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BMP6 (bone morphogenetic protein 6)

Identity

Alias_namesVGR
vegetal related growth factor (TGFB-related)
Alias_symbol (synonym)VGR1
Other alias
HGNC (Hugo) BMP6
LocusID (NCBI) 654
Atlas_Id 813
Location 6p24.3  [Link to chromosome band 6p24]
Location_base_pair Starts at 7726099 and ends at 7881728 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BMP6 (6p24.3) / BMP6 (6p24.3)TXNDC5 (6p24.3) / BMP6 (6p24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BMP6   1073
Cards
Entrez_Gene (NCBI)BMP6  654  bone morphogenetic protein 6
AliasesVGR; VGR1
GeneCards (Weizmann)BMP6
Ensembl hg19 (Hinxton)ENSG00000153162 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153162 [Gene_View]  chr6:7726099-7881728 [Contig_View]  BMP6 [Vega]
ICGC DataPortalENSG00000153162
TCGA cBioPortalBMP6
AceView (NCBI)BMP6
Genatlas (Paris)BMP6
WikiGenes654
SOURCE (Princeton)BMP6
Genetics Home Reference (NIH)BMP6
Genomic and cartography
GoldenPath hg38 (UCSC)BMP6  -     chr6:7726099-7881728 +  6p24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BMP6  -     6p24.3   [Description]    (hg19-Feb_2009)
EnsemblBMP6 - 6p24.3 [CytoView hg19]  BMP6 - 6p24.3 [CytoView hg38]
Mapping of homologs : NCBIBMP6 [Mapview hg19]  BMP6 [Mapview hg38]
OMIM112266   
Gene and transcription
Genbank (Entrez)AA700487 AK300628 BC096084 BC096085 BC099624
RefSeq transcript (Entrez)NM_001718
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BMP6
Cluster EST : UnigeneHs.285671 [ NCBI ]
CGAP (NCI)Hs.285671
Alternative Splicing GalleryENSG00000153162
Gene ExpressionBMP6 [ NCBI-GEO ]   BMP6 [ EBI - ARRAY_EXPRESS ]   BMP6 [ SEEK ]   BMP6 [ MEM ]
Gene Expression Viewer (FireBrowse)BMP6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)654
GTEX Portal (Tissue expression)BMP6
Human Protein AtlasENSG00000153162-BMP6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22004   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22004  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22004
Splice isoforms : SwissVarP22004
PhosPhoSitePlusP22004
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    TGF-b_C    TGF-b_propeptide    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)BMP6
DMDM Disease mutations654
Blocks (Seattle)BMP6
PDB (SRS)2QCW    2R52    2R53   
PDB (PDBSum)2QCW    2R52    2R53   
PDB (IMB)2QCW    2R52    2R53   
PDB (RSDB)2QCW    2R52    2R53   
Structural Biology KnowledgeBase2QCW    2R52    2R53   
SCOP (Structural Classification of Proteins)2QCW    2R52    2R53   
CATH (Classification of proteins structures)2QCW    2R52    2R53   
SuperfamilyP22004
Human Protein Atlas [tissue]ENSG00000153162-BMP6 [tissue]
Peptide AtlasP22004
HPRD00211
IPIIPI00024887   IPI00979989   IPI01014123   IPI01013657   
Protein Interaction databases
DIP (DOE-UCLA)P22004
IntAct (EBI)P22004
FunCoupENSG00000153162
BioGRIDBMP6
STRING (EMBL)BMP6
ZODIACBMP6
Ontologies - Pathways
QuickGOP22004
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  skeletal system development  osteoblast differentiation  eye development  kidney development  positive regulation of endothelial cell proliferation  endochondral ossification  type B pancreatic cell development  cytokine activity  transforming growth factor beta receptor binding  extracellular space  cytoplasm  cellular iron ion homeostasis  inflammatory response  immune response  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  response to activity  positive regulation of bone mineralization  BMP signaling pathway  BMP signaling pathway  BMP signaling pathway  male genitalia development  positive regulation of lipopolysaccharide-mediated signaling pathway  vesicle  response to magnesium ion  positive regulation of chondrocyte differentiation  positive regulation of aldosterone biosynthetic process  response to retinoic acid  regulation of apoptotic process  regulation of MAPK cascade  positive regulation of endothelial cell differentiation  positive regulation of neuron differentiation  positive regulation of osteoblast differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  positive regulation of epithelial cell proliferation  positive