Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

BIRC5 (baculoviral IAP repeat containing 5)

Identity

Alias_namesAPI4
apoptosis inhibitor 4
baculoviral IAP repeat-containing 5
Alias_symbol (synonym)EPR-1
survivin
Other alias
HGNC (Hugo) BIRC5
LocusID (NCBI) 332
Atlas_Id 797
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 78214196 and ends at 78225635 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BIRC5 (17q25.3) / SPDYA (2p23.2)PGS1 (17q25.3) / BIRC5 (17q25.3)STX17 (9q31.1) / BIRC5 (17q25.3)
PGS1 17q25.3 / BIRC5 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Breast: Ductal carcinoma
Head and Neck: Oral leukoplakia


External links

Nomenclature
HGNC (Hugo)BIRC5   593
Cards
Entrez_Gene (NCBI)BIRC5  332  baculoviral IAP repeat containing 5
AliasesAPI4; EPR-1
GeneCards (Weizmann)BIRC5
Ensembl hg19 (Hinxton)ENSG00000089685 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000089685 [Gene_View]  chr17:78214196-78225635 [Contig_View]  BIRC5 [Vega]
ICGC DataPortalENSG00000089685
TCGA cBioPortalBIRC5
AceView (NCBI)BIRC5
Genatlas (Paris)BIRC5
WikiGenes332
SOURCE (Princeton)BIRC5
Genetics Home Reference (NIH)BIRC5
Genomic and cartography
GoldenPath hg38 (UCSC)BIRC5  -     chr17:78214196-78225635 +  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BIRC5  -     17q25.3   [Description]    (hg19-Feb_2009)
EnsemblBIRC5 - 17q25.3 [CytoView hg19]  BIRC5 - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBIBIRC5 [Mapview hg19]  BIRC5 [Mapview hg38]
OMIM603352   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001012270 NM_001012271 NM_001168
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BIRC5
Cluster EST : UnigeneHs.744872 [ NCBI ]
CGAP (NCI)Hs.744872
Alternative Splicing GalleryENSG00000089685
Gene ExpressionBIRC5 [ NCBI-GEO ]   BIRC5 [ EBI - ARRAY_EXPRESS ]   BIRC5 [ SEEK ]   BIRC5 [ MEM ]
Gene Expression Viewer (FireBrowse)BIRC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)332
GTEX Portal (Tissue expression)BIRC5
Human Protein AtlasENSG00000089685-BIRC5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15392   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15392  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15392
Splice isoforms : SwissVarO15392
PhosPhoSitePlusO15392
Domaine pattern : Prosite (Expaxy)BIR_REPEAT_2 (PS50143)   
Domains : Interpro (EBI)BIR_rpt   
Domain families : Pfam (Sanger)BIR (PF00653)   
Domain families : Pfam (NCBI)pfam00653   
Domain families : Smart (EMBL)BIR (SM00238)  
Conserved Domain (NCBI)BIRC5
DMDM Disease mutations332
Blocks (Seattle)BIRC5
PDB (SRS)1E31    1F3H    1XOX    2QFA    2RAW    2RAX    3UEC    3UED    3UEE    3UEF    3UEG    3UEH    3UEI    3UIG    3UIH    3UII    3UIJ    3UIK    4A0I    4A0J    4A0N   
PDB (PDBSum)1E31    1F3H    1XOX    2QFA    2RAW    2RAX    3UEC    3UED    3UEE    3UEF    3UEG    3UEH    3UEI    3UIG    3UIH    3UII    3UIJ    3UIK    4A0I    4A0J    4A0N   
PDB (IMB)1E31    1F3H    1XOX    2QFA    2RAW    2RAX    3UEC    3UED    3UEE    3UEF    3UEG    3UEH    3UEI    3UIG    3UIH    3UII    3UIJ    3UIK    4A0I    4A0J    4A0N   
PDB (RSDB)1E31    1F3H    1XOX    2QFA    2RAW    2RAX    3UEC    3UED    3UEE    3UEF    3UEG    3UEH    3UEI    3UIG    3UIH    3UII    3UIJ    3UIK    4A0I    4A0J    4A0N   
Structural Biology KnowledgeBase1E31    1F3H    1XOX    2QFA    2RAW    2RAX    3UEC    3UED    3UEE    3UEF    3UEG    3UEH    3UEI    3UIG    3UIH    3UII    3UIJ    3UIK    4A0I    4A0J    4A0N   
SCOP (Structural Classification of Proteins)1E31    1F3H    1XOX    2QFA    2RAW    2RAX    3UEC    3UED    3UEE    3UEF    3UEG    3UEH    3UEI    3UIG    3UIH    3UII    3UIJ    3UIK    4A0I    4A0J    4A0N   
CATH (Classification of proteins structures)1E31    1F3H    1XOX    2QFA    2RAW    2RAX    3UEC    3UED    3UEE    3UEF    3UEG    3UEH    3UEI    3UIG    3UIH    3UII    3UIJ    3UIK    4A0I    4A0J    4A0N   
SuperfamilyO15392
Human Protein Atlas [tissue]ENSG00000089685-BIRC5 [tissue]
Peptide AtlasO15392
HPRD04520
IPIIPI00006210   IPI00218095   IPI00735946   IPI00784964   IPI00784916   IPI00784873   IPI00785191   IPI01018308   IPI01019070   IPI01020912   IPI00056412   IPI01014811   
