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BRF1 (BRF1, RNA polymerase III transcription initiation factor subunit)

Identity

Alias_namesTAF3B2
TAF3C
GTF3B
TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
Alias_symbol (synonym)TFIIIB90
BRF
hBRF
Other aliasBRF-1
CFDS
HEL-S-76p
TAFIII90
TF3B90
HGNC (Hugo) BRF1
LocusID (NCBI) 2972
Atlas_Id 50104
Location 14q32.33  [Link to chromosome band 14q32]
Location_base_pair Starts at 105209286 and ends at 105315577 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRF1 (14q32.33) / FOXN3 (14q31.3)BRF1 (14q32.33) / GYS1 (19q13.33)BRF1 (14q32.33) / IFT88 (13q12.11)
CST3 (20p11.21) / BRF1 (14q32.33)UNC79 (14q32.12) / BRF1 (14q32.33)BRF1 14q32.33 / FOXN3 14q31.3
KIAA1409 BRF1 14q32.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BRF1   11551
Cards
Entrez_Gene (NCBI)BRF1  2972  BRF1, RNA polymerase III transcription initiation factor subunit
AliasesBRF; BRF-1; CFDS; GTF3B; 
HEL-S-76p; TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90; hBRF
GeneCards (Weizmann)BRF1
Ensembl hg19 (Hinxton)ENSG00000185024 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185024 [Gene_View]  chr14:105209286-105315577 [Contig_View]  BRF1 [Vega]
ICGC DataPortalENSG00000185024
TCGA cBioPortalBRF1
AceView (NCBI)BRF1
Genatlas (Paris)BRF1
WikiGenes2972
SOURCE (Princeton)BRF1
Genetics Home Reference (NIH)BRF1
Genomic and cartography
GoldenPath hg38 (UCSC)BRF1  -     chr14:105209286-105315577 -  14q32.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BRF1  -     14q32.33   [Description]    (hg19-Feb_2009)
EnsemblBRF1 - 14q32.33 [CytoView hg19]  BRF1 - 14q32.33 [CytoView hg38]
Mapping of homologs : NCBIBRF1 [Mapview hg19]  BRF1 [Mapview hg38]
OMIM604902   616202   
Gene and transcription
Genbank (Entrez)AJ297406 AJ297407 AJ297408 AK096471 AK124665
RefSeq transcript (Entrez)NM_001242786 NM_001242787 NM_001242788 NM_001242789 NM_001242790 NM_001519 NM_145685 NM_145696
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BRF1
Cluster EST : UnigeneHs.424484 [ NCBI ]
CGAP (NCI)Hs.424484
Alternative Splicing GalleryENSG00000185024
Gene ExpressionBRF1 [ NCBI-GEO ]   BRF1 [ EBI - ARRAY_EXPRESS ]   BRF1 [ SEEK ]   BRF1 [ MEM ]
Gene Expression Viewer (FireBrowse)BRF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2972
GTEX Portal (Tissue expression)BRF1
Human Protein AtlasENSG00000185024-BRF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92994   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92994  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92994
Splice isoforms : SwissVarQ92994
PhosPhoSitePlusQ92994
Domaine pattern : Prosite (Expaxy)ZF_TFIIB (PS51134)   
Domains : Interpro (EBI)Brf1    BRF1_TBP-bd_dom    Cyclin-like    TFIIB    TFIIB_cyclin    Znf_TFIIB   
Domain families : Pfam (Sanger)BRF1 (PF07741)    TF_Zn_Ribbon (PF08271)    TFIIB (PF00382)   
Domain families : Pfam (NCBI)pfam07741    pfam08271    pfam00382   
Domain families : Smart (EMBL)CYCLIN (SM00385)  
Conserved Domain (NCBI)BRF1
DMDM Disease mutations2972
Blocks (Seattle)BRF1
SuperfamilyQ92994
Human Protein Atlas [tissue]ENSG00000185024-BRF1 [tissue]
Peptide AtlasQ92994
HPRD05361
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)Q92994
IntAct (EBI)Q92994
FunCoupENSG00000185024
BioGRIDBRF1
STRING (EMBL)BRF1
ZODIACBRF1
Ontologies - Pathways
QuickGOQ92994
Ontology : AmiGOtranscription factor TFIIIB complex  TFIIIB-type transcription factor activity  nucleoplasm  transcription from RNA polymerase III promoter  transcription initiation from RNA polymerase III promoter  rRNA transcription  tRNA transcription  TBP-class protein binding  positive regulation of transcription from RNA polymerase III promoter  metal ion binding  DNA-templated transcriptional preinitiation complex assembly  
Ontology : EGO-EBItranscription factor TFIIIB complex  TFIIIB-type transcription factor activity  nucleoplasm  transcription from RNA polymerase III promoter  transcription initiation from RNA polymerase III promoter  rRNA transcription  tRNA transcription  TBP-class protein binding  positive regulation of transcription from RNA polymerase III promoter  metal ion binding  DNA-templated transcriptional preinitiation complex assembly  
Pathways : BIOCARTARNA polymerase III transcription [Genes]   
NDEx NetworkBRF1
Atlas of Cancer Signalling NetworkBRF1
Wikipedia pathwaysBRF1
Orthology - Evolution
OrthoDB2972
GeneTree (enSembl)ENSG00000185024
Phylogenetic Trees/Animal Genes : TreeFamBRF1
HOVERGENQ92994
HOGENOMQ92994
Homologs : HomoloGeneBRF1
Homology/Alignments : Family Browser (UCSC)BRF1
Gene fusions - Rearrangements
Fusion : MitelmanBRF1/FOXN3 [14q32.33/14q31.3]  
Fusion : MitelmanUNC79/BRF1 [14q32.12/14q32.33]  [t(14;14)(q32;q32)]  
Fusion: TCGA_MDACCBRF1 14q32.33 FOXN3 14q31.3 BRCA
Fusion: TCGA_MDACCKIAA1409 BRF1 14q32.33 LGG
Tumor Fusion PortalBRF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBRF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BRF1
dbVarBRF1
ClinVarBRF1
1000_GenomesBRF1 
Exome Variant ServerBRF1
ExAC (Exome Aggregation Consortium)ENSG00000185024
GNOMAD BrowserENSG00000185024
Genetic variants : HAPMAP2972
Genomic Variants (DGV)BRF1 [DGVbeta]
DECIPHERBRF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBRF1 
Mutations
ICGC Data PortalBRF1 
TCGA Data PortalBRF1 
Broad Tumor PortalBRF1
OASIS PortalBRF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBRF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBRF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BRF1
DgiDB (Drug Gene Interaction Database)BRF1
DoCM (Curated mutations)BRF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BRF1 (select a term)
intoGenBRF1
Cancer3DBRF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604902    616202   
Orphanet23478   
DisGeNETBRF1
MedgenBRF1
Genetic Testing Registry BRF1
NextProtQ92994 [Medical]
TSGene2972
GENETestsBRF1
Target ValidationBRF1
Huge Navigator BRF1 [HugePedia]
snp3D : Map Gene to Disease2972
BioCentury BCIQBRF1
ClinGenBRF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2972
Chemical/Pharm GKB GenePA164741296
Clinical trialBRF1
Miscellaneous
canSAR (ICR)BRF1 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBRF1
EVEXBRF1
GoPubMedBRF1
iHOPBRF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:05:06 CET 2017

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