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BIN2 (bridging integrator 2)

Identity

Alias_symbol (synonym)BRAP-1
Other alias
HGNC (Hugo) BIN2
LocusID (NCBI) 51411
Atlas_Id 54157
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 51281038 and ends at 51324680 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ABI1 (10p12.1) / BIN2 (12q13.13)BAZ2A (12q13.3) / BIN2 (12q13.13)BIN2 (12q13.13) / LYN (8q12.1)
BIN2 (12q13.13) / PDGFRB (5q32)CITED4 (1p34.2) / BIN2 (12q13.13)BAZ2A 12q13.3 / BIN2 12q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BIN2   1053
Cards
Entrez_Gene (NCBI)BIN2  51411  bridging integrator 2
AliasesBRAP-1
GeneCards (Weizmann)BIN2
Ensembl hg19 (Hinxton)ENSG00000110934 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110934 [Gene_View]  chr12:51281038-51324680 [Contig_View]  BIN2 [Vega]
ICGC DataPortalENSG00000110934
TCGA cBioPortalBIN2
AceView (NCBI)BIN2
Genatlas (Paris)BIN2
WikiGenes51411
SOURCE (Princeton)BIN2
Genetics Home Reference (NIH)BIN2
Genomic and cartography
GoldenPath hg38 (UCSC)BIN2  -     chr12:51281038-51324680 -  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BIN2  -     12q13.13   [Description]    (hg19-Feb_2009)
EnsemblBIN2 - 12q13.13 [CytoView hg19]  BIN2 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIBIN2 [Mapview hg19]  BIN2 [Mapview hg38]
OMIM605936   
Gene and transcription
Genbank (Entrez)AB032698 AF146531 AK000783 AK093638 AK225911
RefSeq transcript (Entrez)NM_001290007 NM_001290008 NM_001290009 NM_016293
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BIN2
Cluster EST : UnigeneHs.14770 [ NCBI ]
CGAP (NCI)Hs.14770
Alternative Splicing GalleryENSG00000110934
Gene ExpressionBIN2 [ NCBI-GEO ]   BIN2 [ EBI - ARRAY_EXPRESS ]   BIN2 [ SEEK ]   BIN2 [ MEM ]
Gene Expression Viewer (FireBrowse)BIN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51411
GTEX Portal (Tissue expression)BIN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBW5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBW5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBW5
Splice isoforms : SwissVarQ9UBW5
PhosPhoSitePlusQ9UBW5
Domaine pattern : Prosite (Expaxy)BAR (PS51021)   
Domains : Interpro (EBI)AH/BAR-dom    Amphiphysin    BAR_dom   
Domain families : Pfam (Sanger)BAR (PF03114)   
Domain families : Pfam (NCBI)pfam03114   
Domain families : Smart (EMBL)BAR (SM00721)  
Conserved Domain (NCBI)BIN2
DMDM Disease mutations51411
Blocks (Seattle)BIN2
PDB (SRS)4AVM    4I1Q   
PDB (PDBSum)4AVM    4I1Q   
PDB (IMB)4AVM    4I1Q   
PDB (RSDB)4AVM    4I1Q   
Structural Biology KnowledgeBase4AVM    4I1Q   
SCOP (Structural Classification of Proteins)4AVM    4I1Q   
CATH (Classification of proteins structures)4AVM    4I1Q   
SuperfamilyQ9UBW5
Human Protein AtlasENSG00000110934
Peptide AtlasQ9UBW5
HPRD05805
IPIIPI00550792   IPI00795778   IPI01015509   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBW5
IntAct (EBI)Q9UBW5
FunCoupENSG00000110934
BioGRIDBIN2
STRING (EMBL)BIN2
ZODIACBIN2
Ontologies - Pathways
QuickGOQ9UBW5
Ontology : AmiGOphagocytic cup  podosome  protein binding  phospholipid binding  extracellular region  cell cortex  phagocytosis, engulfment  cell junction  secretory granule lumen  cell projection  neutrophil degranulation  cell chemotaxis  podosome assembly  plasma membrane tubulation  ficolin-1-rich granule lumen  
Ontology : EGO-EBIphagocytic cup  podosome  protein binding  phospholipid binding  extracellular region  cell cortex  phagocytosis, engulfment  cell junction  secretory granule lumen  cell projection  neutrophil degranulation  cell chemotaxis  podosome assembly  plasma membrane tubulation  ficolin-1-rich granule lumen  
NDEx NetworkBIN2
Atlas of Cancer Signalling NetworkBIN2
Wikipedia pathwaysBIN2
Orthology - Evolution
OrthoDB51411
GeneTree (enSembl)ENSG00000110934
Phylogenetic Trees/Animal Genes : TreeFamBIN2
HOVERGENQ9UBW5
HOGENOMQ9UBW5
Homologs : HomoloGeneBIN2
Homology/Alignments : Family Browser (UCSC)BIN2
Gene fusions - Rearrangements
Fusion : MitelmanBAZ2A/BIN2 [12q13.3/12q13.13]  [t(12;12)(q13;q13)]  
Fusion : MitelmanBIN2/PDGFRB [12q13.13/5q32]  [t(5;12)(q32;q13)]  
Fusion: TCGABAZ2A 12q13.3 BIN2 12q13.13 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBIN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BIN2
dbVarBIN2
ClinVarBIN2
1000_GenomesBIN2 
Exome Variant ServerBIN2
ExAC (Exome Aggregation Consortium)BIN2 (select the gene name)
Genetic variants : HAPMAP51411
Genomic Variants (DGV)BIN2 [DGVbeta]
DECIPHERBIN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBIN2 
Mutations
ICGC Data PortalBIN2 
TCGA Data PortalBIN2 
Broad Tumor PortalBIN2
OASIS PortalBIN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBIN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBIN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BIN2
DgiDB (Drug Gene Interaction Database)BIN2
DoCM (Curated mutations)BIN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BIN2 (select a term)
intoGenBIN2
Cancer3DBIN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605936   
Orphanet
MedgenBIN2
Genetic Testing Registry BIN2
NextProtQ9UBW5 [Medical]
TSGene51411
GENETestsBIN2
Target ValidationBIN2
Huge Navigator BIN2 [HugePedia]
snp3D : Map Gene to Disease51411
BioCentury BCIQBIN2
ClinGenBIN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51411
Chemical/Pharm GKB GenePA25356
Clinical trialBIN2
Miscellaneous
canSAR (ICR)BIN2 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBIN2
EVEXBIN2
GoPubMedBIN2
iHOPBIN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:25:33 CEST 2017

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