Atlas of Genetics and Cytogenetics in Oncology and Haematology


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BCO2 (beta-carotene oxygenase 2)

Identity

Alias_namesBCDO2
beta-carotene dioxygenase 2
Alias_symbol (synonym)FLJ34464
B-DIOX-II
Other alias
HGNC (Hugo) BCO2
LocusID (NCBI) 83875
Atlas_Id 60727
Location 11q23.1  [Link to chromosome band 11q23]
Location_base_pair Starts at 112176366 and ends at 112218926 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCO2 (11q23.1) / MYLPF (16p11.2)MYLPF (16p11.2) / BCO2 (11q23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BCO2   18503
Cards
Entrez_Gene (NCBI)BCO2  83875  beta-carotene oxygenase 2
AliasesB-DIOX-II; BCDO2
GeneCards (Weizmann)BCO2
Ensembl hg19 (Hinxton)ENSG00000197580 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197580 [Gene_View]  chr11:112176366-112218926 [Contig_View]  BCO2 [Vega]
ICGC DataPortalENSG00000197580
TCGA cBioPortalBCO2
AceView (NCBI)BCO2
Genatlas (Paris)BCO2
WikiGenes83875
SOURCE (Princeton)BCO2
Genetics Home Reference (NIH)BCO2
Genomic and cartography
GoldenPath hg38 (UCSC)BCO2  -     chr11:112176366-112218926 +  11q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BCO2  -     11q23.1   [Description]    (hg19-Feb_2009)
EnsemblBCO2 - 11q23.1 [CytoView hg19]  BCO2 - 11q23.1 [CytoView hg38]
Mapping of homologs : NCBIBCO2 [Mapview hg19]  BCO2 [Mapview hg38]
OMIM611740   
Gene and transcription
Genbank (Entrez)AB096252 AF276432 AJ290393 AK027801 AK091783
RefSeq transcript (Entrez)NM_001037290 NM_001256397 NM_001256398 NM_001256400 NM_031938
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BCO2
Cluster EST : UnigeneHs.728325 [ NCBI ]
CGAP (NCI)Hs.728325
Alternative Splicing GalleryENSG00000197580
Gene ExpressionBCO2 [ NCBI-GEO ]   BCO2 [ EBI - ARRAY_EXPRESS ]   BCO2 [ SEEK ]   BCO2 [ MEM ]
Gene Expression Viewer (FireBrowse)BCO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83875
GTEX Portal (Tissue expression)BCO2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYV7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYV7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYV7
Splice isoforms : SwissVarQ9BYV7
Catalytic activity : Enzyme1.13.11.71 [ Enzyme-Expasy ]   1.13.11.711.13.11.71 [ IntEnz-EBI ]   1.13.11.71 [ BRENDA ]   1.13.11.71 [ KEGG ]   
PhosPhoSitePlusQ9BYV7
Domains : Interpro (EBI)Carotenoid_Oase   
Domain families : Pfam (Sanger)RPE65 (PF03055)   
Domain families : Pfam (NCBI)pfam03055   
Conserved Domain (NCBI)BCO2
DMDM Disease mutations83875
Blocks (Seattle)BCO2
SuperfamilyQ9BYV7
Human Protein AtlasENSG00000197580
Peptide AtlasQ9BYV7
HPRD12522
IPIIPI00479961   IPI00472555   IPI00978312   IPI00936184   IPI00412161   IPI00985076   IPI00981627   IPI00979255   IPI00982756   IPI00980705   
Protein Interaction databases
DIP (DOE-UCLA)Q9BYV7
IntAct (EBI)Q9BYV7
FunCoupENSG00000197580
BioGRIDBCO2
STRING (EMBL)BCO2
ZODIACBCO2
Ontologies - Pathways
QuickGOQ9BYV7
Ontology : AmiGOretinoid metabolic process  intracellular  mitochondrion  mitochondrion  mitochondrial matrix  carotenoid metabolic process  carotene metabolic process  carotene catabolic process  xanthophyll metabolic process  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  retinoic acid metabolic process  retinal metabolic process  metal ion binding  regulation of mitochondrial membrane potential  oxidation-reduction process  beta,beta-carotene-9',10'-cleaving oxygenase activity  regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIretinoid metabolic process  intracellular  mitochondrion  mitochondrion  mitochondrial matrix  carotenoid metabolic process  carotene metabolic process  carotene catabolic process  xanthophyll metabolic process  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  retinoic acid metabolic process  retinal metabolic process  metal ion binding  regulation of mitochondrial membrane potential  oxidation-reduction process  beta,beta-carotene-9',10'-cleaving oxygenase activity  regulation of reactive oxygen species metabolic process  
NDEx NetworkBCO2
Atlas of Cancer Signalling NetworkBCO2
Wikipedia pathwaysBCO2
Orthology - Evolution
OrthoDB83875
GeneTree (enSembl)ENSG00000197580
Phylogenetic Trees/Animal Genes : TreeFamBCO2
HOVERGENQ9BYV7
HOGENOMQ9BYV7
Homologs : HomoloGeneBCO2
Homology/Alignments : Family Browser (UCSC)BCO2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBCO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BCO2
dbVarBCO2
ClinVarBCO2
1000_GenomesBCO2 
Exome Variant ServerBCO2
ExAC (Exome Aggregation Consortium)BCO2 (select the gene name)
Genetic variants : HAPMAP83875
Genomic Variants (DGV)BCO2 [DGVbeta]
DECIPHERBCO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBCO2 
Mutations
ICGC Data PortalBCO2 
TCGA Data PortalBCO2 
Broad Tumor PortalBCO2
OASIS PortalBCO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBCO2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBCO2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BCO2
DgiDB (Drug Gene Interaction Database)BCO2
DoCM (Curated mutations)BCO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BCO2 (select a term)
intoGenBCO2
Cancer3DBCO2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611740   
Orphanet
MedgenBCO2
Genetic Testing Registry BCO2
NextProtQ9BYV7 [Medical]
TSGene83875
GENETestsBCO2
Target ValidationBCO2
Huge Navigator BCO2 [HugePedia]
snp3D : Map Gene to Disease83875
BioCentury BCIQBCO2
ClinGenBCO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83875
Chemical/Pharm GKB GenePA162377424
Clinical trialBCO2
Miscellaneous
canSAR (ICR)BCO2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBCO2
EVEXBCO2
GoPubMedBCO2
iHOPBCO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 18 13:02:15 CEST 2017

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