BMP7 (bone morphogenetic protein 7)

2003-12-01  

Identity

HGNC
LOCATION
20q13.31
LOCUSID
ALIAS
OP-1
FUSION GENES

Other Information

Locus ID:

NCBI: 655
MIM: 112267
HGNC: 1074
Ensembl: ENSG00000101144

Variants:

dbSNP: 655
ClinVar: 655
TCGA: ENSG00000101144
COSMIC: BMP7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101144ENST00000395863P18075
ENSG00000101144ENST00000395863A8K571
ENSG00000101144ENST00000395864B1AKZ9
ENSG00000101144ENST00000433911H0Y4B5
ENSG00000101144ENST00000450594B1AL00

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
TGF-beta signaling pathwayKEGGko04350
Axon guidanceKEGGko04360
Cytokine-cytokine receptor interactionKEGGhsa04060
TGF-beta signaling pathwayKEGGhsa04350
Axon guidanceKEGGhsa04360
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
BMP signalingKEGGhsa_M00679
BMP signalingKEGGM00679
Extracellular matrix organizationREACTOMER-HSA-1474244
Elastic fibre formationREACTOMER-HSA-1566948
Molecules associated with elastic fibresREACTOMER-HSA-2129379

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164760860pegaspargaseChemicalClinicalAnnotationassociatedPD26590194
PA445187OsteonecrosisDiseaseClinicalAnnotationassociatedPD26590194
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD26590194
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD26590194
PA449177cytarabineChemicalClinicalAnnotationassociatedPD26590194
PA449212daunorubicinChemicalClinicalAnnotationassociatedPD26590194
PA449247dexamethasoneChemicalClinicalAnnotationassociatedPD26590194
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD26590194
PA450428methotrexateChemicalClinicalAnnotationassociatedPD26590194
PA451100prednisoneChemicalClinicalAnnotationassociatedPD26590194
PA451663thioguanineChemicalClinicalAnnotationassociatedPD26590194
PA451879vincristineChemicalClinicalAnnotationassociatedPD26590194

References

Pubmed IDYearTitleCitations
124782852002Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.137
221241122011Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone.128
231264272013Role of the TGF-β/BMP-7/Smad pathways in renal diseases.106
198460672010A genomewide association study of citalopram response in major depressive disorder.102
184365332008BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
126674452003The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.72
127402182003Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells.72
159299822005The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix.62
127341802003Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes.61

Citation

Dessen P

BMP7 (bone morphogenetic protein 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/814/bmp7