Atlas of Genetics and Cytogenetics in Oncology and Haematology

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BMPR2 (bone morphogenetic protein receptor, type II (serine/threonine kinase))

Identity

Other namesBMPR-II
BMPR3
BMR2
BRK-3
PPH1
T-ALK
HGNC (Hugo) BMPR2
LocusID (NCBI) 659
Location 2q33.1
Location_base_pair Starts at 203241050 and ends at 203432474 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)BMPR2   1078
Entrez_Gene (NCBI)BMPR2  659  bone morphogenetic protein receptor, type II (serine/threonine kinase)
Cards
GeneCards (Weizmann)BMPR2
Ensembl (Hinxton)ENSG00000204217 [Gene_View]  chr2:203241050-203432474 [Contig_View]  BMPR2 [Vega]
AceView (NCBI)BMPR2
Genatlas (Paris)BMPR2
SOURCE (Stanford)NM_001204 NM_033346
Genomic and cartography
GoldenPath (UCSC)BMPR2  -  2q33.1   chr2:203241050-203432474 +  2q33.1   [Description]    (hg19-Feb_2009)
EnsemblBMPR2 - 2q33.1 [CytoView]
Mapping of homologs : NCBIBMPR2 [Mapview]
OMIM178600   265450   600799   
Gene and transcription
Genbank (Entrez)AK023426 AK093832 AK123579 AK292430 AY277593
RefSeq transcript (SRS)NM_001204 NM_033346
RefSeq transcript (Entrez)NM_001204 NM_033346
RefSeq genomic (SRS)AC_000134 NC_000002 NC_018913 NG_009363 NT_005403 NW_001838863 NW_004078008
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_009363 NT_005403 NW_001838863 NW_004078008
Consensus coding sequences : CCDS (NCBI)BMPR2
Cluster EST : UnigeneHs.471119 [ SRS ] Hs.471119 [ NCBI ]
CGAP (NCI)Hs.471119
Alternative Splicing : Fast-db (Paris)GSHG0017114
Alternative Splicing GalleryENSG00000204217
Gene ExpressionBMPR2 [ NCBI-GEO ]   BMPR2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13873 (SRS) Q13873 (Uniprot)
NextProtQ13873
With graphics : InterProQ13873
Splice isoforms : SwissVarQ13873(Swissvar)
Domaine pattern : Prosite (SRS)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (SRS)Activin_rcpt    BMPRII    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS   
Domains : Interpro (EBI)Activin_rcpt    BMPRII    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS   
Related proteins : CluSTrQ13873
Domain families : Pfam (SRS)Activin_recp (PF01064)    Pkinase (PF00069)   
Domain families : Pfam (Sanger)Activin_recp (PF01064)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam01064    pfam00069   
DMDM659
Blocks (Seattle)Q13873
PDB (SRS)2HLQ    3G2F   
PDB (PDBSum)2HLQ    3G2F   
PDB (IMB)2HLQ    3G2F   
PDB (RSDB)2HLQ    3G2F   
Human Protein AtlasENSG00000204217
HPRD02880
IPIIPI00783156   IPI00793420   
Protein Interaction databases
DIP (DOE-UCLA)Q13873
IntAct (EBI)Q13873
FunCoupENSG00000204217
REACTOMEBMPR2
Protein Interaction Database659
BioGRIDBMPR2
InParanoidQ13873
Interologous Interaction database Q13873
IntegromeDBBMPR2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)BMPR2
SNP (GeneSNP Utah)BMPR2
SNP : HGBaseBMPR2
Genetic variants : HAPMAPBMPR2
Somatic Mutations in Cancer : COSMICBMPR2 
CONAN: Copy Number AnalysisBMPR2 
Mutations and Diseases : HGMDBMPR2
OMIM178600    265450    600799   
GENETests178600    265450    600799   
Disease Genetic AssociationBMPR2
Huge Navigator BMPR2 [HugePedia]  BMPR2 [HugeCancerGEM]
Genomic VariantsBMPR2  BMPR2 [DGVbeta]
ClinVarBMPR2
snp3D : Map Gene to Disease659
General knowledge
Homologs : HomoloGeneBMPR2
Homology/Alignments : Family Browser (UCSC)BMPR2
Phylogenetic Trees/Animal Genes : TreeFamBMPR2
Catalytic activity : Enzyme2.7.11.30 [ Enzyme-Expasy ]   2.7.11.30 [ Enzyme-SRS ]   2.7.11.30 [ IntEnz-EBI ]   2.7.11.30 [ BRENDA ]   2.7.11.30 [ KEGG ]   
Chemical/Protein Interactions : CTD659
Chemical/Pharm GKB GenePA25388
Clinical trialBMPR2
Cancer Resource (Charite)ENSG00000204217
Ontology : AmiGOmesoderm formation  positive regulation of endothelial cell proliferation  lymphangiogenesis  blood vessel remodeling  negative regulation of systemic arterial blood pressure  transforming growth factor beta-activated receptor activity  protein binding  ATP binding  plasma membrane  plasma membrane  integral to plasma membrane  caveola  transcription from RNA polymerase II promoter  transmembrane receptor protein serine/threonine kinase signaling pathway  cellular response to starvation  anterior/posterior pattern specification  cell surface  positive regulation of endothelial cell migration  positive regulation of epithelial cell migration  positive regulation of pathway-restricted SMAD protein phosphorylation  regulation of lung blood pressure  regulation of lung blood pressure  activin receptor activity, type II  negative regulation of cell growth  positive regulation of bone mineralization  BMP signaling pathway  BMP signaling pathway  BMP signaling pathway  BMP signaling pathway  positive regulation of BMP signaling pathway  regulation of cell proliferation  positive regulation of osteoblast differentiation  negative regulation of vasoconstriction  metal ion binding  vascular endothelial growth factor receptor signaling pathway  lung alveolus development  lymphatic endothelial cell differentiation  artery development  venous blood vessel development  retina vasculature development in camera-type eye  negative regulation of DNA biosynthetic process  
Ontology : EGO-EBImesoderm formation  positive regulation of endothelial cell proliferation  lymphangiogenesis  blood vessel remodeling  negative regulation of systemic arterial blood pressure  transforming growth factor beta-activated receptor activity  protein binding  ATP binding  plasma membrane  plasma membrane  integral to plasma membrane  caveola  transcription from RNA polymerase II promoter  transmembrane receptor protein serine/threonine kinase signaling pathway  cellular response to starvation  anterior/posterior pattern specification  cell surface  positive regulation of endothelial cell migration  positive regulation of epithelial cell migration  positive regulation of pathway-restricted SMAD protein phosphorylation  regulation of lung blood pressure  regulation of lung blood pressure  activin receptor activity, type II  negative regulation of cell growth  positive regulation of bone mineralization  BMP signaling pathway  BMP signaling pathway  BMP signaling pathway  BMP signaling pathway  positive regulation of BMP signaling pathway  regulation of cell proliferation  positive regulation of osteoblast differentiation  negative regulation of vasoconstriction  metal ion binding  vascular endothelial growth factor receptor signaling pathway  lung alveolus development  lymphatic endothelial cell differentiation  artery development  venous blood vessel development  retina vasculature development in camera-type eye  negative regulation of DNA biosynthetic process  
Pathways : BIOCARTAALK in cardiac myocytes [Genes]   
Pathways : KEGGTGF-beta signaling pathwayCytokine-cytokine receptor interaction
Other databases
Probes
Litterature
PubMed161 Pubmed reference(s) in Entrez
PubGeneBMPR2
iHOPBMPR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:52:58 CEST 2013
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