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BECN1 (beclin 1, autophagy related)

Identity

Alias_namesbeclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
beclin 1, autophagy related
Alias_symbol (synonym)ATG6
VPS30
Other aliasbeclin1
HGNC (Hugo) BECN1
LocusID (NCBI) 8678
Atlas_Id 786
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 40962150 and ends at 40976333 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CNTD1 (17q21.31) / BECN1 (17q21.31)RPL27 (17q21.31) / BECN1 (17q21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BECN1   1034
Cards
Entrez_Gene (NCBI)BECN1  8678  beclin 1, autophagy related
AliasesATG6; VPS30; beclin1
GeneCards (Weizmann)BECN1
Ensembl hg19 (Hinxton)ENSG00000126581 [Gene_View]  chr17:40962150-40976333 [Contig_View]  BECN1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000126581 [Gene_View]  chr17:40962150-40976333 [Contig_View]  BECN1 [Vega]
ICGC DataPortalENSG00000126581
TCGA cBioPortalBECN1
AceView (NCBI)BECN1
Genatlas (Paris)BECN1
WikiGenes8678
SOURCE (Princeton)BECN1
Genetics Home Reference (NIH)BECN1
Genomic and cartography
GoldenPath hg19 (UCSC)BECN1  -     chr17:40962150-40976333 -  17q21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)BECN1  -     17q21.31   [Description]    (hg38-Dec_2013)
EnsemblBECN1 - 17q21.31 [CytoView hg19]  BECN1 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIBECN1 [Mapview hg19]  BECN1 [Mapview hg38]
OMIM604378   
Gene and transcription
Genbank (Entrez)AA427906 AF077301 AF139131 AK223411 AK298619
RefSeq transcript (Entrez)NM_001313998 NM_001313999 NM_001314000 NM_003766
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)BECN1
Cluster EST : UnigeneHs.716464 [ NCBI ]
CGAP (NCI)Hs.716464
Alternative Splicing GalleryENSG00000126581
Gene ExpressionBECN1 [ NCBI-GEO ]   BECN1 [ EBI - ARRAY_EXPRESS ]   BECN1 [ SEEK ]   BECN1 [ MEM ]
Gene Expression Viewer (FireBrowse)BECN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8678
GTEX Portal (Tissue expression)BECN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14457   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14457  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14457
Splice isoforms : SwissVarQ14457
PhosPhoSitePlusQ14457
Domains : Interpro (EBI)Atg6/Beclin    BECN1    BH3_dom   
Domain families : Pfam (Sanger)APG6 (PF04111)    BH3 (PF15285)   
Domain families : Pfam (NCBI)pfam04111    pfam15285   
Conserved Domain (NCBI)BECN1
DMDM Disease mutations8678
Blocks (Seattle)BECN1
PDB (SRS)2P1L    2PON    3DVU    4DDP    4MI8   
PDB (PDBSum)2P1L    2PON    3DVU    4DDP    4MI8   
PDB (IMB)2P1L    2PON    3DVU    4DDP    4MI8   
PDB (RSDB)2P1L    2PON    3DVU    4DDP    4MI8   
Structural Biology KnowledgeBase2P1L    2PON    3DVU    4DDP    4MI8   
SCOP (Structural Classification of Proteins)2P1L    2PON    3DVU    4DDP    4MI8   
CATH (Classification of proteins structures)2P1L    2PON    3DVU    4DDP    4MI8   
SuperfamilyQ14457
Human Protein AtlasENSG00000126581
Peptide AtlasQ14457
HPRD05087
IPIIPI00748342   IPI00908910   IPI01014159   
Protein Interaction databases
DIP (DOE-UCLA)Q14457
IntAct (EBI)Q14457
FunCoupENSG00000126581
BioGRIDBECN1
STRING (EMBL)BECN1
ZODIACBECN1
Ontologies - Pathways
QuickGOQ14457
Ontology : AmiGOautophagosome assembly  autophagosome assembly  pre-autophagosomal structure  cytokinesis  response to hypoxia  protein binding  nucleus  mitochondrion  endosome  autophagosome  endoplasmic reticulum  endoplasmic reticulum membrane  trans-Golgi network  cytosol  autophagy  apoptotic process  cellular defense response  cellular response to nitrogen starvation  lysosome organization  mitotic metaphase plate congression  negative regulation of cell proliferation  endosome membrane  positive regulation of autophagy  positive regulation of phosphatidylinositol 3-kinase signaling  cytoplasmic, membrane-bounded vesicle  viral process  macroautophagy  macroautophagy  extrinsic component of membrane  dendrite  ubiquitin protein ligase binding  mitochondrial membrane  CVT pathway  regulation of cytokinesis  receptor catabolic process  response to vitamin E  phosphatidylinositol 3-kinase complex, class III, type I  phosphatidylinositol 3-kinase complex, class III, type II  phosphatidylinositol 3-kinase complex, class III  cellular response to