Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

BLK (BLK proto-oncogene, Src family tyrosine kinase)

Identity

Alias_namesB lymphoid tyrosine kinase
Alias_symbol (synonym)MGC10442
Other aliasMODY11
HGNC (Hugo) BLK
LocusID (NCBI) 640
Atlas_Id 802
Location 8p23.1  [Link to chromosome band 8p23]
Location_base_pair Starts at 11494012 and ends at 11564599 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BLK (8p23.1) / BLK (8p23.1)SLC39A1 (1q21.3) / BLK (8p23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  dic(9;20)(p11-13;q11) PAX5/Various
t(20;21)(q13.2;q22.12) ZFP64/RUNX1

External links

Nomenclature
HGNC (Hugo)BLK   1057
Cards
Entrez_Gene (NCBI)BLK  640  BLK proto-oncogene, Src family tyrosine kinase
AliasesMODY11
GeneCards (Weizmann)BLK
Ensembl hg19 (Hinxton)ENSG00000136573 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136573 [Gene_View]  ENSG00000136573 [Sequence]  chr8:11494012-11564599 [Contig_View]  BLK [Vega]
ICGC DataPortalENSG00000136573
TCGA cBioPortalBLK
AceView (NCBI)BLK
Genatlas (Paris)BLK
WikiGenes640
SOURCE (Princeton)BLK
Genetics Home Reference (NIH)BLK
Genomic and cartography
GoldenPath hg38 (UCSC)BLK  -     chr8:11494012-11564599 +  8p23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BLK  -     8p23.1   [Description]    (hg19-Feb_2009)
EnsemblBLK - 8p23.1 [CytoView hg19]  BLK - 8p23.1 [CytoView hg38]
Mapping of homologs : NCBIBLK [Mapview hg19]  BLK [Mapview hg38]
OMIM191305   613375   
Gene and transcription
Genbank (Entrez)AK313751 AL832875 BC004473 BC007371 BC018703
RefSeq transcript (Entrez)NM_001330465 NM_001715
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BLK
Cluster EST : UnigeneHs.146591 [ NCBI ]
CGAP (NCI)Hs.146591
Alternative Splicing GalleryENSG00000136573
Gene ExpressionBLK [ NCBI-GEO ]   BLK [ EBI - ARRAY_EXPRESS ]   BLK [ SEEK ]   BLK [ MEM ]
Gene Expression Viewer (FireBrowse)BLK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)640
GTEX Portal (Tissue expression)BLK
Human Protein AtlasENSG00000136573-BLK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51451   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51451  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51451
Splice isoforms : SwissVarP51451
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
PhosPhoSitePlusP51451
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH3_domain    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)BLK
DMDM Disease mutations640
Blocks (Seattle)BLK
SuperfamilyP51451
Human Protein Atlas [tissue]ENSG00000136573-BLK [tissue]
Peptide AtlasP51451
HPRD01866
IPIIPI00941870   IPI00554756   IPI00977308   IPI00983083   
Protein Interaction databases
DIP (DOE-UCLA)P51451
IntAct (EBI)P51451
FunCoupENSG00000136573
BioGRIDBLK
STRING (EMBL)BLK
ZODIACBLK
Ontologies - Pathways
QuickGOP51451
Ontology : AmiGOprotein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  cytosol  transmembrane receptor protein tyrosine kinase signaling pathway  cell migration  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  positive regulation of insulin secretion  intracellular signal transduction  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  innate immune response  B cell receptor signaling pathway  regulation of B cell receptor signaling pathway  
Ontology : EGO-EBIprotein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  cytosol  transmembrane receptor protein tyrosine kinase signaling pathway  cell migration  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  positive regulation of insulin secretion  intracellular signal transduction  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  innate immune response  B cell receptor signaling pathway  regulation of B cell receptor signaling pathway  
NDEx NetworkBLK
Atlas of Cancer Signalling NetworkBLK
Wikipedia pathwaysBLK
Orthology - Evolution
OrthoDB640
GeneTree (enSembl)ENSG00000136573
Phylogenetic Trees/Animal Genes : TreeFamBLK
HOVERGENP51451
HOGENOMP51451
Homologs : HomoloGeneBLK
Homology/Alignments : Family Browser (UCSC)BLK
Gene fusions - Rearrangements
Fusion : QuiverBLK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBLK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BLK
dbVarBLK
ClinVarBLK
1000_GenomesBLK 
Exome Variant ServerBLK
ExAC (Exome Aggregation Consortium)ENSG00000136573
GNOMAD BrowserENSG00000136573
Genetic variants : HAPMAP640
Genomic Variants (DGV)BLK [DGVbeta]
DECIPHERBLK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBLK 
Mutations
ICGC Data PortalBLK 
TCGA Data PortalBLK 
Broad Tumor PortalBLK
OASIS PortalBLK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBLK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBLK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BLK
DgiDB (Drug Gene Interaction Database)BLK
DoCM (Curated mutations)BLK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BLK (select a term)
intoGenBLK
Cancer3DBLK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191305    613375   
Orphanet8028   
DisGeNETBLK
MedgenBLK
Genetic Testing Registry BLK
NextProtP51451 [Medical]
TSGene640
GENETestsBLK
Target ValidationBLK
Huge Navigator BLK [HugePedia]
snp3D : Map Gene to Disease640
BioCentury BCIQBLK
ClinGenBLK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD640
Chemical/Pharm GKB GenePA25368
Clinical trialBLK
Miscellaneous
canSAR (ICR)BLK (select the gene name)
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBLK
EVEXBLK
GoPubMedBLK
iHOPBLK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:16:16 CEST 2018
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.