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BRD1 (bromodomain containing 1)

Identity

Other namesBRL
BRPF1
BRPF2
HGNC (Hugo) BRD1
LocusID (NCBI) 23774
Atlas_Id 835
Location 22q13.33
Location_base_pair Starts at 50166926 and ends at 50221196 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BRD1 (22q13.33) / APOL5 (22q12.3)BRD1 (22q13.33) / BRD1 (22q13.33)BRD1 (22q13.33) / MAPK12 (22q13.33)
BRD1 (22q13.33) / MLC1 (22q13.33)C22orf34 (22q13.33) / BRD1 (22q13.33)KLHL7 (7p15.3) / BRD1 (22q13.33)
PAX5 (9p13.2) / BRD1 (22q13.33)BRD1 22q13.33 / APOL5 22q12.3BRD1 22q13.33 / MAPK12 22q13.33
BRD1 22q13.33 / MLC1 22q13.33C22orf34 22q13.33 / BRD1 22q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Protein

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(9;22)(p13;q13) PAX5/BRD1

External links

Nomenclature
HGNC (Hugo)BRD1   1102
Cards
Entrez_Gene (NCBI)BRD1  23774  bromodomain containing 1
GeneCards (Weizmann)BRD1
Ensembl hg19 (Hinxton)ENSG00000100425 [Gene_View]  chr22:50166926-50221196 [Contig_View]  BRD1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000100425 [Gene_View]  chr22:50166926-50221196 [Contig_View]  BRD1 [Vega]
ICGC DataPortalENSG00000100425
TCGA cBioPortalBRD1
AceView (NCBI)BRD1
Genatlas (Paris)BRD1
WikiGenes23774
SOURCE (Princeton)BRD1
Genomic and cartography
GoldenPath hg19 (UCSC)BRD1  -     chr22:50166926-50221196 -  22q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)BRD1  -     22q13.33   [Description]    (hg38-Dec_2013)
EnsemblBRD1 - 22q13.33 [CytoView hg19]  BRD1 - 22q13.33 [CytoView hg38]
Mapping of homologs : NCBIBRD1 [Mapview hg19]  BRD1 [Mapview hg38]
OMIM604589   
Gene and transcription
Genbank (Entrez)AA969405 AB209216 AF005067 AK292428 AK302736
RefSeq transcript (Entrez)NM_001304808 NM_001304809 NM_014577
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)BRD1
Cluster EST : UnigeneHs.127950 [ NCBI ]
CGAP (NCI)Hs.127950
Alternative Splicing GalleryENSG00000100425
Gene ExpressionBRD1 [ NCBI-GEO ]   BRD1 [ EBI - ARRAY_EXPRESS ]   BRD1 [ SEEK ]   BRD1 [ MEM ]
Gene Expression Viewer (FireBrowse)BRD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23774
GTEX Portal (Tissue expression)BRD1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95696 (Uniprot)
NextProtO95696  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95696
Splice isoforms : SwissVarO95696 (Swissvar)
PhosPhoSitePlusO95696
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_1 (PS00633)    BROMODOMAIN_2 (PS50014)    PWWP (PS50812)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)   
Domains : Interpro (EBI)Bromodomain    Bromodomain_CS    Enhancer_polycomb-like_N    PWWP_dom    Zinc_finger_PHD-type_CS    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)Bromodomain (PF00439)    EPL1 (PF10513)    PWWP (PF00855)   
Domain families : Pfam (NCBI)pfam00439    pfam10513    pfam00855   
Domain families : Smart (EMBL)BROMO (SM00297)  PHD (SM00249)  PWWP (SM00293)  
DMDM Disease mutations23774
Blocks (Seattle)BRD1
PDB (SRS)2KU3    2L43    2LQ6    3LYI    3RCW    4Z02    5AME    5AMF    5FG6   
PDB (PDBSum)2KU3    2L43    2LQ6    3LYI    3RCW    4Z02    5AME    5AMF    5FG6   
