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BGN (biglycan)

Identity

Other namesDSPG1
PG-S1
PGI
SLRR1A
HGNC (Hugo) BGN
LocusID (NCBI) 633
Atlas_Id 45965
Location Xq28
Location_base_pair Starts at 152760347 and ends at 152775012 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADCY9 (16p13.3) / BGN (Xq28)BGN (Xq28) / ADAMTS1 (21q21.3)BGN (Xq28) / FLNC (7q32.1)
BGN (Xq28) / KIAA2026 (9p24.1)BGN (Xq28) / NCL (2q37.1)BGN (Xq28) / OPN1LW (Xq28)
BGN (Xq28) / PPP1R12B (1q32.1)BGN (Xq28) / TEX28 (Xq28)BGN (Xq28) / TSHZ1 (18q22.3)
BGN (Xq28) / TTN (2q31.2)BGN (Xq28) / ZNF827 (4q31.21)HAUS7 (Xq28) / BGN (Xq28)
LRRFIP2 (3p22.2) / BGN (Xq28)NFKBIB (19q13.2) / BGN (Xq28)SLC25A26 (3p14.1) / BGN (Xq28)
SUPT6H (17q11.2) / BGN (Xq28)TSHZ1 (18q22.3) / BGN (Xq28)BGN Xq28 / KIAA2026 9p24.1
BGN Xq28 / TTN 2q31.2BGN Xq28 / ZNF827 4q31.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BGN   1044
Cards
Entrez_Gene (NCBI)BGN  633  biglycan
AliasesDSPG1; PG-S1; PGI; SLRR1A
GeneCards (Weizmann)BGN
Ensembl hg19 (Hinxton)ENSG00000182492 [Gene_View]  chrX:152760347-152775012 [Contig_View]  BGN [Vega]
Ensembl hg38 (Hinxton)ENSG00000182492 [Gene_View]  chrX:152760347-152775012 [Contig_View]  BGN [Vega]
ICGC DataPortalENSG00000182492
TCGA cBioPortalBGN
AceView (NCBI)BGN
Genatlas (Paris)BGN
WikiGenes633
SOURCE (Princeton)BGN
Genomic and cartography
GoldenPath hg19 (UCSC)BGN  -     chrX:152760347-152775012 +  Xq28   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)BGN  -     Xq28   [Description]    (hg38-Dec_2013)
EnsemblBGN - Xq28 [CytoView hg19]  BGN - Xq28 [CytoView hg38]
Mapping of homologs : NCBIBGN [Mapview hg19]  BGN [Mapview hg38]
OMIM301870   
Gene and transcription
Genbank (Entrez)AI538325 AI570205 AK092954 AK093023 AK094059
RefSeq transcript (Entrez)NM_001711
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_015961 NT_011681 NW_004929448
Consensus coding sequences : CCDS (NCBI)BGN
Cluster EST : UnigeneHs.821 [ NCBI ]
CGAP (NCI)Hs.821
Alternative Splicing GalleryENSG00000182492
Gene ExpressionBGN [ NCBI-GEO ]   BGN [ EBI - ARRAY_EXPRESS ]   BGN [ SEEK ]   BGN [ MEM ]
Gene Expression Viewer (FireBrowse)BGN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)633
GTEX Portal (Tissue expression)BGN
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21810 (Uniprot)
NextProtP21810  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21810
Splice isoforms : SwissVarP21810 (Swissvar)
PhosPhoSitePlusP21810
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Biglycan    L_dom-like    Leu-rich_rpt    LRRNT    SLRP_I_decor/aspor/byglycan   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    LRRNT (PF01462)   
Domain families : Pfam (NCBI)pfam13855    pfam01462   
Domain families : Smart (EMBL)LRRNT (SM00013)  
DMDM Disease mutations633
Blocks (Seattle)BGN
SuperfamilyP21810
Human Protein AtlasENSG00000182492
Peptide AtlasP21810
HPRD02359
IPIIPI00010790   IPI00903084   IPI00909494   IPI00909809   IPI00385748   IPI00639967   IPI00643384   
Protein Interaction databases
DIP (DOE-UCLA)P21810
IntAct (EBI)P21810
FunCoupENSG00000182492
BioGRIDBGN
STRING (EMBL)BGN
ZODIACBGN
Ontologies - Pathways
QuickGOP21810
