Atlas of Genetics and Cytogenetics in Oncology and Haematology


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BLM (Bloom)

Identity

HGNC (Hugo) BLM
LocusID (NCBI) 641
Location 15q26.1
Location_base_pair Starts at 91260558 and ends at 91358692 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Transcription 4.4kb mRNA

Protein

Description 1417 amino acids; ATP binding in amino acid 689-696; DEAH box in 795-798; two putative nuclear localization signals in the C-term in 1334-1349
Expression accumulates to high levels in S phase of the cell cycle, persists in G2/M and sharply declines in G1. Hyperphoshorylated in mitosis
Localisation nuclear (PML nuclear bodies and nucleolus)
Function
  • 3'-5'DNA helicase; probable role in DNA replication and double-strand break repair
  • Preferred substrates : G-quadruplex DNA, D-loops structures and X-junctions.
  • Recombinant protein promotes ATP-dependent branch migration of Hollyday junctions, effects, with topoisomerase III?, the resolution of a recombination intermediate containing a double Holliday junction with no flanking sequence exchanges, and possess a strand pairing activity.
  • Recombinant BLM possess a strand pairing activity.
  • Participates in a supercomplex of BRCA1 -associated proteins named BASC (BRCA1-Associated genome Surveillance Complex) containing ATM (defective in ataxia telangiectasia), NBS1 (defective in Nijmegen syndrome) and MRE11 (defective in ataxia-telangiectasia-like disorder), MLH1, MSH2 and MSH6, which are involved in human non-polyposis colorectal cancer, RAD50 and DNA replication factor C.
  • Participates in a complex named BRAFT (BLM, RPA, FA, Topoisomerase III) containing five of the Fanconia Anemia (FA) complementation group proteins (FANCA, FANCG, FANCC, FANCE and FANCF).
  • Interacts physically and/or functionally with p53, 53BP1, WRN, MLH1, RAD51, TRF2, ATR, the largest subunit of CAF-1, ligase IV, FEN1, Mus81, the monoubiquitinated FANCD2 isoform
  • Is Associated with telomeres and ribosomal DNA repeats.
  • Is phosphorylated in mitotic cells through the cdc2 pathway, and in response to DNA damaging agents or stalled replication forks.
  • Homology homologous to RecQ helicases, a subfamily of DExH box-containing helicases; in particular, similarity with the four known human members in the RecQ subfamily, human RecQL, human Wrn, the product of the Werner syndrome gene, and the human RecQL4, involved in the Rothmund-Thomson syndrome, and RecQL5 proteins

    Mutations

    Germinal five BLM mutations introducing amino acid substitutions and four BLM mutations introducing premature nonsense codons into the coding sequence have been described to date; one BLM mutation consisting in a 6 bp deletion accompanied by a 7 bp insertion at nucleic acid position 2281 is common in patients from Ashkenazi Jewish ancestry, leading to a truncated protein of 739 amino acids in length; two BLM mutations, 631delCAA and 1610insA were detected in japanese patients.

    Implicated in

    Entity Bloom syndrome
    Disease Bloom syndrome is a chromosome instability syndrome/cancer prone disease (at risk of numerous, early occurring cancers of various types)
    Prognosis 1/3 of patients are dead at mean age 24 yrs, and the mean age of the 2/3 remaining alive patients is 22 yrs
    Cytogenetics chromatid/chromosome breaks; triradial and quadriradial figures, highly elevated spontaneous sister chromatid exchange rate
      

