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BAG6 (BCL2 associated athanogene 6)

Identity

Alias_namesBAT3
HLA-B associated transcript 3
Alias_symbol (synonym)G3
D6S52E
Other aliasBAG-6
HGNC (Hugo) BAG6
LocusID (NCBI) 7917
Atlas_Id 51841
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31639028 and ends at 31652700 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAG6 (6p21.33) / KIAA1522 (1p35.1)BAG6 (6p21.33) / LY6G5C (6p21.33)BAG6 (6p21.33) / SLC44A4 (6p21.33)
BAG6 (6p21.33) / TAF8 (6p21.1)BAG6 (6p21.33) / TMEM175 (4p16.3)C6orf47 (6p21.33) / BAG6 (6p21.33)
MYBBP1A (17p13.2) / BAG6 (6p21.33)NDRG2 (14q11.2) / BAG6 (6p21.33)TMEM175 (4p16.3) / BAG6 (6p21.33)
BAG6 6p21.33 / LY6G5C 6p21.33BAG6 6p21.33 / TAF8 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Nodular lymphocyte-predominant Hodgkin lymphoma


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  BAG6/LY6G5C (6p21)
BAG6/TAF8 (6p21)


External links

Nomenclature
HGNC (Hugo)BAG6   13919
Cards
Entrez_Gene (NCBI)BAG6  7917  BCL2 associated athanogene 6
AliasesBAG-6; BAT3; D6S52E; G3
GeneCards (Weizmann)BAG6
Ensembl hg19 (Hinxton)ENSG00000204463 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204463 [Gene_View]  ENSG00000204463 [Sequence]  chr6:31639028-31652700 [Contig_View]  BAG6 [Vega]
ICGC DataPortalENSG00000204463
TCGA cBioPortalBAG6
AceView (NCBI)BAG6
Genatlas (Paris)BAG6
WikiGenes7917
SOURCE (Princeton)BAG6
Genetics Home Reference (NIH)BAG6
Genomic and cartography
GoldenPath hg38 (UCSC)BAG6  -     chr6:31639028-31652700 -  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BAG6  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblBAG6 - 6p21.33 [CytoView hg19]  BAG6 - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBIBAG6 [Mapview hg19]  BAG6 [Mapview hg38]
OMIM142590   
Gene and transcription
Genbank (Entrez)AK302695 AK304879 AU134255 BC003133 BF515863
RefSeq transcript (Entrez)NM_001098534 NM_001199697 NM_001199698 NM_004639 NM_080702 NM_080703
RefSeq genomic (Entrez)NC_000006 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)BAG6
Cluster EST : UnigeneHs.440900 [ NCBI ]
CGAP (NCI)Hs.440900
Alternative Splicing GalleryENSG00000204463
Gene ExpressionBAG6 [ NCBI-GEO ]   BAG6 [ EBI - ARRAY_EXPRESS ]   BAG6 [ SEEK ]   BAG6 [ MEM ]
Gene Expression Viewer (FireBrowse)BAG6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7917
GTEX Portal (Tissue expression)BAG6
Human Protein AtlasENSG00000204463-BAG6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46379   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46379  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46379
Splice isoforms : SwissVarP46379
PhosPhoSitePlusP46379
Domaine pattern : Prosite (Expaxy)UBIQUITIN_1 (PS00299)    UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)BAG6    Ubiquitin-like_domsf    Ubiquitin_CS    Ubiquitin_dom   
Domain families : Pfam (Sanger)DUF3538 (PF12057)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam12057    pfam00240   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)BAG6
DMDM Disease mutations7917
Blocks (Seattle)BAG6
PDB (SRS)1WX9    2N9P    4DWF    4EEW    4WWR    4X86    6AU8   
PDB (PDBSum)1WX9    2N9P    4DWF    4EEW    4WWR    4X86    6AU8   
PDB (IMB)1WX9    2N9P    4DWF    4EEW    4WWR    4X86    6AU8   
PDB (RSDB)1WX9    2N9P    4DWF    4EEW    4WWR    4X86    6AU8   
Structural Biology KnowledgeBase1WX9    2N9P    4DWF    4EEW    4WWR    4X86    6AU8   
SCOP (Structural Classification of Proteins)1WX9    2N9P    4DWF    4EEW    4WWR    4X86    6AU8   
CATH (Classification of proteins structures)1WX9    2N9P    4DWF    4EEW    4WWR    4X86    6AU8   
SuperfamilyP46379
Human Protein Atlas [tissue]ENSG00000204463-BAG6 [tissue]
Peptide AtlasP46379
HPRD00808
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)P46379
IntAct (EBI)P46379
FunCoupENSG00000204463
BioGRIDBAG6
STRING (EMBL)BAG6
ZODIACBAG6
Ontologies - Pathways
QuickGOP46379
