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BMP2 (bone morphogenetic protein 2)

Identity

Other namesBDA2
BMP2A
HGNC (Hugo) BMP2
LocusID (NCBI) 650
Location 20p12.3
Location_base_pair Starts at 6748745 and ends at 6760910 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)BMP2   1069
Cards
Entrez_Gene (NCBI)BMP2  650  bone morphogenetic protein 2
GeneCards (Weizmann)BMP2
Ensembl (Hinxton)ENSG00000125845 [Gene_View]  chr20:6748745-6760910 [Contig_View]  BMP2 [Vega]
ICGC DataPortalENSG00000125845
AceView (NCBI)BMP2
Genatlas (Paris)BMP2
WikiGenes650
SOURCE (Princeton)NM_001200
Genomic and cartography
GoldenPath (UCSC)BMP2  -  20p12.3   chr20:6748745-6760910 +  20p12.3   [Description]    (hg19-Feb_2009)
EnsemblBMP2 - 20p12.3 [CytoView]
Mapping of homologs : NCBIBMP2 [Mapview]
OMIM112261   112600   235200   
Gene and transcription
Genbank (Entrez)BC069214 BC140325 BC148689 EU832168 EU832262
RefSeq transcript (Entrez)NM_001200
RefSeq genomic (Entrez)AC_000152 NC_000020 NC_018931 NG_023233 NT_011387 NW_001838652 NW_004929416
Consensus coding sequences : CCDS (NCBI)BMP2
Cluster EST : UnigeneHs.73853 [ NCBI ]
CGAP (NCI)Hs.73853
Alternative Splicing : Fast-db (Paris)GSHG0018555
Alternative Splicing GalleryENSG00000125845
Gene ExpressionBMP2 [ NCBI-GEO ]     BMP2 [ SEEK ]   BMP2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12643 (Uniprot)
NextProtP12643  [Medical]
With graphics : InterProP12643
Splice isoforms : SwissVarP12643 (Swissvar)
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    Inhibin_asu    TGF-b_C    TGF-b_N    TGF-beta-rel    TGFb_CS   
Related proteins : CluSTrP12643
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
DMDM Disease mutations650
Blocks (Seattle)P12643
PDB (SRS)1ES7    1REU    1REW    2GOO    2H62    2H64    2QJ9    2QJA    2QJB    3BK3    3BMP    4N1D   
PDB (PDBSum)1ES7    1REU    1REW    2GOO    2H62    2H64    2QJ9    2QJA    2QJB    3BK3    3BMP    4N1D   
PDB (IMB)1ES7    1REU    1REW    2GOO    2H62    2H64    2QJ9    2QJA    2QJB    3BK3    3BMP    4N1D   
PDB (RSDB)1ES7    1REU    1REW    2GOO    2H62    2H64    2QJ9    2QJA    2QJB    3BK3    3BMP    4N1D   
Human Protein AtlasENSG00000125845
Peptide AtlasP12643
HPRD00206
IPIIPI00025069   
Protein Interaction databases
DIP (DOE-UCLA)P12643
IntAct (EBI)P12643
FunCoupENSG00000125845
BioGRIDBMP2
InParanoidP12643
Interologous Interaction database P12643
IntegromeDBBMP2
STRING (EMBL)BMP2
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  activation of MAPK activity  skeletal system development  osteoblast differentiation  branching involved in ureteric bud morphogenesis  response to hypoxia  in utero embryonic development  epithelial to mesenchymal transition  positive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  chondrocyte differentiation  BMP signaling pathway involved in heart induction  atrioventricular valve morphogenesis  endocardial cushion morphogenesis  negative regulation of Wnt signaling pathway involved in heart development  retinol dehydrogenase activity  receptor binding  cytokine activity  protein binding  extracellular region  extracellular space  proteoglycan metabolic process  regulation of transcription, DNA-templated  protein phosphorylation  inflammatory response  Notch signaling pathway  cell-cell signaling  heart development  growth factor activity  negative regulation of cell proliferation  embryo development  organ morphogenesis  cell surface  positive regulation of gene expression  positive regulation of epithelial to mesenchymal transition  positive regulation of pathway-restricted SMAD protein phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  negative regulation of steroid biosynthetic process  positive regulation of phosphatase activity  phosphatase activator activity  telencephalon development  telencephalon regionalization  positive regulation of Wnt signaling pathway  extracellular matrix organization  bone mineralization  positive regulation of cell migration  positive regulation of bone mineralization  BMP signaling pathway  BMP signaling pathway  BMP signaling pathway  BMP signaling pathway  protein destabilization  negative regulation of aldosterone biosynthetic process  positive regulation of osteoblast proliferation  cardiocyte differentiation  cardiocyte differentiation  embryonic heart tube anterior/posterior pattern specification  bone mineralization involved in bone maturation  growth  odontogenesis of dentin-containing tooth  positive regulation of odontogenesis  regulation of odontogenesis of dentin-containing tooth  positive regulation of apoptotic process  positive regulation of MAPK cascade  negative regulation of insulin-like growth factor receptor signaling pathway  cell fate commitment  positive regulation of fat cell differentiation  positive regulation of neuron differentiation  positive regulation of osteoblast differentiation  positive regulation of ossification  negative regulation of cell cycle  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  SMAD binding  protein heterodimerization activity  positive regulation of astrocyte differentiation  mesenchymal cell differentiation  inner ear development  negative regulation of calcium-independent cell-cell adhesion  cardiac muscle cell differentiation  cardiac muscle tissue morphogenesis  oxidation-reduction process  oxidation-reduction process  pericardium development  corticotropin hormone secreting cell differentiation  thyroid-stimulating hormone-secreting cell differentiation  cardiac epithelial to mesenchymal transition  pathway-restricted SMAD protein phosphorylation  SMAD protein signal transduction  mesenchyme development  positive regulation of Wnt signaling pathway by BMP signaling