Atlas of Genetics and Cytogenetics in Oncology and Haematology


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BRD2 (bromodomain containing 2)

Identity

Alias_namesbromodomain-containing 2
Alias_symbol (synonym)KIAA9001
RING3
D6S113E
NAT
FSRG1
Other aliasBRD2-IT1
FSH
O27.1.1
RNF3
HGNC (Hugo) BRD2
LocusID (NCBI) 6046
Atlas_Id 836
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 32970888 and ends at 32981505 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BRD2 (6p21.32) / BRD2 (6p21.32)BRD2 (6p21.32) / CALR (19p13.2)BRD2 (6p21.32) / SLC39A11 (17q24.3)
BRD2 (6p21.32) / TMBIM6 (12q13.12)BRD2 (6p21.32) / YY1AP1 (1q22)CALR (19p13.2) / BRD2 (6p21.32)
EFNA1 (1q22) / BRD2 (6p21.32)NADK2 (5p13.2) / BRD2 (6p21.32)PPP3CA (4q24) / BRD2 (6p21.32)
ZNF445 (3p21.31) / BRD2 (6p21.32)CALR 19p13.2 / BRD2 6p21.32PPP3CA 4q24 / BRD2 6p21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BRD2   1103
Cards
Entrez_Gene (NCBI)BRD2  6046  bromodomain containing 2
AliasesBRD2-IT1; D6S113E; FSH; FSRG1; 
NAT; O27.1.1; RING3; RNF3
GeneCards (Weizmann)BRD2
Ensembl hg19 (Hinxton)ENSG00000204256 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204256 [Gene_View]  chr6:32970888-32981505 [Contig_View]  BRD2 [Vega]
ICGC DataPortalENSG00000204256
TCGA cBioPortalBRD2
AceView (NCBI)BRD2
Genatlas (Paris)BRD2
WikiGenes6046
SOURCE (Princeton)BRD2
Genetics Home Reference (NIH)BRD2
Genomic and cartography
GoldenPath hg38 (UCSC)BRD2  -     chr6:32970888-32981505 +  6p21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BRD2  -     6p21.32   [Description]    (hg19-Feb_2009)
EnsemblBRD2 - 6p21.32 [CytoView hg19]  BRD2 - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBIBRD2 [Mapview hg19]  BRD2 [Mapview hg38]
OMIM601540   
Gene and transcription
Genbank (Entrez)AI983495 AK056504 AK309797 AL832722 AY152720
RefSeq transcript (Entrez)NM_001113182 NM_001199455 NM_001199456 NM_001291986 NM_005104
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_042801 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)BRD2
Cluster EST : UnigeneHs.734797 [ NCBI ]
CGAP (NCI)Hs.734797
Alternative Splicing GalleryENSG00000204256
Gene ExpressionBRD2 [ NCBI-GEO ]   BRD2 [ EBI - ARRAY_EXPRESS ]   BRD2 [ SEEK ]   BRD2 [ MEM ]
Gene Expression Viewer (FireBrowse)BRD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6046
GTEX Portal (Tissue expression)BRD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25440   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25440  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25440
Splice isoforms : SwissVarP25440
PhosPhoSitePlusP25440
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_1 (PS00633)    BROMODOMAIN_2 (PS50014)    NET (PS51525)   
Domains : Interpro (EBI)Bromodomain    Bromodomain_CS    NET_dom   
Domain families : Pfam (Sanger)BET (PF17035)    Bromodomain (PF00439)   
Domain families : Pfam (NCBI)pfam17035    pfam00439   
Domain families : Smart (EMBL)BROMO (SM00297)  
Conserved Domain (NCBI)BRD2
DMDM Disease mutations6046
Blocks (Seattle)BRD2
PDB (SRS)1X0J    2DVQ    2DVR    2DVS    2DVV    2E3K    2G4A    2YDW    2YEK    3AQA    3ONI    4A9E    4A9F    4A9H    4A9I    4A9J    4A9M    4A9N    4A9O    4AKN    4ALG    4ALH    4J1P    4MR5    4MR6    4QEU    4QEV    4QEW    4UYF    4UYG    4UYH    5BT5    5DFB    5DFC    5DFD    5DW1    5EK9    5HEL    5HEM    5HEN    5HFQ    5IBN    5IG6   
PDB (PDBSum)1X0J    2DVQ    2DVR    2DVS    2DVV    2E3K    2G4A    2YDW    2YEK    3AQA    3ONI    4A9E    4A9F    4A9H    4A9I    4A9J    4A9M    4A9N    4A9O    4AKN    4ALG    4ALH    4J1P    4MR5    4MR6    4QEU    4QEV    4QEW    4UYF    4UYG    4UYH    5BT5    5DFB    5DFC    5DFD    5DW1    5EK9    5HEL    5HEM    5HEN    5HFQ    5IBN    5IG6   
PDB (IMB)1X0J    2DVQ    2DVR    2DVS    2DVV    2E3K    2G4A    2YDW    2YEK    3AQA    3ONI    4A9E    4A9F    4A9H    4A9I    4A9J    4A9M    4A9N    4A9O    4AKN    4ALG    4ALH    4J1P    4MR5    4MR6    4QEU    4QEV    4QEW    4UYF    4UYG    4UYH    5BT5    5DFB    5DFC    5DFD    5DW1    5EK9    5HEL    5HEM    5HEN    5HFQ    5IBN    5IG6   
