BPI (bactericidal permeability increasing protein)

2008-10-01  

Identity

HGNC
LOCATION
20q11.23
LOCUSID
ALIAS
BPIFD1,rBPI
FUSION GENES

Other Information

Locus ID:

NCBI: 671
MIM: 109195
HGNC: 1095
Ensembl: ENSG00000101425

Variants:

dbSNP: 671
ClinVar: 671
TCGA: ENSG00000101425
COSMIC: BPI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101425ENST00000262865P17213
ENSG00000101425ENST00000417318H0Y738
ENSG00000101425ENST00000489102A0A0D9SFX6
ENSG00000101425ENST00000642449A0A2R8YDF1

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Antimicrobial peptidesREACTOMER-HSA-6803157
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
118913032002Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
127108512003Antimicrobial peptides in amniotic fluid: defensins, calprotectin and bacterial/permeability-increasing protein in patients with microbial invasion of the amniotic cavity, intra-amniotic inflammation, preterm labor and premature rupture of membranes.63
113734192001Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis.41
204636182010Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.32
176788852007The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease.30
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
163804962006Natural antibiotics and insulin sensitivity: the role of bactericidal/permeability-increasing protein.21
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19

Citation

Dessen P

BPI (bactericidal permeability increasing protein)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50410/bpi