Paris)BAG2
WikiGenes9532
SOURCE (Princeton)BAG2
Genetics Home Reference (NIH)BAG2
Genomic and cartography
GoldenPath hg38 (UCSC)BAG2  -     chr6:57172306-57185214 +  6p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BAG2  -     6p12.1   [Description]    (hg19-Feb_2009)
EnsemblBAG2 - 6p12.1 [CytoView hg19]  BAG2 - 6p12.1 [CytoView hg38]
Mapping of homologs : NCBIBAG2 [Mapview hg19]  BAG2 [Mapview hg38]
OMIM603882   
Gene and transcription
Genbank (Entrez)AF095192 AK001015 AK023735 AK301934 AL050287
RefSeq transcript (Entrez)NM_004282
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BAG2
Cluster EST : UnigeneHs.745046 [ NCBI ]
CGAP (NCI)Hs.745046
Alternative Splicing GalleryENSG00000112208
Gene ExpressionBAG2 [ NCBI-GEO ]   BAG2 [ EBI - ARRAY_EXPRESS ]   BAG2 [ SEEK ]   BAG2 [ MEM ]
Gene Expression Viewer (FireBrowse)BAG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9532
GTEX Portal (Tissue expression)BAG2
Human Protein AtlasENSG00000112208-BAG2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95816   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95816  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95816
Splice isoforms : SwissVarO95816
PhosPhoSitePlusO95816
Domaine pattern : Prosite (Expaxy)BAG (PS51035)   
Domains : Interpro (EBI)BAG2    BAG_domain   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)BAG (SM00264)  
Conserved Domain (NCBI)BAG2
DMDM Disease mutations9532
Blocks (Seattle)BAG2
SuperfamilyO95816
Human Protein Atlas [tissue]ENSG00000112208-BAG2 [tissue]
Peptide AtlasO95816
HPRD04859
IPIIPI00000643   IPI01013106   IPI00657974   
Protein Interaction databases
DIP (DOE-UCLA)O95816
IntAct (EBI)O95816
FunCoupENSG00000112208
BioGRIDBAG2
STRING (EMBL)BAG2
ZODIACBAG2
Ontologies - Pathways
QuickGOO95816
Ontology : AmiGOadenyl-nucleotide exchange factor activity  adenyl-nucleotide exchange factor activity  protein binding  cytosol  microtubule  protein folding  positive regulation of protein processing  protein metabolic process  axon  dendrite  heat shock protein binding  negative regulation of protein ubiquitination  negative regulation of protein ubiquitination  ubiquitin protein ligase binding  negative regulation of protein binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  identical protein binding  ion channel binding  tau protein binding  protein stabilization  chaperone binding  chaperone complex  regulation of cellular response to heat  dendritic microtubule  positive regulation of proteasomal protein catabolic process  negative regulation of ubiquitin protein ligase activity  
Ontology : EGO-EBIadenyl-nucleotide exchange factor activity  adenyl-nucleotide exchange factor activity  protein binding  cytosol  microtubule  protein folding  positive regulation of protein processing  protein metabolic process  axon  dendrite  heat shock protein binding  negative regulation of protein ubiquitination  negative regulation of protein ubiquitination  ubiquitin protein ligase binding  negative regulation of protein binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  identical protein binding  ion channel binding  tau protein binding  protein stabilization  chaperone binding  chaperone complex  regulation of cellular response to heat  dendritic microtubule  positive regulation of proteasomal protein catabolic process  negative regulation of ubiquitin protein ligase activity  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkBAG2
Atlas of Cancer Signalling NetworkBAG2
Wikipedia pathwaysBAG2
Orthology - Evolution
OrthoDB9532
GeneTree (enSembl)ENSG00000112208
Phylogenetic Trees/Animal Genes : TreeFamBAG2
HOVERGENO95816
HOGENOMO95816
Homologs : HomoloGeneBAG2
Homology/Alignments : Family Browser (UCSC)BAG2
Gene fusions - Rearrangements
Fusion : MitelmanBAG2/RNF114 [6p11.2/20q13.13]  
Fusion : MitelmanBAG2/ZNF451 [6p11.2/6p12.1]  [t(6;6)(p11;p12)]  
Fusion PortalBAG2 6p11.2 RNF114 20q13.13 LUAD
Fusion PortalBAG2 6p11.2 ZNF451 6p12.1 BRCA
Fusion : QuiverBAG2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBAG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BAG2
dbVarBAG2
ClinVarBAG2
1000_GenomesBAG2 
Exome Variant ServerBAG2
ExAC (Exome Aggregation Consortium)ENSG00000112208
GNOMAD BrowserENSG00000112208
Varsome BrowserBAG2
Genetic variants : HAPMAP9532
Genomic Variants (DGV)BAG2 [DGVbeta]
DECIPHERBAG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBAG2 
Mutations
ICGC Data PortalBAG2 
TCGA Data PortalBAG2 
Broad Tumor PortalBAG2
OASIS PortalBAG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBAG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBAG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BAG2
DgiDB (Drug Gene Interaction Database)BAG2
DoCM (Curated mutations)BAG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BAG2 (select a term)
intoGenBAG2
Cancer3DBAG2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603882   
Orphanet
DisGeNETBAG2
MedgenBAG2
Genetic Testing Registry BAG2
NextProtO95816 [Medical]
TSGene9532
GENETestsBAG2
Target ValidationBAG2
Huge Navigator BAG2 [HugePedia]
snp3D : Map Gene to Disease9532
BioCentury BCIQBAG2
ClinGenBAG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9532
Chemical/Pharm GKB GenePA25238
Clinical trialBAG2
Miscellaneous
canSAR (ICR)BAG2 (select the gene name)
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBAG2
EVEXBAG2
GoPubMedBAG2
iHOPBAG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:53:28 CET 2018

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