BAG6 (BAG cochaperone 6)

2010-12-01 Affiliation

Identity

HGNC

BAG6

LOCATION

6p21.33

LOCUSID

7917

ALIAS

BAG-6,BAT3,D6S52E,G3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7917
MIM: 142590
HGNC: 13919
Ensembl: ENSG00000204463

Variants:

dbSNP: 7917
ClinVar: 7917
TCGA: ENSG00000204463
COSMIC: BAG6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204463	ENST00000211379	P46379
ENSG00000204463	ENST00000211379	A0A1U9X7A6
ENSG00000204463	ENST00000362049	P46379
ENSG00000204463	ENST00000375964	P46379
ENSG00000204463	ENST00000375976	P46379
ENSG00000204463	ENST00000375976	A0A1U9X7A6
ENSG00000204463	ENST00000422948	H0Y4L1
ENSG00000204463	ENST00000424176	F6XTU0
ENSG00000204463	ENST00000424480	F6VEM6
ENSG00000204463	ENST00000428326	F6U341
ENSG00000204463	ENST00000433828	F6X9W3
ENSG00000204463	ENST00000434444	F6WML8
ENSG00000204463	ENST00000435080	F6S6P2
ENSG00000204463	ENST00000437771	X6REW1
ENSG00000204463	ENST00000438149	H0Y759
ENSG00000204463	ENST00000439687	P46379
ENSG00000204463	ENST00000441054	F6U1F2
ENSG00000204463	ENST00000441793	H0Y710
ENSG00000204463	ENST00000451898	A0A1B0GX79
ENSG00000204463	ENST00000452994	F6U341
ENSG00000204463	ENST00000453833	H0Y7K4
ENSG00000204463	ENST00000454165	F6TC96
ENSG00000204463	ENST00000456286	F6UR09
ENSG00000204463	ENST00000456622	F6WML8

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA448785	carbamazepine	Chemical	ClinicalAnnotation	associated		PD	16538176

References

Pubmed ID	Year	Title	Citations
18978787	2008	Common 5p15.33 and 6p21.33 variants influence lung cancer risk.	243
18055229	2007	Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells.	124
19115949	2009	Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).	119
22863785	2012	Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.	90
18852879	2008	Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function.	86
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
17403783	2007	HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.	63
20713601	2010	BAG-6 is essential for selective elimination of defective proteasomal substrates.	57
19851445	2009	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	51
24981174	2014	Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.	47

Citation

Dessen P

BAG6 (BAG cochaperone 6)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51841/bag6