| Nomenclature | | HGNC (Hugo) | BMP2 1069 |
| Entrez_Gene (NCBI) | BMP2 650 bone morphogenetic protein 2 |
| Cards | | GeneCards (Weizmann) | BMP2 |
| Ensembl (Hinxton) | ENSG00000125845 [Gene_View] chr20:6748745-6760910 [Contig_View] BMP2 [Vega] |
| AceView (NCBI) | BMP2 |
| Genatlas (Paris) | BMP2 |
| SOURCE (Stanford) | NM_001200 |
| Genomic and cartography | | GoldenPath (UCSC) | BMP2 - 20p12.3 chr20:6748745-6760910 + 20p12.3 [Description] (hg19-Feb_2009) |
| Ensembl | BMP2 - 20p12.3 [CytoView] |
| Mapping of homologs : NCBI | BMP2 [Mapview] |
| OMIM | 112261 112600 235200 |
| Gene and transcription |
| Genbank (Entrez) | BC069214 BC140325 BC148689 EU832168 EU832262 |
| RefSeq transcript (SRS) | NM_001200 |
| RefSeq transcript (Entrez) | NM_001200 |
| RefSeq genomic (SRS) | AC_000152 NC_000020 NC_018931 NG_023233 NT_011387 NW_001838652 NW_004078100 |
| RefSeq genomic (Entrez) | AC_000152 NC_000020 NC_018931 NG_023233 NT_011387 NW_001838652 NW_004078100 |
| Consensus coding sequences : CCDS (NCBI) | BMP2 |
| Cluster EST : Unigene | Hs.73853 [ SRS ] Hs.73853 [ NCBI ] |
| CGAP (NCI) | Hs.73853 |
| Alternative Splicing : Fast-db (Paris) | GSHG0018555 |
| Alternative Splicing Gallery | ENSG00000125845 |
| Gene Expression | BMP2 [ NCBI-GEO ] BMP2 [ EBI - ARRAY_EXPRESS ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P12643 (SRS) P12643 (Uniprot) |
| NextProt | P12643 |
| With graphics : InterPro | P12643 |
| Splice isoforms : SwissVar | P12643(Swissvar) |
| Domaine pattern : Prosite (SRS) | TGF_BETA_1 (PS00250) TGF_BETA_2 (PS51362) |
| Domaine pattern : Prosite (Expaxy) | TGF_BETA_1 (PS00250) TGF_BETA_2 (PS51362) |
| Domains : Interpro (SRS) | Inhibin_asu TGF-b_C TGF-b_N TGF-beta-rel TGFb_CS |
| Domains : Interpro (EBI) | Inhibin_asu TGF-b_C TGF-b_N TGF-beta-rel TGFb_CS |
| Related proteins : CluSTr | P12643 |
| Domain families : Pfam (SRS) | TGF_beta (PF00019) TGFb_propeptide (PF00688) |
| Domain families : Pfam (Sanger) | TGF_beta (PF00019) TGFb_propeptide (PF00688) |
| Domain families : Pfam (NCBI) | pfam00019 pfam00688 |
| Domain families : Smart (EMBL) | TGFB (SM00204) |
| DMDM | 650 |
| Blocks (Seattle) | P12643 |
| PDB (SRS) | 1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP |
| PDB (PDBSum) | 1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP |
| PDB (IMB) | 1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP |
| PDB (RSDB) | 1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP |
| Human Protein Atlas | ENSG00000125845 |
| HPRD | 00206 |
| IPI | IPI00025069 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P12643 |
| IntAct (EBI) | P12643 |
| FunCoup | ENSG00000125845 |
| REACTOME | BMP2 |
| Protein Interaction Database | 650 |
| BioGRID | BMP2 |
| InParanoid | P12643 |
| Interologous Interaction database | P12643 |
| IntegromeDB | BMP2 |
| Polymorphism : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | BMP2 |
| SNP (GeneSNP Utah) | BMP2 |
| SNP : HGBase | BMP2 |
| Genetic variants : HAPMAP | BMP2 |
| Somatic Mutations in Cancer : COSMIC | BMP2 |
| CONAN: Copy Number Analysis | BMP2 |
| Mutations and Diseases : HGMD | BMP2 |
| OMIM | 112261 112600 235200 |
| GENETests | 112261 112600 235200 |
| Disease Genetic Association | BMP2 |
| Huge Navigator |
BMP2 [HugePedia] BMP2 [HugeCancerGEM] |
| Genomic Variants | BMP2 BMP2 [DGVbeta] |
| snp3D : Map Gene to Disease | 650 |
| General knowledge |
|---|
| Homologs : HomoloGene | BMP2 |
| Homology/Alignments : Family Browser (UCSC) | BMP2 |
| Phylogenetic Trees/Animal Genes : TreeFam | BMP2 |
| Chemical/Protein Interactions : CTD | 650 |
| Chemical/Pharm GKB Gene | PA25379 |
| Clinical trial | BMP2 |
| Cancer Resource (Charite) | ENSG00000125845 |
| Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast differentiation branching involved in ureteric bud morphogenesis response to hypoxia in utero embryonic development epithelial to mesenchymal transition positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation BMP signaling pathway involved in heart induction atrioventricular valve morphogenesis endocardial cushion morphogenesis negative regulation of Wnt receptor signaling pathway involved in heart development retinol dehydrogenase activity receptor binding cytokine activity protein binding extracellular region extracellular space cytoplasm proteoglycan metabolic process regulation of transcription, DNA-dependent inflammatory response Notch signaling pathway cell-cell signaling heart development growth factor activity negative regulation of cell proliferation response to mechanical stimulus embryo development organ morphogenesis cell surface positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of steroid biosynthetic process positive regulation of phosphatase activity phosphatase activator activity protein domain specific binding telencephalon development telencephalon regionalization positive regulation of Wnt receptor signaling pathway bone mineralization positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway BMP signaling pathway BMP signaling pathway protein destabilization membrane-bounded vesicle negative regulation of aldosterone biosynthetic process response to retinoic acid positive regulation of osteoblast proliferation cardiac cell differentiation cardiac cell differentiation embryonic heart tube anterior/posterior pattern