BCAR3 (BCAR3 adaptor protein, NSP family member)

2003-06-01  

Identity

HGNC
LOCATION
1p22.1
LOCUSID
ALIAS
AND-34,MIG7,NSP2,SH2D3B
FUSION GENES

Other Information

Locus ID:

NCBI: 8412
MIM: 604704
HGNC: 973
Ensembl: ENSG00000137936

Variants:

dbSNP: 8412
ClinVar: 8412
TCGA: ENSG00000137936
COSMIC: BCAR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137936ENST00000260502O75815
ENSG00000137936ENST00000260502A0A384MTS3
ENSG00000137936ENST00000370243O75815
ENSG00000137936ENST00000370243A0A384MTS3
ENSG00000137936ENST00000370244O75815
ENSG00000137936ENST00000370244A0A384MTS3
ENSG00000137936ENST00000370247O75815
ENSG00000137936ENST00000539242O75815

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
176166742007Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling.32
156712472005AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner.21
174271982007AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology.17
194543142009AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern.13
199401592010BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
212623522011BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas.10
237624092013Breast cancer antiestrogen resistance 3 (BCAR3) promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells.10
172703632007Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling.9

Citation

Dessen P

BCAR3 (BCAR3 adaptor protein, NSP family member)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/763/bcar3