Atlas of Genetics and Cytogenetics in Oncology and Haematology

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BCHE (butyrylcholinesterase)

Identity

Other namesCHE1
CHE2
E1
HGNC (Hugo) BCHE
LocusID (NCBI) 590
Location 3q26.1
Location_base_pair Starts at 165490692 and ends at 165555253 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)BCHE   983
Cards
Entrez_Gene (NCBI)BCHE  590  butyrylcholinesterase
GeneCards (Weizmann)BCHE
Ensembl (Hinxton)ENSG00000114200 [Gene_View]  chr3:165490692-165555253 [Contig_View]  BCHE [Vega]
ICGC DataPortalENSG00000114200
cBioPortalBCHE
AceView (NCBI)BCHE
Genatlas (Paris)BCHE
WikiGenes590
SOURCE (Princeton)NM_000055
Genomic and cartography
GoldenPath (UCSC)BCHE  -  3q26.1   chr3:165490692-165555253 -  3q26.1   [Description]    (hg19-Feb_2009)
EnsemblBCHE - 3q26.1 [CytoView]
Mapping of homologs : NCBIBCHE [Mapview]
OMIM177400   
Gene and transcription
Genbank (Entrez)AK292063 BC008396 BC018141 BF056152 DA426203
RefSeq transcript (Entrez)NM_000055
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_009031 NT_005612 NW_001838884 NW_004929311
Consensus coding sequences : CCDS (NCBI)BCHE
Cluster EST : UnigeneHs.420483 [ NCBI ]
CGAP (NCI)Hs.420483
Alternative Splicing : Fast-db (Paris)GSHG0022207
Alternative Splicing GalleryENSG00000114200
Gene ExpressionBCHE [ NCBI-GEO ]     BCHE [ SEEK ]   BCHE [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06276 (Uniprot)
NextProtP06276  [Medical]
With graphics : InterProP06276
Splice isoforms : SwissVarP06276 (Swissvar)
Catalytic activity : Enzyme3.1.1.8 [ Enzyme-Expasy ]   3.1.1.83.1.1.8 [ IntEnz-EBI ]   3.1.1.8 [ BRENDA ]   3.1.1.8 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CARBOXYLESTERASE_B_1 (PS00122)    CARBOXYLESTERASE_B_2 (PS00941)   
Domains : Interpro (EBI)AB_hydrolase [organisation]   AChE_tetra [organisation]   CarbesteraseB [organisation]   Carboxylesterase_B_AS [organisation]   Carboxylesterase_B_CS [organisation]   Cholinesterase [organisation]  
Related proteins : CluSTrP06276
Domain families : Pfam (Sanger)AChE_tetra (PF08674)    COesterase (PF00135)   
Domain families : Pfam (NCBI)pfam08674    pfam00135   
Domain structure : Prodom (Prabi Lyon)AChE_tetra (PD415333)   
DMDM Disease mutations590
Blocks (Seattle)P06276
PDB (SRS)1EHO    1EHQ    1KCJ    1P0I    1P0M    1P0P    1P0Q    1XLU    1XLV    1XLW    2J4C    2PM8    2WID    2WIF    2WIG    2WIJ    2WIK    2WIL    2WSL    2XMB    2XMC    2XMD    2XMG    2XQF    2XQG    2XQI    2XQJ    2XQK    2Y1K    3DJY    3DKK    3O9M    4AQD    4AXB    4B0O    4B0P    4BBZ    4BDS   
PDB (PDBSum)1EHO    1EHQ    1KCJ    1P0I    1P0M    1P0P    1P0Q    1XLU    1XLV    1XLW    2J4C    2PM8    2WID    2WIF    2WIG    2WIJ    2WIK    2WIL    2WSL    2XMB    2XMC    2XMD    2XMG    2XQF    2XQG    2XQI    2XQJ    2XQK    2Y1K    3DJY    3DKK    3O9M    4AQD    4AXB    4B0O    4B0P    4BBZ    4BDS   
PDB (IMB)1EHO    1EHQ    1KCJ    1P0I    1P0M    1P0P    1P0Q    1XLU    1XLV    1XLW    2J4C    2PM8    2WID    2WIF    2WIG    2WIJ    2WIK    2WIL    2WSL    2XMB    2XMC    2XMD    2XMG    2XQF    2XQG    2XQI    2XQJ    2XQK    2Y1K    3DJY    3DKK    3O9M    4AQD    4AXB    4B0O    4B0P    4BBZ    4BDS   
