Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

BRAP (BRCA1 associated protein)

Identity

Alias_symbol (synonym)BRAP2
RNF52
IMP
Other alias
HGNC (Hugo) BRAP
LocusID (NCBI) 8315
Atlas_Id 50122
Location 12q24.12  [Link to chromosome band 12q24]
Location_base_pair Starts at 112079950 and ends at 112123800 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BRAP (12q24.12) / CPT1B (22q13.33)BRAP (12q24.12) / FAM216A (12q24.11)BRAP (12q24.12) / RPS5 (19q13.43)
BRAP 12q24.12 C12orf24

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BRAP   1099
Cards
Entrez_Gene (NCBI)BRAP  8315  BRCA1 associated protein
AliasesBRAP2; IMP; RNF52
GeneCards (Weizmann)BRAP
Ensembl hg19 (Hinxton)ENSG00000089234 [Gene_View]  chr12:112079950-112123800 [Contig_View]  BRAP [Vega]
Ensembl hg38 (Hinxton)ENSG00000089234 [Gene_View]  chr12:112079950-112123800 [Contig_View]  BRAP [Vega]
ICGC DataPortalENSG00000089234
TCGA cBioPortalBRAP
AceView (NCBI)BRAP
Genatlas (Paris)BRAP
WikiGenes8315
SOURCE (Princeton)BRAP
Genetics Home Reference (NIH)BRAP
Genomic and cartography
GoldenPath hg19 (UCSC)BRAP  -     chr12:112079950-112123800 -  12q24.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)BRAP  -     12q24.12   [Description]    (hg38-Dec_2013)
EnsemblBRAP - 12q24.12 [CytoView hg19]  BRAP - 12q24.12 [CytoView hg38]
Mapping of homologs : NCBIBRAP [Mapview hg19]  BRAP [Mapview hg38]
OMIM604986   
Gene and transcription
Genbank (Entrez)AB208878 AF035620 AF035950 AK290379 AK299326
RefSeq transcript (Entrez)NM_006768
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929385
Consensus coding sequences : CCDS (NCBI)BRAP
Cluster EST : UnigeneHs.530940 [ NCBI ]
CGAP (NCI)Hs.530940
Alternative Splicing GalleryENSG00000089234
Gene ExpressionBRAP [ NCBI-GEO ]   BRAP [ EBI - ARRAY_EXPRESS ]   BRAP [ SEEK ]   BRAP [ MEM ]
Gene Expression Viewer (FireBrowse)BRAP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8315
GTEX Portal (Tissue expression)BRAP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z569   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z569  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z569
Splice isoforms : SwissVarQ7Z569
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ7Z569
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)    ZF_UBP (PS50271)   
Domains : Interpro (EBI)BRAP2    Nucleotide-bd_a/b_plait    Znf_RING    Znf_RING/FYVE/PHD    Znf_UBP   
Domain families : Pfam (Sanger)BRAP2 (PF07576)    zf-RING_2 (PF13639)    zf-UBP (PF02148)   
Domain families : Pfam (NCBI)pfam07576    pfam13639    pfam02148   
Domain families : Smart (EMBL)RING (SM00184)  ZnF_UBP (SM00290)  
Domain structure : Prodom (Prabi Lyon)BRAP2 (PD017029)   
Conserved Domain (NCBI)BRAP
DMDM Disease mutations8315
Blocks (Seattle)BRAP
SuperfamilyQ7Z569
Human Protein AtlasENSG00000089234
Peptide AtlasQ7Z569
IPIIPI00396089   IPI00908635   IPI01020901   IPI01022318   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z569
IntAct (EBI)Q7Z569
FunCoupENSG00000089234
BioGRIDBRAP
STRING (EMBL)BRAP
ZODIACBRAP
Ontologies - Pathways
QuickGOQ7Z569
Ontology : AmiGOubiquitin ligase complex  MAPK cascade  MAPK cascade  nucleotide binding  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytosol  Ras protein signal transduction  nuclear localization sequence binding  zinc ion binding  negative regulation of signal transduction  protein ubiquitination  protein ubiquitination  ligase activity  nuclear membrane  identical protein binding  ubiquitin binding  ubiquitin protein ligase activity  ubiquitin protein ligase activity  
Ontology : EGO-EBIubiquitin ligase complex  MAPK cascade  MAPK cascade  nucleotide binding  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytosol  Ras protein signal transduction  nuclear localization sequence binding  zinc ion binding  negative regulation of signal transduction  protein ubiquitination  protein ubiquitination  ligase activity  nuclear membrane  identical protein binding  ubiquitin binding  ubiquitin protein ligase activity  ubiquitin protein ligase activity  
Pathways : KEGGRas signaling pathway   
NDEx NetworkBRAP
Atlas of Cancer Signalling NetworkBRAP
Wikipedia pathwaysBRAP
Orthology - Evolution
OrthoDB8315
GeneTree (enSembl)ENSG00000089234
Phylogenetic Trees/Animal Genes : TreeFamBRAP
HOVERGENQ7Z569
HOGENOMQ7Z569
Homologs : HomoloGeneBRAP
Homology/Alignments : Family Browser (UCSC)BRAP
Gene fusions - Rearrangements
Fusion : MitelmanBRAP/FAM216A [12q24.12/12q24.11]  
Fusion: TCGABRAP 12q24.12 C12orf24 LUSC
Fusion Cancer (Beijing)BRAP [12q24.12]  -  RPS5 [19q13.43]  [FUSC002125]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBRAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BRAP
dbVarBRAP
ClinVarBRAP
1000_GenomesBRAP 
Exome Variant ServerBRAP
ExAC (Exome Aggregation Consortium)BRAP (select the gene name)
Genetic variants : HAPMAP8315
Genomic Variants (DGV)BRAP [DGVbeta]
DECIPHER (Syndromes)12:112079950-112123800  ENSG00000089234
CONAN: Copy Number AnalysisBRAP 
Mutations
ICGC Data PortalBRAP 
TCGA Data PortalBRAP 
Broad Tumor PortalBRAP
OASIS PortalBRAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBRAP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBRAP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BRAP
DgiDB (Drug Gene Interaction Database)BRAP
DoCM (Curated mutations)BRAP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BRAP (select a term)
intoGenBRAP
Cancer3DBRAP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604986   
Orphanet
MedgenBRAP
Genetic Testing Registry BRAP
NextProtQ7Z569 [Medical]
TSGene8315
GENETestsBRAP
Huge Navigator BRAP [HugePedia]
snp3D : Map Gene to Disease8315
BioCentury BCIQBRAP
ClinGenBRAP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8315
Chemical/Pharm GKB GenePA25410
Clinical trialBRAP
Miscellaneous
canSAR (ICR)BRAP (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBRAP
EVEXBRAP
GoPubMedBRAP
iHOPBRAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:54:11 CEST 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.