| Alias (NCBI) | BCL4 |
| D19S37 |
| HGNC (Hugo) |
BCL3 |
| HGNC Alias name | B-cell lymphoma 3-encoded protein |
| B-cell leukemia/lymphoma 3 |
| chronic lymphatic leukemia protein |
| HGNC Previous name | D19S37 |
| BCL4 |
| HGNC Previous name | B cell CLL/lymphoma 3 |
| BCL3, transcription coactivator |
| LocusID (NCBI) |
602 |
| Atlas_Id |
67 |
| Location |
19q13.32 [Link to chromosome band 19q13] |
| Location_base_pair |
Starts at 44748708 and ends at 44760044 bp from pter ( according to hg38-Dec_2013) |
| | BCL3 (19q13.32) / ATP9B (18q23) | BCL3 (19q13.32) / HIPK4 (19q13.2) | BCL3 (19q13.32) / IGH (14q32.33) |
| |
BCL3 (19q13.32) / IGSF23 (19q13.31) | BCL3 (19q13.32) / MYC (8q24.21) | IGH (14q32.33) / BCL3 (19q13.32) |
| |
IGHG1 (14q32.33) / BCL3 (19q13.32) | IGK (14q32.33) / BCL3 (19q13.32) | IGL (22q11.22) / BCL3 (19q13.32) |
| |
IGLV3-10 () / BCL3 (19q13.32) | Ig () / BCL3 (19q13.32) | BCL3 19q13.32 / ATP9B 18q23 |
| |
BCL3 19q13.32 / IGSF23 19q13.31 |
| Nomenclature |
|---|
| HGNC (Hugo) | BCL3 998 |
| Cards |
|---|
| Entrez_Gene (NCBI) | BCL3 BCL3 transcription coactivator |
| Aliases | BCL4; D19S37 |
| GeneCards (Weizmann) | BCL3 |
| Ensembl hg19 (Hinxton) | ENSG00000069399 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000069399 [Gene_View] ENSG00000069399 [Sequence] chr19:44748708-44760044 [Contig_View] BCL3 [Vega] |
| ICGC DataPortal | ENSG00000069399 |
| TCGA cBioPortal | BCL3 |
| AceView (NCBI) | BCL3 |
| Genatlas (Paris) | BCL3 |
| SOURCE (Princeton) | BCL3 |
| Genetics Home Reference (NIH) | BCL3 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | BCL3 - chr19:44748708-44760044 + 19q13.32 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | BCL3 - 19q13.32 [Description] (hg19-Feb_2009) |
| GoldenPath | BCL3 - 19q13.32 [CytoView hg19] BCL3 - 19q13.32 [CytoView hg38] |
| ImmunoBase | ENSG00000069399 |
| Genome Data Viewer NCBI | BCL3 [Mapview hg19] |
| OMIM | 109560 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK296180 AK309453 BC064993 BU501187 M31732 |
| RefSeq transcript (Entrez) | NM_005178 |
| Consensus coding sequences : CCDS (NCBI) | BCL3 |
| Gene Expression | BCL3 [ NCBI-GEO ] BCL3 [ EBI - ARRAY_EXPRESS ]
BCL3 [ SEEK ] BCL3 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | BCL3 [ Firebrowse - Broad ] |
| Genevisible | Expression of BCL3 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 602 |
| GTEX Portal (Tissue expression) | BCL3 |
| Human Protein Atlas | ENSG00000069399-BCL3 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P20749 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P20749 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P20749 |
| PhosPhoSitePlus | P20749 |
| Domaine pattern : Prosite (Expaxy) | ANK_REP_REGION (PS50297) ANK_REPEAT (PS50088) |
| Domains : Interpro (EBI) | Ankyrin_rpt Ankyrin_rpt-contain_dom Ankyrin_rpt-contain_sf |
| Domain families : Pfam (Sanger) | Ank (PF00023) Ank_2 (PF12796) |
| Domain families : Pfam (NCBI) | pfam00023 pfam12796 |
| Domain families : Smart (EMBL) | ANK (SM00248) |
| Conserved Domain (NCBI) | BCL3 |
| PDB (RSDB) | 1K1A 1K1B |
| PDB Europe | 1K1A 1K1B |
| PDB (PDBSum) | 1K1A 1K1B |
| PDB (IMB) | 1K1A 1K1B |
| Structural Biology KnowledgeBase | 1K1A 1K1B |
| SCOP (Structural Classification of Proteins) | 1K1A 1K1B |
| CATH (Classification of proteins structures) | 1K1A 1K1B |
| Superfamily | P20749 |
| AlphaFold pdb e-kb | P20749 |
| Human Protein Atlas [tissue] | ENSG00000069399-BCL3 [tissue] |
| HPRD | 00179 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P20749 |
| IntAct (EBI) | P20749 |
| BioGRID | BCL3 |
| STRING (EMBL) | BCL3 |
| ZODIAC | BCL3 |
| Ontologies - Pathways |
|---|
| QuickGO | P20749 |
| Ontology : AmiGO | follicular dendritic cell differentiation marginal zone B cell differentiation humoral immune response mediated by circulating immunoglobulin germinal center formation transcription coactivator activity protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane transcription, DNA-templated cellular response to DNA damage stimulus I-kappaB kinase/NF-kappaB signaling transcription factor binding response to virus response to UV-C antimicrobial humoral response extracellular matrix organization DNA damage response, signal transduction by p53 class mediator midbody protein-macromolecule adaptor activity negative regulation of interleukin-8 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production positive regulation of interleukin-10 production protein-containing complex Bcl3-Bcl10 complex Bcl3/NF-kappaB2 complex T-helper 1 type immune response defense response to bacterium intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator defense response to protozoan regulation of apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle T-helper 2 cell differentiation positive regulation of translation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of receptor signaling pathway via JAK-STAT perinuclear region of cytoplasm spleen development regulation of DNA binding maintenance of protein location in nucleus regulation of NIK/NF-kappaB signaling |
