| Nomenclature |
|---|
| HGNC (Hugo) | BIRC5 593 |
| Cards |
|---|
| Entrez_Gene (NCBI) | BIRC5 332 baculoviral IAP repeat containing 5 |
| Aliases | API4; EPR-1 |
| GeneCards (Weizmann) | BIRC5 |
| Ensembl hg19 (Hinxton) | ENSG00000089685 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000089685 [Gene_View] chr17:78214196-78225635 [Contig_View] BIRC5 [Vega] |
| ICGC DataPortal | ENSG00000089685 |
| TCGA cBioPortal | BIRC5 |
| AceView (NCBI) | BIRC5 |
| Genatlas (Paris) | BIRC5 |
| WikiGenes | 332 |
| SOURCE (Princeton) | BIRC5 |
| Genetics Home Reference (NIH) | BIRC5 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | BIRC5 - chr17:78214196-78225635 + 17q25.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | BIRC5 - 17q25.3 [Description] (hg19-Feb_2009) |
| Ensembl | BIRC5 - 17q25.3 [CytoView hg19] BIRC5 - 17q25.3 [CytoView hg38] |
| Mapping of homologs : NCBI | BIRC5 [Mapview hg19] BIRC5 [Mapview hg38] |
| OMIM | 603352 |
| Gene and transcription |
|---|
| Genbank (Entrez) | ############################################################################################################################################################################################################################################################### |
| RefSeq transcript (Entrez) | NM_001012270 NM_001012271 NM_001168 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | BIRC5 |
| Cluster EST : Unigene | Hs.744872 [ NCBI ] |
| CGAP (NCI) | Hs.744872 |
| Alternative Splicing Gallery | ENSG00000089685 |
| Gene Expression | BIRC5 [ NCBI-GEO ] BIRC5 [ EBI - ARRAY_EXPRESS ]
BIRC5 [ SEEK ] BIRC5 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | BIRC5 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 332 |
| GTEX Portal (Tissue expression) | BIRC5 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O15392 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O15392 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O15392 |
| Splice isoforms : SwissVar | O15392 |
| PhosPhoSitePlus | O15392 |
| Domaine pattern : Prosite (Expaxy) | BIR_REPEAT_2 (PS50143) |
| Domains : Interpro (EBI) | BIR_rpt |
| Domain families : Pfam (Sanger) | BIR (PF00653) |
| Domain families : Pfam (NCBI) | pfam00653 |
| Domain families : Smart (EMBL) | BIR (SM00238) |
| Conserved Domain (NCBI) | BIRC5 |
| DMDM Disease mutations | 332 |
| Blocks (Seattle) | BIRC5 |
| PDB (SRS) | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| PDB (PDBSum) | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| PDB (IMB) | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| PDB (RSDB) | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| Structural Biology KnowledgeBase | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| SCOP (Structural Classification of Proteins) | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| CATH (Classification of proteins structures) | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| Superfamily | O15392 |
| Human Protein Atlas | ENSG00000089685 |
| Peptide Atlas | O15392 |
| HPRD | 04520 |
| IPI | IPI00006210 IPI00218095 IPI00735946 IPI00784964 IPI00784916 IPI00784873 IPI00785191 IPI01018308 IPI01019070 IPI01020912 IPI00056412 IPI01014811 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O15392 |
| IntAct (EBI) | O15392 |
| FunCoup | ENSG00000089685 |
| BioGRID | BIRC5 |
| STRING (EMBL) | BIRC5 |
| ZODIAC | BIRC5 |
| Ontologies - Pathways |
|---|
| QuickGO | O15392 |