Ontology : AmiGOblood vessel remodeling  protein kinase inhibitor activity  extracellular matrix structural constituent  glycosaminoglycan binding  extracellular region  proteinaceous extracellular matrix  cytoplasm  Golgi lumen  negative regulation of protein kinase activity  biological_process  cell surface  cytokine-mediated signaling pathway  peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan  transport vesicle  extracellular matrix organization  glycosaminoglycan metabolic process  chondroitin sulfate biosynthetic process  chondroitin sulfate catabolic process  dermatan sulfate biosynthetic process  extracellular matrix  extracellular matrix  sarcolemma  lysosomal lumen  negative regulation of JAK-STAT cascade  extracellular matrix binding  extracellular exosome  
Ontology : EGO-EBIblood vessel remodeling  protein kinase inhibitor activity  extracellular matrix structural constituent  glycosaminoglycan binding  extracellular region  proteinaceous extracellular matrix  cytoplasm  Golgi lumen  negative regulation of protein kinase activity  biological_process  cell surface  cytokine-mediated signaling pathway  peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan  transport vesicle  extracellular matrix organization  glycosaminoglycan metabolic process  chondroitin sulfate biosynthetic process  chondroitin sulfate catabolic process  dermatan sulfate biosynthetic process  extracellular matrix  extracellular matrix  sarcolemma  lysosomal lumen  negative regulation of JAK-STAT cascade  extracellular matrix binding  extracellular exosome  
Pathways : BIOCARTASmall Leucine-rich Proteoglycan (SLRP) molecules [Genes]   
NDEx Network
Atlas of Cancer Signalling NetworkBGN
Wikipedia pathwaysBGN
Orthology - Evolution
OrthoDB633
GeneTree (enSembl)ENSG00000182492
Phylogenetic Trees/Animal Genes : TreeFamBGN
Homologs : HomoloGeneBGN
Homology/Alignments : Family Browser (UCSC)BGN
Gene fusions - Rearrangements
Fusion: TCGABGN Xq28 KIAA2026 9p24.1 BRCA
Fusion: TCGABGN Xq28 TTN 2q31.2 HNSC
Fusion: TCGABGN Xq28 ZNF827 4q31.21 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerBGN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BGN
dbVarBGN
ClinVarBGN
1000_GenomesBGN 
Exome Variant ServerBGN
ExAC (Exome Aggregation Consortium)BGN (select the gene name)
Genetic variants : HAPMAP633
Genomic Variants (DGV)BGN [DGVbeta]
Mutations
ICGC Data PortalBGN 
TCGA Data PortalBGN 
Broad Tumor PortalBGN
OASIS PortalBGN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBGN 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch BGN
DgiDB (Drug Gene Interaction Database)BGN
DoCM (Curated mutations)BGN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BGN (select a term)
intoGenBGN
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:152760347-152775012  ENSG00000182492
CONAN: Copy Number AnalysisBGN 
Mutations and Diseases : HGMDBGN
OMIM301870   
MedgenBGN
Genetic Testing Registry BGN
NextProtP21810 [Medical]
TSGene633
GENETestsBGN
Huge Navigator BGN [HugePedia]
snp3D : Map Gene to Disease633
BioCentury BCIQBGN
ClinGenBGN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD633
Chemical/Pharm GKB GenePA25346
Clinical trialBGN
Miscellaneous
canSAR (ICR)BGN (select the gene name)
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBGN
EVEXBGN
GoPubMedBGN
iHOPBGN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 10:55:23 CEST 2016

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