BMPR1A (bone morphogenetic protein receptor, type IA)

Identity

Other names	ACVRLK3
	ALK3
	CD292
HGNC	BMPR1A
Location	10q22.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	BMPR1A   1076
Entrez_Gene	BMPR1A  657  bone morphogenetic protein receptor, type IA
	Cards
GeneCards	BMPR1A
Ensembl	BMPR1A [Search_View]   ENSG00000107779 [Gene_View]
Genatlas	BMPR1A
GeneLynx	BMPR1A
eGenome	BMPR1A
euGene	657
	Genomic and cartography
GoldenPath	BMPR1A  -  10q22.3   chr10:88506376-88674925 +  10q23.2   [Description]    (hg18-March_2006)
Ensembl	BMPR1A - 10q23.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	BMPR1A
	Gene and transcription
Genbank	AK291764 [ ENTREZ ]
Genbank	BC028383 [ ENTREZ ]
Genbank	BM819272 [ ENTREZ ]
Genbank	CR608899 [ ENTREZ ]
Genbank	DQ786215 [ ENTREZ ]
RefSeq	NM_004329 [ SRS ]    NM_004329 [ ENTREZ ]
RefSeq	AC_000053 [ SRS ]    AC_000053 [ ENTREZ ]
RefSeq	AC_000142 [ SRS ]    AC_000142 [ ENTREZ ]
RefSeq	NC_000010 [ SRS ]    NC_000010 [ ENTREZ ]
RefSeq	NT_030059 [ SRS ]    NT_030059 [ ENTREZ ]
RefSeq	NW_001837992 [ SRS ]    NW_001837992 [ ENTREZ ]
RefSeq	NW_924862 [ SRS ]    NW_924862 [ ENTREZ ]
AceView	BMPR1A AceView - NCBI
Unigene	Hs.524477 [ SRS ]    Hs.524477 [ NCBI ]     HS524477 [ spliceNest ]
	Protein : pattern, domain, 3D structure
SwissProt	P36894 [ SRS]    P36894 [ EXPASY ]     P36894 [ INTERPRO ]     P36894 [ UNIPROT ]
Prosite	PS51256 GS [ SRS ]    PS51256 GS [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR000333 Activin_II_recpt [ SRS ]    IPR000333 Activin_II_recpt [ EBI ]
Interpro	IPR000472 Activin_rcpt [ SRS ]    IPR000472 Activin_rcpt [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR003605 TGF_beta_rcpt_GS [ SRS ]    IPR003605 TGF_beta_rcpt_GS [ EBI ]
CluSTr	P36894
Pfam	PF01064 Activin_recp [ SRS ]    PF01064 Activin_recp [ Sanger ]    pfam01064 [ NCBI-CDD ]
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Pfam	PF08515 TGF_beta_GS [ SRS ]    PF08515 TGF_beta_GS [ Sanger ]    pfam08515 [ NCBI-CDD ]
Smart	SM00467 GS [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P36894 BMR1A_HUMAN [ Domain structure ]   P36894 BMR1A_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P36894
PDB	1ES7 [ SRS ]    1ES7 [ PdbSum ],   1ES7 [ IMB ]   1ES7 [ RSDB ]
PDB	1REW [ SRS ]    1REW [ PdbSum ],   1REW [ IMB ]   1REW [ RSDB ]
PDB	2GOO [ SRS ]    2GOO [ PdbSum ],   2GOO [ IMB ]   2GOO [ RSDB ]
PDB	2H62 [ SRS ]    2H62 [ PdbSum ],   2H62 [ IMB ]   2H62 [ RSDB ]
PDB	2H64 [ SRS ]    2H64 [ PdbSum ],   2H64 [ IMB ]   2H64 [ RSDB ]
HPRD	03192
	Protein Interaction databases
DIP	P36894
IntAct	P36894
	Polymorphism : SNP, mutations, diseases
OMIM	158350;174900;601299;610069    [ map ]
GENECLINICS	158350;174900;601299;610069
SNP	BMPR1A [dbSNP-NCBI]
SNP	NM_004329 [SNP-NCI]
SNP	BMPR1A [GeneSNPs - Utah]  BMPR1A] [HGBASE - SRS]
HAPMAP	BMPR1A [HAPMAP]
COSMIC	BMPR1A [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	BMPR1A
	General knowledge
Family Browser	BMPR1A [UCSC Family Browser]
SOURCE	NM_004329
SMD	Hs.524477
SAGE	Hs.524477
Enzyme	2.7.11.30 [ Enzyme-Expasy ]   2.7.11.30 [ Enzyme-SRS ]   2.7.11.30 [ IntEnz-EBI ]   2.7.11.30 [ BRENDA ]   2.7.11.30 [ KEGG ]   2.7.11.30 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	magnesium ion binding [Amigo]  magnesium ion binding
GO	Mullerian duct regression [Amigo]  Mullerian duct regression
GO	receptor activity [Amigo]  receptor activity
GO	transforming growth factor beta receptor activity [Amigo]  transforming growth factor beta receptor activity
GO	ATP binding [Amigo]  ATP binding
GO	plasma membrane [Amigo]  plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	transforming growth factor beta receptor signaling pathway [Amigo]  transforming growth factor beta receptor signaling pathway
GO	ectoderm development [Amigo]  ectoderm development
GO	heart development [Amigo]  heart development
GO	dorsal/ventral axis specification [Amigo]  dorsal/ventral axis specification
GO	anterior/posterior pattern formation [Amigo]  anterior/posterior pattern formation
GO	integral to membrane [Amigo]  integral to membrane
GO	transferase activity [Amigo]  transferase activity
GO	manganese ion binding [Amigo]  manganese ion binding
GO	cell differentiation [Amigo]  cell differentiation
GO	lung development [Amigo]  lung development
GO	positive regulation of bone mineralization [Amigo]  positive regulation of bone mineralization
GO	BMP signaling pathway [Amigo]  BMP signaling pathway
GO	BMP signaling pathway [Amigo]  BMP signaling pathway
GO	hindlimb morphogenesis [Amigo]  hindlimb morphogenesis
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	positive regulation of osteoblast differentiation [Amigo]  positive regulation of osteoblast differentiation
GO	SMAD binding [Amigo]  SMAD binding
GO	mesendoderm development [Amigo]  mesendoderm development
GO	positive regulation of epithelial cell proliferation [Amigo]  positive regulation of epithelial cell proliferation
GO	cartilage development [Amigo]  cartilage development
BIOCARTA	ALK in cardiac myocytes    [Genes]
KEGG	Cytokine-cytokine receptor interaction
KEGG	TGF-beta signaling pathway
PubGene	BMPR1A
TreeFam	BMPR1A
CTD	657 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	BMPR1A Related clones (RZPD - Berlin)
	PubMed
PubMed	60 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:02:06 2008