Atlas of Genetics and Cytogenetics in Oncology and Haematology

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BCL3 (BCL3 transcription coactivator)

Identity

Alias (NCBI)BCL4
D19S37
HGNC (Hugo) BCL3
HGNC Alias nameB-cell lymphoma 3-encoded protein
 B-cell leukemia/lymphoma 3
 chronic lymphatic leukemia protein
HGNC Previous nameD19S37
 BCL4
HGNC Previous nameB cell CLL/lymphoma 3
 BCL3, transcription coactivator
LocusID (NCBI) 602
Atlas_Id 67
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 44748708 and ends at 44760044 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCL3 (19q13.32) / ATP9B (18q23)BCL3 (19q13.32) / HIPK4 (19q13.2)BCL3 (19q13.32) / IGH (14q32.33)
BCL3 (19q13.32) / IGSF23 (19q13.31)BCL3 (19q13.32) / MYC (8q24.21)IGH (14q32.33) / BCL3 (19q13.32)
IGHG1 (14q32.33) / BCL3 (19q13.32)IGK (14q32.33) / BCL3 (19q13.32)IGL (22q11.22) / BCL3 (19q13.32)
IGLV3-10 () / BCL3 (19q13.32)Ig () / BCL3 (19q13.32)BCL3 19q13.32 / ATP9B 18q23
BCL3 19q13.32 / IGSF23 19q13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Protein

 

Breakpoints

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 12 ]
  Classical Hodgkin lymphoma
Chronic lymphocytic leukaemia (CLL)
Hodgkin lymphoma
Small lymphocytic lymphoma
t(1;6)(p36;p21)
t(8;17)(q24;q22) ???BCL3/MYC
t(2;19)(p12;q13.3) IGK/BCL3::t(14;19)(q32;q13.3) IGH/BCL3::t(19;22)(q13.3;q11) BCL3/IGL
t(14;19)(q11;q13) TRA/NECTIN2
t(14;19)(q32;p13) IGH/EPOR::t(14;19)(q32;p13) IGH/BRD4 ?
t(14;19)(q32;q13) IGH/CEBPA
t(14;19)(q32;q13) IGH/Various Partners
t(8;19)(q24;q13) BCL3/MYC

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(18;19)(q23;q13) BCL3/ATP9B
BCL3/IGSF23 (19q13)
BCL3/HIPK4 (19q13)

