BCCIP (BRCA2 and CDKN1A interacting protein)

2003-02-01  

Identity

HGNC
LOCATION
10q26.2
LOCUSID
ALIAS
TOK-1,TOK1
FUSION GENES

Other Information

Locus ID:

NCBI: 56647
MIM: 611883
HGNC: 978
Ensembl: ENSG00000107949

Variants:

dbSNP: 56647
ClinVar: 56647
TCGA: ENSG00000107949
COSMIC: BCCIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107949ENST00000278100Q9P287
ENSG00000107949ENST00000299130Q9P287
ENSG00000107949ENST00000368759Q9P287

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

References

Pubmed IDYearTitleCitations
195783632009New common variants affecting susceptibility to basal cell carcinoma.135
157136482005The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair.36
184403042008LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells.33
184137372008Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress.30
198615172009Predisposition for TMPRSS2-ERG fusion in prostate cancer by variants in DNA repair genes.26
174529822007Roles of BCCIP in chromosome stability and cytokinesis.23
171352432007Abrogation of the transactivation activity of p53 by BCCIP down-regulation.22
147267102004Inhibition of G1 to S cell cycle progression by BCCIP beta.19
196538942009Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas.13
197137482009BCCIP is required for the nuclear localization of the p21 protein.12

Citation

Dessen P

BCCIP (BRCA2 and CDKN1A interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/768/bccip