BDH2 (3-hydroxybutyrate dehydrogenase 2)

2003-05-01  

Identity

HGNC
LOCATION
4q24
LOCUSID
ALIAS
DHRS6,EFA6R,PRO20933,SDR15C1,UCPA-OR,UNQ6308

Other Information

Locus ID:

NCBI: 56898
HGNC: 32389
Ensembl: ENSG00000164039

Variants:

dbSNP: 56898
ClinVar: 56898
TCGA: ENSG00000164039
COSMIC: BDH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164039ENST00000296424Q9BUT1
ENSG00000164039ENST00000296424A0A024RDG9
ENSG00000164039ENST00000504285D6RIR6
ENSG00000164039ENST00000506521D6RBF6
ENSG00000164039ENST00000509245D6R9U8
ENSG00000164039ENST00000511354D6RFG2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Synthesis and degradation of ketone bodiesKEGGko00072
Butanoate metabolismKEGGko00650
Synthesis and degradation of ketone bodiesKEGGhsa00072
Butanoate metabolismKEGGhsa00650
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Ketone body metabolismREACTOMER-HSA-74182
Synthesis of Ketone BodiesREACTOMER-HSA-77111

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
217910852011Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.64
267995872016Knockdown of long non-coding RNA TP73-AS1 inhibits cell proliferation and induces apoptosis in esophageal squamous cell carcinoma.31
163803722006Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase.24
239411092013Human BDH2, an anti-apoptosis factor, is a novel poor prognostic factor for de novo cytogenetically normal acute myeloid leukemia.11
225278852012Siderophore-mediated iron trafficking in humans is regulated by iron.10
257625012014Inflammation and ER stress downregulate BDH2 expression and dysregulate intracellular iron in macrophages.9
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
306430072019LncRNA TP73-AS1 sponges miR-141-3p to promote the migration and invasion of pancreatic cancer cells through the up-regulation of BDH2.3
291138282018Downregulation of BDH2 modulates iron homeostasis and promotes DNA demethylation in CD4+ T cells of systemic lupus erythematosus.2

Citation

Dessen P

BDH2 (3-hydroxybutyrate dehydrogenase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40304/bdh2