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BRAT1 (BRCA1 associated ATM activator 1)

Identity

Alias_namesC7orf27
BAAT1
chromosome 7 open reading frame 27
BRCA1-associated ATM activator 1
Alias_symbol (synonym)MGC22916
Other aliasRMFSL
HGNC (Hugo) BRAT1
LocusID (NCBI) 221927
Atlas_Id 56397
Location 7p22.3  [Link to chromosome band 7p22]
Location_base_pair Starts at 2537810 and ends at 2555758 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GPR107 (9q34.11) / BRAT1 (7p22.3)HDAC4 (2q37.3) / BRAT1 (7p22.3)MBOAT2 (2p25.1) / BRAT1 (7p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BRAT1   21701
Cards
Entrez_Gene (NCBI)BRAT1  221927  BRCA1 associated ATM activator 1
AliasesBAAT1; C7orf27; RMFSL
GeneCards (Weizmann)BRAT1
Ensembl hg19 (Hinxton)ENSG00000106009 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106009 [Gene_View]  chr7:2537810-2555758 [Contig_View]  BRAT1 [Vega]
ICGC DataPortalENSG00000106009
TCGA cBioPortalBRAT1
AceView (NCBI)BRAT1
Genatlas (Paris)BRAT1
WikiGenes221927
SOURCE (Princeton)BRAT1
Genetics Home Reference (NIH)BRAT1
Genomic and cartography
GoldenPath hg38 (UCSC)BRAT1  -     chr7:2537810-2555758 -  7p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BRAT1  -     7p22.3   [Description]    (hg19-Feb_2009)
EnsemblBRAT1 - 7p22.3 [CytoView hg19]  BRAT1 - 7p22.3 [CytoView hg38]
Mapping of homologs : NCBIBRAT1 [Mapview hg19]  BRAT1 [Mapview hg38]
OMIM614498   614506   
Gene and transcription
Genbank (Entrez)AI963076 AK024482 AK131083 AK131097 AK311144
RefSeq transcript (Entrez)NM_001350626 NM_001350627 NM_152743
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BRAT1
Cluster EST : UnigeneHs.520623 [ NCBI ]
CGAP (NCI)Hs.520623
Alternative Splicing GalleryENSG00000106009
Gene ExpressionBRAT1 [ NCBI-GEO ]   BRAT1 [ EBI - ARRAY_EXPRESS ]   BRAT1 [ SEEK ]   BRAT1 [ MEM ]
Gene Expression Viewer (FireBrowse)BRAT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)221927
GTEX Portal (Tissue expression)BRAT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6PJG6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6PJG6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6PJG6
Splice isoforms : SwissVarQ6PJG6
PhosPhoSitePlusQ6PJG6
Domains : Interpro (EBI)ARM-like    ARM-type_fold    HEAT   
Domain families : Pfam (Sanger)HEAT (PF02985)   
Domain families : Pfam (NCBI)pfam02985   
Conserved Domain (NCBI)BRAT1
DMDM Disease mutations221927
Blocks (Seattle)BRAT1
PDB (SRS)4IFI   
PDB (PDBSum)4IFI   
PDB (IMB)4IFI   
PDB (RSDB)4IFI   
Structural Biology KnowledgeBase4IFI   
SCOP (Structural Classification of Proteins)4IFI   
CATH (Classification of proteins structures)4IFI   
SuperfamilyQ6PJG6
Human Protein AtlasENSG00000106009
Peptide AtlasQ6PJG6
HPRD12914
IPIIPI00658145   IPI00798399   IPI00797616   IPI00442347   IPI00442353   IPI00386319   IPI00893866   
Protein Interaction databases
DIP (DOE-UCLA)Q6PJG6
IntAct (EBI)Q6PJG6
FunCoupENSG00000106009
BioGRIDBRAT1
STRING (EMBL)BRAT1
ZODIACBRAT1
Ontologies - Pathways
QuickGOQ6PJG6
Ontology : AmiGOpositive regulation of protein phosphorylation  protein binding  nucleus  nucleoplasm  cytoplasm  glucose metabolic process  apoptotic process  cellular response to DNA damage stimulus  cell proliferation  response to ionizing radiation  membrane  cell growth  cell migration  mitochondrion localization  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  protein binding  nucleus  nucleoplasm  cytoplasm  glucose metabolic process  apoptotic process  cellular response to DNA damage stimulus  cell proliferation  response to ionizing radiation  membrane  cell growth  cell migration  mitochondrion localization  
NDEx NetworkBRAT1
Atlas of Cancer Signalling NetworkBRAT1
Wikipedia pathwaysBRAT1
Orthology - Evolution
OrthoDB221927
GeneTree (enSembl)ENSG00000106009
Phylogenetic Trees/Animal Genes : TreeFamBRAT1
HOVERGENQ6PJG6
HOGENOMQ6PJG6
Homologs : HomoloGeneBRAT1
Homology/Alignments : Family Browser (UCSC)BRAT1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBRAT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BRAT1
dbVarBRAT1
ClinVarBRAT1
1000_GenomesBRAT1 
Exome Variant ServerBRAT1
ExAC (Exome Aggregation Consortium)BRAT1 (select the gene name)
Genetic variants : HAPMAP221927
Genomic Variants (DGV)BRAT1 [DGVbeta]
DECIPHERBRAT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBRAT1 
Mutations
ICGC Data PortalBRAT1 
TCGA Data PortalBRAT1 
Broad Tumor PortalBRAT1
OASIS PortalBRAT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBRAT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBRAT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BRAT1
DgiDB (Drug Gene Interaction Database)BRAT1
DoCM (Curated mutations)BRAT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BRAT1 (select a term)
intoGenBRAT1
Cancer3DBRAT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614498    614506   
Orphanet23318   
MedgenBRAT1
Genetic Testing Registry BRAT1
NextProtQ6PJG6 [Medical]
TSGene221927
GENETestsBRAT1
Target ValidationBRAT1
Huge Navigator BRAT1 [HugePedia]
snp3D : Map Gene to Disease221927
BioCentury BCIQBRAT1
ClinGenBRAT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD221927
Chemical/Pharm GKB GenePA134959439
Clinical trialBRAT1
Miscellaneous
canSAR (ICR)BRAT1 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBRAT1
EVEXBRAT1
GoPubMedBRAT1
iHOPBRAT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:59:29 CEST 2017

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