BANF1 (BAF nuclear assembly factor 1)

2019-04-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
BAF,BCRP1,D14S1460,NGPS

Other Information

Locus ID:

NCBI: 8815
MIM: 603811
HGNC: 17397
Ensembl: ENSG00000175334

Variants:

dbSNP: 8815
ClinVar: 8815
TCGA: ENSG00000175334
COSMIC: BANF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175334ENST00000312175O75531
ENSG00000175334ENST00000312175A0A024R5H0
ENSG00000175334ENST00000445560O75531
ENSG00000175334ENST00000445560A0A024R5H0
ENSG00000175334ENST00000527348O75531
ENSG00000175334ENST00000527348A0A024R5H0
ENSG00000175334ENST00000530204E9PJJ8
ENSG00000175334ENST00000533166O75531
ENSG00000175334ENST00000533166A0A024R5H0

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Early Phase of HIV Life CycleREACTOMER-HSA-162594
Integration of provirusREACTOMER-HSA-162592
Integration of viral DNA into host genomic DNAREACTOMER-HSA-175567
2-LTR circle formationREACTOMER-HSA-164843
Autointegration results in viral DNA circlesREACTOMER-HSA-177539
Host Interactions of HIV factorsREACTOMER-HSA-162909
Interactions of Vpr with host cellular proteinsREACTOMER-HSA-176033
Vpr-mediated nuclear import of PICsREACTOMER-HSA-180910
APOBEC3G mediated resistance to HIV-1 infectionREACTOMER-HSA-180689
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Nuclear Envelope BreakdownREACTOMER-HSA-2980766
Clearance of Nuclear Envelope Membranes from ChromatinREACTOMER-HSA-2993913
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Nuclear Envelope ReassemblyREACTOMER-HSA-2995410
Initiation of Nuclear Envelope ReformationREACTOMER-HSA-2995383

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
117928212001Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF.90
155469162004LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly.77
186283002008Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly.77
124937652003Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro.76
117928222001BAF is required for emerin assembly into the reforming nuclear envelope.75
126638132003The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes.64
215493372011Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome.62
180056982007Poxviral B1 kinase overcomes barrier to autointegration factor, a host defense against virus replication.51
197599132009Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners.49
214476252011Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.47

Citation

Dessen P

BANF1 (BAF nuclear assembly factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57801/banf1