Atlas of Genetics and Cytogenetics in Oncology and Haematology


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BPI (bactericidal/permeability-increasing protein)

Identity

Alias_namesmember 1
Alias_symbol (synonym)BPIFD1
Other aliasrBPI
HGNC (Hugo) BPI
LocusID (NCBI) 671
Atlas_Id 50410
Location 20q11.23  [Link to chromosome band 20q11]
Location_base_pair Starts at 38304150 and ends at 38337503 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DLGAP4 (20q11.23) / BPI (20q11.23)GTF2B (1p22.2) / BPI (20q11.23)SSH2 (17q11.2) / BPI (20q11.23)
DLGAP4 20q11.23 / BPI 20q11.23GTF2B 1p22.2 / BPI 20q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BPI   1095
Cards
Entrez_Gene (NCBI)BPI  671  bactericidal/permeability-increasing protein
AliasesBPIFD1; rBPI
GeneCards (Weizmann)BPI
Ensembl hg19 (Hinxton)ENSG00000101425 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101425 [Gene_View]  chr20:38304150-38337503 [Contig_View]  BPI [Vega]
ICGC DataPortalENSG00000101425
TCGA cBioPortalBPI
AceView (NCBI)BPI
Genatlas (Paris)BPI
WikiGenes671
SOURCE (Princeton)BPI
Genetics Home Reference (NIH)BPI
Genomic and cartography
GoldenPath hg38 (UCSC)BPI  -     chr20:38304150-38337503 +  20q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BPI  -     20q11.23   [Description]    (hg19-Feb_2009)
EnsemblBPI - 20q11.23 [CytoView hg19]  BPI - 20q11.23 [CytoView hg38]
Mapping of homologs : NCBIBPI [Mapview hg19]  BPI [Mapview hg38]
OMIM109195   
Gene and transcription
Genbank (Entrez)AF322588 AI436120 AK296568 AK315328 AX713278
RefSeq transcript (Entrez)NM_001725
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BPI
Cluster EST : UnigeneHs.529019 [ NCBI ]
CGAP (NCI)Hs.529019
Alternative Splicing GalleryENSG00000101425
Gene ExpressionBPI [ NCBI-GEO ]   BPI [ EBI - ARRAY_EXPRESS ]   BPI [ SEEK ]   BPI [ MEM ]
Gene Expression Viewer (FireBrowse)BPI [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)671
GTEX Portal (Tissue expression)BPI
Human Protein AtlasENSG00000101425-BPI [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17213   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17213  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17213
Splice isoforms : SwissVarP17213
PhosPhoSitePlusP17213
Domaine pattern : Prosite (Expaxy)LBP_BPI_CETP (PS00400)   
Domains : Interpro (EBI)Bactericidal_perm-incr_a/b_dom    BPI    BPI/LBP    BPI/LBP/Plunc    Lipid-bd_serum_glycop_C    Lipid-bd_serum_glycop_CS    Lipid-bd_serum_glycop_N   
Domain families : Pfam (Sanger)LBP_BPI_CETP (PF01273)    LBP_BPI_CETP_C (PF02886)   
Domain families : Pfam (NCBI)pfam01273    pfam02886   
Domain families : Smart (EMBL)BPI1 (SM00328)  BPI2 (SM00329)  
Conserved Domain (NCBI)BPI
DMDM Disease mutations671
Blocks (Seattle)BPI
PDB (SRS)1BP1    1EWF   
PDB (PDBSum)1BP1    1EWF   
PDB (IMB)1BP1    1EWF   
PDB (RSDB)1BP1    1EWF   
Structural Biology KnowledgeBase1BP1    1EWF   
SCOP (Structural Classification of Proteins)1BP1    1EWF   
CATH (Classification of proteins structures)1BP1    1EWF   
SuperfamilyP17213
Human Protein Atlas [tissue]ENSG00000101425-BPI [tissue]
Peptide AtlasP17213
HPRD00174
IPIIPI00827847   IPI00552280   IPI00791618   IPI00795844   
Protein Interaction databases
DIP (DOE-UCLA)P17213
IntAct (EBI)P17213
FunCoupENSG00000101425
BioGRIDBPI
STRING (EMBL)BPI
ZODIACBPI
Ontologies - Pathways
QuickGOP17213
Ontology : AmiGOlipopolysaccharide binding  extracellular region  extracellular space  integral component of plasma membrane  antimicrobial humoral response  negative regulation of interleukin-6 production  negative regulation of interleukin-8 production  negative regulation of tumor necrosis factor production  azurophil granule lumen  specific granule lumen  negative regulation of macrophage activation  neutrophil degranulation  defense response to Gram-negative bacterium  extracellular exosome  
Ontology : EGO-EBIlipopolysaccharide binding  extracellular region  extracellular space  integral component of plasma membrane  antimicrobial humoral response  negative regulation of interleukin-6 production  negative regulation of interleukin-8 production  negative regulation of tumor necrosis factor production  azurophil granule lumen  specific granule lumen  negative regulation of macrophage activation  neutrophil degranulation  defense response to Gram-negative bacterium  extracellular exosome  
NDEx NetworkBPI
Atlas of Cancer Signalling NetworkBPI
Wikipedia pathwaysBPI
Orthology - Evolution
OrthoDB671
GeneTree (enSembl)ENSG00000101425
Phylogenetic Trees/Animal Genes : TreeFamBPI
HOVERGENP17213
HOGENOMP17213
Homologs : HomoloGeneBPI
Homology/Alignments : Family Browser (UCSC)BPI
Gene fusions - Rearrangements
Fusion : MitelmanDLGAP4/BPI [20q11.23/20q11.23]  [t(20;20)(q11;q11)]  
Fusion : MitelmanGTF2B/BPI [1p22.2/20q11.23]  [t(1;20)(p22;q11)]  
Fusion: TCGA_MDACCDLGAP4 20q11.23 BPI 20q11.23 LUAD
Fusion: TCGA_MDACCGTF2B 1p22.2 BPI 20q11.23 BRCA
Tumor Fusion PortalBPI
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBPI [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BPI
dbVarBPI
ClinVarBPI
1000_GenomesBPI 
Exome Variant ServerBPI
ExAC (Exome Aggregation Consortium)ENSG00000101425
GNOMAD BrowserENSG00000101425
Genetic variants : HAPMAP671
Genomic Variants (DGV)BPI [DGVbeta]
DECIPHERBPI [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBPI 
Mutations
ICGC Data PortalBPI 
TCGA Data PortalBPI 
Broad Tumor PortalBPI
OASIS PortalBPI [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBPI  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBPI
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BPI
DgiDB (Drug Gene Interaction Database)BPI
DoCM (Curated mutations)BPI (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BPI (select a term)
intoGenBPI
Cancer3DBPI(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109195   
Orphanet
DisGeNETBPI
MedgenBPI
Genetic Testing Registry BPI
NextProtP17213 [Medical]
TSGene671
GENETestsBPI
Target ValidationBPI
Huge Navigator BPI [HugePedia]
snp3D : Map Gene to Disease671
BioCentury BCIQBPI
ClinGenBPI
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD671
Chemical/Pharm GKB GenePA25403
Clinical trialBPI
Miscellaneous
canSAR (ICR)BPI (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBPI
EVEXBPI
GoPubMedBPI
iHOPBPI
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:05:02 CET 2017

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