    External links

    Nomenclature
    HGNC (Hugo)BLM   1058
    Cards
    AtlasBLM109
    Entrez_Gene (NCBI)BLM  641  Bloom syndrome, RecQ helicase-like
    GeneCards (Weizmann)BLM
    Ensembl (Hinxton)ENSG00000197299 [Gene_View]  chr15:91260558-91358692 [Contig_View]  BLM [Vega]
    ICGC DataPortalENSG00000197299
    cBioPortalBLM
    AceView (NCBI)BLM
    Genatlas (Paris)BLM
    WikiGenes641
    SOURCE (Princeton)NM_000057 NM_001287246 NM_001287247 NM_001287248
    Genomic and cartography
    GoldenPath (UCSC)BLM  -  15q26.1   chr15:91260558-91358692 +  15q26.1   [Description]    (hg19-Feb_2009)
    EnsemblBLM - 15q26.1 [CytoView]
    Mapping of homologs : NCBIBLM [Mapview]
    OMIM210900   604610   
    Gene and transcription
    Genbank (Entrez)AK295194 AK303159 AK314262 BC034480 BC062697
    RefSeq transcript (Entrez)NM_000057 NM_001287246 NM_001287247 NM_001287248
    RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_007272 NT_010194 NW_001838222 NW_004929399
    Consensus coding sequences : CCDS (NCBI)BLM
    Cluster EST : UnigeneHs.725208 [ NCBI ]
    CGAP (NCI)Hs.725208
    Alternative Splicing : Fast-db (Paris)GSHG0010155
    Alternative Splicing GalleryENSG00000197299
    Gene ExpressionBLM [ NCBI-GEO ]     BLM [ SEEK ]   BLM [ MEM ]
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtP54132 (Uniprot)
    NextProtP54132  [Medical]
    With graphics : InterProP54132
    Splice isoforms : SwissVarP54132 (Swissvar)
    Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   
    Domaine pattern : Prosite (Expaxy)DEAH_ATP_HELICASE (PS00690)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    HRDC (PS50967)   
    Domains : Interpro (EBI)BDHCT [organisation]   DNA/RNA_helicase_DEAD/DEAH_N [organisation]   DNA/RNA_helicase_DEAH_CS [organisation]   DNA_helicase_ATP-dep_RecQ [organisation]   Helicase_ATP-bd [organisation]   Helicase_C [organisation]   HRDC-like [organisation]   HRDC_dom [organisation]   P-loop_NTPase [organisation]   RQC_domain [organisation]   WHTH_DNA-bd_dom [organisation]  
    Related proteins : CluSTrP54132
    Domain families : Pfam (Sanger)BDHCT (PF08072)    DEAD (PF00270)    Helicase_C (PF00271)    HRDC (PF00570)    RQC (PF09382)   
    Domain families : Pfam (NCBI)pfam08072    pfam00270    pfam00271    pfam00570    pfam09382   
    Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  HRDC (SM00341)  RQC (SM00956)  
    DMDM Disease mutations641
    Blocks (Seattle)P54132
    PDB (SRS)2KV2    2RRD    3WE2    3WE3    4CDG    4CGZ    4O3M   
    PDB (PDBSum)2KV2    2RRD    3WE2    3WE3    4CDG    4CGZ    4O3M   
    PDB (IMB)2KV2    2RRD    3WE2    3WE3    4CDG    4CGZ    4O3M   
    PDB (RSDB)2KV2    2RRD    3WE2    3WE3    4CDG    4CGZ    4O3M   
    Human Protein AtlasENSG00000197299 [gene] [tissue] [antibody] [cell] [cancer]
    Peptide AtlasP54132
    HPRD05211
    IPIIPI00004859   IPI00921897   IPI01010118   
    Protein Interaction databases
    DIP (DOE-UCLA)P54132
    IntAct (EBI)P54132
    FunCoupENSG00000197299
    BioGRIDBLM
    InParanoidP54132
    Interologous Interaction database P54132
    IntegromeDBBLM
    STRING (EMBL)BLM
    Ontologies - Pathways
    Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  mitotic G2 phase  nuclear chromosome  bubble DNA binding  telomere maintenance  double-strand break repair via homologous recombination  DNA double-strand break processing  DNA strand renaturation  chromosome, telomeric region  lateral element  male germ cell nucleus  p53 binding  single-stranded DNA binding  ATP-dependent DNA helicase activity  ATP-dependent DNA helicase activity  helicase activity  protein binding  ATP binding  nucleus  replication fork  nucleolus  cytoplasm  ATP catabolic process  ATP catabolic process  DNA repair  DNA recombination  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  ATP-dependent helicase activity  four-way junction helicase activity  response to X-ray  nuclear matrix  PML body  PML body  ATPase activity  replication fork processing  G2 DNA damage checkpoint  DNA duplex unwinding  DNA duplex unwinding  DNA duplex unwinding  annealing helicase activity  ATP-dependent 3'-5' DNA helicase activity  pronucleus  positive regulation of transcription, DNA-templated  negative regulation of DNA recombination  negative regulation of mitotic recombination  alpha-beta T cell differentiation  positive regulation of alpha-beta T cell proliferation  replication fork protection  regulation of binding  protein oligomerization  negative regulation of cell division  G-quadruplex DNA binding  negative regulation of thymocyte apoptotic process  cellular response to ionizing radiation  cellular response to hydroxyurea  cellular response to camptothecin  
    Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  mitotic G2 phase  nuclear chromosome  bubble DNA binding  telomere maintenance  double-strand break repair via homologous recombination  DNA double-strand break processing  DNA strand renaturation  chromosome, telomeric region  lateral element  male germ cell nucleus  p53 binding  single-stranded DNA binding  ATP-dependent DNA helicase activity  ATP-dependent DNA helicase activity  helicase activity  protein binding  ATP binding  nucleus  replication fork  nucleolus  cytoplasm  ATP catabolic process  ATP catabolic process  DNA repair  DNA recombination  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  ATP-dependent helicase activity  four-way junction helicase activity  response to X-ray  nuclear matrix  PML body  PML body  ATPase activity  replication fork processing  G2 DNA damage checkpoint  DNA duplex unwinding  DNA duplex unwinding  DNA duplex unwinding  annealing helicase activity  ATP-dependent 3'-5' DNA helicase activity  pronucleus  positive regulation of transcription, DNA-templated  negative regulation of DNA recombination  negative regulation of mitotic recombination  alpha-beta T cell differentiation  positive regulation of alpha-beta T cell proliferation  replication fork protection  regulation of binding  protein oligomerization  negative regulation of cell division  G-quadruplex DNA binding  negative regulation of thymocyte apoptotic process  cellular response to ionizing radiation  cellular response to hydroxyurea  cellular response to camptothecin  
    Pathways : KEGGHomologous recombination    Fanconi anemia pathway   
    Protein Interaction DatabaseBLM
    Wikipedia pathwaysBLM
    Gene fusion - rearrangments
    Polymorphisms : SNP, mutations, diseases
    SNP Single Nucleotide Polymorphism (NCBI)BLM
    snp3D : Map Gene to Disease641
    SNP (GeneSNP Utah)BLM
    SNP : HGBaseBLM
    Genetic variants : HAPMAPBLM
    Exome VariantBLM
    1000_GenomesBLM 
    ICGC programENSG00000197299 
    Cancer Gene: CensusBLM 
    Somatic Mutations in Cancer : COSMICBLM 
    CONAN: Copy Number AnalysisBLM 
    Mutations and Diseases : HGMDBLM
    Genomic VariantsBLM  BLM [DGVbeta]
    dbVarBLM
    ClinVarBLM
    Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
    Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
    Diseases
    OMIM210900    604610   
    MedgenBLM
    GENETestsBLM
    Disease Genetic AssociationBLM
    Huge Navigator BLM [HugePedia]  BLM [HugeCancerGEM]
    General knowledge
    Homologs : HomoloGeneBLM
    Homology/Alignments : Family Browser (UCSC)BLM
    Phylogenetic Trees/Animal Genes : TreeFamBLM
    Chemical/Protein Interactions : CTD641
    Chemical/Pharm GKB GenePA25369
    Clinical trialBLM
    Cancer Resource (Charite)ENSG00000197299
    Other databases
    Probes
    Litterature
    PubMed219 Pubmed reference(s) in Entrez
    CoreMineBLM
    iHOPBLM
    OncoSearchBLM