| Ontology : AmiGO | nuclear chromosome chromosome, centromeric region condensed chromosome kinetochore ubiquitin-protein transferase activity cysteine-type endopeptidase inhibitor activity protein binding nucleus nucleoplasm cytoplasm spindle cytosol cytosol microtubule transcription, DNA-templated protein phosphorylation apoptotic process sister chromatid cohesion regulation of mitotic cell cycle microtubule binding positive regulation of cell proliferation Ran GTPase binding regulation of signal transduction protein ubiquitination protein sumoylation enzyme binding midbody protein complex localization chromosome passenger complex identical protein binding regulation of apoptotic process negative regulation of apoptotic process negative regulation of transcription, DNA-templated metal ion binding chaperone binding cell division mitotic spindle assembly inhibition of cysteine-type endopeptidase activity involved in apoptotic process |
| Ontology : EGO-EBI | nuclear chromosome chromosome, centromeric region condensed chromosome kinetochore ubiquitin-protein transferase activity cysteine-type endopeptidase inhibitor activity protein binding nucleus nucleoplasm cytoplasm spindle cytosol cytosol microtubule transcription, DNA-templated protein phosphorylation apoptotic process sister chromatid cohesion regulation of mitotic cell cycle microtubule binding positive regulation of cell proliferation Ran GTPase binding regulation of signal transduction protein ubiquitination protein sumoylation enzyme binding midbody protein complex localization chromosome passenger complex identical protein binding regulation of apoptotic process negative regulation of apoptotic process negative regulation of transcription, DNA-templated metal ion binding chaperone binding cell division mitotic spindle assembly inhibition of cysteine-type endopeptidase activity involved in apoptotic process |
| Pathways : BIOCARTA | B Cell Survival Pathway [Genes] |
| Pathways : KEGG | Hippo signaling pathway Hepatitis B Pathways in cancer Colorectal cancer |
| NDEx Network | BIRC5 |
| Atlas of Cancer Signalling Network | BIRC5 |
| Wikipedia pathways | BIRC5 |
| Orthology - Evolution |
|---|
| OrthoDB | 332 |
| GeneTree (enSembl) | ENSG00000089685 |
| Phylogenetic Trees/Animal Genes : TreeFam | BIRC5 |
| HOVERGEN | O15392 |
| HOGENOM | O15392 |
| Homologs : HomoloGene | BIRC5 |
| Homology/Alignments : Family Browser (UCSC) | BIRC5 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | PGS1/BIRC5 [17q25.3/17q25.3] [t(17;17)(q25;q25)] |
| Fusion: TCGA | PGS1 17q25.3 BIRC5 17q25.3 BRCA |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | BIRC5 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | BIRC5 |
| dbVar | BIRC5 |
| ClinVar | BIRC5 |
| 1000_Genomes | BIRC5 |
| Exome Variant Server | BIRC5 |
| ExAC (Exome Aggregation Consortium) | BIRC5 (select the gene name) |
| Genetic variants : HAPMAP | 332 |
| Genomic Variants (DGV) | BIRC5 [DGVbeta] |
| DECIPHER | BIRC5 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | BIRC5 |
| Mutations |
|---|
| ICGC Data Portal | BIRC5 |
| TCGA Data Portal | BIRC5 |
| Broad Tumor Portal | BIRC5 |
| OASIS Portal | BIRC5 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | BIRC5 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | BIRC5 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| BioMuta | search BIRC5 |
| DgiDB (Drug Gene Interaction Database) | BIRC5 |
| DoCM (Curated mutations) | BIRC5 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | BIRC5 (select a term) |
| intoGen | BIRC5 |
| Cancer3D | BIRC5(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 603352 |
| Orphanet | |
| Medgen | BIRC5 |
| Genetic Testing Registry | BIRC5
|
| NextProt | O15392 [Medical] |
| TSGene | 332 |
| GENETests | BIRC5 |
| Target Validation | BIRC5 |
| Huge Navigator |
BIRC5 [HugePedia] |
| snp3D : Map Gene to Disease | 332 |
| BioCentury BCIQ | BIRC5 |
| ClinGen | BIRC5 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 332 |
| Chemical/Pharm GKB Gene | PA25362 |
| Clinical trial | BIRC5 |
| Miscellaneous |
|---|
| canSAR (ICR) | BIRC5 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | BIRC5 |
| EVEX | BIRC5 |
| GoPubMed | BIRC5 |
| iHOP | BIRC5 |
