BNIP2 (BCL2 interacting protein 2)

2003-11-01  

Identity

HGNC
BNIP2
LOCATION
15q22.2
LOCUSID
663
ALIAS
BNIP-2,NIP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 663
MIM: 603292
HGNC: 1083
Ensembl: ENSG00000140299

Variants:

dbSNP: 663
ClinVar: 663
TCGA: ENSG00000140299
COSMIC: BNIP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140299ENST00000267859J3KN59
ENSG00000140299ENST00000415213Q12982
ENSG00000140299ENST00000439052H7C096
ENSG00000140299ENST00000448414H7C142
ENSG00000140299ENST00000607373Q12982
ENSG00000140299ENST00000612191J3KN59

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
MyogenesisREACTOMER-HSA-525793
CDO in myogenesisREACTOMER-HSA-375170

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208555362010Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.18
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
129444072003Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1.15
156523412005BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain.11
129018802003BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.10
179615072007Cleavage of BNIP-2 and BNIP-XL by caspases.8
211300872011SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells.8
117440982001Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2.7
253785812015KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.5
207045642010Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing.4

Citation

Dessen P

BNIP2 (BCL2 interacting protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/821/bnip2