PDB (RSDB)1EHO    1EHQ    1KCJ    1P0I    1P0M    1P0P    1P0Q    1XLU    1XLV    1XLW    2J4C    2PM8    2WID    2WIF    2WIG    2WIJ    2WIK    2WIL    2WSL    2XMB    2XMC    2XMD    2XMG    2XQF    2XQG    2XQI    2XQJ    2XQK    2Y1K    3DJY    3DKK    3O9M    4AQD    4AXB    4B0O    4B0P    4BBZ    4BDS   
Human Protein AtlasENSG00000114200 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP06276
HPRD01519
IPIIPI00025864   IPI00797309   IPI00946206   IPI00946310   IPI00945517   
Protein Interaction databases
DIP (DOE-UCLA)P06276
IntAct (EBI)P06276
FunCoupENSG00000114200
BioGRIDBCHE
InParanoidP06276
Interologous Interaction database P06276
IntegromeDBBCHE
STRING (EMBL)BCHE
Ontologies - Pathways
Ontology : AmiGObeta-amyloid binding  catalytic activity  acetylcholinesterase activity  acetylcholinesterase activity  cholinesterase activity  extracellular region  extracellular region  extracellular space  nuclear envelope lumen  endoplasmic reticulum lumen  synaptic transmission, cholinergic  learning  negative regulation of cell proliferation  neuroblast differentiation  membrane  choline metabolic process  enzyme binding  choline binding  response to drug  identical protein binding  response to alkaloid  cellular protein metabolic process  cocaine metabolic process  negative regulation of synaptic transmission  response to glucocorticoid  response to folic acid  blood microparticle  
Ontology : EGO-EBIbeta-amyloid binding  catalytic activity  acetylcholinesterase activity  acetylcholinesterase activity  cholinesterase activity  extracellular region  extracellular region  extracellular space  nuclear envelope lumen  endoplasmic reticulum lumen  synaptic transmission, cholinergic  learning  negative regulation of cell proliferation  neuroblast differentiation  membrane  choline metabolic process  enzyme binding  choline binding  response to drug  identical protein binding  response to alkaloid  cellular protein metabolic process  cocaine metabolic process  negative regulation of synaptic transmission  response to glucocorticoid  response to folic acid  blood microparticle  
Protein Interaction DatabaseBCHE
Wikipedia pathwaysBCHE
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)BCHE
snp3D : Map Gene to Disease590
SNP (GeneSNP Utah)BCHE
SNP : HGBaseBCHE
Genetic variants : HAPMAPBCHE
Exome VariantBCHE
1000_GenomesBCHE 
ICGC programENSG00000114200 
Somatic Mutations in Cancer : COSMICBCHE 
CONAN: Copy Number AnalysisBCHE 
Mutations and Diseases : HGMDBCHE
Genomic VariantsBCHE  BCHE [DGVbeta]
dbVarBCHE
ClinVarBCHE
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM177400   
MedgenBCHE
GENETestsBCHE
Disease Genetic AssociationBCHE
Huge Navigator BCHE [HugePedia]  BCHE [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneBCHE
Homology/Alignments : Family Browser (UCSC)BCHE
Phylogenetic Trees/Animal Genes : TreeFamBCHE
Chemical/Protein Interactions : CTD590
Chemical/Pharm GKB GenePA25294
Clinical trialBCHE
Cancer Resource (Charite)ENSG00000114200
Other databases
Probes
Litterature
PubMed187 Pubmed reference(s) in Entrez
CoreMineBCHE
iHOPBCHE
OncoSearchBCHE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:44:39 CEST 2014
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