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BMP3 (bone morphogenetic protein 3)

Identity

Alias_namesbone morphogenetic protein 3 (osteogenic)
Other aliasBMP-3A
HGNC (Hugo) BMP3
LocusID (NCBI) 651
Atlas_Id 810
Location 4q21.21  [Link to chromosome band 4q21]
Location_base_pair Starts at 81030965 and ends at 81057625 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TRAF3 (14q32.32) / BMP3 (4q21.21)TRAF3 14q32.32 / BMP3 4q21.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BMP3   1070
Cards
Entrez_Gene (NCBI)BMP3  651  bone morphogenetic protein 3
AliasesBMP-3A
GeneCards (Weizmann)BMP3
Ensembl hg19 (Hinxton)ENSG00000152785 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152785 [Gene_View]  chr4:81030965-81057625 [Contig_View]  BMP3 [Vega]
ICGC DataPortalENSG00000152785
TCGA cBioPortalBMP3
AceView (NCBI)BMP3
Genatlas (Paris)BMP3
WikiGenes651
SOURCE (Princeton)BMP3
Genetics Home Reference (NIH)BMP3
Genomic and cartography
GoldenPath hg38 (UCSC)BMP3  -     chr4:81030965-81057625 +  4q21.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BMP3  -     4q21.21   [Description]    (hg19-Feb_2009)
EnsemblBMP3 - 4q21.21 [CytoView hg19]  BMP3 - 4q21.21 [CytoView hg38]
Mapping of homologs : NCBIBMP3 [Mapview hg19]  BMP3 [Mapview hg38]
OMIM112263   
Gene and transcription
Genbank (Entrez)BC096269 BC096270 BC096271 BC117514 M22491
RefSeq transcript (Entrez)NM_001201
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BMP3
Cluster EST : UnigeneHs.387411 [ NCBI ]
CGAP (NCI)Hs.387411
Alternative Splicing GalleryENSG00000152785
Gene ExpressionBMP3 [ NCBI-GEO ]   BMP3 [ EBI - ARRAY_EXPRESS ]   BMP3 [ SEEK ]   BMP3 [ MEM ]
Gene Expression Viewer (FireBrowse)BMP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)651
GTEX Portal (Tissue expression)BMP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12645   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP12645  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP12645
Splice isoforms : SwissVarP12645
PhosPhoSitePlusP12645
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)BMP3/BMP3B    Cystine-knot_cytokine    TGF-b_C    TGF-b_propeptide    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)BMP3
DMDM Disease mutations651
Blocks (Seattle)BMP3
PDB (SRS)2QCQ   
PDB (PDBSum)2QCQ   
PDB (IMB)2QCQ   
PDB (RSDB)2QCQ   
Structural Biology KnowledgeBase2QCQ   
SCOP (Structural Classification of Proteins)2QCQ   
CATH (Classification of proteins structures)2QCQ   
SuperfamilyP12645
Human Protein AtlasENSG00000152785
Peptide AtlasP12645
HPRD00208
IPIIPI00025073   IPI00872129   
Protein Interaction databases
DIP (DOE-UCLA)P12645
IntAct (EBI)P12645
FunCoupENSG00000152785
BioGRIDBMP3
STRING (EMBL)BMP3
ZODIACBMP3
Ontologies - Pathways
QuickGOP12645
Ontology : AmiGOskeletal system development  osteoblast differentiation  receptor binding  cytokine activity  transforming growth factor beta receptor binding  extracellular space  cell-cell signaling  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  BMP signaling pathway  regulation of apoptotic process  regulation of MAPK cascade  cell development  cartilage development  SMAD protein signal transduction  extracellular exosome  BMP receptor binding  
Ontology : EGO-EBIskeletal system development  osteoblast differentiation  receptor binding  cytokine activity  transforming growth factor beta receptor binding  extracellular space  cell-cell signaling  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  BMP signaling pathway  regulation of apoptotic process  regulation of MAPK cascade  cell development  cartilage development  SMAD protein signal transduction  extracellular exosome  BMP receptor binding  
NDEx NetworkBMP3
Atlas of Cancer Signalling NetworkBMP3
Wikipedia pathwaysBMP3
Orthology - Evolution
OrthoDB651
GeneTree (enSembl)ENSG00000152785
Phylogenetic Trees/Animal Genes : TreeFamBMP3
HOVERGENP12645
HOGENOMP12645
Homologs : HomoloGeneBMP3
Homology/Alignments : Family Browser (UCSC)BMP3
Gene fusions - Rearrangements
Fusion : MitelmanTRAF3/BMP3 [14q32.32/4q21.21]  [t(4;14)(q21;q32)]  
Fusion: TCGATRAF3 14q32.32 BMP3 4q21.21 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBMP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BMP3
dbVarBMP3
ClinVarBMP3
1000_GenomesBMP3 
Exome Variant ServerBMP3
ExAC (Exome Aggregation Consortium)BMP3 (select the gene name)
Genetic variants : HAPMAP651
Genomic Variants (DGV)BMP3 [DGVbeta]
DECIPHERBMP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBMP3 
Mutations
ICGC Data PortalBMP3 
TCGA Data PortalBMP3 
Broad Tumor PortalBMP3
OASIS PortalBMP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBMP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBMP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BMP3
DgiDB (Drug Gene Interaction Database)BMP3
DoCM (Curated mutations)BMP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BMP3 (select a term)
intoGenBMP3
Cancer3DBMP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM112263   
Orphanet
MedgenBMP3
Genetic Testing Registry BMP3
NextProtP12645 [Medical]
TSGene651
GENETestsBMP3
Target ValidationBMP3
Huge Navigator BMP3 [HugePedia]
snp3D : Map Gene to Disease651
BioCentury BCIQBMP3
ClinGenBMP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD651
Chemical/Pharm GKB GenePA25380
Clinical trialBMP3
Miscellaneous
canSAR (ICR)BMP3 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBMP3
EVEXBMP3
GoPubMedBMP3
iHOPBMP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:48:02 CEST 2017

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