BMP2 (bone morphogenetic protein 2)

2003-12-01  

Identity

HGNC
LOCATION
20p12.3
LOCUSID
ALIAS
BDA2,BMP2A,SSFSC,SSFSC1
FUSION GENES

Other Information

Locus ID:

NCBI: 650
MIM: 112261
HGNC: 1069
Ensembl: ENSG00000125845

Variants:

dbSNP: 650
ClinVar: 650
TCGA: ENSG00000125845
COSMIC: BMP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125845ENST00000378827P12643
ENSG00000125845ENST00000378827C8C060

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
TGF-beta signaling pathwayKEGGko04350
Basal cell carcinomaKEGGko05217
Cytokine-cytokine receptor interactionKEGGhsa04060
TGF-beta signaling pathwayKEGGhsa04350
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
BMP signalingKEGGhsa_M00679
BMP signalingKEGGM00679
Signal TransductionREACTOMER-HSA-162582
Signaling by BMPREACTOMER-HSA-201451
Extracellular matrix organizationREACTOMER-HSA-1474244
Elastic fibre formationREACTOMER-HSA-1566948
Molecules associated with elastic fibresREACTOMER-HSA-2129379

References

Pubmed IDYearTitleCitations
183827652008An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.162
166138562006Bone morphogenetic protein-2 stimulates Runx2 acetylation.119
212473442011High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo.114
216550892011Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.111
170031132006Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.105
165983842006BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype.99
160003032005BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways.94
177118572007Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human.92
181798002008BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells.87
183268172008Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.86

Citation

Dessen P

BMP2 (bone morphogenetic protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/809/bmp2