Atlas of Genetics and Cytogenetics in Oncology and Haematology


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BDKRB2 (bradykinin receptor B2)

Identity

Alias_symbol (synonym)BK-2
Other aliasB2R
BK2
BKR2
BRB2
HGNC (Hugo) BDKRB2
LocusID (NCBI) 624
Atlas_Id 45798
Location 14q32.2  [Link to chromosome band 14q32]
Location_base_pair Starts at 96671135 and ends at 96710666 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CCDC92 (12q24.31) / BDKRB2 (14q32.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BDKRB2   1030
Cards
Entrez_Gene (NCBI)BDKRB2  624  bradykinin receptor B2
AliasesB2R; BK-2; BK2; BKR2; 
BRB2
GeneCards (Weizmann)BDKRB2
Ensembl hg19 (Hinxton)ENSG00000168398 [Gene_View]  chr14:96671135-96710666 [Contig_View]  BDKRB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000168398 [Gene_View]  chr14:96671135-96710666 [Contig_View]  BDKRB2 [Vega]
ICGC DataPortalENSG00000168398
TCGA cBioPortalBDKRB2
AceView (NCBI)BDKRB2
Genatlas (Paris)BDKRB2
WikiGenes624
SOURCE (Princeton)BDKRB2
Genetics Home Reference (NIH)BDKRB2
Genomic and cartography
GoldenPath hg19 (UCSC)BDKRB2  -     chr14:96671135-96710666 +  14q32.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)BDKRB2  -     14q32.2   [Description]    (hg38-Dec_2013)
EnsemblBDKRB2 - 14q32.2 [CytoView hg19]  BDKRB2 - 14q32.2 [CytoView hg38]
Mapping of homologs : NCBIBDKRB2 [Mapview hg19]  BDKRB2 [Mapview hg38]
OMIM113503   
Gene and transcription
Genbank (Entrez)AI095360 AK299316 AK311049 AY275465 BC074894
RefSeq transcript (Entrez)NM_000623
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)BDKRB2
Cluster EST : UnigeneHs.726620 [ NCBI ]
CGAP (NCI)Hs.726620
Alternative Splicing GalleryENSG00000168398
Gene ExpressionBDKRB2 [ NCBI-GEO ]   BDKRB2 [ EBI - ARRAY_EXPRESS ]   BDKRB2 [ SEEK ]   BDKRB2 [ MEM ]
Gene Expression Viewer (FireBrowse)BDKRB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)624
GTEX Portal (Tissue expression)BDKRB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30411   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30411  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30411
Splice isoforms : SwissVarP30411
PhosPhoSitePlusP30411
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Brdyknn_2_rcpt    Brdyknn_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)BDKRB2
DMDM Disease mutations624
Blocks (Seattle)BDKRB2
SuperfamilyP30411
Human Protein AtlasENSG00000168398
Peptide AtlasP30411
HPRD00213
IPIIPI00026534   IPI00218209   
Protein Interaction databases
DIP (DOE-UCLA)P30411
IntAct (EBI)P30411
FunCoupENSG00000168398
BioGRIDBDKRB2
STRING (EMBL)BDKRB2
ZODIACBDKRB2
Ontologies - Pathways
QuickGOP30411
Ontology : AmiGOprotease binding  acute inflammatory response to antigenic stimulus  phosphatidylinositol phospholipase C activity  bradykinin receptor activity  protein binding  endosome  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  smooth muscle contraction  inflammatory response  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  blood circulation  negative regulation of cell proliferation  response to salt stress  regulation of vasoconstriction  beta-2 adrenergic receptor binding  type 1 angiotensin receptor binding  negative regulation of peptidyl-serine phosphorylation  maintenance of blood-brain barrier  vasoconstriction  vasodilation  response to drug  regulation of vascular permeability  negative regulation of blood pressure  protein heterodimerization activity  arachidonic acid secretion  cellular response to hypoxia  negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator  
Ontology : EGO-EBIprotease binding  acute inflammatory response to antigenic stimulus  phosphatidylinositol phospholipase C activity  bradykinin receptor activity  protein binding  endosome  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  smooth muscle contraction  inflammatory response  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  blood circulation  negative regulation of cell proliferation  response to salt stress  regulation of vasoconstriction  beta-2 adrenergic receptor binding  type 1 angiotensin receptor binding  negative regulation of peptidyl-serine phosphorylation  maintenance of blood-brain barrier  vasoconstriction  vasodilation  response to drug  regulation of vascular permeability  negative regulation of blood pressure  protein heterodimerization activity  arachidonic acid secretion  cellular response to hypoxia  negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator  
Pathways : BIOCARTAActions of Nitric Oxide in the Heart [Genes]   
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Complement and coagulation cascades    Regulation of actin cytoskeleton    Endocrine and other factor-regulated calcium reabsorption    Chagas disease (American trypanosomiasis)   
NDEx NetworkBDKRB2
Atlas of Cancer Signalling NetworkBDKRB2
Wikipedia pathwaysBDKRB2
Orthology - Evolution
OrthoDB624
GeneTree (enSembl)ENSG00000168398
Phylogenetic Trees/Animal Genes : TreeFamBDKRB2
HOVERGENP30411
HOGENOMP30411
Homologs : HomoloGeneBDKRB2
Homology/Alignments : Family Browser (UCSC)BDKRB2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBDKRB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BDKRB2
dbVarBDKRB2
ClinVarBDKRB2
1000_GenomesBDKRB2 
Exome Variant ServerBDKRB2
ExAC (Exome Aggregation Consortium)BDKRB2 (select the gene name)
Genetic variants : HAPMAP624
Genomic Variants (DGV)BDKRB2 [DGVbeta]
DECIPHER (Syndromes)14:96671135-96710666  ENSG00000168398
CONAN: Copy Number AnalysisBDKRB2 
Mutations
ICGC Data PortalBDKRB2 
TCGA Data PortalBDKRB2 
Broad Tumor PortalBDKRB2
OASIS PortalBDKRB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBDKRB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBDKRB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BDKRB2
DgiDB (Drug Gene Interaction Database)BDKRB2
DoCM (Curated mutations)BDKRB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BDKRB2 (select a term)
intoGenBDKRB2
Cancer3DBDKRB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM113503   
Orphanet
MedgenBDKRB2
Genetic Testing Registry BDKRB2
NextProtP30411 [Medical]
TSGene624
GENETestsBDKRB2
Huge Navigator BDKRB2 [HugePedia]
snp3D : Map Gene to Disease624
BioCentury BCIQBDKRB2
ClinGenBDKRB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD624
Chemical/Pharm GKB GenePA80
Clinical trialBDKRB2
Miscellaneous
canSAR (ICR)BDKRB2 (select the gene name)
Probes
Litterature
PubMed189 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBDKRB2
EVEXBDKRB2
GoPubMedBDKRB2
iHOPBDKRB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 14:53:56 CEST 2017

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