PDB (RSDB)1X0J    2DVQ    2DVR    2DVS    2DVV    2E3K    2G4A    2YDW    2YEK    3AQA    3ONI    4A9E    4A9F    4A9H    4A9I    4A9J    4A9M    4A9N    4A9O    4AKN    4ALG    4ALH    4J1P    4MR5    4MR6    4QEU    4QEV    4QEW    4UYF    4UYG    4UYH    5BT5    5DFB    5DFC    5DFD    5DW1    5EK9    5HEL    5HEM    5HEN    5HFQ    5IBN    5IG6   
Structural Biology KnowledgeBase1X0J    2DVQ    2DVR    2DVS    2DVV    2E3K    2G4A    2YDW    2YEK    3AQA    3ONI    4A9E    4A9F    4A9H    4A9I    4A9J    4A9M    4A9N    4A9O    4AKN    4ALG    4ALH    4J1P    4MR5    4MR6    4QEU    4QEV    4QEW    4UYF    4UYG    4UYH    5BT5    5DFB    5DFC    5DFD    5DW1    5EK9    5HEL    5HEM    5HEN    5HFQ    5IBN    5IG6   
SCOP (Structural Classification of Proteins)1X0J    2DVQ    2DVR    2DVS    2DVV    2E3K    2G4A    2YDW    2YEK    3AQA    3ONI    4A9E    4A9F    4A9H    4A9I    4A9J    4A9M    4A9N    4A9O    4AKN    4ALG    4ALH    4J1P    4MR5    4MR6    4QEU    4QEV    4QEW    4UYF    4UYG    4UYH    5BT5    5DFB    5DFC    5DFD    5DW1    5EK9    5HEL    5HEM    5HEN    5HFQ    5IBN    5IG6   
CATH (Classification of proteins structures)1X0J    2DVQ    2DVR    2DVS    2DVV    2E3K    2G4A    2YDW    2YEK    3AQA    3ONI    4A9E    4A9F    4A9H    4A9I    4A9J    4A9M    4A9N    4A9O    4AKN    4ALG    4ALH    4J1P    4MR5    4MR6    4QEU    4QEV    4QEW    4UYF    4UYG    4UYH    5BT5    5DFB    5DFC    5DFD    5DW1    5EK9    5HEL    5HEM    5HEN    5HFQ    5IBN    5IG6   
SuperfamilyP25440
Human Protein AtlasENSG00000204256
Peptide AtlasP25440
HPRD03326
IPIIPI00014414   IPI00440502   IPI01021446   IPI00973934   IPI00893622   IPI00797929   IPI01011047   IPI00893088   IPI00894013   IPI00893701   IPI00894118   IPI00892847   IPI00893552   IPI00894424   IPI00894298   IPI00794051   IPI00982514   IPI00981776   IPI00978820   
Protein Interaction databases
DIP (DOE-UCLA)P25440
IntAct (EBI)P25440
FunCoupENSG00000204256
BioGRIDBRD2
STRING (EMBL)BRD2
ZODIACBRD2
Ontologies - Pathways
QuickGOP25440
Ontology : AmiGOchromatin binding  protein binding  nucleus  cytoplasm  nucleosome assembly  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  spermatogenesis  covalent chromatin modification  lysine-acetylated histone binding  
Ontology : EGO-EBIchromatin binding  protein binding  nucleus  cytoplasm  nucleosome assembly  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  spermatogenesis  covalent chromatin modification  lysine-acetylated histone binding  
NDEx NetworkBRD2
Atlas of Cancer Signalling NetworkBRD2
Wikipedia pathwaysBRD2
Orthology - Evolution
OrthoDB6046
GeneTree (enSembl)ENSG00000204256
Phylogenetic Trees/Animal Genes : TreeFamBRD2
HOVERGENP25440
HOGENOMP25440
Homologs : HomoloGeneBRD2
Homology/Alignments : Family Browser (UCSC)BRD2
Gene fusions - Rearrangements
Fusion : MitelmanCALR/BRD2 [19p13.2/6p21.32]  [t(6;19)(p21;p13)]  
Fusion : MitelmanPPP3CA/BRD2 [4q24/6p21.32]  [t(4;6)(q24;p21)]  
Fusion: TCGACALR 19p13.2 BRD2 6p21.32 PRAD
Fusion: TCGAPPP3CA 4q24 BRD2 6p21.32 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBRD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BRD2
dbVarBRD2
ClinVarBRD2
1000_GenomesBRD2 
Exome Variant ServerBRD2
ExAC (Exome Aggregation Consortium)BRD2 (select the gene name)
Genetic variants : HAPMAP6046
Genomic Variants (DGV)BRD2 [DGVbeta]
DECIPHERBRD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBRD2 
Mutations
ICGC Data PortalBRD2 
TCGA Data PortalBRD2 
Broad Tumor PortalBRD2
OASIS PortalBRD2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDBRD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BRD2
DgiDB (Drug Gene Interaction Database)BRD2
DoCM (Curated mutations)BRD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BRD2 (select a term)
intoGenBRD2
Cancer3DBRD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601540   
Orphanet
MedgenBRD2
Genetic Testing Registry BRD2
NextProtP25440 [Medical]
TSGene6046
GENETestsBRD2
Target ValidationBRD2
Huge Navigator BRD2 [HugePedia]
snp3D : Map Gene to Disease6046
BioCentury BCIQBRD2
ClinGenBRD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6046
Chemical/Pharm GKB GenePA25414
Clinical trialBRD2
Miscellaneous
canSAR (ICR)BRD2 (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBRD2
EVEXBRD2
GoPubMedBRD2
iHOPBRD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:25:46 CEST 2017

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