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BID (BH3 interacting domain death agonist)

Identity

Alias (NCBI)FP497
HGNC (Hugo) BID
LocusID (NCBI) 637
Atlas_Id 792
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 17734140 and ends at 17774495 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BID (22q11.21)::COPG1 (3q21.3)BID (22q11.21)::NOP58 (2q33.1)BID (22q11.21)::SLC4A1AP (2p23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;18)(p11;q21)IGK::BCL2 and IGK::KDSR


External links

 

Nomenclature
HGNC (Hugo)BID   1050
Cards
Entrez_Gene (NCBI)BID    BH3 interacting domain death agonist
AliasesFP497
GeneCards (Weizmann)BID
Ensembl hg19 (Hinxton)ENSG00000015475 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000015475 [Gene_View]  ENSG00000015475 [Sequence]  chr22:17734140-17774495 [Contig_View]  BID [Vega]
ICGC DataPortalENSG00000015475
TCGA cBioPortalBID
AceView (NCBI)BID
Genatlas (Paris)BID
SOURCE (Princeton)BID
Genetics Home Reference (NIH)BID
Genomic and cartography
GoldenPath hg38 (UCSC)BID  -     chr22:17734140-17774495 -  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BID  -     22q11.21   [Description]    (hg19-Feb_2009)
GoldenPathBID - 22q11.21 [CytoView hg19]  BID - 22q11.21 [CytoView hg38]
ImmunoBaseENSG00000015475
Genome Data Viewer NCBIBID [Mapview hg19]  
OMIM601997   
Gene and transcription
Genbank (Entrez)AF042083 AF087891 AF250233 AF370380 AK094795
RefSeq transcript (Entrez)NM_001196 NM_001244567 NM_001244569 NM_001244570 NM_001244572 NM_197966 NM_197967
Consensus coding sequences : CCDS (NCBI)BID
Gene ExpressionBID [ NCBI-GEO ]   BID [ EBI - ARRAY_EXPRESS ]   BID [ SEEK ]   BID [ MEM ]
Gene Expression Viewer (FireBrowse)BID [ Firebrowse - Broad ]
GenevisibleExpression of BID in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)637
GTEX Portal (Tissue expression)BID
Human Protein AtlasENSG00000015475-BID [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55957   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55957  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55957
PhosPhoSitePlusP55957
Domaine pattern : Prosite (Expaxy)BH3 (PS01259)   
Domains : Interpro (EBI)Bcl2_BH3_motif_CS    BID    Blc2-like_sf   
Domain families : Pfam (Sanger)BID (PF06393)   
Domain families : Pfam (NCBI)pfam06393   
Conserved Domain (NCBI)BID
PDB (RSDB)1ZY3    2BID    2KBW    2M5B    2M5I    4BD2    4QVE    4ZEQ    4ZIG    4ZII    5AJJ    5C3F   
PDB Europe1ZY3    2BID    2KBW    2M5B    2M5I    4BD2    4QVE    4ZEQ    4ZIG    4ZII    5AJJ    5C3F   
PDB (PDBSum)1ZY3    2BID    2KBW    2M5B    2M5I    4BD2    4QVE    4ZEQ    4ZIG    4ZII    5AJJ    5C3F   
PDB (IMB)1ZY3    2BID    2KBW    2M5B    2M5I    4BD2    4QVE    4ZEQ    4ZIG    4ZII    5AJJ    5C3F   
Structural Biology KnowledgeBase1ZY3    2BID    2KBW    2M5B    2M5I    4BD2    4QVE    4ZEQ    4ZIG    4ZII    5AJJ    5C3F   
SCOP (Structural Classification of Proteins)1ZY3    2BID    2KBW    2M5B    2M5I    4BD2    4QVE    4ZEQ    4ZIG    4ZII    5AJJ    5C3F   
CATH (Classification of proteins structures)1ZY3    2BID    2KBW    2M5B    2M5I    4BD2    4QVE    4ZEQ    4ZIG    4ZII    5AJJ    5C3F   
SuperfamilyP55957
AlphaFold pdb e-kbP55957   
Human Protein Atlas [tissue]ENSG00000015475-BID [tissue]
HPRD03590
Protein Interaction databases
DIP (DOE-UCLA)P55957
IntAct (EBI)P55957
BioGRIDBID
STRING (EMBL)BID
ZODIACBID
Ontologies - Pathways
QuickGOP55957
Ontology : AmiGOrelease of cytochrome c from mitochondria  death receptor binding  protein binding  mitochondrion  mitochondrial outer membrane  mitochondrial outer membrane  cytosol  cytosol  cytosol  protein targeting to mitochondrion  activation of cysteine-type endopeptidase activity involved in apoptotic process  extrinsic apoptotic signaling pathway via death domain receptors  apoptotic mitochondrial changes  positive regulation of mitochondrial membrane potential  membrane  positive regulation of protein-containing complex assembly  ubiquitin protein ligase binding  integral component of mitochondrial membrane  regulation of cell population proliferation  signal transduction in response to DNA damage  mitochondrial ATP synthesis coupled electron transport  positive regulation of apoptotic process  neuron apoptotic process  protein-containing complex assembly  establishment of protein localization to membrane  positive regulation of release of cytochrome c from mitochondria  positive regulation of release of