BPIFB1 (BPI fold containing family B member 1)

2011-08-01  

Identity

HGNC
LOCATION
20q11.21
LOCUSID
ALIAS
C20orf114,LPLUNC1
FUSION GENES

Other Information

Locus ID:

NCBI: 92747
HGNC: 16108
Ensembl: ENSG00000125999

Variants:

dbSNP: 92747
ClinVar: 92747
TCGA: ENSG00000125999
COSMIC: BPIFB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125999ENST00000253354Q8TDL5
ENSG00000125999ENST00000423645A2A2R0

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
237086612014LPLUNC1 suppresses IL-6-induced nasopharyngeal carcinoma cell proliferation via inhibiting the Stat3 activation.51
241077782013BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease.32
291232672018BPIFB1 (LPLUNC1) inhibits migration and invasion of nasopharyngeal carcinoma by interacting with VTN and VIM.32
295680642018BPIFB1 (LPLUNC1) inhibits radioresistance in nasopharyngeal carcinoma by inhibiting VTN expression.28
236505332013LPLUNC1 inhibits nasopharyngeal carcinoma cell growth via down-regulation of the MAP kinase and cyclin D1/E2F pathways.25
219004862011LPLUNC1 modulates innate immune responses to Vibrio cholerae.24
128747882003Identification of tissue-specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray.19
192123282009A variant in long palate, lung and nasal epithelium clone 1 is associated with cholera in a Bangladeshi population.18
202377942010Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts.15
227670252012BPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung disease.9

Citation

Dessen P

BPIFB1 (BPI fold containing family B member 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52308/bpifb1