BRD8 (bromodomain containing 8)

2010-01-01  

Identity

HGNC
LOCATION
5q31.2
LOCUSID
ALIAS
SMAP,SMAP2,p120
FUSION GENES

Other Information

Locus ID:

NCBI: 10902
MIM: 602848
HGNC: 19874
Ensembl: ENSG00000112983

Variants:

dbSNP: 10902
ClinVar: 10902
TCGA: ENSG00000112983
COSMIC: BRD8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112983ENST00000230901Q9H0E9
ENSG00000112983ENST00000254900Q9H0E9
ENSG00000112983ENST00000402931B5MCW3
ENSG00000112983ENST00000411594Q9H0E9
ENSG00000112983ENST00000418329H7C179
ENSG00000112983ENST00000427976H7C026
ENSG00000112983ENST00000428808F8WDX5
ENSG00000112983ENST00000430331C9JV05
ENSG00000112983ENST00000432618F8WBH2
ENSG00000112983ENST00000441656H7C128
ENSG00000112983ENST00000450756F8WCS7
ENSG00000112983ENST00000453824H7C2P4
ENSG00000112983ENST00000454473H7C127
ENSG00000112983ENST00000472478H0Y8F9
ENSG00000112983ENST00000506167H0YAH7
ENSG00000112983ENST00000511898H0YA84
ENSG00000112983ENST00000512140D6RID0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
165716802006SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network.21
197872642009BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy.8
269400392016MiR-185 attenuates androgen receptor function in prostate cancer indirectly by targeting bromodomain containing 8 isoform 2, an androgen receptor co-activator.5
230640152012The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes.4
302375202018Cellular Depletion of BRD8 Causes p53-Dependent Apoptosis and Induces a DNA Damage Response in Non-Stressed Cells.2

Citation

Dessen P

BRD8 (bromodomain containing 8)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51290/brd8