| Nomenclature |
|---|
| HGNC (Hugo) | BIRC5 593 |
| Cards |
|---|
| Entrez_Gene (NCBI) | BIRC5 332 baculoviral IAP repeat containing 5 |
| Aliases | API4; EPR-1 |
| GeneCards (Weizmann) | BIRC5 |
| Ensembl hg19 (Hinxton) | ENSG00000089685 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000089685 [Gene_View] ENSG00000089685 [Sequence] chr17:78214196-78225635 [Contig_View] BIRC5 [Vega] |
| ICGC DataPortal | ENSG00000089685 |
| TCGA cBioPortal | BIRC5 |
| AceView (NCBI) | BIRC5 |
| Genatlas (Paris) | BIRC5 |
| WikiGenes | 332 |
| SOURCE (Princeton) | BIRC5 |
| Genetics Home Reference (NIH) | BIRC5 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | BIRC5 - chr17:78214196-78225635 + 17q25.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | BIRC5 - 17q25.3 [Description] (hg19-Feb_2009) |
| Ensembl | BIRC5 - 17q25.3 [CytoView hg19] BIRC5 - 17q25.3 [CytoView hg38] |
| Mapping of homologs : NCBI | BIRC5 [Mapview hg19] BIRC5 [Mapview hg38] |
| OMIM | 603352 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB028869 AB154416 AF077350 AI800528 AK223428 |
| RefSeq transcript (Entrez) | NM_001012270 NM_001012271 NM_001168 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | BIRC5 |
| Cluster EST : Unigene | Hs.744872 [ NCBI ] |
| CGAP (NCI) | Hs.744872 |
| Alternative Splicing Gallery | ENSG00000089685 |
| Gene Expression | BIRC5 [ NCBI-GEO ] BIRC5 [ EBI - ARRAY_EXPRESS ]
BIRC5 [ SEEK ] BIRC5 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | BIRC5 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 332 |
| GTEX Portal (Tissue expression) | BIRC5 |
| Human Protein Atlas | ENSG00000089685-BIRC5 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O15392 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O15392 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O15392 |
| Splice isoforms : SwissVar | O15392 |
| PhosPhoSitePlus | O15392 |
| Domaine pattern : Prosite (Expaxy) | BIR_REPEAT_2 (PS50143) |
| Domains : Interpro (EBI) | BIR_rpt |
| Domain families : Pfam (Sanger) | BIR (PF00653) |
| Domain families : Pfam (NCBI) | pfam00653 |
| Domain families : Smart (EMBL) | BIR (SM00238) |
| Conserved Domain (NCBI) | BIRC5 |
| DMDM Disease mutations | 332 |
| Blocks (Seattle) | BIRC5 |
| PDB (SRS) | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| PDB (PDBSum) | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| PDB (IMB) | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| PDB (RSDB) | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| Structural Biology KnowledgeBase | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| SCOP (Structural Classification of Proteins) | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| CATH (Classification of proteins structures) | 1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N |
| Superfamily | O15392 |
| Human Protein Atlas [tissue] | ENSG00000089685-BIRC5 [tissue] |
| Peptide Atlas | O15392 |
| HPRD | 04520 |
| IPI | IPI00006210 IPI00218095 IPI00735946 IPI00784964 IPI00784916 IPI00784873 IPI00785191 IPI01018308 IPI01019070 IPI01020912 IPI00056412 IPI01014811 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O15392 |
| IntAct (EBI) | O15392 |
| FunCoup | ENSG00000089685 |
| BioGRID | BIRC5 |
| STRING (EMBL) | BIRC5 |
| ZODIAC | BIRC5 |
| Ontologies - Pathways |
|---|
| QuickGO | O15392 |
