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BMP7 (bone morphogenetic protein 7)

Identity

Alias_symbol (synonym)OP-1
Other alias
HGNC (Hugo) BMP7
LocusID (NCBI) 655
Atlas_Id 814
Location 20q13.31  [Link to chromosome band 20q13]
Location_base_pair Starts at 57168753 and ends at 57266651 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADNP (20q13.13) / BMP7 (20q13.31)BMP7 (20q13.31) / HOOK3 (8p11.21)BMP7 (20q13.31) / PLD6 (17p11.2)
BMP7 (20q13.31) / RAE1 (20q13.31)BMP7 (20q13.31) / RBM38 (20q13.31)ADNP 20q13.13 / BMP7 20q13.31
BMP7 20q13.31 / RBM38 20q13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(9;13)(p12;q21) PAX5/DACH1


External links

Nomenclature
HGNC (Hugo)BMP7   1074
Cards
Entrez_Gene (NCBI)BMP7  655  bone morphogenetic protein 7
AliasesOP-1
GeneCards (Weizmann)BMP7
Ensembl hg19 (Hinxton)ENSG00000101144 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101144 [Gene_View]  chr20:57168753-57266651 [Contig_View]  BMP7 [Vega]
ICGC DataPortalENSG00000101144
TCGA cBioPortalBMP7
AceView (NCBI)BMP7
Genatlas (Paris)BMP7
WikiGenes655
SOURCE (Princeton)BMP7
Genetics Home Reference (NIH)BMP7
Genomic and cartography
GoldenPath hg38 (UCSC)BMP7  -     chr20:57168753-57266651 -  20q13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BMP7  -     20q13.31   [Description]    (hg19-Feb_2009)
EnsemblBMP7 - 20q13.31 [CytoView hg19]  BMP7 - 20q13.31 [CytoView hg38]
Mapping of homologs : NCBIBMP7 [Mapview hg19]  BMP7 [Mapview hg38]
OMIM112267   
Gene and transcription
Genbank (Entrez)AK094784 AK291186 AK312419 BC004248 BC008584
RefSeq transcript (Entrez)NM_001719
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BMP7
Cluster EST : UnigeneHs.473163 [ NCBI ]
CGAP (NCI)Hs.473163
Alternative Splicing GalleryENSG00000101144
Gene ExpressionBMP7 [ NCBI-GEO ]   BMP7 [ EBI - ARRAY_EXPRESS ]   BMP7 [ SEEK ]   BMP7 [ MEM ]
Gene Expression Viewer (FireBrowse)BMP7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)655
GTEX Portal (Tissue expression)BMP7
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18075   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18075  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18075
Splice isoforms : SwissVarP18075
PhosPhoSitePlusP18075
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    TGF-b_C    TGF-b_propeptide    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)BMP7
DMDM Disease mutations655
Blocks (Seattle)BMP7
PDB (SRS)1BMP    1LX5    1LXI    1M4U   
PDB (PDBSum)1BMP    1LX5    1LXI    1M4U   
PDB (IMB)1BMP    1LX5    1LXI    1M4U   
PDB (RSDB)1BMP    1LX5    1LXI    1M4U   
Structural Biology KnowledgeBase1BMP    1LX5    1LXI    1M4U   
SCOP (Structural Classification of Proteins)1BMP    1LX5    1LXI    1M4U   
CATH (Classification of proteins structures)1BMP    1LX5    1LXI    1M4U   
SuperfamilyP18075
Human Protein AtlasENSG00000101144
Peptide AtlasP18075
HPRD00212
IPIIPI00550949   IPI00794292   IPI00795839   IPI00794036   
Protein Interaction databases
DIP (DOE-UCLA)P18075
IntAct (EBI)P18075
FunCoupENSG00000101144
BioGRIDBMP7
STRING (EMBL)BMP7
ZODIACBMP7
Ontologies - Pathways
QuickGOP18075
Ontology : AmiGOskeletal system development  ossification  metanephros development  ureteric bud development  mesoderm formation  mesonephros development  epithelial to mesenchymal transition  endocardial cushion formation  pericardium morphogenesis  cytokine activity  transforming growth factor beta receptor binding  protein binding  extracellular region  extracellular space  axon guidance  growth factor activity  heparin binding  embryonic pattern specification  negative regulation of striated muscle cell apoptotic process  positive regulation of peptidyl-threonine phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  dendrite development  neural fold elevation formation  embryonic limb morphogenesis  positive regulation of bone mineralization  BMP signaling pathway  BMP signaling pathway  epithelial cell differentiation  hindbrain development  extracellular matrix  vesicle  negative regulation of NF-kappaB transcription factor activity  response to estradiol  response to vitamin D  positive regulation of heterotypic cell-cell adhesion  protein localization to nucleus  negative regulation of phosphorylation  negative regulation of NF-kappaB import into nucleus  odontogenesis of dentin-containing tooth  regulation of apoptotic process  positive regulation of apoptotic process  steroid hormone mediated signaling pathway  negative regulation of MAP kinase activity  response to peptide hormone  negative regulation of neuron differentiation  positive regulation of osteoblast differentiation  negative regulation of Notch signaling pathway  negative regulation of cell cycle  negative regulation of mitotic nuclear division  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  embryonic camera-type eye morphogenesis  cardiac muscle tissue development  branching morphogenesis of an epithelial tube  mesenchymal cell differentiation  neuron projection morphogenesis  cartilage development  pharyngeal system development  embryonic skeletal joint morphogenesis  regulation of pathway-restricted SMAD protein phosphorylation  SMAD protein signal transduction  cardiac septum morphogenesis  branching involved in salivary gland morphogenesis  mesenchyme development  negative regulation of cell death  negative regulation of prostatic bud formation  regulation of branching involved in prostate gland morphogenesis  chorio-allantoic fusion  heart trabecula morphogenesis  monocyte aggregation  BMP receptor binding  cellular response to hypoxia  cellular response to BMP stimulus  negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis  negative regulation of glomerular mesangial cell proliferation  metanephric mesenchyme morphogenesis  nephrogenic mesenchyme morphogenesis  metanephric mesenchymal cell proliferation involved in metanephros development  positive regulation of dendrite development  positive regulation of hyaluranon cable assembly  allantois development  regulation of removal of superoxide radicals  
