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BRDT (bromodomain testis associated)

Identity

Alias_namesbromodomain
Alias_symbol (synonym)BRD6
CT9
Other aliasSPGF21
HGNC (Hugo) BRDT
LocusID (NCBI) 676
Atlas_Id 43172
Location 1p22.1  [Link to chromosome band 1p22]
Location_base_pair Starts at 91949371 and ends at 92014428 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRDT (1p22.1) / LANCL2 (7p11.2)MTF2 (1p22.1) / BRDT (1p22.1)PICALM (11q14.2) / BRDT (1p22.1)
MTF2 1p22.1 / BRDT 1p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  MTF2/BRDT (1p22)


External links

Nomenclature
HGNC (Hugo)BRDT   1105
Cards
Entrez_Gene (NCBI)BRDT  676  bromodomain testis associated
AliasesBRD6; CT9; SPGF21
GeneCards (Weizmann)BRDT
Ensembl hg19 (Hinxton)ENSG00000137948 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137948 [Gene_View]  ENSG00000137948 [Sequence]  chr1:91949371-92014428 [Contig_View]  BRDT [Vega]
ICGC DataPortalENSG00000137948
TCGA cBioPortalBRDT
AceView (NCBI)BRDT
Genatlas (Paris)BRDT
WikiGenes676
SOURCE (Princeton)BRDT
Genetics Home Reference (NIH)BRDT
Genomic and cartography
GoldenPath hg38 (UCSC)BRDT  -     chr1:91949371-92014428 +  1p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BRDT  -     1p22.1   [Description]    (hg19-Feb_2009)
EnsemblBRDT - 1p22.1 [CytoView hg19]  BRDT - 1p22.1 [CytoView hg38]
Mapping of homologs : NCBIBRDT [Mapview hg19]  BRDT [Mapview hg38]
OMIM602144   617644   
Gene and transcription
Genbank (Entrez)AF019085 AK302758 AK303008 AK316442 AY338951
RefSeq transcript (Entrez)NM_001242805 NM_001242806 NM_001242807 NM_001242808 NM_001242810 NM_001726 NM_207189
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BRDT
Cluster EST : UnigeneHs.482520 [ NCBI ]
CGAP (NCI)Hs.482520
Alternative Splicing GalleryENSG00000137948
Gene ExpressionBRDT [ NCBI-GEO ]   BRDT [ EBI - ARRAY_EXPRESS ]   BRDT [ SEEK ]   BRDT [ MEM ]
Gene Expression Viewer (FireBrowse)BRDT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)676
GTEX Portal (Tissue expression)BRDT
Human Protein AtlasENSG00000137948-BRDT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ58F21   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ58F21  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ58F21
Splice isoforms : SwissVarQ58F21
PhosPhoSitePlusQ58F21
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_1 (PS00633)    BROMODOMAIN_2 (PS50014)    NET (PS51525)   
Domains : Interpro (EBI)BRD4_CDT    Bromodomain    Bromodomain-like_sf    Bromodomain_CS    NET_dom    NET_sf   
Domain families : Pfam (Sanger)BET (PF17035)    BRD4_CDT (PF17105)    Bromodomain (PF00439)   
Domain families : Pfam (NCBI)pfam17035    pfam17105    pfam00439   
Domain families : Smart (EMBL)BROMO (SM00297)  
Conserved Domain (NCBI)BRDT
DMDM Disease mutations676
Blocks (Seattle)BRDT
PDB (SRS)2RFJ    4FLP    4KCX   
PDB (PDBSum)2RFJ    4FLP    4KCX   
PDB (IMB)2RFJ    4FLP    4KCX   
PDB (RSDB)2RFJ    4FLP    4KCX   
Structural Biology KnowledgeBase2RFJ    4FLP    4KCX   
SCOP (Structural Classification of Proteins)2RFJ    4FLP    4KCX   
CATH (Classification of proteins structures)2RFJ    4FLP    4KCX   
SuperfamilyQ58F21
Human Protein Atlas [tissue]ENSG00000137948-BRDT [tissue]
Peptide AtlasQ58F21
HPRD03684
IPIIPI00479548   IPI00759691   IPI00645771   IPI00878115   IPI01009902   IPI00639955   IPI00640477   IPI00878750   IPI00878911   IPI00878644   IPI00878286   
Protein Interaction databases
DIP (DOE-UCLA)Q58F21
IntAct (EBI)Q58F21
FunCoupENSG00000137948
BioGRIDBRDT
STRING (EMBL)BRDT
ZODIACBRDT
Ontologies - Pathways
QuickGOQ58F21
Ontology : AmiGOhistone displacement  transcription coactivator activity  nucleus  chromatin remodeling  transcription, DNA-templated  regulation of transcription, DNA-templated  mRNA processing  male meiotic nuclear division  male meiosis I  spermatogenesis  RNA splicing  cell differentiation  histone binding  regulation of RNA splicing  positive regulation of transcription involved in meiotic cell cycle  lysine-acetylated histone binding  
Ontology : EGO-EBIhistone displacement  transcription coactivator activity  nucleus  chromatin remodeling  transcription, DNA-templated  regulation of transcription, DNA-templated  mRNA processing  male meiotic nuclear division  male meiosis I  spermatogenesis  RNA splicing  cell differentiation  histone binding  regulation of RNA splicing  positive regulation of transcription involved in meiotic cell cycle  lysine-acetylated histone binding  
NDEx NetworkBRDT
Atlas of Cancer Signalling NetworkBRDT
Wikipedia pathwaysBRDT
Orthology - Evolution
OrthoDB676
GeneTree (enSembl)ENSG00000137948
Phylogenetic Trees/Animal Genes : TreeFamBRDT
HOVERGENQ58F21
HOGENOMQ58F21
Homologs : HomoloGeneBRDT
Homology/Alignments : Family Browser (UCSC)BRDT
Gene fusions - Rearrangements
Fusion : MitelmanMTF2/BRDT [1p22.1/1p22.1]  [t(1;1)(p22;p22)]  
Fusion PortalMTF2 1p22.1 BRDT 1p22.1 BRCA
Fusion : QuiverBRDT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBRDT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BRDT
dbVarBRDT
ClinVarBRDT
1000_GenomesBRDT 
Exome Variant ServerBRDT
ExAC (Exome Aggregation Consortium)ENSG00000137948
GNOMAD BrowserENSG00000137948
Varsome BrowserBRDT
Genetic variants : HAPMAP676
Genomic Variants (DGV)BRDT [DGVbeta]
DECIPHERBRDT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBRDT 
Mutations
ICGC Data PortalBRDT 
TCGA Data PortalBRDT 
Broad Tumor PortalBRDT
OASIS PortalBRDT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBRDT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBRDT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BRDT
DgiDB (Drug Gene Interaction Database)BRDT
DoCM (Curated mutations)BRDT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BRDT (select a term)
intoGenBRDT
Cancer3DBRDT(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602144    617644   
Orphanet
DisGeNETBRDT
MedgenBRDT
Genetic Testing Registry BRDT
NextProtQ58F21 [Medical]
TSGene676
GENETestsBRDT
Target ValidationBRDT
Huge Navigator BRDT [HugePedia]
snp3D : Map Gene to Disease676
BioCentury BCIQBRDT
ClinGenBRDT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD676
Chemical/Pharm GKB GenePA25418
Clinical trialBRDT
Miscellaneous
canSAR (ICR)BRDT (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBRDT
EVEXBRDT
GoPubMedBRDT
iHOPBRDT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:11:53 CEST 2018

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