glucose starvation  response to drug  negative regulation of apoptotic process  phosphatidylinositol 3-kinase binding  engulfment of apoptotic cell  nucleophagy  late endosome to vacuole transport  phagocytic vesicle  neuron development  beta-amyloid metabolic process  regulation of catalytic activity  defense response to virus  negative regulation of cell death  cellular response to aluminum ion  cellular response to epidermal growth factor stimulus  mitophagy in response to mitochondrial depolarization  positive regulation of attachment of mitotic spindle microtubules to kinetochore  positive regulation of mitophagy  negative regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIautophagosome assembly  autophagosome assembly  pre-autophagosomal structure  cytokinesis  response to hypoxia  protein binding  nucleus  mitochondrion  endosome  autophagosome  endoplasmic reticulum  endoplasmic reticulum membrane  trans-Golgi network  cytosol  autophagy  apoptotic process  cellular defense response  cellular response to nitrogen starvation  lysosome organization  mitotic metaphase plate congression  negative regulation of cell proliferation  endosome membrane  positive regulation of autophagy  positive regulation of phosphatidylinositol 3-kinase signaling  cytoplasmic, membrane-bounded vesicle  viral process  macroautophagy  macroautophagy  extrinsic component of membrane  dendrite  ubiquitin protein ligase binding  mitochondrial membrane  CVT pathway  regulation of cytokinesis  receptor catabolic process  response to vitamin E  phosphatidylinositol 3-kinase complex, class III, type I  phosphatidylinositol 3-kinase complex, class III, type II  phosphatidylinositol 3-kinase complex, class III  cellular response to glucose starvation  response to drug  negative regulation of apoptotic process  phosphatidylinositol 3-kinase binding  engulfment of apoptotic cell  nucleophagy  late endosome to vacuole transport  phagocytic vesicle  neuron development  beta-amyloid metabolic process  regulation of catalytic activity  defense response to virus  negative regulation of cell death  cellular response to aluminum ion  cellular response to epidermal growth factor stimulus  mitophagy in response to mitochondrial depolarization  positive regulation of attachment of mitotic spindle microtubules to kinetochore  positive regulation of mitophagy  negative regulation of reactive oxygen species metabolic process  
Pathways : KEGGRegulation of autophagy   
NDEx NetworkBECN1
Atlas of Cancer Signalling NetworkBECN1
Wikipedia pathwaysBECN1
Orthology - Evolution
OrthoDB8678
GeneTree (enSembl)ENSG00000126581
Phylogenetic Trees/Animal Genes : TreeFamBECN1
HOVERGENQ14457
HOGENOMQ14457
Homologs : HomoloGeneBECN1
Homology/Alignments : Family Browser (UCSC)BECN1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBECN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BECN1
dbVarBECN1
ClinVarBECN1
1000_GenomesBECN1 
Exome Variant ServerBECN1
ExAC (Exome Aggregation Consortium)BECN1 (select the gene name)
Genetic variants : HAPMAP8678
Genomic Variants (DGV)BECN1 [DGVbeta]
DECIPHER (Syndromes)17:40962150-40976333  ENSG00000126581
CONAN: Copy Number AnalysisBECN1 
Mutations
ICGC Data PortalBECN1 
TCGA Data PortalBECN1 
Broad Tumor PortalBECN1
OASIS PortalBECN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBECN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBECN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BECN1
DgiDB (Drug Gene Interaction Database)BECN1
DoCM (Curated mutations)BECN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BECN1 (select a term)
intoGenBECN1
Cancer3DBECN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604378   
Orphanet
MedgenBECN1
Genetic Testing Registry BECN1
NextProtQ14457 [Medical]
TSGene8678
GENETestsBECN1
Huge Navigator BECN1 [HugePedia]
snp3D : Map Gene to Disease8678
BioCentury BCIQBECN1
ClinGenBECN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8678
Chemical/Pharm GKB GenePA25337
Clinical trialBECN1
Miscellaneous
canSAR (ICR)BECN1 (select the gene name)
Probes
Litterature
PubMed329 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBECN1
EVEXBECN1
GoPubMedBECN1
iHOPBECN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:57:31 CET 2017

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