Atlas of Genetics and Cytogenetics in Oncology and Haematology


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BCAR3 (breast cancer anti-estrogen resistance 3)

Identity

Alias_symbol (synonym)NSP2
SH2D3B
Other alias
HGNC (Hugo) BCAR3
LocusID (NCBI) 8412
Atlas_Id 763
Location 1p22.1  [Link to chromosome band 1p22]
Location_base_pair Starts at 93561786 and ends at 93847150 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCAR3 (1p22.1) / ABCA4 (1p22.1)BCAR3 (1p22.1) / BCAR3 (1p22.1)BCAR3 (1p22.1) / CTSL (9q21.33)
BCAR3 (1p22.1) / ODF3L2 (19p13.3)BCAR3 (1p22.1) / RAD23B (9q31.2)C10orf12 (10q24.1) / BCAR3 (1p22.1)
CAMSAP2 (1q32.1) / BCAR3 (1p22.1)SH3PXD2B (5q35.1) / BCAR3 (1p22.1)BCAR3 1p22.1 / ODF3L2 19p13.3
CAMSAP1L1 BCAR3 1p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BCAR3   973
Cards
Entrez_Gene (NCBI)BCAR3  8412  breast cancer anti-estrogen resistance 3
AliasesNSP2; SH2D3B
GeneCards (Weizmann)BCAR3
Ensembl hg19 (Hinxton)ENSG00000137936 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137936 [Gene_View]  chr1:93561786-93847150 [Contig_View]  BCAR3 [Vega]
ICGC DataPortalENSG00000137936
TCGA cBioPortalBCAR3
AceView (NCBI)BCAR3
Genatlas (Paris)BCAR3
WikiGenes8412
SOURCE (Princeton)BCAR3
Genetics Home Reference (NIH)BCAR3
Genomic and cartography
GoldenPath hg38 (UCSC)BCAR3  -     chr1:93561786-93847150 -  1p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BCAR3  -     1p22.1   [Description]    (hg19-Feb_2009)
EnsemblBCAR3 - 1p22.1 [CytoView hg19]  BCAR3 - 1p22.1 [CytoView hg38]
Mapping of homologs : NCBIBCAR3 [Mapview hg19]  BCAR3 [Mapview hg38]
OMIM604704   
Gene and transcription
Genbank (Entrez)AF124250 AK027785 AK055442 AK301570 AK310970
RefSeq transcript (Entrez)NM_001261408 NM_001261409 NM_001261410 NM_001308251 NM_003567
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BCAR3
Cluster EST : UnigeneHs.36958 [ NCBI ]
CGAP (NCI)Hs.36958
Alternative Splicing GalleryENSG00000137936
Gene ExpressionBCAR3 [ NCBI-GEO ]   BCAR3 [ EBI - ARRAY_EXPRESS ]   BCAR3 [ SEEK ]   BCAR3 [ MEM ]
Gene Expression Viewer (FireBrowse)BCAR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8412
GTEX Portal (Tissue expression)BCAR3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75815   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75815  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75815
Splice isoforms : SwissVarO75815
PhosPhoSitePlusO75815
Domaine pattern : Prosite (Expaxy)RASGEF_CAT (PS50009)    SH2 (PS50001)   
Domains : Interpro (EBI)BCAR3    Ras_GEF_dom    RASGEF_cat_dom    SH2   
Domain families : Pfam (Sanger)RasGEF (PF00617)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00617    pfam00017   
Domain families : Smart (EMBL)RasGEF (SM00147)  SH2 (SM00252)  
Conserved Domain (NCBI)BCAR3
DMDM Disease mutations8412
Blocks (Seattle)BCAR3
PDB (SRS)3T6A   
PDB (PDBSum)3T6A   
PDB (IMB)3T6A   
PDB (RSDB)3T6A   
Structural Biology KnowledgeBase3T6A   
SCOP (Structural Classification of Proteins)3T6A   
CATH (Classification of proteins structures)3T6A   
SuperfamilyO75815
Human Protein AtlasENSG00000137936
Peptide AtlasO75815
HPRD05268
IPIIPI00179053   IPI01009616   IPI00642957   
Protein Interaction databases
DIP (DOE-UCLA)O75815
IntAct (EBI)O75815
FunCoupENSG00000137936
BioGRIDBCAR3
STRING (EMBL)BCAR3
ZODIACBCAR3
Ontologies - Pathways
QuickGOO75815
Ontology : AmiGOlens morphogenesis in camera-type eye  SH3/SH2 adaptor activity  guanyl-nucleotide exchange factor activity  protein binding  intracellular  signal transduction  small GTPase mediated signal transduction  positive regulation of signal transduction  positive regulation of peptidyl-serine phosphorylation  response to drug  positive regulation of GTPase activity  
Ontology : EGO-EBIlens morphogenesis in camera-type eye  SH3/SH2 adaptor activity  guanyl-nucleotide exchange factor activity  protein binding  intracellular  signal transduction  small GTPase mediated signal transduction  positive regulation of signal transduction  positive regulation of peptidyl-serine phosphorylation  response to drug  positive regulation of GTPase activity  
NDEx NetworkBCAR3
Atlas of Cancer Signalling NetworkBCAR3
Wikipedia pathwaysBCAR3
Orthology - Evolution
OrthoDB8412
GeneTree (enSembl)ENSG00000137936
Phylogenetic Trees/Animal Genes : TreeFamBCAR3
HOVERGENO75815
HOGENOMO75815
Homologs : HomoloGeneBCAR3
Homology/Alignments : Family Browser (UCSC)BCAR3
Gene fusions - Rearrangements
Fusion : MitelmanBCAR3/ABCA4 [1p22.1/1p22.1]  
Fusion : MitelmanBCAR3/ODF3L2 [1p22.1/19p13.3]  [t(1;19)(p22;p13)]  
Fusion : MitelmanCAMSAP2/BCAR3 [1q32.1/1p22.1]  [t(1;1)(p22;q32)]  
Fusion: TCGABCAR3 1p22.1 ODF3L2 19p13.3 BRCA
Fusion: TCGACAMSAP1L1 BCAR3 1p22.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBCAR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BCAR3
dbVarBCAR3
ClinVarBCAR3
1000_GenomesBCAR3 
Exome Variant ServerBCAR3
ExAC (Exome Aggregation Consortium)BCAR3 (select the gene name)
Genetic variants : HAPMAP8412
Genomic Variants (DGV)BCAR3 [DGVbeta]
DECIPHERBCAR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBCAR3 
Mutations
ICGC Data PortalBCAR3 
TCGA Data PortalBCAR3 
Broad Tumor PortalBCAR3
OASIS PortalBCAR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBCAR3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBCAR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BCAR3
DgiDB (Drug Gene Interaction Database)BCAR3
DoCM (Curated mutations)BCAR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BCAR3 (select a term)
intoGenBCAR3
Cancer3DBCAR3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604704   
Orphanet
MedgenBCAR3
Genetic Testing Registry BCAR3
NextProtO75815 [Medical]
TSGene8412
GENETestsBCAR3
Target ValidationBCAR3
Huge Navigator BCAR3 [HugePedia]
snp3D : Map Gene to Disease8412
BioCentury BCIQBCAR3
ClinGenBCAR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8412
Chemical/Pharm GKB GenePA25283
Clinical trialBCAR3
Miscellaneous
canSAR (ICR)BCAR3 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBCAR3
EVEXBCAR3
GoPubMedBCAR3
iHOPBCAR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:25:19 CEST 2017

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