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BRCC3 (BRCA1/BRCA2-containing complex subunit 3)

Identity

Alias_namesCXorf53
chromosome X open reading frame 53
BRCA1/BRCA2-containing complex, subunit 3
Alias_symbol (synonym)C6.1A
BRCC36
Other alias
HGNC (Hugo) BRCC3
LocusID (NCBI) 79184
Atlas_Id 50949
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 155071420 and ends at 155123074 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRCC3 (Xq28) / FUNDC2 (Xq28)BRCC3 (Xq28) / TRA ()VBP1 (Xq28) / BRCC3 (Xq28)
VBP1 Xq28 / BRCC3 Xq28

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BRCC3   24185
Cards
Entrez_Gene (NCBI)BRCC3  79184  BRCA1/BRCA2-containing complex subunit 3
AliasesBRCC36; C6.1A; CXorf53
GeneCards (Weizmann)BRCC3
Ensembl hg19 (Hinxton)ENSG00000185515 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185515 [Gene_View]  ENSG00000185515 [Sequence]  chrX:155071420-155123074 [Contig_View]  BRCC3 [Vega]
ICGC DataPortalENSG00000185515
TCGA cBioPortalBRCC3
AceView (NCBI)BRCC3
Genatlas (Paris)BRCC3
WikiGenes79184
SOURCE (Princeton)BRCC3
Genetics Home Reference (NIH)BRCC3
Genomic and cartography
GoldenPath hg38 (UCSC)BRCC3  -     chrX:155071420-155123074 +  Xq28   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BRCC3  -     Xq28   [Description]    (hg19-Feb_2009)
EnsemblBRCC3 - Xq28 [CytoView hg19]  BRCC3 - Xq28 [CytoView hg38]
Mapping of homologs : NCBIBRCC3 [Mapview hg19]  BRCC3 [Mapview hg38]
OMIM300617   
Gene and transcription
Genbank (Entrez)AK298886 AK299194 AK310286 AK313544 AY438030
RefSeq transcript (Entrez)NM_001018055 NM_001242640 NM_024332
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BRCC3
Cluster EST : UnigeneHs.558537 [ NCBI ]
CGAP (NCI)Hs.558537
Alternative Splicing GalleryENSG00000185515
Gene ExpressionBRCC3 [ NCBI-GEO ]   BRCC3 [ EBI - ARRAY_EXPRESS ]   BRCC3 [ SEEK ]   BRCC3 [ MEM ]
Gene Expression Viewer (FireBrowse)BRCC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79184
GTEX Portal (Tissue expression)BRCC3
Human Protein AtlasENSG00000185515-BRCC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46736   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46736  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46736
Splice isoforms : SwissVarP46736
PhosPhoSitePlusP46736
Domaine pattern : Prosite (Expaxy)MPN (PS50249)   
Domains : Interpro (EBI)JAMM/MPN+_dom    MPN    MPN_BRCC36   
Domain families : Pfam (Sanger)JAB (PF01398)   
Domain families : Pfam (NCBI)pfam01398   
Domain families : Smart (EMBL)JAB_MPN (SM00232)  
Conserved Domain (NCBI)BRCC3
DMDM Disease mutations79184
Blocks (Seattle)BRCC3
SuperfamilyP46736
Human Protein Atlas [tissue]ENSG00000185515-BRCC3 [tissue]
Peptide AtlasP46736
HPRD06465
IPIIPI00939471   IPI00871617   IPI00936224   IPI01010909   IPI00853631   IPI00929376   IPI00008289   IPI00853437   IPI00880128   
Protein Interaction databases
DIP (DOE-UCLA)P46736
IntAct (EBI)P46736
FunCoupENSG00000185515
BioGRIDBRCC3
STRING (EMBL)BRCC3
ZODIACBRCC3
Ontologies - Pathways
QuickGOP46736
Ontology : AmiGOubiquitin ligase complex  nuclear ubiquitin ligase complex  spindle pole  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  DNA repair  double-strand break repair  double-strand break repair  double-strand break repair via nonhomologous end joining  cell cycle  metallopeptidase activity  metallopeptidase activity  response to X-ray  response to ionizing radiation  protein deubiquitination  enzyme regulator activity  polyubiquitin modification-dependent protein binding  polyubiquitin modification-dependent protein binding  thiol-dependent ubiquitinyl hydrolase activity  thiol-dependent ubiquitinyl hydrolase activity  positive regulation of DNA repair  metal ion binding  regulation of catalytic activity  cell division  Lys63-specific deubiquitinase activity  BRCA1-A complex  BRCA1-A complex  protein K63-linked deubiquitination  protein K63-linked deubiquitination  protein K63-linked deubiquitination  histone H2A K63-linked deubiquitination  histone H2A K63-linked deubiquitination  histone H2A K63-linked deubiquitination  BRISC complex  BRISC complex  signal transduction involved in G2 DNA damage checkpoint  
