BDKRB2 (bradykinin receptor B2)

2007-02-01 Affiliation

Identity

HGNC

BDKRB2

LOCATION

14q32.2

LOCUSID

624

ALIAS

B2R,BK-2,BK2,BKR2,BRB2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 624
MIM: 113503
HGNC: 1030
Ensembl: ENSG00000168398

Variants:

dbSNP: 624
ClinVar: 624
TCGA: ENSG00000168398
COSMIC: BDKRB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000168398	ENST00000539359	P30411
ENSG00000168398	ENST00000542454	P30411
ENSG00000168398	ENST00000554311	P30411

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Complement and coagulation cascades	KEGG	ko04610
Regulation of actin cytoskeleton	KEGG	ko04810
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Complement and coagulation cascades	KEGG	hsa04610
Regulation of actin cytoskeleton	KEGG	hsa04810
Pathways in cancer	KEGG	hsa05200
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Endocrine and other factor-regulated calcium reabsorption	KEGG	ko04961
Endocrine and other factor-regulated calcium reabsorption	KEGG	hsa04961
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164712308	Ace Inhibitors, Plain	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	10904024, 11699055, 12522467, 19744011, 21052031, 21832968, 30672376
PA443803	Cough	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	10904024, 11699055, 12522467, 19744011, 21052031, 21832968, 30672376
PA444552	Hypertension	Disease	ClinicalAnnotation	associated		PD	21052031
PA447288	Essential hypertension	Disease	ClinicalAnnotation	associated		PD	12522467
PA448500	atorvastatin	Chemical	ClinicalAnnotation	associated	PK
PA449456	enalapril	Chemical	ClinicalAnnotation	associated		PD	12522467, 22706620
PA450242	lisinopril	Chemical	ClinicalAnnotation	associated		PD	12522467
PA452640	imidapril	Chemical	ClinicalAnnotation	associated		PD	12522467

References

Pubmed ID	Year	Title	Citations
17030791	2006	G protein-coupled receptors sense fluid shear stress in endothelial cells.	140
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
21451024	2011	Bradykinin promotes the chemotactic invasion of primary brain tumors.	48
15117835	2004	Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries.	47
17363739	2007	CD13/APN regulates endothelial invasion and filopodia formation.	47
20201926	2010	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	45
17420253	2007	Signaling through a G Protein-coupled receptor and its corresponding G protein follows a stoichiometrically limited model.	40
18258629	2008	Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease.	38
18927465	2008	Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential.	36
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34

Citation

Dessen P

BDKRB2 (bradykinin receptor B2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45798/bdkrb2