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BMP8B (bone morphogenetic protein 8b)

Identity

Alias_namesBMP8
bone morphogenetic protein 8 (osteogenic protein 2)
Alias_symbol (synonym)OP-2
Other aliasOP2
HGNC (Hugo) BMP8B
LocusID (NCBI) 656
Atlas_Id 815
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 39757182 and ends at 39788861 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCL2L1 (20q11.21) / BMP8B (1p34.2)BMP8B (1p34.2) / RLF (1p34.2)CAP1 (1p34.2) / BMP8B (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)BMP8B   1075
Cards
Entrez_Gene (NCBI)BMP8B  656  bone morphogenetic protein 8b
AliasesBMP8; OP2
GeneCards (Weizmann)BMP8B
Ensembl hg19 (Hinxton)ENSG00000116985 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116985 [Gene_View]  chr1:39757182-39788861 [Contig_View]  BMP8B [Vega]
ICGC DataPortalENSG00000116985
TCGA cBioPortalBMP8B
AceView (NCBI)BMP8B
Genatlas (Paris)BMP8B
WikiGenes656
SOURCE (Princeton)BMP8B
Genetics Home Reference (NIH)BMP8B
Genomic and cartography
GoldenPath hg38 (UCSC)BMP8B  -     chr1:39757182-39788861 -  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BMP8B  -     1p34.2   [Description]    (hg19-Feb_2009)
EnsemblBMP8B - 1p34.2 [CytoView hg19]  BMP8B - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIBMP8B [Mapview hg19]  BMP8B [Mapview hg38]
OMIM602284   
Gene and transcription
Genbank (Entrez)AB075489 AY303955 BC023526 BC080618 BC108678
RefSeq transcript (Entrez)NM_001720
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BMP8B
Cluster EST : UnigeneHs.734367 [ NCBI ]
CGAP (NCI)Hs.734367
Alternative Splicing GalleryENSG00000116985
Gene ExpressionBMP8B [ NCBI-GEO ]   BMP8B [ EBI - ARRAY_EXPRESS ]   BMP8B [ SEEK ]   BMP8B [ MEM ]
Gene Expression Viewer (FireBrowse)BMP8B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)656
GTEX Portal (Tissue expression)BMP8B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP34820   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP34820  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP34820
Splice isoforms : SwissVarP34820
PhosPhoSitePlusP34820
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    TGF-b_C    TGF-b_propeptide    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)BMP8B
DMDM Disease mutations656
Blocks (Seattle)BMP8B
SuperfamilyP34820
Human Protein AtlasENSG00000116985
Peptide AtlasP34820
HPRD03792
IPIIPI00300779   IPI00655791   
Protein Interaction databases
DIP (DOE-UCLA)P34820
IntAct (EBI)P34820
FunCoupENSG00000116985
BioGRIDBMP8B
STRING (EMBL)BMP8B
ZODIACBMP8B
Ontologies - Pathways
QuickGOP34820
Ontology : AmiGOskeletal system development  ossification  cytokine activity  transforming growth factor beta receptor binding  extracellular space  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  BMP signaling pathway  regulation of apoptotic process  regulation of MAPK cascade  cell development  cartilage development  SMAD protein signal transduction  BMP receptor binding  
Ontology : EGO-EBIskeletal system development  ossification  cytokine activity  transforming growth factor beta receptor binding  extracellular space  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  BMP signaling pathway  regulation of apoptotic process  regulation of MAPK cascade  cell development  cartilage development  SMAD protein signal transduction  BMP receptor binding  
Pathways : KEGGTGF-beta signaling pathway    Hippo signaling pathway   
NDEx NetworkBMP8B
Atlas of Cancer Signalling NetworkBMP8B
Wikipedia pathwaysBMP8B
Orthology - Evolution
OrthoDB656
GeneTree (enSembl)ENSG00000116985
Phylogenetic Trees/Animal Genes : TreeFamBMP8B
HOVERGENP34820
HOGENOMP34820
Homologs : HomoloGeneBMP8B
Homology/Alignments : Family Browser (UCSC)BMP8B
Gene fusions - Rearrangements
Fusion : MitelmanBCL2L1/BMP8B [20q11.21/1p34.2]  [t(1;20)(p34;q11)]  
Fusion : MitelmanBMP8B/RLF [1p34.2/1p34.2]  [inv(1)(p34p34)]  
Fusion : MitelmanCAP1/BMP8B [1p34.2/1p34.2]  [inv(1)(p34p34)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBMP8B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BMP8B
dbVarBMP8B
ClinVarBMP8B
1000_GenomesBMP8B 
Exome Variant ServerBMP8B
ExAC (Exome Aggregation Consortium)BMP8B (select the gene name)
Genetic variants : HAPMAP656
Genomic Variants (DGV)BMP8B [DGVbeta]
DECIPHERBMP8B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBMP8B 
Mutations
ICGC Data PortalBMP8B 
TCGA Data PortalBMP8B 
Broad Tumor PortalBMP8B
OASIS PortalBMP8B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBMP8B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBMP8B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BMP8B
DgiDB (Drug Gene Interaction Database)BMP8B
DoCM (Curated mutations)BMP8B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BMP8B (select a term)
intoGenBMP8B
Cancer3DBMP8B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602284   
Orphanet
MedgenBMP8B
Genetic Testing Registry BMP8B
NextProtP34820 [Medical]
TSGene656
GENETestsBMP8B
Target ValidationBMP8B
Huge Navigator BMP8B [HugePedia]
snp3D : Map Gene to Disease656
BioCentury BCIQBMP8B
ClinGenBMP8B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD656
Chemical/Pharm GKB GenePA25385
Clinical trialBMP8B
Miscellaneous
canSAR (ICR)BMP8B (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBMP8B
EVEXBMP8B
GoPubMedBMP8B
iHOPBMP8B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:59:23 CEST 2017

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