pathway  positive regulation of cartilage development  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  BMP receptor binding  cellular response to organic cyclic compound  cellular response to BMP stimulus  mesenchymal cell proliferation involved in ureteric bud development  negative regulation of canonical Wnt signaling pathway  positive regulation of p38MAPK cascade  positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus  negative regulation of cortisol biosynthetic process  negative regulation of cardiac muscle cell differentiation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  activation of MAPK activity  skeletal system development  osteoblast differentiation  branching involved in ureteric bud morphogenesis  response to hypoxia  in utero embryonic development  epithelial to mesenchymal transition  positive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  chondrocyte differentiation  BMP signaling pathway involved in heart induction  atrioventricular valve morphogenesis  endocardial cushion morphogenesis  negative regulation of Wnt signaling pathway involved in heart development  retinol dehydrogenase activity  receptor binding  cytokine activity  protein binding  extracellular region  extracellular space  proteoglycan metabolic process  regulation of transcription, DNA-templated  protein phosphorylation  inflammatory response  Notch signaling pathway  cell-cell signaling  heart development  growth factor activity  negative regulation of cell proliferation  embryo development  organ morphogenesis  cell surface  positive regulation of gene expression  positive regulation of epithelial to mesenchymal transition  positive regulation of pathway-restricted SMAD protein phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  negative regulation of steroid biosynthetic process  positive regulation of phosphatase activity  phosphatase activator activity  telencephalon development  telencephalon regionalization  positive regulation of Wnt signaling pathway  extracellular matrix organization  bone mineralization  positive regulation of cell migration  positive regulation of bone mineralization  BMP signaling pathway  BMP signaling pathway  BMP signaling pathway  BMP signaling pathway  protein destabilization  negative regulation of aldosterone biosynthetic process  positive regulation of osteoblast proliferation  cardiocyte differentiation  cardiocyte differentiation  embryonic heart tube anterior/posterior pattern specification  bone mineralization involved in bone maturation  growth  odontogenesis of dentin-containing tooth  positive regulation of odontogenesis  regulation of odontogenesis of dentin-containing tooth  positive regulation of apoptotic process  positive regulation of MAPK cascade  negative regulation of insulin-like growth factor receptor signaling pathway  cell fate commitment  positive regulation of fat cell differentiation  positive regulation of neuron differentiation  positive regulation of osteoblast differentiation  positive regulation of ossification  negative regulation of cell cycle  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  SMAD binding  protein heterodimerization activity  positive regulation of astrocyte differentiation  mesenchymal cell differentiation  inner ear development  negative regulation of calcium-independent cell-cell adhesion  cardiac muscle cell differentiation  cardiac muscle tissue morphogenesis  oxidation-reduction process  oxidation-reduction process  pericardium development  corticotropin hormone secreting cell differentiation  thyroid-stimulating hormone-secreting cell differentiation  cardiac epithelial to mesenchymal transition  pathway-restricted SMAD protein phosphorylation  SMAD protein signal transduction  mesenchyme development  positive regulation of Wnt signaling pathway by BMP signaling pathway  positive regulation of cartilage development  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  BMP receptor binding  cellular response to organic cyclic compound  cellular response to BMP stimulus  mesenchymal cell proliferation involved in ureteric bud development  negative regulation of canonical Wnt signaling pathway  positive regulation of p38MAPK cascade  positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus  negative regulation of cortisol biosynthetic process  negative regulation of cardiac muscle cell differentiation  
Pathways : BIOCARTAALK in cardiac myocytes [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Hedgehog signaling pathway    TGF-beta signaling pathway    Hippo signaling pathway    Pathways in cancer    Basal cell carcinoma   
Protein Interaction DatabaseBMP2
Wikipedia pathwaysBMP2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)BMP2
SNP (GeneSNP Utah)BMP2
SNP : HGBaseBMP2
Genetic variants : HAPMAPBMP2
1000_GenomesBMP2 
ICGC programENSG00000125845 
CONAN: Copy Number AnalysisBMP2 
Somatic Mutations in Cancer : COSMICBMP2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDBMP2
OMIM112261    112600    235200   
MedgenBMP2
GENETestsBMP2
Disease Genetic AssociationBMP2
Huge Navigator BMP2 [HugePedia]  BMP2 [HugeCancerGEM]
Genomic VariantsBMP2  BMP2 [DGVbeta]
Exome VariantBMP2
dbVarBMP2
ClinVarBMP2
snp3D : Map Gene to Disease650
General knowledge
Homologs : HomoloGeneBMP2
Homology/Alignments : Family Browser (UCSC)BMP2
Phylogenetic Trees/Animal Genes : TreeFamBMP2
Chemical/Protein Interactions : CTD650
Chemical/Pharm GKB GenePA25379
Clinical trialBMP2
Cancer Resource (Charite)ENSG00000125845
Other databases
Probes
Litterature
PubMed397 Pubmed reference(s) in Entrez
CoreMineBMP2
iHOPBMP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:34:47 CEST 2014

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