Ontology : EGO-EBIubiquitin ligase complex  nuclear ubiquitin ligase complex  spindle pole  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  DNA repair  double-strand break repair  double-strand break repair  double-strand break repair via nonhomologous end joining  cell cycle  metallopeptidase activity  metallopeptidase activity  response to X-ray  response to ionizing radiation  protein deubiquitination  enzyme regulator activity  polyubiquitin modification-dependent protein binding  polyubiquitin modification-dependent protein binding  thiol-dependent ubiquitinyl hydrolase activity  thiol-dependent ubiquitinyl hydrolase activity  positive regulation of DNA repair  metal ion binding  regulation of catalytic activity  cell division  Lys63-specific deubiquitinase activity  BRCA1-A complex  BRCA1-A complex  protein K63-linked deubiquitination  protein K63-linked deubiquitination  protein K63-linked deubiquitination  histone H2A K63-linked deubiquitination  histone H2A K63-linked deubiquitination  histone H2A K63-linked deubiquitination  BRISC complex  BRISC complex  signal transduction involved in G2 DNA damage checkpoint  
NDEx NetworkBRCC3
Atlas of Cancer Signalling NetworkBRCC3
Wikipedia pathwaysBRCC3
Orthology - Evolution
OrthoDB79184
GeneTree (enSembl)ENSG00000185515
Phylogenetic Trees/Animal Genes : TreeFamBRCC3
HOVERGENP46736
HOGENOMP46736
Homologs : HomoloGeneBRCC3
Homology/Alignments : Family Browser (UCSC)BRCC3
Gene fusions - Rearrangements
Fusion PortalVBP1 Xq28 BRCC3 Xq28 BRCA
Fusion : QuiverBRCC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBRCC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BRCC3
dbVarBRCC3
ClinVarBRCC3
1000_GenomesBRCC3 
Exome Variant ServerBRCC3
ExAC (Exome Aggregation Consortium)ENSG00000185515
GNOMAD BrowserENSG00000185515
Varsome BrowserBRCC3
Genetic variants : HAPMAP79184
Genomic Variants (DGV)BRCC3 [DGVbeta]
DECIPHERBRCC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBRCC3 
Mutations
ICGC Data PortalBRCC3 
TCGA Data PortalBRCC3 
Broad Tumor PortalBRCC3
OASIS PortalBRCC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBRCC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBRCC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BRCC3
DgiDB (Drug Gene Interaction Database)BRCC3
DoCM (Curated mutations)BRCC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BRCC3 (select a term)
intoGenBRCC3
Cancer3DBRCC3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300617   
Orphanet20497   
DisGeNETBRCC3
MedgenBRCC3
Genetic Testing Registry BRCC3
NextProtP46736 [Medical]
TSGene79184
GENETestsBRCC3
Target ValidationBRCC3
Huge Navigator BRCC3 [HugePedia]
snp3D : Map Gene to Disease79184
BioCentury BCIQBRCC3
ClinGenBRCC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79184
Chemical/Pharm GKB GenePA134922847
Clinical trialBRCC3
Miscellaneous
canSAR (ICR)BRCC3 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBRCC3
EVEXBRCC3
GoPubMedBRCC3
iHOPBRCC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 10:54:26 CET 2018

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