Atlas of Genetics and Cytogenetics in Oncology and Haematology

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BNIP1 (BCL2 interacting protein 1)

Identity

Alias_namesBCL2/adenovirus E1B 19kDa interacting protein 1
Alias_symbol (synonym)Nip1
SEC20
Other aliasNIP1
TRG-8
HGNC (Hugo) BNIP1
LocusID (NCBI) 662
Atlas_Id 820
Location 5q35.1  [Link to chromosome band 5q35]
Location_base_pair Starts at 173144531 and ends at 173164387 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LNX2 (13q12.2) / BNIP1 (5q35.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;14)(q35;q11) TRD/NKX2-5

External links

Nomenclature
HGNC (Hugo)BNIP1   1082
Cards
Entrez_Gene (NCBI)BNIP1  662  BCL2 interacting protein 1
AliasesNIP1; SEC20; TRG-8
GeneCards (Weizmann)BNIP1
Ensembl hg19 (Hinxton)ENSG00000113734 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113734 [Gene_View]  ENSG00000113734 [Sequence]  chr5:173144531-173164387 [Contig_View]  BNIP1 [Vega]
ICGC DataPortalENSG00000113734
TCGA cBioPortalBNIP1
AceView (NCBI)BNIP1
Genatlas (Paris)BNIP1
WikiGenes662
SOURCE (Princeton)BNIP1
Genetics Home Reference (NIH)BNIP1
Genomic and cartography
GoldenPath hg38 (UCSC)BNIP1  -     chr5:173144531-173164387 +  5q35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BNIP1  -     5q35.1   [Description]    (hg19-Feb_2009)
GoldenPathBNIP1 - 5q35.1 [CytoView hg19]  BNIP1 - 5q35.1 [CytoView hg38]
Genome Data Viewer NCBIBNIP1 [Mapview hg19]  
OMIM603291   
Gene and transcription
Genbank (Entrez)AF083956 AF083957 AF083958 AU311051 AY216799
RefSeq transcript (Entrez)NM_001205 NM_013978 NM_013979 NM_013980
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BNIP1
Alternative Splicing GalleryENSG00000113734
Gene ExpressionBNIP1 [ NCBI-GEO ]   BNIP1 [ EBI - ARRAY_EXPRESS ]   BNIP1 [ SEEK ]   BNIP1 [ MEM ]
Gene Expression Viewer (FireBrowse)BNIP1 [ Firebrowse - Broad ]
GenevisibleExpression of BNIP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)662
GTEX Portal (Tissue expression)BNIP1
Human Protein AtlasENSG00000113734-BNIP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12981   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12981  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12981
Splice isoforms : SwissVarQ12981
PhosPhoSitePlusQ12981
Domains : Interpro (EBI)Sec20   
Domain families : Pfam (Sanger)Sec20 (PF03908)   
Domain families : Pfam (NCBI)pfam03908   
Conserved Domain (NCBI)BNIP1
DMDM Disease mutations662
SuperfamilyQ12981
Human Protein Atlas [tissue]ENSG00000113734-BNIP1 [tissue]
Peptide AtlasQ12981
HPRD04480
IPIIPI00030397   IPI00215701   IPI00215703   IPI00215704   IPI00980355   
Protein Interaction databases
DIP (DOE-UCLA)Q12981
IntAct (EBI)Q12981
FunCoupENSG00000113734
BioGRIDBNIP1
STRING (EMBL)BNIP1
ZODIACBNIP1
Ontologies - Pathways
QuickGOQ12981
Ontology : AmiGOSNAP receptor activity  protein binding  nuclear envelope  cytoplasm  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  retrograde vesicle-mediated transport, Golgi to ER  retrograde vesicle-mediated transport, Golgi to ER  apoptotic process  endoplasmic reticulum organization  response to activity  viral process  endoplasmic reticulum membrane fusion  COPI-coated vesicle  integral component of endoplasmic reticulum membrane  SNARE complex  SNARE complex  mitochondrial membrane  response to starvation  negative regulation of apoptotic process  intracellular membrane-bounded organelle  response to oxygen-glucose deprivation  execution phase of apoptosis  
Ontology : EGO-EBISNAP receptor activity  protein binding  nuclear envelope  cytoplasm  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  retrograde vesicle-mediated transport, Golgi to ER  retrograde vesicle-mediated transport, Golgi to ER  apoptotic process  endoplasmic reticulum organization  response to activity  viral process  endoplasmic reticulum membrane fusion  COPI-coated vesicle  integral component of endoplasmic reticulum membrane  SNARE complex  SNARE complex  mitochondrial membrane  response to starvation  negative regulation of apoptotic process  intracellular membrane-bounded organelle  response to oxygen-glucose deprivation  execution phase of apoptosis  
Pathways : KEGGSNARE interactions in vesicular transport   
NDEx NetworkBNIP1
Atlas of Cancer Signalling NetworkBNIP1
Wikipedia pathwaysBNIP1
Orthology - Evolution
OrthoDB662
GeneTree (enSembl)ENSG00000113734
Phylogenetic Trees/Animal Genes : TreeFamBNIP1
HOGENOMQ12981
Homologs : HomoloGeneBNIP1
Homology/Alignments : Family Browser (UCSC)BNIP1
Gene fusions - Rearrangements
Fusion : QuiverBNIP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBNIP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BNIP1
dbVarBNIP1
ClinVarBNIP1
1000_GenomesBNIP1 
Exome Variant ServerBNIP1
GNOMAD BrowserENSG00000113734
Varsome BrowserBNIP1
Genetic variants : HAPMAP662
Genomic Variants (DGV)BNIP1 [DGVbeta]
DECIPHERBNIP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBNIP1 
Mutations
ICGC Data PortalBNIP1 
TCGA Data PortalBNIP1 
Broad Tumor PortalBNIP1
OASIS PortalBNIP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBNIP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DBNIP1
Mutations and Diseases : HGMDBNIP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect BNIP1
DgiDB (Drug Gene Interaction Database)BNIP1
DoCM (Curated mutations)BNIP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BNIP1 (select a term)
intoGenBNIP1
Cancer3DBNIP1 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603291   
Orphanet
DisGeNETBNIP1
MedgenBNIP1
Genetic Testing Registry BNIP1
NextProtQ12981 [Medical]
TSGene662
GENETestsBNIP1
Open Targets GeneticsENSG00000113734  [validation]
snp3D : Map Gene to Disease662
BioCentury BCIQBNIP1
ClinGenBNIP1
Clinical trials, drugs, therapy
Protein Interactions : CTD662
Pharm GKB GenePA25392
Clinical trialBNIP1
Miscellaneous
canSAR (ICR)BNIP1 (select the gene name)
HarmonizomeBNIP1
DataMed IndexBNIP1
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBNIP1
EVEXBNIP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 19:40:51 CEST 2020
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