    Bibliography

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    The Journal of biological chemistry. 1994 ; 269 (47) : 29838-29845.
    PMID 7961977
     
    Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12.
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    Molecular genetics of Bloom's syndrome.
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    Characterization of a new BLM mutation associated with a topoisomerase II alpha defect in a patient with Bloom's syndrome.
    Foucault F, Vaury C, Barakat A, Thibout D, Planchon P, Jaulin C, Praz F, Amor-Guˆ©ret M
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    BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal.
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    The Bloom's syndrome gene product is a 3'-5' DNA helicase.
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    Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes.
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    The Bloom's syndrome helicase unwinds G4 DNA.
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    PMID 9765292
     
    PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1.
    Ishov AM, Sotnikov AG, Negorev D, Vladimirova OV, Neff N, Kamitani T, Yeh ET, Strauss JF 3rd, Maul GG
    The Journal of cell biology. 1999 ; 147 (2) : 221-234.
    PMID 10525530
     
    Nuclear structure in normal and Bloom syndrome cells.
    Yankiwski V, Marciniak RA, Guarente L, Neff NF
    Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (10) : 5214-5219.
    PMID 10779560
     
    Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
    Lindor NM, Furuichi Y, Kitao S, Shimamoto A, Arndt C, Jalal S
    American journal of medical genetics. 2000 ; 90 (3) : 223-228.
    PMID 10678659
     
    Cell cycle regulation of the endogenous wild type Bloom's syndrome DNA helicase.
    Dutertre S, Ababou M, Onclercq R, Delic J, Chatton B, Jaulin C, Amor-Guˆ©ret M
    Oncogene. 2000 ; 19 (23) : 2731-2738.
    PMID 10851073
     