specification bone mineralization involved in bone maturation growth odontogenesis of dentin-containing tooth positive regulation of odontogenesis regulation of odontogenesis of dentin-containing tooth ovulation cycle protein homodimerization activity positive regulation of apoptotic process protein complex negative regulation of insulin-like growth factor receptor signaling pathway cell fate commitment positive regulation of fat cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of cell cycle negative regulation of transcription, DNA-dependent positive regulation of transcription, DNA-dependent positive regulation of transcription from RNA polymerase II promoter SMAD binding protein heterodimerization activity positive regulation of astrocyte differentiation mesenchymal cell differentiation inner ear development cartilage development cardiac muscle cell differentiation cardiac muscle tissue morphogenesis pericardium development corticotropin hormone secreting cell differentiation thyroid-stimulating hormone-secreting cell differentiation cardiac epithelial to mesenchymal transition pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction mesenchyme development positive regulation of Wnt receptor signaling pathway by BMP signaling pathway positive regulation of cartilage development positive regulation of ERK1 and ERK2 cascade BMP receptor binding cellular response to organic cyclic compound cellular response to BMP stimulus mesenchymal cell proliferation involved in ureteric bud development positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus negative regulation of cortisol biosynthetic process negative regulation of cardiac muscle cell differentiation |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast differentiation branching involved in ureteric bud morphogenesis response to hypoxia in utero embryonic development epithelial to mesenchymal transition positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation BMP signaling pathway involved in heart induction atrioventricular valve morphogenesis endocardial cushion morphogenesis negative regulation of Wnt receptor signaling pathway involved in heart development retinol dehydrogenase activity receptor binding cytokine activity protein binding extracellular region extracellular space cytoplasm proteoglycan metabolic process regulation of transcription, DNA-dependent inflammatory response Notch signaling pathway cell-cell signaling heart development growth factor activity negative regulation of cell proliferation response to mechanical stimulus embryo development organ morphogenesis cell surface positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of steroid biosynthetic process positive regulation of phosphatase activity phosphatase activator activity protein domain specific binding telencephalon development telencephalon regionalization positive regulation of Wnt receptor signaling pathway bone mineralization positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway BMP signaling pathway BMP signaling pathway protein destabilization membrane-bounded vesicle negative regulation of aldosterone biosynthetic process response to retinoic acid positive regulation of osteoblast proliferation cardiac cell differentiation cardiac cell differentiation embryonic heart tube anterior/posterior pattern specification bone mineralization involved in bone maturation growth odontogenesis of dentin-containing tooth positive regulation of odontogenesis regulation of odontogenesis of dentin-containing tooth ovulation cycle protein homodimerization activity positive regulation of apoptotic process protein complex negative regulation of insulin-like growth factor receptor signaling pathway cell fate commitment positive regulation of fat cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of cell cycle negative regulation of transcription, DNA-dependent positive regulation of transcription, DNA-dependent positive regulation of transcription from RNA polymerase II promoter SMAD binding protein heterodimerization activity positive regulation of astrocyte differentiation mesenchymal cell differentiation inner ear development cartilage development cardiac muscle cell differentiation cardiac muscle tissue morphogenesis pericardium development corticotropin hormone secreting cell differentiation thyroid-stimulating hormone-secreting cell differentiation cardiac epithelial to mesenchymal transition pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction mesenchyme development positive regulation of Wnt receptor signaling pathway by BMP signaling pathway positive regulation of cartilage development positive regulation of ERK1 and ERK2 cascade BMP receptor binding cellular response to organic cyclic compound cellular response to BMP stimulus mesenchymal cell proliferation involved in ureteric bud development positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus negative regulation of cortisol biosynthetic process negative regulation of cardiac muscle cell differentiation |
| Pathways : BIOCARTA | ALK in cardiac myocytes [Genes] |
| Pathways : KEGG | TGF-beta signaling pathwayCytokine-cytokine receptor interactionHedgehog signaling pathway |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 344 Pubmed reference(s) in Entrez |
| PubGene | BMP2 |
| iHOP | BMP2 |