Ontology : AmiGOkidney development  immune response-activating cell surface receptor signaling pathway  signaling receptor binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  chromatin organization  ubiquitin-dependent protein catabolic process  apoptotic process  synaptonemal complex assembly  spermatogenesis  brain development  proteasomal protein catabolic process  membrane  membrane  internal peptidyl-lysine acetylation  natural killer cell activation  cell differentiation  lung development  ubiquitin-dependent ERAD pathway  ubiquitin-dependent ERAD pathway  Hsp70 protein binding  polyubiquitin modification-dependent protein binding  ubiquitin protein ligase binding  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of cell proliferation  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  ribosome binding  negative regulation of apoptotic process  intracellular membrane-bounded organelle  negative regulation of proteolysis  regulation of embryonic development  protein stabilization  misfolded protein binding  endoplasmic reticulum stress-induced pre-emptive quality control  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  extracellular exosome  proteasome binding  ER-associated misfolded protein catabolic process  tail-anchored membrane protein insertion into ER membrane  BAT3 complex  positive regulation of ERAD pathway  maintenance of unfolded protein involved in ERAD pathway  protein localization to cytosolic proteasome complex involved in ERAD pathway  ubiquitin-specific protease binding  
Ontology : EGO-EBIkidney development  immune response-activating cell surface receptor signaling pathway  signaling receptor binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  chromatin organization  ubiquitin-dependent protein catabolic process  apoptotic process  synaptonemal complex assembly  spermatogenesis  brain development  proteasomal protein catabolic process  membrane  membrane  internal peptidyl-lysine acetylation  natural killer cell activation  cell differentiation  lung development  ubiquitin-dependent ERAD pathway  ubiquitin-dependent ERAD pathway  Hsp70 protein binding  polyubiquitin modification-dependent protein binding  ubiquitin protein ligase binding  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of cell proliferation  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  ribosome binding  negative regulation of apoptotic process  intracellular membrane-bounded organelle  negative regulation of proteolysis  regulation of embryonic development  protein stabilization  misfolded protein binding  endoplasmic reticulum stress-induced pre-emptive quality control  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  extracellular exosome  proteasome binding  ER-associated misfolded protein catabolic process  tail-anchored membrane protein insertion into ER membrane  BAT3 complex  positive regulation of ERAD pathway  maintenance of unfolded protein involved in ERAD pathway  protein localization to cytosolic proteasome complex involved in ERAD pathway  ubiquitin-specific protease binding  
NDEx NetworkBAG6
Atlas of Cancer Signalling NetworkBAG6
Wikipedia pathwaysBAG6
Orthology - Evolution
OrthoDB7917
GeneTree (enSembl)ENSG00000204463
Phylogenetic Trees/Animal Genes : TreeFamBAG6
HOVERGENP46379
HOGENOMP46379
Homologs : HomoloGeneBAG6
Homology/Alignments : Family Browser (UCSC)BAG6
Gene fusions - Rearrangements
Fusion : MitelmanBAG6/LY6G5C [6p21.33/6p21.33]  
Fusion : MitelmanBAG6/TAF8 [6p21.33/6p21.1]  [t(6;6)(p21;p21)]  
Fusion PortalBAG6 6p21.33 LY6G5C 6p21.33 BRCA
Fusion PortalBAG6 6p21.33 TAF8 6p21.1 LUSC
Fusion Cancer (Beijing)BAG6 [6p21.33]  -  SLC44A4 [6p21.33]  [FUSC001403]  [FUSC001403]  [FUSC001403]
Fusion : QuiverBAG6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBAG6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BAG6
dbVarBAG6
ClinVarBAG6
1000_GenomesBAG6 
Exome Variant ServerBAG6
ExAC (Exome Aggregation Consortium)ENSG00000204463
GNOMAD BrowserENSG00000204463
Varsome BrowserBAG6
Genetic variants : HAPMAP7917
Genomic Variants (DGV)BAG6 [DGVbeta]
DECIPHERBAG6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBAG6 
Mutations
ICGC Data PortalBAG6 
TCGA Data PortalBAG6 
Broad Tumor PortalBAG6
OASIS PortalBAG6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBAG6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBAG6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BAG6
DgiDB (Drug Gene Interaction Database)BAG6
DoCM (Curated mutations)BAG6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BAG6 (select a term)
intoGenBAG6
Cancer3DBAG6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142590   
Orphanet
DisGeNETBAG6
MedgenBAG6
Genetic Testing Registry BAG6
NextProtP46379 [Medical]
TSGene7917
GENETestsBAG6
Target ValidationBAG6
Huge Navigator BAG6 [HugePedia]
snp3D : Map Gene to Disease7917
BioCentury BCIQBAG6
ClinGenBAG6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7917
Chemical/Pharm GKB GenePA25264
Clinical trialBAG6
Miscellaneous
canSAR (ICR)BAG6 (select the gene name)
Probes
Litterature
PubMed148 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBAG6
EVEXBAG6
GoPubMedBAG6
iHOPBAG6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:11:06 CEST 2018

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