BMF (Bcl2 modifying factor)

2003-02-01  

Identity

HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 90427
MIM: 606266
HGNC: 24132
Ensembl: ENSG00000104081

Variants:

dbSNP: 90427
ClinVar: 90427
TCGA: ENSG00000104081
COSMIC: BMF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104081ENST00000354670Q96LC9
ENSG00000104081ENST00000397573Q96LC9
ENSG00000104081ENST00000431415Q96LC9
ENSG00000104081ENST00000557870H0YNT3
ENSG00000104081ENST00000558774Q96LC9
ENSG00000104081ENST00000559701Q96LC9
ENSG00000104081ENST00000560430H0YK50
ENSG00000104081ENST00000561282Q96LC9
ENSG00000104081ENST00000561360Q96LC9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BMF and translocation to mitochondriaREACTOMER-HSA-139910
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 membersREACTOMER-HSA-111453

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196718672009MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality.117
173604312007Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis.73
196415062008Bim and Bmf in tissue homeostasis and malignant disease.51
183540372008BH3-only proteins Noxa, Bmf, and Bim are necessary for arsenic trioxide-induced cell death in myeloma.36
261812062015Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF).27
207062762010BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis.26
208197782010MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.21
208613052010Hypoxia suppression of Bim and Bmf blocks anoikis and luminal clearing during mammary morphogenesis.21
145743342004Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells.18
193005162009Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection.18

Citation

Dessen P

BMF (Bcl2 modifying factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/242/bmf