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BMP15 (bone morphogenetic protein 15)

Identity

Alias_symbol (synonym)GDF9B
Other aliasODG2
POF4
HGNC (Hugo) BMP15
LocusID (NCBI) 9210
Atlas_Id 808
Location Xp11.22  [Link to chromosome band Xp11]
Location_base_pair Starts at 50910735 and ends at 50916641 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BMP15   1068
Cards
Entrez_Gene (NCBI)BMP15  9210  bone morphogenetic protein 15
AliasesGDF9B; ODG2; POF4
GeneCards (Weizmann)BMP15
Ensembl hg19 (Hinxton)ENSG00000130385 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130385 [Gene_View]  ENSG00000130385 [Sequence]  chrX:50910735-50916641 [Contig_View]  BMP15 [Vega]
ICGC DataPortalENSG00000130385
TCGA cBioPortalBMP15
AceView (NCBI)BMP15
Genatlas (Paris)BMP15
WikiGenes9210
SOURCE (Princeton)BMP15
Genetics Home Reference (NIH)BMP15
Genomic and cartography
GoldenPath hg38 (UCSC)BMP15  -     chrX:50910735-50916641 +  Xp11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BMP15  -     Xp11.22   [Description]    (hg19-Feb_2009)
EnsemblBMP15 - Xp11.22 [CytoView hg19]  BMP15 - Xp11.22 [CytoView hg38]
Mapping of homologs : NCBIBMP15 [Mapview hg19]  BMP15 [Mapview hg38]
OMIM300247   300510   
Gene and transcription
Genbank (Entrez)BC069155 BC117264 BC117266
RefSeq transcript (Entrez)NM_005448
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BMP15
Cluster EST : UnigeneHs.532692 [ NCBI ]
CGAP (NCI)Hs.532692
Alternative Splicing GalleryENSG00000130385
Gene ExpressionBMP15 [ NCBI-GEO ]   BMP15 [ EBI - ARRAY_EXPRESS ]   BMP15 [ SEEK ]   BMP15 [ MEM ]
Gene Expression Viewer (FireBrowse)BMP15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9210
GTEX Portal (Tissue expression)BMP15
Human Protein AtlasENSG00000130385-BMP15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95972   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95972  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95972
Splice isoforms : SwissVarO95972
PhosPhoSitePlusO95972
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)BMP-15    Cystine-knot_cytokine    TGF-b_C    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)   
Domain families : Pfam (NCBI)pfam00019   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)BMP15
DMDM Disease mutations9210
Blocks (Seattle)BMP15
SuperfamilyO95972
Human Protein Atlas [tissue]ENSG00000130385-BMP15 [tissue]
Peptide AtlasO95972
HPRD02216
IPIIPI00001485   
Protein Interaction databases
DIP (DOE-UCLA)O95972
IntAct (EBI)O95972
FunCoupENSG00000130385
BioGRIDBMP15
STRING (EMBL)BMP15
ZODIACBMP15
Ontologies - Pathways
QuickGOO95972
Ontology : AmiGOovarian follicle development  cytokine activity  transforming growth factor beta receptor binding  extracellular space  endoplasmic reticulum lumen  female gamete generation  growth factor activity  regulation of receptor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  BMP signaling pathway  regulation of apoptotic process  regulation of MAPK cascade  post-translational protein modification  cellular protein metabolic process  positive regulation of transcription, DNA-templated  cell development  granulosa cell development  SMAD protein signal transduction  
Ontology : EGO-EBIovarian follicle development  cytokine activity  transforming growth factor beta receptor binding  extracellular space  endoplasmic reticulum lumen  female gamete generation  growth factor activity  regulation of receptor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  BMP signaling pathway  regulation of apoptotic process  regulation of MAPK cascade  post-translational protein modification  cellular protein metabolic process  positive regulation of transcription, DNA-templated  cell development  granulosa cell development  SMAD protein signal transduction  
NDEx NetworkBMP15
Atlas of Cancer Signalling NetworkBMP15
Wikipedia pathwaysBMP15
Orthology - Evolution
OrthoDB9210
GeneTree (enSembl)ENSG00000130385
Phylogenetic Trees/Animal Genes : TreeFamBMP15
HOVERGENO95972
HOGENOMO95972
Homologs : HomoloGeneBMP15
Homology/Alignments : Family Browser (UCSC)BMP15
Gene fusions - Rearrangements
Fusion : QuiverBMP15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBMP15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BMP15
dbVarBMP15
ClinVarBMP15
1000_GenomesBMP15 
Exome Variant ServerBMP15
ExAC (Exome Aggregation Consortium)ENSG00000130385
GNOMAD BrowserENSG00000130385
Genetic variants : HAPMAP9210
Genomic Variants (DGV)BMP15 [DGVbeta]
DECIPHERBMP15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBMP15 
Mutations
ICGC Data PortalBMP15 
TCGA Data PortalBMP15 
Broad Tumor PortalBMP15
OASIS PortalBMP15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBMP15  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBMP15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch BMP15
DgiDB (Drug Gene Interaction Database)BMP15
DoCM (Curated mutations)BMP15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BMP15 (select a term)
intoGenBMP15
Cancer3DBMP15(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300247    300510   
Orphanet1011   
DisGeNETBMP15
MedgenBMP15
Genetic Testing Registry BMP15
NextProtO95972 [Medical]
TSGene9210
GENETestsBMP15
Target ValidationBMP15
Huge Navigator BMP15 [HugePedia]
snp3D : Map Gene to Disease9210
BioCentury BCIQBMP15
ClinGenBMP15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9210
Chemical/Pharm GKB GenePA25378
Clinical trialBMP15
Miscellaneous
canSAR (ICR)BMP15 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBMP15
EVEXBMP15
GoPubMedBMP15
iHOPBMP15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:16:19 CEST 2018

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