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BMP15 (bone morphogenetic protein 15)

Identity

Alias (NCBI)GDF9B
ODG2
POF4
HGNC (Hugo) BMP15
HGNC Alias symbGDF9B
LocusID (NCBI) 9210
Atlas_Id 808
Location Xp11.22  [Link to chromosome band Xp11]
Location_base_pair Starts at 50910735 and ends at 50916641 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)BMP15   1068
Cards
Entrez_Gene (NCBI)BMP15    bone morphogenetic protein 15
AliasesGDF9B; ODG2; POF4
GeneCards (Weizmann)BMP15
Ensembl hg19 (Hinxton)ENSG00000130385 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130385 [Gene_View]  ENSG00000130385 [Sequence]  chrX:50910735-50916641 [Contig_View]  BMP15 [Vega]
ICGC DataPortalENSG00000130385
TCGA cBioPortalBMP15
AceView (NCBI)BMP15
Genatlas (Paris)BMP15
SOURCE (Princeton)BMP15
Genetics Home Reference (NIH)BMP15
Genomic and cartography
GoldenPath hg38 (UCSC)BMP15  -     chrX:50910735-50916641 +  Xp11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BMP15  -     Xp11.22   [Description]    (hg19-Feb_2009)
GoldenPathBMP15 - Xp11.22 [CytoView hg19]  BMP15 - Xp11.22 [CytoView hg38]
ImmunoBaseENSG00000130385
Genome Data Viewer NCBIBMP15 [Mapview hg19]  
OMIM300247   300510   
Gene and transcription
Genbank (Entrez)BC069155 BC117264 BC117266
RefSeq transcript (Entrez)NM_005448
Consensus coding sequences : CCDS (NCBI)BMP15
Gene ExpressionBMP15 [ NCBI-GEO ]   BMP15 [ EBI - ARRAY_EXPRESS ]   BMP15 [ SEEK ]   BMP15 [ MEM ]
Gene Expression Viewer (FireBrowse)BMP15 [ Firebrowse - Broad ]
GenevisibleExpression of BMP15 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9210
GTEX Portal (Tissue expression)BMP15
Human Protein AtlasENSG00000130385-BMP15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95972   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95972  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95972
PhosPhoSitePlusO95972
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)BMP-15    Cystine-knot_cytokine    TGF-b_C    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)   
Domain families : Pfam (NCBI)pfam00019   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)BMP15
SuperfamilyO95972
AlphaFold pdb e-kbO95972   
Human Protein Atlas [tissue]ENSG00000130385-BMP15 [tissue]
HPRD02216
Protein Interaction databases
DIP (DOE-UCLA)O95972
IntAct (EBI)O95972
BioGRIDBMP15
STRING (EMBL)BMP15
ZODIACBMP15
Ontologies - Pathways
QuickGOO95972
Ontology : AmiGOovarian follicle development  cytokine activity  extracellular space  endoplasmic reticulum lumen  female gamete generation  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  BMP signaling pathway  post-translational protein modification  cellular protein metabolic process  positive regulation of transcription, DNA-templated  granulosa cell development  SMAD protein signal transduction  type I activin receptor binding  
Ontology : EGO-EBIovarian follicle development  cytokine activity  extracellular space  endoplasmic reticulum lumen  female gamete generation  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  BMP signaling pathway  post-translational protein modification  cellular protein metabolic process  positive regulation of transcription, DNA-templated  granulosa cell development  SMAD protein signal transduction  type I activin receptor binding  
Pathways : KEGGOvarian steroidogenesis   
NDEx NetworkBMP15
Atlas of Cancer Signalling NetworkBMP15
Wikipedia pathwaysBMP15
Orthology - Evolution
OrthoDB9210
GeneTree (enSembl)ENSG00000130385
Phylogenetic Trees/Animal Genes : TreeFamBMP15
Homologs : HomoloGeneBMP15
Homology/Alignments : Family Browser (UCSC)BMP15
Gene fusions - Rearrangements
Fusion : QuiverBMP15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBMP15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BMP15
dbVarBMP15
ClinVarBMP15
MonarchBMP15
1000_GenomesBMP15 
Exome Variant ServerBMP15
GNOMAD BrowserENSG00000130385
Varsome BrowserBMP15
ACMGBMP15 variants
VarityO95972
Genomic Variants (DGV)BMP15 [DGVbeta]
DECIPHERBMP15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBMP15 
Mutations
ICGC Data PortalBMP15 
TCGA Data PortalBMP15 
Broad Tumor PortalBMP15
OASIS PortalBMP15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBMP15  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DBMP15
Mutations and Diseases : HGMDBMP15
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaBMP15
DgiDB (Drug Gene Interaction Database)BMP15
DoCM (Curated mutations)BMP15
CIViC (Clinical Interpretations of Variants in Cancer)BMP15
Cancer3DBMP15
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300247    300510   
Orphanet1011   
DisGeNETBMP15
MedgenBMP15
Genetic Testing Registry BMP15
NextProtO95972 [Medical]
GENETestsBMP15
Target ValidationBMP15
Huge Navigator BMP15 [HugePedia]
ClinGenBMP15
Clinical trials, drugs, therapy
MyCancerGenomeBMP15
Protein Interactions : CTDBMP15
Pharm GKB GenePA25378
PharosO95972
Clinical trialBMP15
Miscellaneous
canSAR (ICR)BMP15
HarmonizomeBMP15
DataMed IndexBMP15
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXBMP15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:01:17 CEST 2021

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