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BCAS4 (breast carcinoma amplified sequence 4)

Written2004-05Jean-Loup Huret, Sylvie Senon
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)BHLHB4
FLJ20495
HGNC (Hugo) BCAS4
HGNC Alias symbFLJ20495
CNOL
LocusID (NCBI) 55653
Atlas_Id 767
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 50794894 and ends at 50877177 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping BCAS4.png]
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAIAP2L1 (7q21.3)::BCAS4 (20q13.13)BCAS4 (20q13.13)::ADNP (20q13.13)BCAS4 (20q13.13)::AURKA (20q13.2)
BCAS4 (20q13.13)::BCAS3 (17q23.2)BCAS4 (20q13.13)::PTPN1 (20q13.13)BCAS4 (20q13.13)::ZMYND8 (20q13.12)
ZNRF1 (16q23.1)::BCAS4 (20q13.13)

DNA/RNA

Description spans 82 kb; orientation direct strand; 19 exons
Transcription alternate splicings

Protein

Expression ubiquitous
Localisation cytoplasmic

Implicated in

Note
  
Entity BCAS4 is overexpressed in 3.5% of breast cancers, and a hybrid gene BCAS4-BCAS3 was found in breat cancer cell line with a t(17;20)(q23;q13)
Hybrid/Mutated Gene 5' BCAS4 is fused to the 2 last exons (23 and 24) of BCAS3; transcript includes exon 1 from BCAS4 and 21 bp from BCAS3 exon 23; it encodes a 66 aminoacids protein; no reciprocal transcript
  

Bibliography

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation.
Melino G, Bernassola F, Ranalli M, Yee K, Zong WX, Corazzari M, Knight RA, Green DR, Thompson C, Vousden KH
The Journal of biological chemistry. 2004 ; 279 (9) : 8076-8083.
PMID 14634023
 

Citation

This paper should be referenced as such :
Huret, JL ; Senon, S
BCAS4 (breast carcinoma amplified sequence 4)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):189-189.
Free journal version : [ pdf ]   [ DOI ]


External links

Nomenclature
HGNC (Hugo)BCAS4   14367
Cards
AtlasBCAS4ID767
Entrez_Gene (NCBI)BCAS4    breast carcinoma amplified sequence 4
AliasesCNOL
GeneCards (Weizmann)BCAS4
Ensembl hg19 (Hinxton)ENSG00000124243 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124243 [Gene_View]  ENSG00000124243 [Sequence]  chr20:50794894-50877177 [Contig_View]  BCAS4 [Vega]
ICGC DataPortalENSG00000124243
TCGA cBioPortalBCAS4
AceView (NCBI)BCAS4
Genatlas (Paris)BCAS4
SOURCE (Princeton)BCAS4
Genetics Home Reference (NIH)BCAS4
Genomic and cartography
GoldenPath hg38 (UCSC)BCAS4  -     chr20:50794894-50877177 +  20q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BCAS4  -     20q13.13   [Description]    (hg19-Feb_2009)
GoldenPathBCAS4 - 20q13.13 [CytoView hg19]  BCAS4 - 20q13.13 [CytoView hg38]
ImmunoBaseENSG00000124243
Genome Data Viewer NCBIBCAS4 [Mapview hg19]  
OMIM607471   
Gene and transcription
Genbank (Entrez)AF361220 AJ511266 AK000502 BC038381 BC047337
RefSeq transcript (Entrez)NM_001010974 NM_017843 NM_198799
Consensus coding sequences : CCDS (NCBI)BCAS4
Gene ExpressionBCAS4 [ NCBI-GEO ]   BCAS4 [ EBI - ARRAY_EXPRESS ]   BCAS4 [ SEEK ]   BCAS4 [ MEM ]
Gene Expression Viewer (FireBrowse)BCAS4 [ Firebrowse - Broad ]
GenevisibleExpression of BCAS4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55653
GTEX Portal (Tissue expression)BCAS4
Human Protein AtlasENSG00000124243-BCAS4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)BCAS4
Human Protein Atlas [tissue]ENSG00000124243-BCAS4 [tissue]
HPRD06314
Protein Interaction databases
BioGRIDBCAS4
STRING (EMBL)BCAS4
ZODIACBCAS4
Ontologies - Pathways
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXBCAS4
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:13:13 CEST 2021

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