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BCAS3 (breast carcinoma amplified sequence 3)

Written2004-05Jean-Loup Huret, Sylvie Senon
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)MAAB
GAOB1
HGNC (Hugo) BCAS3
HGNC Alias symbFLJ20128
PHAF2
HGNC Alias nameRudhira
 phagophore assembly factor 2
HGNC Previous namebreast carcinoma amplified sequence 3
 BCAS3, microtubule associated cell migration factor
LocusID (NCBI) 54828
Atlas_Id 766
Location 17q23.2  [Link to chromosome band 17q23]
Location_base_pair Starts at 60677851 and ends at 61392831 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping BCAS3.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABCA5 (17q24.3)::BCAS3 (17q23.2)B4GALT3 (1q23.3)::BCAS3 (17q23.2)BCAS3 (17q23.2)::ABCA8 (17q24.2)
BCAS3 (17q23.2)::ADGRB2 (1p35.2)BCAS3 (17q23.2)::APPBP2 (17q23.2)BCAS3 (17q23.2)::ARHGAP15 (2q22.2)
BCAS3 (17q23.2)::ATXN7 (3p14.1)BCAS3 (17q23.2)::AXIN2 (17q24.1)BCAS3 (17q23.2)::BCAS3 (17q23.2)
BCAS3 (17q23.2)::BRIP1 (17q23.2)BCAS3 (17q23.2)::CYTH1 (17q25.3)BCAS3 (17q23.2)::DISP1 (1q41)
BCAS3 (17q23.2)::DPY19L2P1 (7p14.2)BCAS3 (17q23.2)::GH2 (17q23.3)BCAS3 (17q23.2)::GIT1 (17q11.2)
BCAS3 (17q23.2)::GOLPH3L (1q21.3)BCAS3 (17q23.2)::GRIK2 (6q16.3)BCAS3 (17q23.2)::HOXB9 (17q21.32)
BCAS3 (17q23.2)::KAT7 (17q21.33)BCAS3 (17q23.2)::MAP3K3 (17q23.3)BCAS3 (17q23.2)::MARCH10 (17q23.2)
BCAS3 (17q23.2)::MED13 (17q23.2)BCAS3 (17q23.2)::NFS1 (20q11.22)BCAS3 (17q23.2)::POLD4 (11q13.2)
BCAS3 (17q23.2)::PRKAA2 (1p32.2)BCAS3 (17q23.2)::RAD51C (17q22)BCAS3 (17q23.2)::REG4 (1p12)
BCAS3 (17q23.2)::RNF169 (11q13.4)BCAS3 (17q23.2)::RNFT1 (17q23.1)BCAS3 (17q23.2)::SMURF1 (7q22.1)
BCAS3 (17q23.2)::VMP1 (17q23.1)BCAS3 (17q23.2)::WIPI1 (17q24.2)BCAS3 (17q23.2)::XRRA1 (11q13.4)
BCAS4 (20q13.13)::BCAS3 (17q23.2)BPTF (17q24.2)::BCAS3 (17q23.2)CLTC (17q23.1)::BCAS3 (17q23.2)
FBXL20 (17q12)::BCAS3 (17q23.2)GMDS (6p25.3)::BCAS3 (17q23.2)IKZF3 (17q12)::BCAS3 (17q23.2)
MED13 (17q23.2)::BCAS3 (17q23.2)NLK (17q11.2)::BCAS3 (17q23.2)PIGU (20q11.22)::BCAS3 (17q23.2)
RAD51C (17q22)::BCAS3 (17q23.2)SKAP1 (17q21.32)::BCAS3 (17q23.2)TAOK1 (17q11.2)::BCAS3 (17q23.2)
USP32 (17q23.1)::BCAS3 (17q23.2)ZNF217 (20q13.2)::BCAS3 (17q23.2)

DNA/RNA

Description spans 715 kb; orientation direct strand; at least 77 exons
Transcription alternate splicings: 3.9 kb, 3.3 kb, 2.3 kb, 1.5 kb, 1.3 kb.

Protein

Expression ubiquitous
Localisation nuclear (potential)

Implicated in

Note
  
Entity BCAS3 is overexpressed in about 10% of breast cancers, and a hybrid gene BCAS4-BCAS3 was found in breat cancer cell line with a t(17;20)(q23;q13)
Hybrid/Mutated Gene 5' BCAS4 is fused to the 2 last exons (23 and 24) of BCAS3; transcript includes exon 1 from BCAS4 and 21 bp from BCAS3 exon 23; it encodes a 66 aminoacids protein; no reciprocal transcript
  

Bibliography

Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer.
Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A
Genes, chromosomes & cancer. 2002 ; 35 (4) : 311-317.
PMID 12378525
 

Citation

This paper should be referenced as such :
Huret, JL ; Senon, S
BCAS3 (breast carcinoma amplified sequence 3)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):188-188.
Free journal version : [ pdf ]   [ DOI ]


External links

Nomenclature
HGNC (Hugo)BCAS3   14347
Cards
AtlasBCAS3ID766
Entrez_Gene (NCBI)BCAS3    BCAS3 microtubule associated cell migration factor
AliasesGAOB1; MAAB; PHAF2
GeneCards (Weizmann)BCAS3
Ensembl hg19 (Hinxton)ENSG00000141376 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141376 [Gene_View]  ENSG00000141376 [Sequence]  chr17:60677851-61392831 [Contig_View]  BCAS3 [Vega]
ICGC DataPortalENSG00000141376
TCGA cBioPortalBCAS3
AceView (NCBI)BCAS3
Genatlas (Paris)BCAS3
SOURCE (Princeton)BCAS3
Genetics Home Reference (NIH)BCAS3
Genomic and cartography
GoldenPath hg38 (UCSC)BCAS3  -     chr17:60677851-61392831 +  17q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BCAS3  -     17q23.2   [Description]    (hg19-Feb_2009)
GoldenPathBCAS3 - 17q23.2 [CytoView hg19]  BCAS3 - 17q23.2 [CytoView hg38]
ImmunoBaseENSG00000141376
Genome Data Viewer NCBIBCAS3 [Mapview hg19]  
OMIM607470   
Gene and transcription
Genbank (Entrez)AF260268 AF361219 AJ511332 AJ518105 AJ518836
RefSeq transcript (Entrez)NM_001099432 NM_001320470 NM_001330413 NM_001330414 NM_001353144 NM_001353145 NM_001353146 NM_017679
Consensus coding sequences : CCDS (NCBI)BCAS3
Gene ExpressionBCAS3 [ NCBI-GEO ]   BCAS3 [ EBI - ARRAY_EXPRESS ]   BCAS3 [ SEEK ]   BCAS3 [ MEM ]
Gene Expression Viewer (FireBrowse)BCAS3 [ Firebrowse - Broad ]
GenevisibleExpression of BCAS3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54828
GTEX Portal (Tissue expression)BCAS3
Human Protein AtlasENSG00000141376-BCAS3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)BCAS3
Human Protein Atlas [tissue]ENSG00000141376-BCAS3 [tissue]
HPRD06313
Protein Interaction databases
BioGRIDBCAS3
STRING (EMBL)BCAS3
ZODIACBCAS3
Ontologies - Pathways
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXBCAS3
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:13:12 CEST 2021

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