Ontology : EGO-EBIskeletal system development  ossification  metanephros development  ureteric bud development  mesoderm formation  mesonephros development  epithelial to mesenchymal transition  endocardial cushion formation  pericardium morphogenesis  cytokine activity  transforming growth factor beta receptor binding  protein binding  extracellular region  extracellular space  axon guidance  growth factor activity  heparin binding  embryonic pattern specification  negative regulation of striated muscle cell apoptotic process  positive regulation of peptidyl-threonine phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  dendrite development  neural fold elevation formation  embryonic limb morphogenesis  positive regulation of bone mineralization  BMP signaling pathway  BMP signaling pathway  epithelial cell differentiation  hindbrain development  extracellular matrix  vesicle  negative regulation of NF-kappaB transcription factor activity  response to estradiol  response to vitamin D  positive regulation of heterotypic cell-cell adhesion  protein localization to nucleus  negative regulation of phosphorylation  negative regulation of NF-kappaB import into nucleus  odontogenesis of dentin-containing tooth  regulation of apoptotic process  positive regulation of apoptotic process  steroid hormone mediated signaling pathway  negative regulation of MAP kinase activity  response to peptide hormone  negative regulation of neuron differentiation  positive regulation of osteoblast differentiation  negative regulation of Notch signaling pathway  negative regulation of cell cycle  negative regulation of mitotic nuclear division  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  embryonic camera-type eye morphogenesis  cardiac muscle tissue development  branching morphogenesis of an epithelial tube  mesenchymal cell differentiation  neuron projection morphogenesis  cartilage development  pharyngeal system development  embryonic skeletal joint morphogenesis  regulation of pathway-restricted SMAD protein phosphorylation  SMAD protein signal transduction  cardiac septum morphogenesis  branching involved in salivary gland morphogenesis  mesenchyme development  negative regulation of cell death  negative regulation of prostatic bud formation  regulation of branching involved in prostate gland morphogenesis  chorio-allantoic fusion  heart trabecula morphogenesis  monocyte aggregation  BMP receptor binding  cellular response to hypoxia  cellular response to BMP stimulus  negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis  negative regulation of glomerular mesangial cell proliferation  metanephric mesenchyme morphogenesis  nephrogenic mesenchyme morphogenesis  metanephric mesenchymal cell proliferation involved in metanephros development  positive regulation of dendrite development  positive regulation of hyaluranon cable assembly  allantois development  regulation of removal of superoxide radicals  
Pathways : BIOCARTAALK in cardiac myocytes [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    TGF-beta signaling pathway    Hippo signaling pathway   
NDEx NetworkBMP7
Atlas of Cancer Signalling NetworkBMP7
Wikipedia pathwaysBMP7
Orthology - Evolution
OrthoDB655
GeneTree (enSembl)ENSG00000101144
Phylogenetic Trees/Animal Genes : TreeFamBMP7
HOVERGENP18075
HOGENOMP18075
Homologs : HomoloGeneBMP7
Homology/Alignments : Family Browser (UCSC)BMP7
Gene fusions - Rearrangements
Fusion : MitelmanADNP/BMP7 [20q13.13/20q13.31]  [t(20;20)(q13;q13)]  
Fusion : MitelmanBMP7/RBM38 [20q13.31/20q13.31]  [t(20;20)(q13;q13)]  
Fusion: TCGAADNP 20q13.13 BMP7 20q13.31 SKCM
Fusion: TCGABMP7 20q13.31 RBM38 20q13.31 OV
Fusion Cancer (Beijing)BMP7 [20q13.31]  -  RAE1 [20q13.31]  [FUSC000517]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBMP7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BMP7
dbVarBMP7
ClinVarBMP7
1000_GenomesBMP7 
Exome Variant ServerBMP7
ExAC (Exome Aggregation Consortium)BMP7 (select the gene name)
Genetic variants : HAPMAP655
Genomic Variants (DGV)BMP7 [DGVbeta]
DECIPHERBMP7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBMP7 
Mutations
ICGC Data PortalBMP7 
TCGA Data PortalBMP7 
Broad Tumor PortalBMP7
OASIS PortalBMP7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBMP7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBMP7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch BMP7
DgiDB (Drug Gene Interaction Database)BMP7
DoCM (Curated mutations)BMP7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BMP7 (select a term)
intoGenBMP7
Cancer3DBMP7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM112267   
Orphanet
MedgenBMP7
Genetic Testing Registry BMP7
NextProtP18075 [Medical]
TSGene655
GENETestsBMP7
Huge Navigator BMP7 [HugePedia]
snp3D : Map Gene to Disease655
BioCentury BCIQBMP7
ClinGenBMP7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD655
Chemical/Pharm GKB GenePA25384
Clinical trialBMP7
Miscellaneous
canSAR (ICR)BMP7 (select the gene name)
Probes
Litterature
PubMed236 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBMP7
EVEXBMP7
GoPubMedBMP7
iHOPBMP7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:07:53 CEST 2017

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