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BICD2 (BICD cargo adaptor 2)

Identity

Alias (NCBI)SMALED2
SMALED2A
SMALED2B
bA526D8.1
HGNC (Hugo) BICD2
HGNC Alias symbKIAA0699
HGNC Previous namebicaudal D homolog 2 (Drosophila)
LocusID (NCBI) 23299
Atlas_Id 46791
Location 9q22.31  [Link to chromosome band 9q22]
Location_base_pair Starts at 92711363 and ends at 92764833 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BICD2 (9q22.31)::BICD2 (9q22.31)BICD2 (9q22.31)::JAK2 (9p24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(9;9)(p24;q22) BICD2::JAK2

External links

 

Nomenclature
HGNC (Hugo)BICD2   17208
Cards
Entrez_Gene (NCBI)BICD2    BICD cargo adaptor 2
AliasesSMALED2; SMALED2A; SMALED2B; bA526D8.1
GeneCards (Weizmann)BICD2
Ensembl hg19 (Hinxton)ENSG00000185963 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185963 [Gene_View]  ENSG00000185963 [Sequence]  chr9:92711363-92764833 [Contig_View]  BICD2 [Vega]
ICGC DataPortalENSG00000185963
TCGA cBioPortalBICD2
AceView (NCBI)BICD2
Genatlas (Paris)BICD2
SOURCE (Princeton)BICD2
Genetics Home Reference (NIH)BICD2
Genomic and cartography
GoldenPath hg38 (UCSC)BICD2  -     chr9:92711363-92764833 -  9q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BICD2  -     9q22.31   [Description]    (hg19-Feb_2009)
GoldenPathBICD2 - 9q22.31 [CytoView hg19]  BICD2 - 9q22.31 [CytoView hg38]
ImmunoBaseENSG00000185963
Genome Data Viewer NCBIBICD2 [Mapview hg19]  
OMIM609797   615290   618291   
Gene and transcription
Genbank (Entrez)AB014599 AY052562 BC004296 BC010428 BC073970
RefSeq transcript (Entrez)NM_001003800 NM_015250
Consensus coding sequences : CCDS (NCBI)BICD2
Gene ExpressionBICD2 [ NCBI-GEO ]   BICD2 [ EBI - ARRAY_EXPRESS ]   BICD2 [ SEEK ]   BICD2 [ MEM ]
Gene Expression Viewer (FireBrowse)BICD2 [ Firebrowse - Broad ]
GenevisibleExpression of BICD2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23299
GTEX Portal (Tissue expression)BICD2
Human Protein AtlasENSG00000185963-BICD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TD16   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TD16  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TD16
PhosPhoSitePlusQ8TD16
Domains : Interpro (EBI)BICD   
Domain families : Pfam (Sanger)BicD (PF09730)   
Domain families : Pfam (NCBI)pfam09730   
Conserved Domain (NCBI)BICD2
PDB (RSDB)6OFP    6PSE   
PDB Europe6OFP    6PSE   
PDB (PDBSum)6OFP    6PSE   
PDB (IMB)6OFP    6PSE   
Structural Biology KnowledgeBase6OFP    6PSE   
SCOP (Structural Classification of Proteins)6OFP    6PSE   
CATH (Classification of proteins structures)6OFP    6PSE   
SuperfamilyQ8TD16
AlphaFold pdb e-kbQ8TD16   
Human Protein Atlas [tissue]ENSG00000185963-BICD2 [tissue]
HPRD09826
Protein Interaction databases
DIP (DOE-UCLA)Q8TD16
IntAct (EBI)Q8TD16
BioGRIDBICD2
STRING (EMBL)BICD2
ZODIACBICD2
Ontologies - Pathways
QuickGOQ8TD16
Ontology : AmiGOprotein binding  nuclear envelope  annulate lamellae  nuclear pore  cytoplasm  Golgi apparatus  Golgi apparatus  centrosome  cytosol  cytosol  plasma membrane  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  microtubule-based movement  cytoskeletal anchor activity  protein transport  small GTPase binding  cytoplasmic vesicle  protein localization to organelle  protein localization to Golgi apparatus  protein localization to Golgi apparatus  dynactin binding  dynactin binding  mRNA transport  centrosome localization  dynein light intermediate chain binding  regulation of microtubule cytoskeleton organization  regulation of microtubule cytoskeleton organization  dynein complex binding  dynein complex binding  minus-end-directed organelle transport along microtubule  microtubule anchoring at microtubule organizing center  microtubule anchoring at microtubule organizing center  
Ontology : EGO-EBIprotein binding  nuclear envelope  annulate lamellae  nuclear pore  cytoplasm  Golgi apparatus  Golgi apparatus  centrosome  cytosol  cytosol  plasma membrane  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  microtubule-based movement  cytoskeletal anchor activity  protein transport  small GTPase binding  cytoplasmic vesicle  protein localization to organelle  protein localization to Golgi apparatus  protein localization to Golgi apparatus  dynactin binding  dynactin binding  mRNA transport  centrosome localization  dynein light intermediate chain binding  regulation of microtubule cytoskeleton organization  regulation of microtubule cytoskeleton organization  dynein complex binding  dynein complex binding  minus-end-directed organelle transport along microtubule  microtubule anchoring at microtubule organizing center  microtubule anchoring at microtubule organizing center  
NDEx NetworkBICD2
Atlas of Cancer Signalling NetworkBICD2
Wikipedia pathwaysBICD2
Orthology - Evolution
OrthoDB23299
GeneTree (enSembl)ENSG00000185963
Phylogenetic Trees/Animal Genes : TreeFamBICD2
Homologs : HomoloGeneBICD2
Homology/Alignments : Family Browser (UCSC)BICD2
Gene fusions - Rearrangements
Fusion : QuiverBICD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBICD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BICD2
dbVarBICD2
ClinVarBICD2
MonarchBICD2
1000_GenomesBICD2 
Exome Variant ServerBICD2
GNOMAD BrowserENSG00000185963
Varsome BrowserBICD2
ACMGBICD2 variants
VarityQ8TD16
Genomic Variants (DGV)BICD2 [DGVbeta]
DECIPHERBICD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBICD2 
Mutations
ICGC Data PortalBICD2 
TCGA Data PortalBICD2 
Broad Tumor PortalBICD2
OASIS PortalBICD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBICD2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DBICD2
Mutations and Diseases : HGMDBICD2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaBICD2
DgiDB (Drug Gene Interaction Database)BICD2
DoCM (Curated mutations)BICD2
CIViC (Clinical Interpretations of Variants in Cancer)BICD2
Cancer3DBICD2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609797    615290    618291   
Orphanet22307   
DisGeNETBICD2
MedgenBICD2
Genetic Testing Registry BICD2
NextProtQ8TD16 [Medical]
GENETestsBICD2
Target ValidationBICD2
Huge Navigator BICD2 [HugePedia]
ClinGenBICD2
Clinical trials, drugs, therapy
MyCancerGenomeBICD2
Protein Interactions : CTDBICD2
Pharm GKB GenePA134969018
PharosQ8TD16
Clinical trialBICD2
Miscellaneous
canSAR (ICR)BICD2
HarmonizomeBICD2
ARCHS4BICD2
DataMed IndexBICD2
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXBICD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:24:30 CET 2022
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