BMP2 (bone morphogenetic protein 2)

Identity

Other names	BMP2A
HGNC	BMP2
Location	20p12
Location_base_pair	Starts at 6696745 and ends at 6708910 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	BMP2   1069
Entrez_Gene	BMP2  650  bone morphogenetic protein 2
	Cards
GeneCards	BMP2
Ensembl	BMP2 [Search_View]   ENSG00000125845 [Gene_View]
Genatlas	BMP2
GeneLynx	BMP2
eGenome	BMP2
euGene	650
	Genomic and cartography
GoldenPath	BMP2  -  20p12   chr20:6696745-6708910 +  20p12.3   [Description]    (hg18-March_2006)
Ensembl	BMP2 - 20p12.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	BMP2
	Gene and transcription
Genbank	BC069214 [ ENTREZ ]
Genbank	BC140325 [ ENTREZ ]
Genbank	BC148689 [ ENTREZ ]
Genbank	CR618407 [ ENTREZ ]
Genbank	EU832168 [ ENTREZ ]
RefSeq	NM_001200 [ SRS ]    NM_001200 [ ENTREZ ]
RefSeq	AC_000063 [ SRS ]    AC_000063 [ ENTREZ ]
RefSeq	AC_000152 [ SRS ]    AC_000152 [ ENTREZ ]
RefSeq	NC_000020 [ SRS ]    NC_000020 [ ENTREZ ]
RefSeq	NT_011387 [ SRS ]    NT_011387 [ ENTREZ ]
RefSeq	NW_001838652 [ SRS ]    NW_001838652 [ ENTREZ ]
RefSeq	NW_927317 [ SRS ]    NW_927317 [ ENTREZ ]
AceView	BMP2 AceView - NCBI
Unigene	Hs.73853 [ SRS ]    Hs.73853 [ NCBI ]     HS73853 [ spliceNest ]
Fast-db	5007 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P12643 [ SRS]    P12643 [ EXPASY ]     P12643 [ INTERPRO ]     P12643 [ UNIPROT ]
Prosite	PS00250 TGF_BETA_1 [ SRS ]    PS00250 TGF_BETA_1 [ Expasy ]
Prosite	PS51362 TGF_BETA_2 [ SRS ]    PS51362 TGF_BETA_2 [ Expasy ]
Interpro	IPR002405 Inhibin_asu [ SRS ]    IPR002405 Inhibin_asu [ EBI ]
Interpro	IPR001839 TGFb [ SRS ]    IPR001839 TGFb [ EBI ]
Interpro	IPR001111 TGFb_N [ SRS ]    IPR001111 TGFb_N [ EBI ]
Interpro	IPR015615 TGFbeta [ SRS ]    IPR015615 TGFbeta [ EBI ]
CluSTr	P12643
Pfam	PF00019 TGF_beta [ SRS ]    PF00019 TGF_beta [ Sanger ]    pfam00019 [ NCBI-CDD ]
Pfam	PF00688 TGFb_propeptide [ SRS ]    PF00688 TGFb_propeptide [ Sanger ]    pfam00688 [ NCBI-CDD ]
Smart	SM00204 TGFB [EMBL]
Prodom	PD000357 TGFb[INRA-Toulouse]
Prodom	P12643 BMP2_HUMAN [ Domain structure ]   P12643 BMP2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P12643
PDB	1ES7 [ SRS ]    1ES7 [ PdbSum ],   1ES7 [ IMB ]   1ES7 [ RSDB ]
PDB	1REU [ SRS ]    1REU [ PdbSum ],   1REU [ IMB ]   1REU [ RSDB ]
PDB	1REW [ SRS ]    1REW [ PdbSum ],   1REW [ IMB ]   1REW [ RSDB ]
PDB	2GOO [ SRS ]    2GOO [ PdbSum ],   2GOO [ IMB ]   2GOO [ RSDB ]
PDB	2H62 [ SRS ]    2H62 [ PdbSum ],   2H62 [ IMB ]   2H62 [ RSDB ]
PDB	2H64 [ SRS ]    2H64 [ PdbSum ],   2H64 [ IMB ]   2H64 [ RSDB ]
PDB	2QJ9 [ SRS ]    2QJ9 [ PdbSum ],   2QJ9 [ IMB ]   2QJ9 [ RSDB ]
PDB	2QJA [ SRS ]    2QJA [ PdbSum ],   2QJA [ IMB ]   2QJA [ RSDB ]
PDB	2QJB [ SRS ]    2QJB [ PdbSum ],   2QJB [ IMB ]   2QJB [ RSDB ]
PDB	3BMP [ SRS ]    3BMP [ PdbSum ],   3BMP [ IMB ]   3BMP [ RSDB ]
HPRD	00206
	Protein Interaction databases
DIP	P12643
IntAct	P12643
	Polymorphism : SNP, mutations, diseases
OMIM	112261;235200    [ map ]
GENECLINICS	112261;235200
SNP	BMP2 [dbSNP-NCBI]
SNP	NM_001200 [SNP-NCI]
SNP	BMP2 [GeneSNPs - Utah]  BMP2] [HGBASE - SRS]
HAPMAP	BMP2 [HAPMAP]
COSMIC	BMP2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	BMP2
	General knowledge
Family Browser	BMP2 [UCSC Family Browser]
SOURCE	NM_001200
SMD	Hs.73853
SAGE	Hs.73853
GO	ureteric bud branching [Amigo]  ureteric bud branching
GO	epithelial to mesenchymal transition [Amigo]  epithelial to mesenchymal transition
GO	cytokine activity [Amigo]  cytokine activity
GO	extracellular region [Amigo]  extracellular region
GO	extracellular region [Amigo]  extracellular region
GO	extracellular space [Amigo]  extracellular space
GO	inflammatory response [Amigo]  inflammatory response
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	growth factor activity [Amigo]  growth factor activity
GO	negative regulation of cell proliferation [Amigo]  negative regulation of cell proliferation
GO	embryonic development [Amigo]  embryonic development
GO	organ morphogenesis [Amigo]  organ morphogenesis
GO	specific transcriptional repressor activity [Amigo]  specific transcriptional repressor activity
GO	positive regulation of bone mineralization [Amigo]  positive regulation of bone mineralization
GO	BMP signaling pathway [Amigo]  BMP signaling pathway
GO	BMP signaling pathway [Amigo]  BMP signaling pathway
GO	negative regulation of gene-specific transcription [Amigo]  negative regulation of gene-specific transcription
GO	cardiac cell differentiation [Amigo]  cardiac cell differentiation
GO	growth [Amigo]  growth
GO	odontogenesis of dentine-containing tooth [Amigo]  odontogenesis of dentine-containing tooth
GO	cell fate commitment [Amigo]  cell fate commitment
GO	positive regulation of osteoblast differentiation [Amigo]  positive regulation of osteoblast differentiation
GO	negative regulation of cell cycle [Amigo]  negative regulation of cell cycle
GO	positive regulation of transcription [Amigo]  positive regulation of transcription
GO	positive regulation of astrocyte differentiation [Amigo]  positive regulation of astrocyte differentiation
GO	cartilage development [Amigo]  cartilage development
BIOCARTA	ALK in cardiac myocytes    [Genes]
KEGG	Cytokine-cytokine receptor interaction
KEGG	Hedgehog signaling pathway
KEGG	TGF-beta signaling pathway
PubGene	BMP2
TreeFam	BMP2
CTD	650 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	BMP2 Related clones (RZPD - Berlin)
	PubMed
PubMed	154 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:04:52 2008