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BCL2L2 (BCL2 like 2)

Identity

Alias_namesregulatory subunit 51
Alias_symbol (synonym)KIAA0271
BCL-W
PPP1R51
Other aliasBCL2-L-2
BCLW
HGNC (Hugo) BCL2L2
LocusID (NCBI) 599
Atlas_Id 775
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 23306860 and ends at 23311759 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PABPN1 (14q11.2) / BCL2L2 (14q11.2)PABPN1 14q11.2 / BCL2L2 14q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BCL2L2   995
Cards
Entrez_Gene (NCBI)BCL2L2  599  BCL2 like 2
AliasesBCL-W; BCL2-L-2; BCLW; PPP1R51
GeneCards (Weizmann)BCL2L2
Ensembl hg19 (Hinxton)ENSG00000129473 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129473 [Gene_View]  chr14:23306860-23311759 [Contig_View]  BCL2L2 [Vega]
ICGC DataPortalENSG00000129473
TCGA cBioPortalBCL2L2
AceView (NCBI)BCL2L2
Genatlas (Paris)BCL2L2
WikiGenes599
SOURCE (Princeton)BCL2L2
Genetics Home Reference (NIH)BCL2L2
Genomic and cartography
GoldenPath hg38 (UCSC)BCL2L2  -     chr14:23306860-23311759 +  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BCL2L2  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblBCL2L2 - 14q11.2 [CytoView hg19]  BCL2L2 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIBCL2L2 [Mapview hg19]  BCL2L2 [Mapview hg38]
OMIM601931   
Gene and transcription
Genbank (Entrez)AA524030 AA741032 AK289519 BC021198 BC104789
RefSeq transcript (Entrez)NM_001199839 NM_004050
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BCL2L2
Cluster EST : UnigeneHs.735863 [ NCBI ]
CGAP (NCI)Hs.735863
Alternative Splicing GalleryENSG00000129473
Gene ExpressionBCL2L2 [ NCBI-GEO ]   BCL2L2 [ EBI - ARRAY_EXPRESS ]   BCL2L2 [ SEEK ]   BCL2L2 [ MEM ]
Gene Expression Viewer (FireBrowse)BCL2L2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)599
GTEX Portal (Tissue expression)BCL2L2
Human Protein AtlasENSG00000129473-BCL2L2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92843   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92843  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92843
Splice isoforms : SwissVarQ92843
PhosPhoSitePlusQ92843
Domaine pattern : Prosite (Expaxy)BCL2_FAMILY (PS50062)    BH1 (PS01080)    BH2 (PS01258)    BH4_1 (PS01260)    BH4_2 (PS50063)   
Domains : Interpro (EBI)Apop_reg_BclW    Bcl2-like    Bcl2_BH1_motif_CS    Bcl2_BH2_motif_CS    Bcl2_BH4    Bcl2_BH4_motif_CS    Blc2_fam   
Domain families : Pfam (Sanger)Bcl-2 (PF00452)    BH4 (PF02180)   
Domain families : Pfam (NCBI)pfam00452    pfam02180   
Domain families : Smart (EMBL)BH4 (SM00265)  
Conserved Domain (NCBI)BCL2L2
DMDM Disease mutations599
Blocks (Seattle)BCL2L2
PDB (SRS)1MK3    1O0L    1ZY3    2Y6W    4CIM   
PDB (PDBSum)1MK3    1O0L    1ZY3    2Y6W    4CIM   
PDB (IMB)1MK3    1O0L    1ZY3    2Y6W    4CIM   
PDB (RSDB)1MK3    1O0L    1ZY3    2Y6W    4CIM   
Structural Biology KnowledgeBase1MK3    1O0L    1ZY3    2Y6W    4CIM   
SCOP (Structural Classification of Proteins)1MK3    1O0L    1ZY3    2Y6W    4CIM   
CATH (Classification of proteins structures)1MK3    1O0L    1ZY3    2Y6W    4CIM   
SuperfamilyQ92843
Human Protein Atlas [tissue]ENSG00000129473-BCL2L2 [tissue]
Peptide AtlasQ92843
HPRD03569
IPIIPI00023787   IPI01026544   IPI01025747   IPI01025873   IPI01025945   IPI01026051   
Protein Interaction databases
DIP (DOE-UCLA)Q92843
IntAct (EBI)Q92843
FunCoupENSG00000129473
BioGRIDBCL2L2
STRING (EMBL)BCL2L2
ZODIACBCL2L2
Ontologies - Pathways
QuickGOQ92843
Ontology : AmiGOprotein binding  cytosol  spermatogenesis  mitochondrial membrane  negative regulation of apoptotic process  protein heterodimerization activity  BH domain binding  Sertoli cell proliferation  extracellular exosome  Bcl-2 family protein complex  extrinsic apoptotic signaling pathway in absence of ligand  disordered domain specific binding  
Ontology : EGO-EBIprotein binding  cytosol  spermatogenesis  mitochondrial membrane  negative regulation of apoptotic process  protein heterodimerization activity  BH domain binding  Sertoli cell proliferation  extracellular exosome  Bcl-2 family protein complex  extrinsic apoptotic signaling pathway in absence of ligand  disordered domain specific binding  
Pathways : KEGGMicroRNAs in cancer   
NDEx NetworkBCL2L2
Atlas of Cancer Signalling NetworkBCL2L2
Wikipedia pathwaysBCL2L2
Orthology - Evolution
OrthoDB599
GeneTree (enSembl)ENSG00000129473
Phylogenetic Trees/Animal Genes : TreeFamBCL2L2
HOVERGENQ92843
HOGENOMQ92843
Homologs : HomoloGeneBCL2L2
Homology/Alignments : Family Browser (UCSC)BCL2L2
Gene fusions - Rearrangements
Fusion : MitelmanPABPN1/BCL2L2 [14q11.2/14q11.2]  [t(14;14)(q11;q11)]  
Fusion: TCGA_MDACCPABPN1 14q11.2 BCL2L2 14q11.2 BRCA
Tumor Fusion PortalBCL2L2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBCL2L2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BCL2L2
dbVarBCL2L2
ClinVarBCL2L2
1000_GenomesBCL2L2 
Exome Variant ServerBCL2L2
ExAC (Exome Aggregation Consortium)ENSG00000129473
GNOMAD BrowserENSG00000129473
Genetic variants : HAPMAP599
Genomic Variants (DGV)BCL2L2 [DGVbeta]
DECIPHERBCL2L2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBCL2L2 
Mutations
ICGC Data PortalBCL2L2 
TCGA Data PortalBCL2L2 
Broad Tumor PortalBCL2L2
OASIS PortalBCL2L2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBCL2L2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBCL2L2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BCL2L2
DgiDB (Drug Gene Interaction Database)BCL2L2
DoCM (Curated mutations)BCL2L2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BCL2L2 (select a term)
intoGenBCL2L2
Cancer3DBCL2L2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601931   
Orphanet
DisGeNETBCL2L2
MedgenBCL2L2
Genetic Testing Registry BCL2L2
NextProtQ92843 [Medical]
TSGene599
GENETestsBCL2L2
Target ValidationBCL2L2
Huge Navigator BCL2L2 [HugePedia]
snp3D : Map Gene to Disease599
BioCentury BCIQBCL2L2
ClinGenBCL2L2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD599
Chemical/Pharm GKB GenePA25307
Clinical trialBCL2L2
Miscellaneous
canSAR (ICR)BCL2L2 (select the gene name)
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBCL2L2
EVEXBCL2L2
GoPubMedBCL2L2
iHOPBCL2L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 21 14:04:41 CET 2017

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