PDB (IMB)2KU3    2L43    2LQ6    3LYI    3RCW    4Z02    5AME    5AMF    5FG6   
PDB (RSDB)2KU3    2L43    2LQ6    3LYI    3RCW    4Z02    5AME    5AMF    5FG6   
Structural Biology KnowledgeBase2KU3    2L43    2LQ6    3LYI    3RCW    4Z02    5AME    5AMF    5FG6   
SCOP (Structural Classification of Proteins)2KU3    2L43    2LQ6    3LYI    3RCW    4Z02    5AME    5AMF    5FG6   
CATH (Classification of proteins structures)2KU3    2L43    2LQ6    3LYI    3RCW    4Z02    5AME    5AMF    5FG6   
SuperfamilyO95696
Human Protein AtlasENSG00000100425
Peptide AtlasO95696
HPRD06848
IPIIPI00032214   IPI00384471   IPI00922474   IPI00941079   IPI01011372   IPI00556201   
Protein Interaction databases
DIP (DOE-UCLA)O95696
IntAct (EBI)O95696
FunCoupENSG00000100425
BioGRIDBRD1
STRING (EMBL)BRD1
ZODIACBRD1
Ontologies - Pathways
QuickGOO95696
Ontology : AmiGOnucleus  nucleus  nucleoplasm  zinc ion binding  dendrite  response to immobilization stress  histone binding  perikaryon  histone H3 acetylation  response to electrical stimulus  MOZ/MORF histone acetyltransferase complex  
Ontology : EGO-EBInucleus  nucleus  nucleoplasm  zinc ion binding  dendrite  response to immobilization stress  histone binding  perikaryon  histone H3 acetylation  response to electrical stimulus  MOZ/MORF histone acetyltransferase complex  
NDEx Network
Atlas of Cancer Signalling NetworkBRD1
Wikipedia pathwaysBRD1
Orthology - Evolution
OrthoDB23774
GeneTree (enSembl)ENSG00000100425
Phylogenetic Trees/Animal Genes : TreeFamBRD1
Homologs : HomoloGeneBRD1
Homology/Alignments : Family Browser (UCSC)BRD1
Gene fusions - Rearrangements
Fusion: TCGABRD1 22q13.33 APOL5 22q12.3 LUAD
Fusion: TCGABRD1 22q13.33 MAPK12 22q13.33 GBM
Fusion: TCGABRD1 22q13.33 MLC1 22q13.33 LUAD
Fusion: TCGAC22orf34 22q13.33 BRD1 22q13.33 LAML
Polymorphisms : SNP, variants
NCBI Variation ViewerBRD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BRD1
dbVarBRD1
ClinVarBRD1
1000_GenomesBRD1 
Exome Variant ServerBRD1
ExAC (Exome Aggregation Consortium)BRD1 (select the gene name)
Genetic variants : HAPMAP23774
Genomic Variants (DGV)BRD1 [DGVbeta]
Mutations
ICGC Data PortalBRD1 
TCGA Data PortalBRD1 
Broad Tumor PortalBRD1
OASIS PortalBRD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBRD1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BRD1
DgiDB (Drug Gene Interaction Database)BRD1
DoCM (Curated mutations)BRD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BRD1 (select a term)
intoGenBRD1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:50166926-50221196  ENSG00000100425
CONAN: Copy Number AnalysisBRD1 
Mutations and Diseases : HGMDBRD1
OMIM604589   
MedgenBRD1
Genetic Testing Registry BRD1
NextProtO95696 [Medical]
TSGene23774
GENETestsBRD1
Huge Navigator BRD1 [HugePedia]
snp3D : Map Gene to Disease23774
BioCentury BCIQBRD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23774
Chemical/Pharm GKB GenePA25413
Clinical trialBRD1
Miscellaneous
canSAR (ICR)BRD1 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBRD1
EVEXBRD1
GoPubMedBRD1
iHOPBRD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 18:38:55 CEST 2016

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