Protein Interaction databases
DIP (DOE-UCLA)O15392
IntAct (EBI)O15392
FunCoupENSG00000089685
BioGRIDBIRC5
STRING (EMBL)BIRC5
ZODIACBIRC5
Ontologies - Pathways
QuickGOO15392
Ontology : AmiGOnuclear chromosome  chromosome, centromeric region  condensed chromosome kinetochore  ubiquitin-protein transferase activity  cysteine-type endopeptidase inhibitor activity  protein binding  nucleus  nucleoplasm  cytoplasm  spindle  cytosol  cytosol  microtubule  transcription, DNA-templated  protein phosphorylation  apoptotic process  sister chromatid cohesion  regulation of mitotic cell cycle  microtubule binding  positive regulation of cell proliferation  Ran GTPase binding  regulation of signal transduction  protein ubiquitination  protein sumoylation  enzyme binding  midbody  protein complex localization  chromosome passenger complex  identical protein binding  regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of transcription, DNA-templated  metal ion binding  chaperone binding  cell division  mitotic spindle assembly  inhibition of cysteine-type endopeptidase activity involved in apoptotic process  
Ontology : EGO-EBInuclear chromosome  chromosome, centromeric region  condensed chromosome kinetochore  ubiquitin-protein transferase activity  cysteine-type endopeptidase inhibitor activity  protein binding  nucleus  nucleoplasm  cytoplasm  spindle  cytosol  cytosol  microtubule  transcription, DNA-templated  protein phosphorylation  apoptotic process  sister chromatid cohesion  regulation of mitotic cell cycle  microtubule binding  positive regulation of cell proliferation  Ran GTPase binding  regulation of signal transduction  protein ubiquitination  protein sumoylation  enzyme binding  midbody  protein complex localization  chromosome passenger complex  identical protein binding  regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of transcription, DNA-templated  metal ion binding  chaperone binding  cell division  mitotic spindle assembly  inhibition of cysteine-type endopeptidase activity involved in apoptotic process  
Pathways : BIOCARTAB Cell Survival Pathway [Genes]   
Pathways : KEGGHippo signaling pathway    Hepatitis B    Pathways in cancer    Colorectal cancer   
NDEx NetworkBIRC5
Atlas of Cancer Signalling NetworkBIRC5
Wikipedia pathwaysBIRC5
Orthology - Evolution
OrthoDB332
GeneTree (enSembl)ENSG00000089685
Phylogenetic Trees/Animal Genes : TreeFamBIRC5
HOVERGENO15392
HOGENOMO15392
Homologs : HomoloGeneBIRC5
Homology/Alignments : Family Browser (UCSC)BIRC5
Gene fusions - Rearrangements
Fusion : MitelmanPGS1/BIRC5 [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Fusion: TCGA_MDACCPGS1 17q25.3 BIRC5 17q25.3 BRCA
Tumor Fusion PortalBIRC5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBIRC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BIRC5
dbVarBIRC5
ClinVarBIRC5
1000_GenomesBIRC5 
Exome Variant ServerBIRC5
ExAC (Exome Aggregation Consortium)ENSG00000089685
GNOMAD BrowserENSG00000089685
Genetic variants : HAPMAP332
Genomic Variants (DGV)BIRC5 [DGVbeta]
DECIPHERBIRC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBIRC5 
Mutations
ICGC Data PortalBIRC5 
TCGA Data PortalBIRC5 
Broad Tumor PortalBIRC5
OASIS PortalBIRC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBIRC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBIRC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch BIRC5
DgiDB (Drug Gene Interaction Database)BIRC5
DoCM (Curated mutations)BIRC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BIRC5 (select a term)
intoGenBIRC5
Cancer3DBIRC5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603352   
Orphanet
DisGeNETBIRC5
MedgenBIRC5
Genetic Testing Registry BIRC5
NextProtO15392 [Medical]
TSGene332
GENETestsBIRC5
Target ValidationBIRC5
Huge Navigator BIRC5 [HugePedia]
snp3D : Map Gene to Disease332
BioCentury BCIQBIRC5
ClinGenBIRC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD332
Chemical/Pharm GKB GenePA25362
Clinical trialBIRC5
Miscellaneous
canSAR (ICR)BIRC5 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBIRC5
EVEXBIRC5
GoPubMedBIRC5
iHOPBIRC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:04:52 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.