    Identification of a novel BLM missense mutation (2706T>C) in a Moroccan patient with Bloom's syndrome.
    Barakat A, Ababou M, Onclercq R, Dutertre S, Chadli E, Hda N, Benslimane A, Amor-Guˆ©ret M
    Human mutation. 2000 ; 15 (6) : 584-585.
    PMID 10862105
     
    Binding and melting of D-loops by the Bloom syndrome helicase.
    van Brabant AJ, Ye T, Sanz M, German III JL, Ellis NA, Holloman WK
    Biochemistry. 2000 ; 39 (47) : 14617-14625.
    PMID 11087418
     
    ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation.
    Ababou M, Dutertre S, Lˆ©cluse Y, Onclercq R, Chatton B, Amor-Guˆ©ret M
    Oncogene. 2000 ; 19 (52) : 5955-5963.
    PMID 11146546
     
    The Bloom's syndrome gene product promotes branch migration of holliday junctions.
    Karow JK, Constantinou A, Li JL, West SC, Hickson ID
    Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (12) : 6504-6508.
    PMID 10823897
     
    BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
    Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J
    Genes & development. 2000 ; 14 (8) : 927-939.
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    The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.
    Mohaghegh P, Karow JK, Brosh Jr RM Jr, Bohr VA, Hickson ID
    Nucleic acids research. 2001 ; 29 (13) : 2843-2849.
    PMID 11433031
     
    The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair.
    Langland G, Kordich J, Creaney J, Goss KH, Lillard-Wetherell K, Bebenek K, Kunkel TA, Groden J
    The Journal of biological chemistry. 2001 ; 276 (32) : 30031-30035.
    PMID 11325959
     
    Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1.
    Pedrazzi G, Perrera C, Blaser H, Kuster P, Marra G, Davies SL, Ryu GH, Freire R, Hickson ID, Jiricny J, Stagljar I
    Nucleic acids research. 2001 ; 29 (21) : 4378-4386.
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    The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control.
    Garkavtsev IV, Kley N, Grigorian IA, Gudkov AV
    Oncogene. 2001 ; 20 (57) : 8276-8280.
    PMID 11781842
     
    Functional interaction of p53 and BLM DNA helicase in apoptosis.
    Wang XW, Tseng A, Ellis NA, Spillare EA, Linke SP, Robles AI, Seker H, Yang Q, Hu P, Beresten S, Bemmels NA, Garfield S, Harris CC
    The Journal of biological chemistry. 2001 ; 276 (35) : 32948-32955.
    PMID 11399766
     
    Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51.
    Wu L, Davies SL, Levitt NC, Hickson ID
    The Journal of biological chemistry. 2001 ; 276 (22) : 19375-19381.
    PMID 11278509
     
    Regulation and localization of the Bloom syndrome protein in response to DNA damage.
    Bischof O, Kim SH, Irving J, Beresten S, Ellis NA, Campisi J
    The Journal of cell biology. 2001 ; 153 (2) : 367-380.
    PMID 11309417
     
    The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.
    Yang Q, Zhang R, Wang XW, Spillare EA, Linke SP, Subramanian D, Griffith JD, Li JL, Hickson ID, Shen JC, Loeb LA, Mazur SJ, Appella E, Brosh RM Jr, Karmakar P, Bohr VA, Harris CC
    The Journal of biological chemistry. 2002 ; 277 (35) : 31980-31987.
    PMID 12080066
     
    Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition.
    Ababou M, Dumaire V, Lˆ©cluse Y, Amor-Guˆ©ret M
    Oncogene. 2002 ; 21 (13) : 2079-2088.
    PMID 11960380
     
    Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.
    von Kobbe C, Karmakar P, Dawut L, Opresko P, Zeng X, Brosh RM Jr, Hickson ID, Bohr VA
    The Journal of biological chemistry. 2002 ; 277 (24) : 22035-22044.
    PMID 11919194
     
    The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis.
    Stavropoulos DJ, Bradshaw PS, Li X, Pasic I, Truong K, Ikura M, Ungrin M, Meyn MS
    Human molecular genetics. 2002 ; 11 (25) : 3135-3144.
    PMID 12444098
     
    Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.
    Opresko PL, von Kobbe C, Laine JP, Harrigan J, Hickson ID, Bohr VA
    The Journal of biological chemistry. 2002 ; 277 (43) : 41110-41119.
    PMID 12181313
     
    The BLM helicase is necessary for normal DNA double-strand break repair.
    Langland G, Elliott J, Li Y, Creaney J, Dixon K, Groden J
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    PMID 12019152
     
