Atlas of Genetics and Cytogenetics in Oncology and Haematology

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BLK (BLK proto-oncogene, Src family tyrosine kinase)

Identity

Other namesMODY11
HGNC (Hugo) BLK
LocusID (NCBI) 640
Location 8p23.1
Location_base_pair Starts at 11351521 and ends at 11422108 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias t0817q24q22ID1494

External links

Nomenclature
HGNC (Hugo)BLK   1057
Cards
Entrez_Gene (NCBI)BLK  640  BLK proto-oncogene, Src family tyrosine kinase
GeneCards (Weizmann)BLK
Ensembl (Hinxton)ENSG00000136573 [Gene_View]  chr8:11351521-11422108 [Contig_View]  BLK [Vega]
ICGC DataPortalENSG00000136573
cBioPortalBLK
AceView (NCBI)BLK
Genatlas (Paris)BLK
WikiGenes640
SOURCE (Princeton)NM_001715
Genomic and cartography
GoldenPath (UCSC)BLK  -  8p23.1   chr8:11351521-11422108 +  8p23.1   [Description]    (hg19-Feb_2009)
EnsemblBLK - 8p23.1 [CytoView]
Mapping of homologs : NCBIBLK [Mapview]
OMIM191305   613375   
Gene and transcription
Genbank (Entrez)AK313751 AL832875 BC004473 BC007371 BC018703
RefSeq transcript (Entrez)NM_001715
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NG_023543 NT_077531 NW_001839122 NW_004929336
Consensus coding sequences : CCDS (NCBI)BLK
Cluster EST : UnigeneHs.146591 [ NCBI ]
CGAP (NCI)Hs.146591
Alternative Splicing : Fast-db (Paris)GSHG0028812
Alternative Splicing GalleryENSG00000136573
Gene ExpressionBLK [ NCBI-GEO ]     BLK [ SEEK ]   BLK [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51451 (Uniprot)
NextProtP51451  [Medical]
With graphics : InterProP51451
Splice isoforms : SwissVarP51451 (Swissvar)
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser-Thr/Tyr_kinase_cat_dom [organisation]   SH2 [organisation]   SH3_domain [organisation]   Tyr_kinase_cat_dom [organisation]  
Related proteins : CluSTrP51451
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
DMDM Disease mutations640
Blocks (Seattle)P51451
Human Protein AtlasENSG00000136573 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP51451
HPRD01866
IPIIPI00941870   IPI00554756   IPI00977308   IPI00983083   
Protein Interaction databases
DIP (DOE-UCLA)P51451
IntAct (EBI)P51451
FunCoupENSG00000136573
BioGRIDBLK
InParanoidP51451
Interologous Interaction database P51451
IntegromeDBBLK
STRING (EMBL)BLK
Ontologies - Pathways
Ontology : AmiGOprotein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  plasma membrane  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  positive regulation of insulin secretion  intracellular signal transduction  B cell receptor signaling pathway  
Ontology : EGO-EBIprotein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  plasma membrane  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  positive regulation of insulin secretion  intracellular signal transduction  B cell receptor signaling pathway  
Protein Interaction DatabaseBLK
Wikipedia pathwaysBLK
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)BLK
snp3D : Map Gene to Disease640
SNP (GeneSNP Utah)BLK
SNP : HGBaseBLK
Genetic variants : HAPMAPBLK
Exome VariantBLK
1000_GenomesBLK 
ICGC programENSG00000136573 
Somatic Mutations in Cancer : COSMICBLK 
CONAN: Copy Number AnalysisBLK 
Mutations and Diseases : HGMDBLK
Genomic VariantsBLK  BLK [DGVbeta]
dbVarBLK
ClinVarBLK
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM191305    613375   
MedgenBLK
GENETestsBLK
Disease Genetic AssociationBLK
Huge Navigator BLK [HugePedia]  BLK [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneBLK
Homology/Alignments : Family Browser (UCSC)BLK
Phylogenetic Trees/Animal Genes : TreeFamBLK
Chemical/Protein Interactions : CTD640
Chemical/Pharm GKB GenePA25368
Clinical trialBLK
Cancer Resource (Charite)ENSG00000136573
Other databases
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
CoreMineBLK
iHOPBLK
OncoSearchBLK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:44:58 CEST 2014
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