| Ontology : AmiGO | nuclear chromosome chromosome, centromeric region condensed chromosome kinetochore protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm spindle cytosol cytosol microtubule transcription, DNA-templated protein phosphorylation apoptotic process chromosome segregation sensory perception of sound microtubule binding positive regulation of cell proliferation Ran GTPase binding protein ubiquitination cytokine-mediated signaling pathway enzyme binding midbody protein-containing complex localization chromosome passenger complex identical protein binding regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of transcription, DNA-templated metal ion binding chaperone binding cell division mitotic spindle assembly |
| Ontology : EGO-EBI | nuclear chromosome chromosome, centromeric region condensed chromosome kinetochore protein binding nucleus nucleus nucleoplasm cytoplasm cytoplasm spindle cytosol cytosol microtubule transcription, DNA-templated protein phosphorylation apoptotic process chromosome segregation sensory perception of sound microtubule binding positive regulation of cell proliferation Ran GTPase binding protein ubiquitination cytokine-mediated signaling pathway enzyme binding midbody protein-containing complex localization chromosome passenger complex identical protein binding regulation of apoptotic process negative regulation of apoptotic process negative regulation of apoptotic process negative regulation of transcription, DNA-templated metal ion binding chaperone binding cell division mitotic spindle assembly |
| Pathways : KEGG | Hippo signaling pathway Hepatitis B Pathways in cancer Colorectal cancer |
| NDEx Network | BIRC5 |
| Atlas of Cancer Signalling Network | BIRC5 |
| Wikipedia pathways | BIRC5 |
| Orthology - Evolution |
|---|
| OrthoDB | 332 |
| GeneTree (enSembl) | ENSG00000089685 |
| Phylogenetic Trees/Animal Genes : TreeFam | BIRC5 |
| HOVERGEN | O15392 |
| HOGENOM | O15392 |
| Homologs : HomoloGene | BIRC5 |
| Homology/Alignments : Family Browser (UCSC) | BIRC5 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | PGS1/BIRC5 [17q25.3/17q25.3] [t(17;17)(q25;q25)] |
| Fusion Portal | PGS1 17q25.3 BIRC5 17q25.3 BRCA |
| Fusion : Quiver | BIRC5 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | BIRC5 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | BIRC5 |
| dbVar | BIRC5 |
| ClinVar | BIRC5 |
| 1000_Genomes | BIRC5 |
| Exome Variant Server | BIRC5 |
| ExAC (Exome Aggregation Consortium) | ENSG00000089685 |
| GNOMAD Browser | ENSG00000089685 |
| Varsome Browser | BIRC5 |
| Genetic variants : HAPMAP | 332 |
| Genomic Variants (DGV) | BIRC5 [DGVbeta] |
| DECIPHER | BIRC5 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | BIRC5 |
| Mutations |
|---|
| ICGC Data Portal | BIRC5 |
| TCGA Data Portal | BIRC5 |
| Broad Tumor Portal | BIRC5 |
| OASIS Portal | BIRC5 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | BIRC5 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | BIRC5 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| BioMuta | search BIRC5 |
| DgiDB (Drug Gene Interaction Database) | BIRC5 |
| DoCM (Curated mutations) | BIRC5 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | BIRC5 (select a term) |
| intoGen | BIRC5 |
| Cancer3D | BIRC5(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 603352 |
| Orphanet | |
| DisGeNET | BIRC5 |
| Medgen | BIRC5 |
| Genetic Testing Registry | BIRC5
|
| NextProt | O15392 [Medical] |
| TSGene | 332 |
| GENETests | BIRC5 |
| Target Validation | BIRC5 |
| Huge Navigator |
BIRC5 [HugePedia] |
| snp3D : Map Gene to Disease | 332 |
| BioCentury BCIQ | BIRC5 |
| ClinGen | BIRC5 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 332 |
| Chemical/Pharm GKB Gene | PA25362 |
| Clinical trial | BIRC5 |
| Miscellaneous |
|---|
| canSAR (ICR) | BIRC5 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | BIRC5 |
| EVEX | BIRC5 |
| GoPubMed | BIRC5 |
| iHOP | BIRC5 |
