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BIK (BCL2 interacting killer)

Identity

Alias_namesBCL2-interacting killer (apoptosis-inducing)
Alias_symbol (synonym)NBK
Other aliasBIP1
BP4
HGNC (Hugo) BIK
LocusID (NCBI) 638
Atlas_Id 793
Location 22q13.2  [Link to chromosome band 22q13]
Location_base_pair Starts at 43110748 and ends at 43129712 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TBX3 (12q24.21) / BIK (22q13.2)TBX3 12q24.21 / BIK 22q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BIK   1051
Cards
Entrez_Gene (NCBI)BIK  638  BCL2 interacting killer
AliasesBIP1; BP4; NBK
GeneCards (Weizmann)BIK
Ensembl hg19 (Hinxton)ENSG00000100290 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100290 [Gene_View]  chr22:43110748-43129712 [Contig_View]  BIK [Vega]
ICGC DataPortalENSG00000100290
TCGA cBioPortalBIK
AceView (NCBI)BIK
Genatlas (Paris)BIK
WikiGenes638
SOURCE (Princeton)BIK
Genetics Home Reference (NIH)BIK
Genomic and cartography
GoldenPath hg38 (UCSC)BIK  -     chr22:43110748-43129712 +  22q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BIK  -     22q13.2   [Description]    (hg19-Feb_2009)
EnsemblBIK - 22q13.2 [CytoView hg19]  BIK - 22q13.2 [CytoView hg38]
Mapping of homologs : NCBIBIK [Mapview hg19]  BIK [Mapview hg38]
OMIM603392   
Gene and transcription
Genbank (Entrez)BC001599 BM765910 BP329261 BT006728 CR456390
RefSeq transcript (Entrez)NM_001197
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BIK
Cluster EST : UnigeneHs.475055 [ NCBI ]
CGAP (NCI)Hs.475055
Alternative Splicing GalleryENSG00000100290
Gene ExpressionBIK [ NCBI-GEO ]   BIK [ EBI - ARRAY_EXPRESS ]   BIK [ SEEK ]   BIK [ MEM ]
Gene Expression Viewer (FireBrowse)BIK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)638
GTEX Portal (Tissue expression)BIK
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13323   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13323  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13323
Splice isoforms : SwissVarQ13323
PhosPhoSitePlusQ13323
Domaine pattern : Prosite (Expaxy)BH3 (PS01259)   
Domains : Interpro (EBI)Bcl2-int_killer    Bcl2_BH3_motif_CS   
Domain families : Pfam (Sanger)bcl-2I13 (PF12201)   
Domain families : Pfam (NCBI)pfam12201   
Domain structure : Prodom (Prabi Lyon)PD032623 (PD032623)   
Conserved Domain (NCBI)BIK
DMDM Disease mutations638
Blocks (Seattle)BIK
PDB (SRS)2IPE   
PDB (PDBSum)2IPE   
PDB (IMB)2IPE   
PDB (RSDB)2IPE   
Structural Biology KnowledgeBase2IPE   
SCOP (Structural Classification of Proteins)2IPE   
CATH (Classification of proteins structures)2IPE   
SuperfamilyQ13323
Human Protein AtlasENSG00000100290
Peptide AtlasQ13323
HPRD04547
IPIIPI00012753   
Protein Interaction databases
DIP (DOE-UCLA)Q13323
IntAct (EBI)Q13323
FunCoupENSG00000100290
BioGRIDBIK
STRING (EMBL)BIK
ZODIACBIK
Ontologies - Pathways
QuickGOQ13323
Ontology : AmiGOprotein binding  apoptotic process  spermatogenesis  male gonad development  apoptotic mitochondrial changes  endomembrane system  integral component of membrane  mitochondrial membrane  positive regulation of protein homooligomerization  protein heterodimerization activity  BH domain binding  positive regulation of release of cytochrome c from mitochondria  
Ontology : EGO-EBIprotein binding  apoptotic process  spermatogenesis  male gonad development  apoptotic mitochondrial changes  endomembrane system  integral component of membrane  mitochondrial membrane  positive regulation of protein homooligomerization  protein heterodimerization activity  BH domain binding  positive regulation of release of cytochrome c from mitochondria  
Pathways : BIOCARTARole of Mitochondria in Apoptotic Signaling [Genes]   
NDEx NetworkBIK
Atlas of Cancer Signalling NetworkBIK
Wikipedia pathwaysBIK
Orthology - Evolution
OrthoDB638
GeneTree (enSembl)ENSG00000100290
Phylogenetic Trees/Animal Genes : TreeFamBIK
HOVERGENQ13323
HOGENOMQ13323
Homologs : HomoloGeneBIK
Homology/Alignments : Family Browser (UCSC)BIK
Gene fusions - Rearrangements
Fusion : MitelmanTBX3/BIK [12q24.21/22q13.2]  [t(12;22)(q24;q13)]  
Fusion: TCGATBX3 12q24.21 BIK 22q13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBIK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BIK
dbVarBIK
ClinVarBIK
1000_GenomesBIK 
Exome Variant ServerBIK
ExAC (Exome Aggregation Consortium)BIK (select the gene name)
Genetic variants : HAPMAP638
Genomic Variants (DGV)BIK [DGVbeta]
DECIPHERBIK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBIK 
Mutations
ICGC Data PortalBIK 
TCGA Data PortalBIK 
Broad Tumor PortalBIK
OASIS PortalBIK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBIK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBIK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BIK
DgiDB (Drug Gene Interaction Database)BIK
DoCM (Curated mutations)BIK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BIK (select a term)
intoGenBIK
Cancer3DBIK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603392   
Orphanet
MedgenBIK
Genetic Testing Registry BIK
NextProtQ13323 [Medical]
TSGene638
GENETestsBIK
Target ValidationBIK
Huge Navigator BIK [HugePedia]
snp3D : Map Gene to Disease638
BioCentury BCIQBIK
ClinGenBIK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD638
Chemical/Pharm GKB GenePA25354
Clinical trialBIK
Miscellaneous
canSAR (ICR)BIK (select the gene name)
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBIK
EVEXBIK
GoPubMedBIK
iHOPBIK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:25:32 CEST 2017

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