    Increased error-prone non homologous DNA end-joining--a proposed mechanism of chromosomal instability in Bloom's syndrome.
    Gaymes TJ, North PS, Brady N, Hickson ID, Mufti GJ, Rassool FV
    Oncogene. 2002 ; 21 (16) : 2525-2533.
    PMID 11971187
     
    Dephosphorylation and subcellular compartment change of the mitotic Bloom's syndrome DNA helicase in response to ionizing radiation.
    Dutertre S, Sekhri R, Tintignac LA, Onclercq-Delic R, Chatton B, Jaulin C, Amor-Guˆ©ret M
    The Journal of biological chemistry. 2002 ; 277 (8) : 6280-6286.
    PMID 11741924
     
    A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.
    Meetei AR, Sechi S, Wallisch M, Yang D, Young MK, Joenje H, Hoatlin ME, Wang W
    Molecular and cellular biology. 2003 ; 23 (10) : 3417-3426.
    PMID 12724401
     
    BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination.
    Sengupta S, Linke SP, Pedeux R, Yang Q, Farnsworth J, Garfield SH, Valerie K, Shay JW, Ellis NA, Wasylyk B, Harris CC
    The EMBO journal. 2003 ; 22 (5) : 1210-1222.
    PMID 12606585
     
    Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.
    Onclercq-Delic R, Calsou P, Delteil C, Salles B, Papadopoulo D, Amor-Guˆ©ret M
    Nucleic acids research. 2003 ; 31 (21) : 6272-6282.
    PMID 14576316
     
    Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase.
    Schawalder J, Paric E, Neff NF
    BMC cell biology. 2003 ; 4 : page 15.
    PMID 14577841
     
    Relatively common mutations of the Bloom syndrome gene in the Japanese population.
    Kaneko H, Isogai K, Fukao T, Matsui E, Kasahara K, Yachie A, Seki H, Koizumi S, Arai M, Utunomiya J, Miki Y, Kondo N
    International journal of molecular medicine. 2004 ; 14 (3) : 439-442.
    PMID 15289897
     
    Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1.
    Jiao R, Bachrati CZ, Pedrazzi G, Kuster P, Petkovic M, Li JL, Egli D, Hickson ID, Stagljar I
    Molecular and cellular biology. 2004 ; 24 (11) : 4710-4719.
    PMID 15143166
     
    Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
    Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC
    The Journal of cell biology. 2004 ; 166 (6) : 801-813.
    PMID 15364958
     
    Human Bloom protein stimulates flap endonuclease 1 activity by resolving DNA secondary structure.
    Wang W, Bambara RA
    The Journal of biological chemistry. 2005 ; 280 (7) : 5391-5399.
    PMID 15579905
     
    Genetic interactions between BLM and DNA ligase IV in human cells.
    So S, Adachi N, Lieber MR, Koyama H
    The Journal of biological chemistry. 2004 ; 279 (53) : 55433-55442.
    PMID 15509577
     
    A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint.
    Bayart E, Grigorieva O, Leibovitch S, Onclercq-Delic R, Amor-Guˆ©ret M
    Cancer research. 2004 ; 64 (24) : 8954-8959.
    PMID 15604258
     
    BLM helicase facilitates Mus81 endonuclease activity in human cells.
    Zhang R, Sengupta S, Yang Q, Linke SP, Yanaihara N, Bradsher J, Blais V, McGowan CH, Harris CC
    Cancer research. 2005 ; 65 (7) : 2526-2531.
    PMID 15805243
     
    RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange.
    Machwe A, Xiao L, Groden J, Matson SW, Orren DK
    The Journal of biological chemistry. 2005 ; 280 (24) : 23397-23407.
    PMID 15845538
     
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    Contributor(s)

    Written02-1998Jean-Loup Huret
    Updated09-2000Mounira Amor-Guéret
    Updated05-2005Mounira Amor-Guéret

    Citation

    This paper should be referenced as such :
    Amor-Guéret, M
    BLM (Bloom)
    Atlas Genet Cytogenet Oncol Haematol. 2005;9(3):224-226.
    Free online version   Free pdf version   [Bibliographic record ]
    History of this paper:
    Amor-Guéret, M. BLM (Bloom). Atlas Genet Cytogenet Oncol Haematol. 2005;9(3):224-226.
    http://documents.irevues.inist.fr/bitstream/2042/38210/1/05-2005-BLM109.pdf
    Atlas Genet Cytogenet Oncol Haematol. September 2000
    http://documents.irevues.inist.fr/bitstream/handle/2042/32095/02-1998-BLM109.pdf
    URL : http://AtlasGeneticsOncology.org/Genes/BLM109.html

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    indexed on : Sat Jul 26 15:10:25 CEST 2014

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