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BMP2K (BMP2 inducible kinase)

Identity

Alias_symbol (synonym)DKFZp434K0614
BIKe
Other aliasBIKE
HRIHFB2017
HGNC (Hugo) BMP2K
LocusID (NCBI) 55589
Atlas_Id 60766
Location 4q21.21  [Link to chromosome band 4q21]
Location_base_pair Starts at 78776378 and ends at 78879440 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BMP2K (4q21.21) / NCOR2 (12q24.31)BMP2K (4q21.21) / SHROOM3 (4q21.1)BMP2K (4q21.21) / SLC25A31 (4q28.1)
LEKR1 (3q25.31) / BMP2K (4q21.21)BMP2K SLC25A31BMP2K SHROOM3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BMP2K   18041
Cards
Entrez_Gene (NCBI)BMP2K  55589  BMP2 inducible kinase
AliasesBIKE; HRIHFB2017
GeneCards (Weizmann)BMP2K
Ensembl hg19 (Hinxton)ENSG00000138756 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138756 [Gene_View]  chr4:78776378-78879440 [Contig_View]  BMP2K [Vega]
ICGC DataPortalENSG00000138756
TCGA cBioPortalBMP2K
AceView (NCBI)BMP2K
Genatlas (Paris)BMP2K
WikiGenes55589
SOURCE (Princeton)BMP2K
Genetics Home Reference (NIH)BMP2K
Genomic and cartography
GoldenPath hg38 (UCSC)BMP2K  -     chr4:78776378-78879440 +  4q21.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BMP2K  -     4q21.21   [Description]    (hg19-Feb_2009)
EnsemblBMP2K - 4q21.21 [CytoView hg19]  BMP2K - 4q21.21 [CytoView hg38]
Mapping of homologs : NCBIBMP2K [Mapview hg19]  BMP2K [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB015331 AF527532 AK021620 AK021725 AK075278
RefSeq transcript (Entrez)NM_017593 NM_198892
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BMP2K
Cluster EST : UnigeneHs.146551 [ NCBI ]
CGAP (NCI)Hs.146551
Alternative Splicing GalleryENSG00000138756
Gene ExpressionBMP2K [ NCBI-GEO ]   BMP2K [ EBI - ARRAY_EXPRESS ]   BMP2K [ SEEK ]   BMP2K [ MEM ]
Gene Expression Viewer (FireBrowse)BMP2K [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55589
GTEX Portal (Tissue expression)BMP2K
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NSY1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NSY1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NSY1
Splice isoforms : SwissVarQ9NSY1
PhosPhoSitePlusQ9NSY1
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)BMP-2-ind_kinase    BMP2K_C    Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)BMP2K_C (PF15282)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam15282    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)BMP2K
DMDM Disease mutations55589
Blocks (Seattle)BMP2K
PDB (SRS)4W9W    4W9X    5I3O    5I3R    5IKW   
PDB (PDBSum)4W9W    4W9X    5I3O    5I3R    5IKW   
PDB (IMB)4W9W    4W9X    5I3O    5I3R    5IKW   
PDB (RSDB)4W9W    4W9X    5I3O    5I3R    5IKW   
Structural Biology KnowledgeBase4W9W    4W9X    5I3O    5I3R    5IKW   
SCOP (Structural Classification of Proteins)4W9W    4W9X    5I3O    5I3R    5IKW   
CATH (Classification of proteins structures)4W9W    4W9X    5I3O    5I3R    5IKW   
SuperfamilyQ9NSY1
Human Protein AtlasENSG00000138756
Peptide AtlasQ9NSY1
HPRD09828
IPIIPI00337426   IPI00412057   IPI00033606   
Protein Interaction databases
DIP (DOE-UCLA)Q9NSY1
IntAct (EBI)Q9NSY1
FunCoupENSG00000138756
BioGRIDBMP2K
STRING (EMBL)BMP2K
ZODIACBMP2K
Ontologies - Pathways
QuickGOQ9NSY1
Ontology : AmiGOprotein serine/threonine kinase activity  ATP binding  cytoplasm  protein phosphorylation  nuclear speck  phosphatase regulator activity  regulation of bone mineralization  AP-2 adaptor complex binding  positive regulation of Notch signaling pathway  regulation of catalytic activity  regulation of clathrin-dependent endocytosis  
Ontology : EGO-EBIprotein serine/threonine kinase activity  ATP binding  cytoplasm  protein phosphorylation  nuclear speck  phosphatase regulator activity  regulation of bone mineralization  AP-2 adaptor complex binding  positive regulation of Notch signaling pathway  regulation of catalytic activity  regulation of clathrin-dependent endocytosis  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx NetworkBMP2K
Atlas of Cancer Signalling NetworkBMP2K
Wikipedia pathwaysBMP2K
Orthology - Evolution
OrthoDB55589
GeneTree (enSembl)ENSG00000138756
Phylogenetic Trees/Animal Genes : TreeFamBMP2K
HOVERGENQ9NSY1
HOGENOMQ9NSY1
Homologs : HomoloGeneBMP2K
Homology/Alignments : Family Browser (UCSC)BMP2K
Gene fusions - Rearrangements
Fusion: TCGABMP2K SLC25A31
Fusion: TCGABMP2K SHROOM3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBMP2K [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BMP2K
dbVarBMP2K
ClinVarBMP2K
1000_GenomesBMP2K 
Exome Variant ServerBMP2K
ExAC (Exome Aggregation Consortium)BMP2K (select the gene name)
Genetic variants : HAPMAP55589
Genomic Variants (DGV)BMP2K [DGVbeta]
DECIPHERBMP2K [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBMP2K 
Mutations
ICGC Data PortalBMP2K 
TCGA Data PortalBMP2K 
Broad Tumor PortalBMP2K
OASIS PortalBMP2K [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBMP2K  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBMP2K
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BMP2K
DgiDB (Drug Gene Interaction Database)BMP2K
DoCM (Curated mutations)BMP2K (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BMP2K (select a term)
intoGenBMP2K
Cancer3DBMP2K(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenBMP2K
Genetic Testing Registry BMP2K
NextProtQ9NSY1 [Medical]
TSGene55589
GENETestsBMP2K
Target ValidationBMP2K
Huge Navigator BMP2K [HugePedia]
snp3D : Map Gene to Disease55589
BioCentury BCIQBMP2K
ClinGenBMP2K
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55589
Chemical/Pharm GKB GenePA134992822
Clinical trialBMP2K
Miscellaneous
canSAR (ICR)BMP2K (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBMP2K
EVEXBMP2K
GoPubMedBMP2K
iHOPBMP2K
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:02:21 CEST 2017

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