Atlas of Genetics and Cytogenetics in Oncology and Haematology

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BAG4 (BCL2 associated athanogene 4)

Identity

Alias_symbol (synonym)SODD
Other aliasBAG-4
HGNC (Hugo) BAG4
LocusID (NCBI) 9530
Atlas_Id 743
Location 8p11.23  [Link to chromosome band 8p11]
Location_base_pair Starts at 38176588 and ends at 38213301 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAG4 (8p11.23) / FGFR1 (8p11.23)BAG4 (8p11.23) / NEDD8 (14q12)BAG4 (8p11.23) / NEDD8-MDP1 (14q12)
BAG4 (8p11.23) / TP53INP1 (8q22.1)BAG4 (8p11.23) / ZMAT4 (8p11.21)BAG4 8p11.23 / FGFR1 8p11.23
BAG4 8p11.23 / NEDD8 14q12BAG4 8p11.23 / NEDD8-MDP1 14q12BAG4 8p11.23 / TP53INP1 8q22.1
BAG4 8p11.23 / ZMAT4 8p11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  Lung: Translocations in Squamous Cell Carcinoma
BAG4/ZMAT4 (8p11)
BAG4/FGFR1 (8p11)
t(8;8)(p11;q22) BAG4/TP53INP1
t(8;14)(p11;q12) BAG4/NEDD8-MDP1
t(8;14)(p11;q12) BAG4/NEDD8