regulation of protein secretion  cartilage development  response to glucocorticoid  positive regulation of SMAD protein import into nucleus  SMAD protein signal transduction  SMAD protein signal transduction  multicellular organismal iron ion homeostasis  BMP receptor binding  cellular response to mechanical stimulus  cellular response to iron ion  cellular response to BMP stimulus  positive regulation of DNA-dependent DNA replication  positive regulation of aldosterone secretion  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  skeletal system development  osteoblast differentiation  eye development  kidney development  positive regulation of endothelial cell proliferation  endochondral ossification  type B pancreatic cell development  cytokine activity  transforming growth factor beta receptor binding  extracellular space  cytoplasm  cellular iron ion homeostasis  inflammatory response  immune response  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  response to activity  positive regulation of bone mineralization  BMP signaling pathway  BMP signaling pathway  BMP signaling pathway  male genitalia development  positive regulation of lipopolysaccharide-mediated signaling pathway  vesicle  response to magnesium ion  positive regulation of chondrocyte differentiation  positive regulation of aldosterone biosynthetic process  response to retinoic acid  regulation of apoptotic process  regulation of MAPK cascade  positive regulation of endothelial cell differentiation  positive regulation of neuron differentiation  positive regulation of osteoblast differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  positive regulation of epithelial cell proliferation  positive regulation of protein secretion  cartilage development  response to glucocorticoid  positive regulation of SMAD protein import into nucleus  SMAD protein signal transduction  SMAD protein signal transduction  multicellular organismal iron ion homeostasis  BMP receptor binding  cellular response to mechanical stimulus  cellular response to iron ion  cellular response to BMP stimulus  positive regulation of DNA-dependent DNA replication  positive regulation of aldosterone secretion  
Pathways : KEGGTGF-beta signaling pathway    Hedgehog signaling pathway   
NDEx NetworkBMP6
Atlas of Cancer Signalling NetworkBMP6
Wikipedia pathwaysBMP6
Orthology - Evolution
OrthoDB654
GeneTree (enSembl)ENSG00000153162
Phylogenetic Trees/Animal Genes : TreeFamBMP6
HOVERGENP22004
HOGENOMP22004
Homologs : HomoloGeneBMP6
Homology/Alignments : Family Browser (UCSC)BMP6
Gene fusions - Rearrangements
Fusion : QuiverBMP6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBMP6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BMP6
dbVarBMP6
ClinVarBMP6
1000_GenomesBMP6 
Exome Variant ServerBMP6
ExAC (Exome Aggregation Consortium)ENSG00000153162
GNOMAD BrowserENSG00000153162
Genetic variants : HAPMAP654
Genomic Variants (DGV)BMP6 [DGVbeta]
DECIPHERBMP6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBMP6 
Mutations
ICGC Data PortalBMP6 
TCGA Data PortalBMP6 
Broad Tumor PortalBMP6
OASIS PortalBMP6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBMP6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBMP6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BMP6
DgiDB (Drug Gene Interaction Database)BMP6
DoCM (Curated mutations)BMP6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BMP6 (select a term)
intoGenBMP6
Cancer3DBMP6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM112266   
Orphanet23545   
DisGeNETBMP6
MedgenBMP6
Genetic Testing Registry BMP6
NextProtP22004 [Medical]
TSGene654
GENETestsBMP6
Target ValidationBMP6
Huge Navigator BMP6 [HugePedia]
snp3D : Map Gene to Disease654
BioCentury BCIQBMP6
ClinGenBMP6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD654
Chemical/Pharm GKB GenePA25383
Clinical trialBMP6
Miscellaneous
canSAR (ICR)BMP6 (select the gene name)
Probes
Litterature
PubMed123 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBMP6
EVEXBMP6
GoPubMedBMP6
iHOPBMP6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 5 11:44:09 CET 2018

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