External links

Nomenclature
HGNC (Hugo)BCL3   998
Cards
Entrez_Gene (NCBI)BCL3    BCL3 transcription coactivator
AliasesBCL4; D19S37
GeneCards (Weizmann)BCL3
Ensembl hg19 (Hinxton)ENSG00000069399 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069399 [Gene_View]  ENSG00000069399 [Sequence]  chr19:44748708-44760044 [Contig_View]  BCL3 [Vega]
ICGC DataPortalENSG00000069399
TCGA cBioPortalBCL3
AceView (NCBI)BCL3
Genatlas (Paris)BCL3
SOURCE (Princeton)BCL3
Genetics Home Reference (NIH)BCL3
Genomic and cartography
GoldenPath hg38 (UCSC)BCL3  -     chr19:44748708-44760044 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BCL3  -     19q13.32   [Description]    (hg19-Feb_2009)
GoldenPathBCL3 - 19q13.32 [CytoView hg19]  BCL3 - 19q13.32 [CytoView hg38]
ImmunoBaseENSG00000069399
genome Data Viewer NCBIBCL3 [Mapview hg19]  
OMIM109560   
Gene and transcription
Genbank (Entrez)AK296180 AK309453 BC064993 BU501187 M31732
RefSeq transcript (Entrez)NM_005178
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BCL3
Alternative Splicing GalleryENSG00000069399
Gene ExpressionBCL3 [ NCBI-GEO ]   BCL3 [ EBI - ARRAY_EXPRESS ]   BCL3 [ SEEK ]   BCL3 [ MEM ]
Gene Expression Viewer (FireBrowse)BCL3 [ Firebrowse - Broad ]
GenevisibleExpression of BCL3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)602
GTEX Portal (Tissue expression)BCL3
Human Protein AtlasENSG00000069399-BCL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20749   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20749  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20749
Splice isoforms : SwissVarP20749
PhosPhoSitePlusP20749
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf   
Domain families : Pfam (Sanger)Ank_2 (PF12796)   
Domain families : Pfam (NCBI)pfam12796   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)BCL3
Blocks (Seattle)BCL3
PDB (RSDB)1K1A    1K1B   
PDB Europe1K1A    1K1B   
PDB (PDBSum)1K1A    1K1B   
PDB (IMB)1K1A    1K1B   
Structural Biology KnowledgeBase1K1A    1K1B   
SCOP (Structural Classification of Proteins)1K1A    1K1B   
CATH (Classification of proteins structures)1K1A    1K1B   
SuperfamilyP20749
Human Protein Atlas [tissue]ENSG00000069399-BCL3 [tissue]
Peptide AtlasP20749
HPRD00179
IPIIPI00791379   IPI00922258   IPI00893435   
Protein Interaction databases
DIP (DOE-UCLA)P20749
IntAct (EBI)P20749
BioGRIDBCL3
STRING (EMBL)BCL3
ZODIACBCL3
Ontologies - Pathways
QuickGOP20749
Ontology : AmiGORNA polymerase II proximal promoter sequence-specific DNA binding  follicular dendritic cell differentiation  marginal zone B cell differentiation  humoral immune response mediated by circulating immunoglobulin  germinal center formation  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  transcription, DNA-templated  cellular response to DNA damage stimulus  I-kappaB kinase/NF-kappaB signaling  transcription factor binding  response to virus  response to UV-C  antimicrobial humoral response  extracellular matrix organization  DNA damage response, signal transduction by p53 class mediator  midbody  protein binding, bridging  positive regulation of interferon-gamma production  protein-containing complex  Bcl3-Bcl10 complex  Bcl3/NF-kappaB2 complex  T-helper 1 type immune response  negative regulation of tumor necrosis factor biosynthetic process  defense response to bacterium  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  defense response to protozoan  regulation of apoptotic process  negative regulation of apoptotic process  intracellular membrane-bounded organelle  T-helper 2 cell differentiation  positive regulation of interleukin-10 biosynthetic process  negative regulation of interleukin-8 biosynthetic process  positive regulation of translation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  negative regulation of JAK-STAT cascade  perinuclear region of cytoplasm  spleen development  regulation of DNA binding  maintenance of protein location in nucleus  regulation of NIK/NF-kappaB signaling  
Ontology : EGO-EBIRNA polymerase II proximal promoter sequence-specific DNA binding  follicular dendritic cell differentiation  marginal zone B cell differentiation  humoral immune response mediated by circulating immunoglobulin  germinal center formation  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  transcription, DNA-templated  cellular response to DNA damage stimulus  I-kappaB kinase/NF-kappaB signaling  transcription factor binding  response to virus  response to UV-C  antimicrobial humoral response  extracellular matrix organization  DNA damage response, signal transduction by p53 class mediator  midbody  protein binding, bridging  positive regulation of interferon-gamma production  protein-containing complex  Bcl3-Bcl10 complex  Bcl3/NF-kappaB2 complex  T-helper 1 type immune response  negative regulation of tumor necrosis factor biosynthetic process  defense response to bacterium  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  defense response to protozoan  regulation of apoptotic process  negative regulation of apoptotic process  intracellular membrane-bounded organelle  T-helper 2 cell differentiation  positive regulation of interleukin-10 biosynthetic process  negative regulation of interleukin-8 biosynthetic process  positive regulation of translation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  negative regulation of JAK-STAT cascade  perinuclear region of cytoplasm  spleen development  regulation of DNA binding  maintenance of protein location in nucleus  regulation of NIK/NF-kappaB signaling  
Pathways : KEGGTNF signaling pathway   
NDEx NetworkBCL3
Atlas of Cancer Signalling NetworkBCL3
Wikipedia pathwaysBCL3
Orthology - Evolution
OrthoDB602
GeneTree (enSembl)ENSG00000069399
Phylogenetic Trees/Animal Genes : TreeFamBCL3
HOGENOMP20749
Homologs : HomoloGeneBCL3
Homology/Alignments : Family Browser (UCSC)BCL3
Gene fusions - Rearrangements
Fusion : MitelmanBCL3/ATP9B [19q13.32/18q23]  
Fusion : MitelmanBCL3/HIPK4 [19q13.32/19q13.2]  
Fusion : MitelmanBCL3/IGSF23 [19q13.32/19q13.31]  
Fusion : MitelmanBCL3/MYC [19q13.32/8q24.21]  
Fusion : MitelmanIGH/BCL3 [14q32.33/19q13.32]  
Fusion : MitelmanIGK/BCL3 [2p11.2/19q13.32]  
Fusion : MitelmanIGL/BCL3 [22q11.22/19q13.32]  
Fusion PortalBCL3 19q13.32 ATP9B 18q23 BRCA
Fusion PortalBCL3 19q13.32 IGSF23 19q13.31 BRCA
Fusion : QuiverBCL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBCL3 [hg38]
dbVarBCL3
ClinVarBCL3
MonarchBCL3
1000_GenomesBCL3 
Exome Variant ServerBCL3
GNOMAD BrowserENSG00000069399
Varsome BrowserBCL3
Genomic Variants (DGV)BCL3 [DGVbeta]
DECIPHERBCL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBCL3 
Mutations
ICGC Data PortalBCL3 
TCGA Data PortalBCL3 
Broad Tumor PortalBCL3
OASIS PortalBCL3 [ Somatic mutations - Copy number]
Cancer Gene: CensusBCL3 
Somatic Mutations in Cancer : COSMICBCL3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DBCL3
Mutations and Diseases : HGMDBCL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BCL3
DgiDB (Drug Gene Interaction Database)BCL3
DoCM (Curated mutations)BCL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BCL3 (select a term)
intoGenBCL3
Cancer3DBCL3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109560   
Orphanet
DisGeNETBCL3
MedgenBCL3
Genetic Testing Registry BCL3
NextProtP20749 [Medical]
GENETestsBCL3
Target ValidationBCL3
Huge Navigator BCL3 [HugePedia]
ClinGenBCL3
Clinical trials, drugs, therapy
MyCancerGenomeBCL3
Protein Interactions : CTD
Pharm GKB GenePA25310
PharosP20749
Clinical trialBCL3
Miscellaneous
canSAR (ICR)BCL3 (select the gene name)
HarmonizomeBCL3
DataMed IndexBCL3
Probes
Litterature
PubMed125 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXBCL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:07:06 CET 2021
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