Atlas of Genetics and Cytogenetics in Oncology and Haematology


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BLK (BLK proto-oncogene, Src family tyrosine kinase)

Identity

Alias (NCBI)MODY11
HGNC (Hugo) BLK
HGNC Alias symbMGC10442
HGNC Previous nameB lymphoid tyrosine kinase
LocusID (NCBI) 640
Atlas_Id 802
Location 8p23.1  [Link to chromosome band 8p23]
Location_base_pair Starts at 11494387 and ends at 11564599 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BLK (8p23.1) / BLK (8p23.1)SLC39A1 (1q21.3) / BLK (8p23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  dic(9;20)(p11-13;q11) PAX5/Various
t(20;21)(q13.2;q22.12) ZFP64/RUNX1


External links

Nomenclature
HGNC (Hugo)BLK   1057
Cards
Entrez_Gene (NCBI)BLK  640  BLK proto-oncogene, Src family tyrosine kinase
AliasesMODY11
GeneCards (Weizmann)BLK
Ensembl hg19 (Hinxton)ENSG00000136573 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136573 [Gene_View]  ENSG00000136573 [Sequence]  chr8:11494387-11564599 [Contig_View]  BLK [Vega]
ICGC DataPortalENSG00000136573
TCGA cBioPortalBLK
AceView (NCBI)BLK
Genatlas (Paris)BLK
WikiGenes640
SOURCE (Princeton)BLK
Genetics Home Reference (NIH)BLK
Genomic and cartography
GoldenPath hg38 (UCSC)BLK  -     chr8:11494387-11564599 +  8p23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BLK  -     8p23.1   [Description]    (hg19-Feb_2009)
GoldenPathBLK - 8p23.1 [CytoView hg19]  BLK - 8p23.1 [CytoView hg38]
ImmunoBaseENSG00000136573
genome Data Viewer NCBIBLK [Mapview hg19]  
OMIM191305   613375   
Gene and transcription
Genbank (Entrez)AK313751 AL832875 BC004473 BC007371 BC018703
RefSeq transcript (Entrez)NM_001330465 NM_001715
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BLK
Alternative Splicing GalleryENSG00000136573
Gene ExpressionBLK [ NCBI-GEO ]   BLK [ EBI - ARRAY_EXPRESS ]   BLK [ SEEK ]   BLK [ MEM ]
Gene Expression Viewer (FireBrowse)BLK [ Firebrowse - Broad ]
GenevisibleExpression of BLK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)640
GTEX Portal (Tissue expression)BLK
Human Protein AtlasENSG00000136573-BLK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51451   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51451  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51451
Splice isoforms : SwissVarP51451
PhosPhoSitePlusP51451
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Blk_SH2    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    SH3-like_dom_sf    SH3_domain    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)BLK
DMDM Disease mutations640
Blocks (Seattle)BLK
SuperfamilyP51451
Human Protein Atlas [tissue]ENSG00000136573-BLK [tissue]
Peptide AtlasP51451
HPRD01866
IPIIPI00941870   IPI00554756   IPI00977308   IPI00983083   
Protein Interaction databases
DIP (DOE-UCLA)P51451
IntAct (EBI)P51451
FunCoupENSG00000136573
BioGRIDBLK
STRING (EMBL)BLK
ZODIACBLK
Ontologies - Pathways
QuickGOP51451
Ontology : AmiGOFc receptor mediated stimulatory signaling pathway  tolerance induction to self antigen  platelet degranulation  regulation of B cell apoptotic process  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  cytosol  cellular response to DNA damage stimulus  transmembrane receptor protein tyrosine kinase signaling pathway  peptidyl-tyrosine phosphorylation  cell differentiation  negative regulation of B cell proliferation  neuron projection development  extrinsic component of cytoplasmic side of plasma membrane  positive regulation of insulin secretion  intracellular signal transduction  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  regulation of mast cell degranulation  innate immune response  B cell receptor signaling pathway  regulation of B cell receptor signaling pathway  regulation of B cell receptor signaling pathway  negative regulation of mast cell proliferation  regulation of platelet aggregation  dendritic cell differentiation  positive regulation of dendritic cell apoptotic process  
Ontology : EGO-EBIFc receptor mediated stimulatory signaling pathway  tolerance induction to self antigen  platelet degranulation  regulation of B cell apoptotic process  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  cytosol  cellular response to DNA damage stimulus  transmembrane receptor protein tyrosine kinase signaling pathway  peptidyl-tyrosine phosphorylation  cell differentiation  negative regulation of B cell proliferation  neuron projection development  extrinsic component of cytoplasmic side of plasma membrane  positive regulation of insulin secretion  intracellular signal transduction  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  regulation of mast cell degranulation  innate immune response  B cell receptor signaling pathway  regulation of B cell receptor signaling pathway  regulation of B cell receptor signaling pathway  negative regulation of mast cell proliferation  regulation of platelet aggregation  dendritic cell differentiation  positive regulation of dendritic cell apoptotic process  
NDEx NetworkBLK
Atlas of Cancer Signalling NetworkBLK
Wikipedia pathwaysBLK
Orthology - Evolution
OrthoDB640
GeneTree (enSembl)ENSG00000136573
Phylogenetic Trees/Animal Genes : TreeFamBLK
HOGENOMP51451
Homologs : HomoloGeneBLK
Homology/Alignments : Family Browser (UCSC)BLK
Gene fusions - Rearrangements
Fusion : QuiverBLK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBLK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BLK
dbVarBLK
ClinVarBLK
MonarchBLK
1000_GenomesBLK 
Exome Variant ServerBLK
GNOMAD BrowserENSG00000136573
Varsome BrowserBLK
Genetic variants : HAPMAP640
Genomic Variants (DGV)BLK [DGVbeta]
DECIPHERBLK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBLK 
Mutations
ICGC Data PortalBLK 
TCGA Data PortalBLK 
Broad Tumor PortalBLK
OASIS PortalBLK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBLK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DBLK
Mutations and Diseases : HGMDBLK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BLK
DgiDB (Drug Gene Interaction Database)BLK
DoCM (Curated mutations)BLK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BLK (select a term)
intoGenBLK
Cancer3DBLK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191305    613375   
Orphanet8028   
DisGeNETBLK
MedgenBLK
Genetic Testing Registry BLK
NextProtP51451 [Medical]
TSGene640
GENETestsBLK
Target ValidationBLK
Huge Navigator BLK [HugePedia]
snp3D : Map Gene to Disease640
BioCentury BCIQBLK
ClinGenBLK
Clinical trials, drugs, therapy
Protein Interactions : CTD640
Pharm GKB GenePA25368
Clinical trialBLK
Miscellaneous
canSAR (ICR)BLK (select the gene name)
HarmonizomeBLK
DataMed IndexBLK
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBLK
EVEXBLK
GoPubMedBLK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:03:18 CEST 2020

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