Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death. |
Abe T, Toyota M, Suzuki H, Murai M, Akino K, Ueno M, Nojima M, Yawata A, Miyakawa H, Suga T, Ito H, Endo T, Tokino T, Hinoda Y, Imai K |
Journal of gastroenterology. 2005 ; 40 (5) : 504-510. |
PMID 15942716 |
|
Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer. |
Akada M, Crnogorac-Jurcevic T, Lattimore S, Mahon P, Lopes R, Sunamura M, Matsuno S, Lemoine NR |
Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 ; 11 (8) : 3094-3101. |
PMID 15837765 |
|
Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. |
An HJ, Maeng O, Kang KH, Lee JO, Kim YS, Paik SG, Lee H |
The Journal of biological chemistry. 2006 ; 281 (45) : 33939-33948. |
PMID 16954213 |
|
Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer. |
Bacon AL, Fox S, Turley H, Harris AL |
Oncogene. 2007 ; 26 (1) : 132-141. |
PMID 16799636 |
|
Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. |
Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G |
Cell. 1994 ; 79 (2) : 341-351. |
PMID 7954800 |
|
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. |
Bruick RK |
Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (16) : 9082-9087. |
PMID 10922063 |
|
The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis. |
Chen G, Ray R, Dubik D, Shi L, Cizeau J, Bleackley RC, Saxena S, Gietz RD, Greenberg AH |
The Journal of experimental medicine. 1997 ; 186 (12) : 1975-1983. |
PMID 9396766 |
|
Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. |
Erkan M, Kleeff J, Esposito I, Giese T, Ketterer K, Büchler MW, Giese NA, Friess H |
Oncogene. 2005 ; 24 (27) : 4421-4432. |
PMID 15856026 |
|
The carboxy terminal C-tail of BNip3 is crucial in induction of mitochondrial permeability transition in isolated mitochondria. |
Kim JY, Cho JJ, Ha J, Park JH |
Archives of biochemistry and biophysics. 2002 ; 398 (2) : 147-152. |
PMID 11831844 |
|
Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. |
Kubasiak LA, Hernandez OM, Bishopric NH, Webster KA |
Proceedings of the National Academy of Sciences of the United States of America. 2002 ; 99 (20) : 12825-12830. |
PMID 12226479 |
|
Regulation of BNIP3 in normal and cancer cells. |
Lee H, Paik SG |
Molecules and cells. 2006 ; 21 (1) : 1-6. |
PMID 16511341 |
|
Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. |
Murai M, Toyota M, Suzuki H, Satoh A, Sasaki Y, Akino K, Ueno M, Takahashi F, Kusano M, Mita H, Yanagihara K, Endo T, Hinoda Y, Tokino T, Imai K |
Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 ; 11 (3) : 1021-1027. |
PMID 15709167 |
|
Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. |
Okami J, Simeone DM, Logsdon CD |
Cancer research. 2004 ; 64 (15) : 5338-5346. |
PMID 15289340 |
|
BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. |
Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC, Gietz RD, Greenberg AH |
The Journal of biological chemistry. 2000 ; 275 (2) : 1439-1448. |
PMID 10625696 |
|
BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. |
Vande Velde C, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S, Hakem R, Greenberg AH |
Molecular and cellular biology. 2000 ; 20 (15) : 5454-5468. |
PMID 10891486 |
|
BNip3 and signal-specific programmed death in the heart. |
Webster KA, Graham RM, Bishopric NH |
Journal of molecular and cellular cardiology. 2005 ; 38 (1) : 35-45. |
PMID 15623420 |
|
Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence. |
Yasuda M, Theodorakis P, Subramanian T, Chinnadurai G |
The Journal of biological chemistry. 1998 ; 273 (20) : 12415-12421. |
PMID 9575197 |
|
Nitric oxide induces BNIP3 expression that causes cell death in macrophages. |
Yook YH, Kang KH, Maeng O, Kim TR, Lee JO, Kang KI, Kim YS, Paik SG, Lee H |
Biochemical and biophysical research communications. 2004 ; 321 (2) : 298-305. |
PMID 15358175 |
|