BLK (B lymphoid tyrosine kinase)

Identity

Other names	MGC10442
HGNC	BLK
Location	8p23-p22
Location_base_pair	Starts at 11388930 and ends at 11459517 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	BLK   1057
Entrez_Gene	BLK  640  B lymphoid tyrosine kinase
	Cards
GeneCards	BLK
Ensembl	BLK [Search_View]   ENSG00000136573 [Gene_View]
Genatlas	BLK
GeneLynx	BLK
eGenome	BLK
euGene	640
	Genomic and cartography
GoldenPath	BLK  -     chr8:11388930-11459517 +  8p23.1   [Description]    (hg18-March_2006)
Ensembl	BLK - 8p23.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	BLK
	Gene and transcription
Genbank	AK313751 [ ENTREZ ]
Genbank	AL832875 [ ENTREZ ]
Genbank	BC004473 [ ENTREZ ]
Genbank	BC007371 [ ENTREZ ]
Genbank	BC018703 [ ENTREZ ]
RefSeq	NM_001715 [ SRS ]    NM_001715 [ ENTREZ ]
RefSeq	AC_000051 [ SRS ]    AC_000051 [ ENTREZ ]
RefSeq	AC_000140 [ SRS ]    AC_000140 [ ENTREZ ]
RefSeq	NC_000008 [ SRS ]    NC_000008 [ ENTREZ ]
RefSeq	NT_077531 [ SRS ]    NT_077531 [ ENTREZ ]
RefSeq	NW_001839122 [ SRS ]    NW_001839122 [ ENTREZ ]
RefSeq	NW_923873 [ SRS ]    NW_923873 [ ENTREZ ]
AceView	BLK AceView - NCBI
Unigene	Hs.146591 [ SRS ]    Hs.146591 [ NCBI ]     HS146591 [ spliceNest ]
Fast-db	1305 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P51451 [ SRS]    P51451 [ EXPASY ]     P51451 [ INTERPRO ]     P51451 [ UNIPROT ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00109 PROTEIN_KINASE_TYR [ SRS ]    PS00109 PROTEIN_KINASE_TYR [ Expasy ]
Prosite	PS50001 SH2 [ SRS ]    PS50001 SH2 [ Expasy ]
Prosite	PS50002 SH3 [ SRS ]    PS50002 SH3 [ Expasy ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR000980 SH2 [ SRS ]    IPR000980 SH2 [ EBI ]
Interpro	IPR001452 SH3 [ SRS ]    IPR001452 SH3 [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
Interpro	IPR008266 Tyr_pkinase_AS [ SRS ]    IPR008266 Tyr_pkinase_AS [ EBI ]
CluSTr	P51451
Pfam	PF07714 Pkinase_Tyr [ SRS ]    PF07714 Pkinase_Tyr [ Sanger ]    pfam07714 [ NCBI-CDD ]
Pfam	PF00017 SH2 [ SRS ]    PF00017 SH2 [ Sanger ]    pfam00017 [ NCBI-CDD ]
Pfam	PF00018 SH3_1 [ SRS ]    PF00018 SH3_1 [ Sanger ]    pfam00018 [ NCBI-CDD ]
Smart	SM00252 SH2 [EMBL]
Smart	SM00326 SH3 [EMBL]
Smart	SM00219 TyrKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P51451 BLK_HUMAN [ Domain structure ]   P51451 BLK_HUMAN  [ sequences sharing at least 1 domain ]
Prodom	PD000001[INRA-Toulouse]
Prodom	P51451 BLK_HUMAN [ Domain structure ]   P51451 BLK_HUMAN  [ sequences sharing at least 1 domain ]
Prodom	PD000001[INRA-Toulouse]
Prodom	P51451 BLK_HUMAN [ Domain structure ]   P51451 BLK_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P51451
HPRD	01866
	Protein Interaction databases
DIP	P51451
IntAct	P51451
	Polymorphism : SNP, mutations, diseases
OMIM	191305    [ map ]
GENECLINICS	191305
SNP	BLK [dbSNP-NCBI]
SNP	NM_001715 [SNP-NCI]
SNP	BLK [GeneSNPs - Utah]  BLK] [HGBASE - SRS]
HAPMAP	BLK [HAPMAP]
COSMIC	BLK [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	BLK
	General knowledge
Family Browser	BLK [UCSC Family Browser]
SOURCE	NM_001715
SMD	Hs.146591
SAGE	Hs.146591
Enzyme	2.7.10.2 [ Enzyme-Expasy ]   2.7.10.2 [ Enzyme-SRS ]   2.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   2.7.10.2 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	non-membrane spanning protein tyrosine kinase activity [Amigo]  non-membrane spanning protein tyrosine kinase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	protein kinase cascade [Amigo]  protein kinase cascade
GO	transferase activity [Amigo]  transferase activity
PubGene	BLK
TreeFam	BLK
CTD	640 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	BLK Related clones (RZPD - Berlin)
	PubMed
PubMed	17 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:04:49 2008