cytochrome c from mitochondria  positive regulation of release of cytochrome c from mitochondria  positive regulation of release of cytochrome c from mitochondria  hepatocyte apoptotic process  mitochondrial outer membrane permeabilization  supramolecular fiber organization  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  regulation of G1/S transition of mitotic cell cycle  positive regulation of fibroblast apoptotic process  positive regulation of extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  positive regulation of intrinsic apoptotic signaling pathway  positive regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIrelease of cytochrome c from mitochondria  death receptor binding  protein binding  mitochondrion  mitochondrial outer membrane  mitochondrial outer membrane  cytosol  cytosol  cytosol  protein targeting to mitochondrion  activation of cysteine-type endopeptidase activity involved in apoptotic process  extrinsic apoptotic signaling pathway via death domain receptors  apoptotic mitochondrial changes  positive regulation of mitochondrial membrane potential  membrane  positive regulation of protein-containing complex assembly  ubiquitin protein ligase binding  integral component of mitochondrial membrane  regulation of cell population proliferation  signal transduction in response to DNA damage  mitochondrial ATP synthesis coupled electron transport  positive regulation of apoptotic process  neuron apoptotic process  protein-containing complex assembly  establishment of protein localization to membrane  positive regulation of release of cytochrome c from mitochondria  positive regulation of release of cytochrome c from mitochondria  positive regulation of release of cytochrome c from mitochondria  positive regulation of release of cytochrome c from mitochondria  hepatocyte apoptotic process  mitochondrial outer membrane permeabilization  supramolecular fiber organization  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  regulation of G1/S transition of mitotic cell cycle  positive regulation of fibroblast apoptotic process  positive regulation of extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  positive regulation of intrinsic apoptotic signaling pathway  positive regulation of intrinsic apoptotic signaling pathway  
Pathways : BIOCARTABIOCARTA_CHEMICALPATHWAY    BIOCARTA_HIVNEFPATHWAY    BIOCARTA_DEATHPATHWAY    BIOCARTA_MITOCHONDRIAPATHWAY   
Pathways : KEGGKEGG_P53_SIGNALING    KEGG_APOPTOSIS    KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY    KEGG_ALZHEIMERS_DISEASE    KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS    KEGG_PATHWAYS_IN_CANCER    KEGG_VIRAL_MYOCARDITIS   
NDEx NetworkBID
Atlas of Cancer Signalling NetworkBID
Wikipedia pathwaysBID
Orthology - Evolution
OrthoDB637
GeneTree (enSembl)ENSG00000015475
Phylogenetic Trees/Animal Genes : TreeFamBID
Homologs : HomoloGeneBID
Homology/Alignments : Family Browser (UCSC)BID
Gene fusions - Rearrangements
Fusion : QuiverBID
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBID [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BID
dbVarBID
ClinVarBID
MonarchBID
1000_GenomesBID 
Exome Variant ServerBID
GNOMAD BrowserENSG00000015475
Varsome BrowserBID
ACMGBID variants
VarityP55957
Genomic Variants (DGV)BID [DGVbeta]
DECIPHERBID [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBID 
Mutations
ICGC Data PortalBID 
TCGA Data PortalBID 
Broad Tumor PortalBID
OASIS PortalBID [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBID  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DBID
Mutations and Diseases : HGMDBID
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaBID
DgiDB (Drug Gene Interaction Database)BID
DoCM (Curated mutations)BID
CIViC (Clinical Interpretations of Variants in Cancer)BID
Cancer3DBID
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601997   
Orphanet
DisGeNETBID
MedgenBID
Genetic Testing Registry BID
NextProtP55957 [Medical]
GENETestsBID
Target ValidationBID
Huge Navigator BID [HugePedia]
ClinGenBID
Clinical trials, drugs, therapy
MyCancerGenomeBID
Protein Interactions : CTDBID
Pharm GKB GenePA25353
PharosP55957
Clinical trialBID
Miscellaneous
canSAR (ICR)BID
HarmonizomeBID
ARCHS4BID
DataMed IndexBID
Probes
Litterature
PubMed255 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXBID
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:24:31 CET 2022

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