External links

Nomenclature
HGNC (Hugo)BAG4   940
Cards
Entrez_Gene (NCBI)BAG4  9530  BCL2 associated athanogene 4
AliasesBAG-4; SODD
GeneCards (Weizmann)BAG4
Ensembl hg19 (Hinxton)ENSG00000156735 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156735 [Gene_View]  ENSG00000156735 [Sequence]  chr8:38176588-38213301 [Contig_View]  BAG4 [Vega]
ICGC DataPortalENSG00000156735
TCGA cBioPortalBAG4
AceView (NCBI)BAG4
Genatlas (Paris)BAG4
WikiGenes9530
SOURCE (Princeton)BAG4
Genetics Home Reference (NIH)BAG4
Genomic and cartography
GoldenPath hg38 (UCSC)BAG4  -     chr8:38176588-38213301 +  8p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BAG4  -     8p11.23   [Description]    (hg19-Feb_2009)
EnsemblBAG4 - 8p11.23 [CytoView hg19]  BAG4 - 8p11.23 [CytoView hg38]
Mapping of homologs : NCBIBAG4 [Mapview hg19]  BAG4 [Mapview hg38]
OMIM603884   
Gene and transcription
Genbank (Entrez)AF095194 AF111116 AI640615 AK304072 AK314020
RefSeq transcript (Entrez)NM_001204878 NM_004874
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BAG4
Cluster EST : UnigeneHs.194726 [ NCBI ]
CGAP (NCI)Hs.194726
Alternative Splicing GalleryENSG00000156735
Gene ExpressionBAG4 [ NCBI-GEO ]   BAG4 [ EBI - ARRAY_EXPRESS ]   BAG4 [ SEEK ]   BAG4 [ MEM ]
Gene Expression Viewer (FireBrowse)BAG4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9530
GTEX Portal (Tissue expression)BAG4
Human Protein AtlasENSG00000156735-BAG4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95429   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95429  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95429
Splice isoforms : SwissVarO95429
PhosPhoSitePlusO95429
Domaine pattern : Prosite (Expaxy)BAG (PS51035)   
Domains : Interpro (EBI)BAG_dom_sf    BAG_domain   
Domain families : Pfam (Sanger)BAG (PF02179)   
Domain families : Pfam (NCBI)pfam02179   
Domain families : Smart (EMBL)BAG (SM00264)  
Conserved Domain (NCBI)BAG4
DMDM Disease mutations9530
Blocks (Seattle)BAG4
PDB (RSDB)1M62    1M7K   
PDB Europe1M62    1M7K   
PDB (PDBSum)1M62    1M7K   
PDB (IMB)1M62    1M7K   
Structural Biology KnowledgeBase1M62    1M7K   
SCOP (Structural Classification of Proteins)1M62    1M7K   
CATH (Classification of proteins structures)1M62    1M7K   
SuperfamilyO95429
Human Protein Atlas [tissue]ENSG00000156735-BAG4 [tissue]
Peptide AtlasO95429
HPRD04861
IPIIPI00030695   IPI00798092   IPI00982893   
Protein Interaction databases
DIP (DOE-UCLA)O95429
IntAct (EBI)O95429
FunCoupENSG00000156735
BioGRIDBAG4
STRING (EMBL)BAG4
ZODIACBAG4
Ontologies - Pathways
QuickGOO95429
Ontology : AmiGOadenyl-nucleotide exchange factor activity  RNA binding  protein binding  nucleus  cytosol  cytosol  plasma membrane  protein folding  positive regulation of fibroblast migration  positive regulation of actin filament polymerization  ubiquitin protein ligase binding  positive regulation of peptidyl-serine phosphorylation  tumor necrosis factor-mediated signaling pathway  negative regulation of apoptotic process  positive regulation of cell adhesion  chaperone binding  positive regulation of stress fiber assembly  positive regulation of protein kinase B signaling  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  protein localization to plasma membrane  ruffle assembly  regulation of cellular response to heat  negative regulation of protein targeting to mitochondrion  negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity  
Ontology : EGO-EBIadenyl-nucleotide exchange factor activity  RNA binding  protein binding  nucleus  cytosol  cytosol  plasma membrane  protein folding  positive regulation of fibroblast migration  positive regulation of actin filament polymerization  ubiquitin protein ligase binding  positive regulation of peptidyl-serine phosphorylation  tumor necrosis factor-mediated signaling pathway  negative regulation of apoptotic process  positive regulation of cell adhesion  chaperone binding  positive regulation of stress fiber assembly  positive regulation of protein kinase B signaling  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  protein localization to plasma membrane  ruffle assembly  regulation of cellular response to heat  negative regulation of protein targeting to mitochondrion  negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity  
Pathways : KEGGTNF signaling pathway   
NDEx NetworkBAG4
Atlas of Cancer Signalling NetworkBAG4
Wikipedia pathwaysBAG4
Orthology - Evolution
OrthoDB9530
GeneTree (enSembl)ENSG00000156735
Phylogenetic Trees/Animal Genes : TreeFamBAG4
HOGENOMO95429
Homologs : HomoloGeneBAG4
Homology/Alignments : Family Browser (UCSC)BAG4
Gene fusions - Rearrangements
Fusion : MitelmanBAG4/FGFR1 [8p11.23/8p11.23]  
Fusion : MitelmanBAG4/NEDD8 [8p11.23/14q12]  [t(8;14)(p11;q12)]  
Fusion : MitelmanBAG4/NEDD8-MDP1 [8p11.23/14q12]  [t(8;14)(p11;q12)]  
Fusion : MitelmanBAG4/TP53INP1 [8p11.23/8q22.1]  [t(8;8)(p11;q22)]  
Fusion : MitelmanBAG4/ZMAT4 [8p11.23/8p11.21]  [t(8;8)(p11;p11)]  
Fusion PortalBAG4 8p11.23 FGFR1 8p11.23 LUSC
Fusion PortalBAG4 8p11.23 NEDD8 14q12 BRCA
Fusion PortalBAG4 8p11.23 NEDD8-MDP1 14q12 BRCA
Fusion PortalBAG4 8p11.23 TP53INP1 8q22.1 BRCA
Fusion PortalBAG4 8p11.23 ZMAT4 8p11.21 BRCA
Fusion : QuiverBAG4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBAG4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BAG4
dbVarBAG4
ClinVarBAG4
1000_GenomesBAG4 
Exome Variant ServerBAG4
ExAC (Exome Aggregation Consortium)ENSG00000156735
GNOMAD BrowserENSG00000156735
Varsome BrowserBAG4
Genetic variants : HAPMAP9530
Genomic Variants (DGV)BAG4 [DGVbeta]
DECIPHERBAG4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBAG4 
Mutations
ICGC Data PortalBAG4 
TCGA Data PortalBAG4 
Broad Tumor PortalBAG4
OASIS PortalBAG4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBAG4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBAG4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BAG4
DgiDB (Drug Gene Interaction Database)BAG4
DoCM (Curated mutations)BAG4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BAG4 (select a term)
intoGenBAG4
Cancer3DBAG4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603884   
Orphanet
DisGeNETBAG4
MedgenBAG4
Genetic Testing Registry BAG4
NextProtO95429 [Medical]
TSGene9530
GENETestsBAG4
Target ValidationBAG4
Huge Navigator BAG4 [HugePedia]
snp3D : Map Gene to Disease9530
BioCentury BCIQBAG4
ClinGenBAG4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9530
Chemical/Pharm GKB GenePA25240
Clinical trialBAG4
Miscellaneous
canSAR (ICR)BAG4 (select the gene name)
DataMed IndexBAG4
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBAG4
EVEXBAG4
GoPubMedBAG4
iHOPBAG4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:02:49 CET 2019
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