Atlas of Genetics and Cytogenetics in Oncology and Haematology

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BGLAP (bone gamma-carboxyglutamate protein)

Identity

Alias_namesbone gamma-carboxyglutamate (gla) protein
Alias_symbol (synonym)OCN
Other aliasBGP
OC
HGNC (Hugo) BGLAP
LocusID (NCBI) 632
Atlas_Id 50008
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 156241962 and ends at 156243332 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)BGLAP   1043
Cards
Entrez_Gene (NCBI)BGLAP  632  bone gamma-carboxyglutamate protein
AliasesBGP; OC; OCN
GeneCards (Weizmann)BGLAP
Ensembl hg19 (Hinxton)ENSG00000242252 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000242252 [Gene_View]  ENSG00000242252 [Sequence]  chr1:156241962-156243332 [Contig_View]  BGLAP [Vega]
ICGC DataPortalENSG00000242252
TCGA cBioPortalBGLAP
AceView (NCBI)BGLAP
Genatlas (Paris)BGLAP
WikiGenes632
SOURCE (Princeton)BGLAP
Genetics Home Reference (NIH)BGLAP
Genomic and cartography
GoldenPath hg38 (UCSC)BGLAP  -     chr1:156241962-156243332 +  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BGLAP  -     1q22   [Description]    (hg19-Feb_2009)
EnsemblBGLAP - 1q22 [CytoView hg19]  BGLAP - 1q22 [CytoView hg38]
Mapping of homologs : NCBIBGLAP [Mapview hg19]  BGLAP [Mapview hg38]
OMIM112260   
Gene and transcription
Genbank (Entrez)BC113432 BC113434 BU622466 CA428336 X51699
RefSeq transcript (Entrez)NM_199173
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BGLAP
Cluster EST : UnigeneHs.654541 [ NCBI ]
CGAP (NCI)Hs.654541
Alternative Splicing GalleryENSG00000242252
Gene ExpressionBGLAP [ NCBI-GEO ]   BGLAP [ EBI - ARRAY_EXPRESS ]   BGLAP [ SEEK ]   BGLAP [ MEM ]
Gene Expression Viewer (FireBrowse)BGLAP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)632
GTEX Portal (Tissue expression)BGLAP
Human Protein AtlasENSG00000242252-BGLAP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02818   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02818  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02818
Splice isoforms : SwissVarP02818
PhosPhoSitePlusP02818
Domaine pattern : Prosite (Expaxy)GLA_1 (PS00011)    GLA_2 (PS50998)   
Domains : Interpro (EBI)GLA-like_dom_SF    GLA_domain    Osteocalcin/MGP   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)GLA (SM00069)  
Conserved Domain (NCBI)BGLAP
DMDM Disease mutations632
Blocks (Seattle)BGLAP
SuperfamilyP02818
Human Protein Atlas [tissue]ENSG00000242252-BGLAP [tissue]
Peptide AtlasP02818
HPRD00205
IPIIPI00023015   
Protein Interaction databases
DIP (DOE-UCLA)P02818
IntAct (EBI)P02818
FunCoupENSG00000242252
BioGRIDBGLAP
STRING (EMBL)BGLAP
ZODIACBGLAP
Ontologies - Pathways
QuickGOP02818
Ontology : AmiGOskeletal system development  ossification  osteoblast differentiation  osteoblast differentiation  osteoblast development  structural molecule activity  calcium ion binding  extracellular region  extracellular space  cytoplasm  endoplasmic reticulum lumen  rough endoplasmic reticulum  Golgi lumen  ER to Golgi vesicle-mediated transport  cell adhesion  cell aging  structural constituent of bone  structural constituent of bone  response to mechanical stimulus  response to gravity  response to zinc ion  response to activity  bone mineralization  dendrite  regulation of bone mineralization  vesicle  response to vitamin K  response to vitamin D  response to testosterone  response to hydroxyisoflavone  odontogenesis  perikaryon  response to estrogen  regulation of bone resorption  response to ethanol  regulation of osteoclast differentiation  hydroxyapatite binding  hydroxyapatite binding  response to glucocorticoid  bone development  cellular response to vitamin D  cellular response to growth factor stimulus  regulation of cellular response to insulin stimulus  
Ontology : EGO-EBIskeletal system development  ossification  osteoblast differentiation  osteoblast differentiation  osteoblast development  structural molecule activity  calcium ion binding  extracellular region  extracellular space  cytoplasm  endoplasmic reticulum lumen  rough endoplasmic reticulum  Golgi lumen  ER to Golgi vesicle-mediated transport  cell adhesion  cell aging  structural constituent of bone  structural constituent of bone  response to mechanical stimulus  response to gravity  response to zinc ion  response to activity  bone mineralization  dendrite  regulation of bone mineralization  vesicle  response to vitamin K  response to vitamin D  response to testosterone  response to hydroxyisoflavone  odontogenesis  perikaryon  response to estrogen  regulation of bone resorption  response to ethanol  regulation of osteoclast differentiation  hydroxyapatite binding  hydroxyapatite binding  response to glucocorticoid  bone development  cellular response to vitamin D  cellular response to growth factor stimulus  regulation of cellular response to insulin stimulus  
NDEx NetworkBGLAP
Atlas of Cancer Signalling NetworkBGLAP
Wikipedia pathwaysBGLAP
Orthology - Evolution
OrthoDB632
GeneTree (enSembl)ENSG00000242252
Phylogenetic Trees/Animal Genes : TreeFamBGLAP
HOGENOMP02818
Homologs : HomoloGeneBGLAP
Homology/Alignments : Family Browser (UCSC)BGLAP
Gene fusions - Rearrangements
Fusion : QuiverBGLAP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBGLAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BGLAP
dbVarBGLAP
ClinVarBGLAP
1000_GenomesBGLAP 
Exome Variant ServerBGLAP
ExAC (Exome Aggregation Consortium)ENSG00000242252
GNOMAD BrowserENSG00000242252
Varsome BrowserBGLAP
Genetic variants : HAPMAP632
Genomic Variants (DGV)BGLAP [DGVbeta]
DECIPHERBGLAP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBGLAP 
Mutations
ICGC Data PortalBGLAP 
TCGA Data PortalBGLAP 
Broad Tumor PortalBGLAP
OASIS PortalBGLAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBGLAP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBGLAP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BGLAP
DgiDB (Drug Gene Interaction Database)BGLAP
DoCM (Curated mutations)BGLAP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BGLAP (select a term)
intoGenBGLAP
Cancer3DBGLAP(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM112260   
Orphanet
DisGeNETBGLAP
MedgenBGLAP
Genetic Testing Registry BGLAP
NextProtP02818 [Medical]
TSGene632
GENETestsBGLAP
Target ValidationBGLAP
Huge Navigator BGLAP [HugePedia]
snp3D : Map Gene to Disease632
BioCentury BCIQBGLAP
ClinGenBGLAP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD632
Chemical/Pharm GKB GenePA25345
Clinical trialBGLAP
Miscellaneous
canSAR (ICR)BGLAP (select the gene name)
DataMed IndexBGLAP
Probes
Litterature
PubMed232 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBGLAP
EVEXBGLAP
GoPubMedBGLAP
iHOPBGLAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Feb 14 16:19:50 CET 2019
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