| Ontology : EGO-EBI | follicular dendritic cell differentiation marginal zone B cell differentiation humoral immune response mediated by circulating immunoglobulin germinal center formation transcription coactivator activity protein binding nucleus nucleoplasm cytoplasm cytosol plasma membrane transcription, DNA-templated cellular response to DNA damage stimulus I-kappaB kinase/NF-kappaB signaling transcription factor binding response to virus response to UV-C antimicrobial humoral response extracellular matrix organization DNA damage response, signal transduction by p53 class mediator midbody protein-macromolecule adaptor activity negative regulation of interleukin-8 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production positive regulation of interleukin-10 production protein-containing complex Bcl3-Bcl10 complex Bcl3/NF-kappaB2 complex T-helper 1 type immune response defense response to bacterium intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator defense response to protozoan regulation of apoptotic process negative regulation of apoptotic process intracellular membrane-bounded organelle T-helper 2 cell differentiation positive regulation of translation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of receptor signaling pathway via JAK-STAT perinuclear region of cytoplasm spleen development regulation of DNA binding maintenance of protein location in nucleus regulation of NIK/NF-kappaB signaling |
| Pathways : KEGG | TNF signaling pathway |
| NDEx Network | BCL3 |
| Atlas of Cancer Signalling Network | BCL3 |
| Wikipedia pathways | BCL3 |
| Orthology - Evolution |
|---|
| OrthoDB | 602 |
| GeneTree (enSembl) | ENSG00000069399 |
| Phylogenetic Trees/Animal Genes : TreeFam | BCL3 |
| Homologs : HomoloGene | BCL3 |
| Homology/Alignments : Family Browser (UCSC) | BCL3 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | BCL3/ATP9B [19q13.32/18q23] |
| Fusion : Mitelman | BCL3/HIPK4 [19q13.32/19q13.2] |
| Fusion : Mitelman | BCL3/IGSF23 [19q13.32/19q13.31] |
| Fusion : Mitelman | BCL3/MYC [19q13.32/8q24.21] |
| Fusion : Mitelman | IGH/BCL3 [14q32.33/19q13.32] |
| |
| Fusion : Mitelman | IGK/BCL3 [2p11.2/19q13.32] |
| Fusion : Mitelman | IGL/BCL3 [22q11.22/19q13.32] |
| |
| Fusion : Quiver | BCL3 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | BCL3 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | BCL3 |
| dbVar | BCL3 |
| ClinVar | BCL3 |
| Monarch | BCL3 |
| 1000_Genomes | BCL3 |
| Exome Variant Server | BCL3 |
| GNOMAD Browser | ENSG00000069399 |
| Varsome Browser | BCL3 |
| ACMG | BCL3 variants |
| Varity | P20749 |
| Genomic Variants (DGV) | BCL3 [DGVbeta] |
| DECIPHER | BCL3 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | BCL3 |
| Mutations |
|---|
| ICGC Data Portal | BCL3 |
| TCGA Data Portal | BCL3 |
| Broad Tumor Portal | BCL3 |
| OASIS Portal | BCL3 [ Somatic mutations - Copy number] |
| Cancer Gene: Census | BCL3 |
| Somatic Mutations in Cancer : COSMIC | BCL3 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | BCL3 |
| Mutations and Diseases : HGMD | BCL3 |
| LOVD (Leiden Open Variation Database) | [gene] [transcripts] [variants] |
| BioMuta | BCL3 |
| DgiDB (Drug Gene Interaction Database) | BCL3 |
| DoCM (Curated mutations) | BCL3 |
| CIViC (Clinical Interpretations of Variants in Cancer) | BCL3 |
| Cancer3D | BCL3 |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 109560 |
| Orphanet | |
| DisGeNET | BCL3 |
| Medgen | BCL3 |
| Genetic Testing Registry | BCL3
|
| NextProt | P20749 [Medical] |
| GENETests | BCL3 |
| Target Validation | BCL3 |
| Huge Navigator |
BCL3 [HugePedia] |
| ClinGen | BCL3 |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | BCL3 |
| Protein Interactions : CTD | BCL3 |
| Pharm GKB Gene | PA25310 |
| Pharos | P20749 |
| Clinical trial | BCL3 |
| Miscellaneous |
|---|
| canSAR (ICR) | BCL3 |
| Harmonizome | BCL3 |
| DataMed Index | BCL3 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 131 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | BCL3 |
