Atlas of Genetics and Cytogenetics in Oncology and Haematology

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BCL9L (B cell CLL/lymphoma 9 like)

Identity

Alias_symbol (synonym)DLNB11
Other aliasBCL9-2
HGNC (Hugo) BCL9L
LocusID (NCBI) 283149
Atlas_Id 782
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 118896141 and ends at 118910904 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCL9L (11q23.3) / BCL9L (11q23.3)BCL9L (11q23.3) / PIP5K1C (19p13.3)CTTNBP2NL (1p13.2) / BCL9L (11q23.3)
KMT2A (11q23.3) / BCL9L (11q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q23;q23) KMT2A/BCL9L

External links

Nomenclature
HGNC (Hugo)BCL9L   23688
Cards
Entrez_Gene (NCBI)BCL9L  283149  B cell CLL/lymphoma 9 like
AliasesBCL9-2; DLNB11
GeneCards (Weizmann)BCL9L
Ensembl hg19 (Hinxton)ENSG00000186174 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186174 [Gene_View]  chr11:118896141-118910904 [Contig_View]  BCL9L [Vega]
ICGC DataPortalENSG00000186174
TCGA cBioPortalBCL9L
AceView (NCBI)BCL9L
Genatlas (Paris)BCL9L
WikiGenes283149
SOURCE (Princeton)BCL9L
Genetics Home Reference (NIH)BCL9L
Genomic and cartography
GoldenPath hg38 (UCSC)BCL9L  -     chr11:118896141-118910904 -  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BCL9L  -     11q23.3   [Description]    (hg19-Feb_2009)
EnsemblBCL9L - 11q23.3 [CytoView hg19]  BCL9L - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBIBCL9L [Mapview hg19]  BCL9L [Mapview hg38]
OMIM609004   
Gene and transcription
Genbank (Entrez)AB094091 AK122650 AK122882 AY296059 BC033257
RefSeq transcript (Entrez)NM_182557
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BCL9L
Cluster EST : UnigeneHs.414740 [ NCBI ]
CGAP (NCI)Hs.414740
Alternative Splicing GalleryENSG00000186174
Gene ExpressionBCL9L [ NCBI-GEO ]   BCL9L [ EBI - ARRAY_EXPRESS ]   BCL9L [ SEEK ]   BCL9L [ MEM ]
Gene Expression Viewer (FireBrowse)BCL9L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)283149
GTEX Portal (Tissue expression)BCL9L
Human Protein AtlasENSG00000186174-BCL9L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UU0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UU0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UU0
Splice isoforms : SwissVarQ86UU0
PhosPhoSitePlusQ86UU0
Domains : Interpro (EBI)Bcl-9    BCL9_beta-catenin-bd_dom   
Domain families : Pfam (Sanger)BCL9 (PF11502)   
Domain families : Pfam (NCBI)pfam11502   
Conserved Domain (NCBI)BCL9L
DMDM Disease mutations283149
Blocks (Seattle)BCL9L
PDB (SRS)2XB1    4UP0    4UP5   
PDB (PDBSum)2XB1    4UP0    4UP5   
PDB (IMB)2XB1    4UP0    4UP5   
PDB (RSDB)2XB1    4UP0    4UP5   
Structural Biology KnowledgeBase2XB1    4UP0    4UP5   
SCOP (Structural Classification of Proteins)2XB1    4UP0    4UP5   
CATH (Classification of proteins structures)2XB1    4UP0    4UP5   
SuperfamilyQ86UU0
Human Protein Atlas [tissue]ENSG00000186174-BCL9L [tissue]
Peptide AtlasQ86UU0
HPRD10612
IPIIPI00328798   IPI00878029   IPI00746747   IPI00877936   IPI00953632   IPI00939359   IPI00984710   IPI00985407   
Protein Interaction databases
DIP (DOE-UCLA)Q86UU0
IntAct (EBI)Q86UU0
FunCoupENSG00000186174
BioGRIDBCL9L
STRING (EMBL)BCL9L
ZODIACBCL9L
Ontologies - Pathways
QuickGOQ86UU0
Ontology : AmiGOtranscription coactivator activity  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  transcription, DNA-templated  beta-catenin binding  positive regulation of epithelial to mesenchymal transition  regulation of cell morphogenesis  negative regulation of transforming growth factor beta receptor signaling pathway  somatic stem cell population maintenance  skeletal muscle cell differentiation  positive regulation of transcription by RNA polymerase II  canonical Wnt signaling pathway  beta-catenin-TCF complex assembly  beta-catenin-TCF complex  
Ontology : EGO-EBItranscription coactivator activity  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  transcription, DNA-templated  beta-catenin binding  positive regulation of epithelial to mesenchymal transition  regulation of cell morphogenesis  negative regulation of transforming growth factor beta receptor signaling pathway  somatic stem cell population maintenance  skeletal muscle cell differentiation  positive regulation of transcription by RNA polymerase II  canonical Wnt signaling pathway  beta-catenin-TCF complex assembly  beta-catenin-TCF complex  
NDEx NetworkBCL9L
Atlas of Cancer Signalling NetworkBCL9L
Wikipedia pathwaysBCL9L
Orthology - Evolution
OrthoDB283149
GeneTree (enSembl)ENSG00000186174
Phylogenetic Trees/Animal Genes : TreeFamBCL9L
HOVERGENQ86UU0
HOGENOMQ86UU0
Homologs : HomoloGeneBCL9L
Homology/Alignments : Family Browser (UCSC)BCL9L
Gene fusions - Rearrangements
Fusion : QuiverBCL9L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBCL9L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BCL9L
dbVarBCL9L
ClinVarBCL9L
1000_GenomesBCL9L 
Exome Variant ServerBCL9L
ExAC (Exome Aggregation Consortium)ENSG00000186174
GNOMAD BrowserENSG00000186174
Genetic variants : HAPMAP283149
Genomic Variants (DGV)BCL9L [DGVbeta]
DECIPHERBCL9L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBCL9L 
Mutations
ICGC Data PortalBCL9L 
TCGA Data PortalBCL9L 
Broad Tumor PortalBCL9L
OASIS PortalBCL9L [ Somatic mutations - Copy number]
Cancer Gene: CensusBCL9L 
Somatic Mutations in Cancer : COSMICBCL9L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBCL9L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BCL9L
DgiDB (Drug Gene Interaction Database)BCL9L
DoCM (Curated mutations)BCL9L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BCL9L (select a term)
intoGenBCL9L
Cancer3DBCL9L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609004   
Orphanet
DisGeNETBCL9L
MedgenBCL9L
Genetic Testing Registry BCL9L
NextProtQ86UU0 [Medical]
TSGene283149
GENETestsBCL9L
Target ValidationBCL9L
Huge Navigator BCL9L [HugePedia]
snp3D : Map Gene to Disease283149
BioCentury BCIQBCL9L
ClinGenBCL9L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD283149
Chemical/Pharm GKB GenePA134974002
Clinical trialBCL9L
Miscellaneous
canSAR (ICR)BCL9L (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBCL9L
EVEXBCL9L
GoPubMedBCL9L
iHOPBCL9L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:02:58 CET 2018
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